{"ATC Code":["C01DA02","C - Cardiovascular system","C01 - Cardiac therapy","C01D - Vasodilators used in cardiac diseases","C01DA - Organic nitrates","C01DA02 - Glyceryl trinitrate","C - Cardiovascular system","C05 - Vasoprotectives","C05A - Agents for treatment of hemorrhoids and anal fissures for topical use","C05AE - Muscle relaxants","C05AE01 - Glyceryl trinitrate","QC - Cardiovascular system","QC01 - Cardiac therapy","QC01D - Vasodilators used in cardiac diseases","QC01DA - Organic nitrates","QC01DA02 - Glyceryl trinitrate","QC - Cardiovascular system","QC05 - Vasoprotectives","QC05A - Agents for treatment of hemorrhoids and anal fissures for topical use","QC05AE - Muscle relaxants","QC05AE01 - Glyceryl trinitrate","C01DA02"],"Abbreviation":["NG"],"Absorption, Distribution and Excretion":"Nitroglycerin is rapidly absorbed and is often used in emergency situations for this reason. After a sublingual dose of 0.5 mg of nitroglycerin in patients with ischemic heart disease, the peak concentration (Cmax) was 2.56 ng/mL and the mean Tmax was 4.4 minutes.   The Cmax following a 0.6mg dose of sublingual nitroglycerin was 2.1 ng/mL and the Tmax was 7.2 minutes. The absolute bioavailability following sublingual administration was about 40%. The bioavailability of nitroglycerin depends on several factors, such as mucosal metabolism and hydration status, which both affect the absorption of sublingual drugs.","Adverse Effects":"Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect","Aliases":["Nitroglycerin","Glyceryl trinitrate","Trinitroglycerin","Nitrostat","Nitroglycerine","Nitroglycerol","55-63-0","Trinitroglycerol","Glycerol trinitrate","Nitro-dur","Minitran","Trinitrin","Nitronet","Tridil","Nitroglyn","Nitrolingual","Nitrong","Niong","Nitora","Transderm-nitro","Nitro-Bid","Lenitral","Natispray","Nitrocine","Nitrolan","NitroMist","Glycerin trinitrate","Nitroglicerina","Angiolingual","Cardamist","Klavikordal","Myoglycerin","Niglycon","Nitrodisc","Nitrogard","Nitrolowe","Nitromel","Nitronal","Nitrorectal","Percutol","Perglottal","Rectogesic","Trinalgon","Vasoglyn","Angibid","Angorin","Deponit","Glonoin","Glytrin","Myocon","NitroBid","Soup","Blasting gelatin","Glyceryl nitrate","Nitro-lent","Nitrozell retard","Coro-Nitro","Nitrine-TDC","propane-1,2,3-triyl trinitrate","Nitrolingual Spray","Nitrogliceryna","Cardabid","Glonoinum","Nitrolin","Rectiv","Nitro-Time","Glyceroltrinitraat","Nitriderm TTS","Propanetriol Trinitrate","Deponit 5","Nitroglycerin-ACC","Transderm-N TTS","NITRO IV","1,2,3-Propanetriol, trinitrate","1,2,3-Propanetriyl nitrate","Nitrocontin Continus","Gonitro","Glycerol, nitric acid triester","Glycerintrinitrate","Rcra waste number P081","1,2,3-Propanetriol trinitrate","Trinitrine","SK-106N","Glycerol(trinitrate de)","NK-843","IMX-150","Diluted nitroglycerin","Nitrolingual pumpspray","1,2,3-propanetrioltrinitrate","Nitroglycerin in Dextrose 5%","Dtxsid1021407","Nitric acid triester of gylcerol","Nitroglycerin tablets","G59M7S0WS3","2,3-bis(nitrooxy)propyl nitrate","C01DA02","Mechlorethamine oxide hcl","Chlormethine oxide hydrochloride","Chebi:28787","NitroDur","Nitro Bid","Nitro Dur","Trinitrate, Glyceryl","trinitroglycerine","Trinitrin Tablets","Deponit 10","Glonoine","Natirose","Suscard buccal","Nitro-mack ret","Minitran 5","Trintek 5","Minitran 10","Minitran 15","nitroglycerin tablet","Transiderm-nitro 5","Trintek 10","Trintek 15","Lenitral 7.5","Nitroglycerin Lingual","Nitroglycerin Slocaps","Transiderm-nitro 10","Nitroglycerin In Dextrose","Nitroglycerin, dextrose","Rxhomeo Homeopathic Family Kit","Dtxcid701407","Nitroglycerin Transdermal System","Chebi:25560","Rxhomeo Homeopathic Childrens Kit","Bestmade Natural Products Glonoine","NK 843","Nitroglycerin Sustained-release capsules","Nitroglycerin Transdermal Delivery System","Nitroglycerin Transdermal Infusion System","200-240-8","Model 2004FAA Model 3-EEMK Model 3-EEMK-1 Model AA-8565 Model AA-8565-LATAM Model AWFAREMK Model CHAUTAUQUAEMK Model emk1000-10 Model FAREMK Model PMONTFAREMK Model SWEEMK Model SWEEMK-1 Model QXEMK Model G4FAREMK Model AA-8565","Anginine","Nitroderm","Nitrospan","Transderm Nitro","Nitroderm TTS","Epinitril","Millisrol","Perlinganit","Susadrin","Sustonit","Cordipatch","Corditrine","Nitroletten","Nitroplast","Nitroretard","Nitrostabilin","Nysconitrine","Temponitrin","Trinitrosan","Adesitrin","Chitamite","Nitroglin","Nitromex","Nitromint","Suscard","Triniplas","Trinitrol","Niglin","Gilucor nitro","NitroCor","Transiderm-nitro","Nitro-Span","Transderm-Nitro TTS","NG","NTG","Glycerol Nitric Acid Triester","Gilustenon","Trinitrolong","Vasolator","Nitropen","Sustak","GTN","1,2,3-Propanetriol, 1,2,3-trinitrate","Aldonitrin","Cardiodisco","Colenitral","Discotrine","Glycerylnitrat","Lentonitrina","Nitrobukal","Nitrocerin","Nitrocontin","Nitropatch","Nitropercuten","Nitroperlinit","Nitropront","Nitroprontan","Plastranit","Ratiopharm","TNG","Trinipatch","Angiplex","Angonist","Buccard","Cardinit","Dauxona","Diafusor","Glyceryl","Herwicard","Minitram","Mionitrat","Nitradisc","Nitroard","Nitrobaat","Nitroclyn","Nitrocot","Nitrodyl","Nitroprol","Nitrorex","Nitrovis","Perganit","Polnitrin","Trinitron","Turicard","Vernies","Willong","Anglix","Herzer","Myovin","Nirmin","Nitrek","Sustac","Nitrol Ointment","Trinitrina Erba","Nitradisc Pad","Nitro-Pflaster","Nitrobid Oint","Nitrong Retard","Niong Retard","Nitro Retard","Aquo-Trimitrosan","Nitro Rorer","Nitromack Retard","Nitromint Retard","Nitronal Aqueous","Nitrogard-SR","Mi-Trates","Nitradisc TTS","Nitro-Par","Top-Nitro","Nitrocine 5","Nitrodyl TTS","Nitromint Aerosol","Nitrong-SR","Deponit-5","Neos nitro OPT","Nit-Ret","Nitro Mack Retard","Nitro-M-Bid","Nitro-Mack Retard","Gepan Nitroglicerin","Nitro Dur TTS","Nitroderm TTS-5","GTN-Pohl","Nitroderm TTS Ext","Nitro-Dur 5","Deponit TTS 5","Nitro-Gesanit Retard","Cellegesic","Deponit TTS 10","Minitro","Nitro-Dur 10","Nitrocap","NitroQuick","NitroQuik","Percutol Oint.","Nitrong parenteral","NitrocapT.D.","Glycerine trinitrate","Corangin Nitrokapseln","Trinitroglicerina Fabra","Anogesic","Nitriderm","Nitroject","Vascana","Buccal","Nitrol","Tridil sublin","Trinitrine Simple Laleuf","Aquo-trinitrosan","Nitromist","HSDB 30","SDM No. 17","Nitro-bid","CCRIS 4089","nitroglycerin ointment","Glycerol","Einecs 200-240-8","SK-866","SK-878","UN0143","UN1204","UN3064","UN3319","RCRA waste no. P081","Brn 1802063","Unii-g59m7s0ws3","2,3-dinitrooxypropyl nitrate","Nitrofortin","Nitrolande","Nitrosigma","Reminitrol","Solinitrina","Corangil","Nitrolar","Nitromed","Sutonit","Myocor","trans-nitro","Nitro mack","S.N.G.","MQX-503","Nitro-PRN","MED-2002","UN0144","1,3-bis(nitrooxy)propan-2-yl nitrate","Nitroglycerin Injection","1,2,3-trinitrooxypropane","CHEMBL730","Ec 200-240-8","1,2,3-trinitroglycerin-d5","Schembl15421","4-01-00-02762","UN 0143","UN 0144","UN 1204","Bidd:gt0142","Nitroglycerin, liquid, not desensitized","SDM No. 27","1,2,3-Propanetriol trinatrate","1,2,3-tris-nitryloxy-propane","GTPL7053","Trinitrate 1,2,3-propanetriol","Glyceryl trinitrate solution CRS","Nitric acid triester of glycerol","HMS2094M15","c0061","EBC-26247","Akos030254238","DB00727","Nitroglycerin 100 microg/mL in Acetonitrile","NS00004622","C07455","D00515","En300-7352804","Q162867","Sr-01000944510","Sr-01000944510-1","Nitroglycerin, desensitized with not \u003c40% non-volatile water insoluble phlegmatizer, by mass","Nitroglycerin, desensitized with not \u003c40% non-volatile water insoluble phlegmatizer, by mass [UN0143] "],"Associated Disorders and Diseases":"Contact dermatitis, allergic [Category: Skin Disease]","Biological Half-Life":"Following intravenous administration, the plasma half-life is about three minutes. The estimated plasma half-life following sublingual administration is approximately six minutes. The elimination half-lives of metabolites 1,2-dinitroglycerin and 1,3-dinitroglycerin range between 32 to 26 minutes.","Boiling Point":"Begins to decompose at 122-140 °F (NIOSH, 2024)","CAS":"55-63-0","Chemical Classes":"Other Uses -\u003e Explosives","ChemicalClasses":[],"Chirality":"achiral","Color/Form":"VISCOUS LIQUID","Decomposition":"Begins to decompose at 50-60 °C, appreciable volatile at 100 °C evolves nitrous yellow vapors at 135 °C.","Density":"1.6 (NIOSH, 2024) - Denser than water; will sink g/cm\u003csup\u003e3\u003c/sup\u003e","Drug Classes":["Breast Feeding","Lactation","Milk, Human","Cardiovascular Agents","Vasodilator Agents"],"Drug Indication":"Sublingual nitroglycerin is indicated for the acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease. Transdermal nitroglycerin is indicated for the prevention of angina pectoris due to coronary artery disease.  Intravenous nitroglycerin is indicated for the treatment of peri-operative hypertension; for control of congestive heart failure in the setting of acute myocardial infarction; for treatment of angina pectoris in patients who have not responded to sublingual nitroglycerin and beta (β)-blockers; and for induction of intraoperative hypotension.   Topical nitroglycerin ointment is used to treat moderate to severe pain associated with chronic anal fissure.","Drug Warnings":"Untoward responses to therapeutic use of nitrites are almost all secondary to actions on cardiovascular system. Headache is common ... Transient episodes of dizziness, weakness, and other manifestations of cerebral ischemia associated with postural hypotension may develop. ... In many pt, particularly if standing immobile, and may ... progress to loss of consciousness. This reaction appears to be accentuated by alcohol. ... methemoglobinemia. /organic nitrites/","Ecotoxicity Values":"LC50 Bluegill 1.28 mg/l/96 hr @ pH 6.0. /Static bioassay/","Esters":[],"European Community (EC) Number":"200-240-8","FDA Pharmacological Classification":[{"Name":"FDA UNII","ReferenceNumber":43,"Value":{"StringWithMarkup":[{"String":"G59M7S0WS3"}]}},{"Name":"Active Moiety","ReferenceNumber":43,"Value":{"StringWithMarkup":[{"String":"NITROGLYCERIN"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":43,"Value":{"StringWithMarkup":[{"Markup":[{"Extra":"CID-943","Length":7,"Start":40,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/Nitrate"}],"String":"Established Pharmacologic Class [EPC] - Nitrate Vasodilator"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":43,"Value":{"StringWithMarkup":[{"String":"Chemical Structure [CS] - Nitrates"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":43,"Value":{"StringWithMarkup":[{"String":"Physiologic Effects [PE] - Vasodilation"}]}},{"Name":"FDA Pharmacology Summary","ReferenceNumber":43,"Value":{"StringWithMarkup":[{"Markup":[{"Extra":"CID-4510","Length":13,"Start":0,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/Nitroglycerin"},{"Extra":"CID-943","Length":7,"Start":19,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/Nitrate"},{"Extra":"CID-4510","Length":13,"Start":66,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/nitroglycerin"}],"String":"Nitroglycerin is a Nitrate Vasodilator. The physiologic effect of nitroglycerin is by means of Vasodilation."}]}},{"Name":"Non-Proprietary Name","ReferenceNumber":55,"Value":{"StringWithMarkup":[{"String":"GLONOINUM"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":55,"Value":{"StringWithMarkup":[{"Markup":[{"Extra":"CID-943","Length":7,"Start":0,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/Nitrate"}],"String":"Nitrate Vasodilator [EPC]; Vasodilation [PE]; Nitrates [CS]"}]}},{"Name":"Non-Proprietary Name","ReferenceNumber":56,"Value":{"StringWithMarkup":[{"String":"NITROGLYCERIN"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":56,"Value":{"StringWithMarkup":[{"Markup":[{"Extra":"CID-943","Length":7,"Start":0,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/Nitrate"}],"String":"Nitrate Vasodilator [EPC]; Vasodilation [PE]; Nitrates [CS]"}]}},{"Name":"Non-Proprietary Name","ReferenceNumber":57,"Value":{"StringWithMarkup":[{"String":"NITROGLYCERIN LINGUAL"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":57,"Value":{"StringWithMarkup":[{"Markup":[{"Extra":"CID-943","Length":7,"Start":0,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/Nitrate"}],"String":"Nitrate Vasodilator [EPC]; Vasodilation [PE]; Nitrates [CS]"}]}},{"Name":"Non-Proprietary Name","ReferenceNumber":58,"Value":{"StringWithMarkup":[{"String":"NITROGLYCERIN, DEXTROSE"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":58,"Value":{"StringWithMarkup":[{"Markup":[{"Extra":"CID-943","Length":7,"Start":34,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/Nitrate"}],"String":"Nitrates [CS]; Vasodilation [PE]; Nitrate Vasodilator [EPC]"}]}},{"Name":"Non-Proprietary Name","ReferenceNumber":59,"Value":{"StringWithMarkup":[{"String":"NITROGLYCERIN TABLET"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":59,"Value":{"StringWithMarkup":[{"Markup":[{"Extra":"CID-943","Length":7,"Start":0,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/Nitrate"}],"String":"Nitrate Vasodilator [EPC]; Vasodilation [PE]; Nitrates [CS]"}]}},{"Name":"Non-Proprietary Name","ReferenceNumber":60,"Value":{"StringWithMarkup":[{"String":"GLONOINE"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":60,"Value":{"StringWithMarkup":[{"Markup":[{"Extra":"CID-943","Length":7,"Start":15,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/Nitrate"}],"String":"Nitrates [CS]; Nitrate Vasodilator [EPC]; Vasodilation [PE]"}]}}],"Flash Point":"Explodes (NIOSH, 2024)","Formating":[],"HMDB ID":"HMDB0014865","HeavyAtomCount":15,"Human Drugs":"Breast Feeding; Lactation; Milk, Human; Cardiovascular Agents; Vasodilator Agents","IUPACName":"1,3-dinitrooxypropan-2-yl nitrate","Impurities":"Nitric acid, arising from imperfect washing, hydrolysis or thermal aging (eg heating to 50 °C)","InChI":"InChI=1S/C3H5N3O9/c7-4(8)13-1-3(15-6(11)12)2-14-5(9)10/h3H,1-2H2","InChIKey":"SNIOPGDIGTZGOP-UHFFFAOYSA-N","Interactions":"Alcoholic beverages may precipitate /nitroglycerin/ poisoning and increase its severity.","MeSH Headers":[{"Id":"M0009426","Link":"https://id.nlm.nih.gov/mesh/M0009426.html","Name":"Nitroglycerin","Ref":109},{"Id":"M0009427","Link":"https://id.nlm.nih.gov/mesh/M0009427.html","Name":"Nitro-Dur","Ref":111},{"Id":"M0009429","Link":"https://id.nlm.nih.gov/mesh/M0009429.html","Name":"Tridil","Ref":112},{"Id":"M0009430","Link":"https://id.nlm.nih.gov/mesh/M0009430.html","Name":"Trinitrin","Ref":113},{"Id":"M0009431","Link":"https://id.nlm.nih.gov/mesh/M0009431.html","Name":"Anginine","Ref":114},{"Id":"M0009434","Link":"https://id.nlm.nih.gov/mesh/M0009434.html","Name":"Nitro-Bid","Ref":115},{"Id":"M0009438","Link":"https://id.nlm.nih.gov/mesh/M0009438.html","Name":"Nitroglyn","Ref":116},{"Id":"M0009440","Link":"https://id.nlm.nih.gov/mesh/M0009440.html","Name":"Nitrolan","Ref":117},{"Id":"M0009441","Link":"https://id.nlm.nih.gov/mesh/M0009441.html","Name":"Nitrong","Ref":118},{"Id":"M0009443","Link":"https://id.nlm.nih.gov/mesh/M0009443.html","Name":"Nitrostat","Ref":119},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":120},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":148},{"Id":"M0022559","Link":"https://id.nlm.nih.gov/mesh/M0022559.html","Name":"Vasodilator Agents","Ref":149},{"Id":"M0496773","Link":"https://id.nlm.nih.gov/mesh/M0496773.html","Name":"Explosive Agents","Ref":150}],"MeSH Pharmacological Classification":[{"Id":"M0022559","Link":"https://id.nlm.nih.gov/mesh/M0022559.html","Name":"Vasodilator Agent","Ref":149},{"Id":"M0496773","Link":"https://id.nlm.nih.gov/mesh/M0496773.html","Name":"Explosive Agent","Ref":150}],"Mechanism of Action":"Nitroglycerin is converted by mitochondrial aldehyde dehydrogenase in smooth muscle cells to nitric oxide (NO), a potent vasodilator. NO activates the enzyme guanylate cyclase, which converts guanosine triphosphate (GTP) to cyclic guanosine 3',5'-monophosphate (cGMP) in vascular smooth muscle and other tissues. cGMP is an endogenous vasodilator of vascular smooth muscle: it causes protein kinase-dependent phosphorylation and activates downstream cascades that promote relaxation and increased blood flow in veins, arteries and cardiac tissue. An _in vitro_ study using mouse aorta suggests that nitric oxide, an active metabolite of nitroglycerin, targets the natriuretic peptide receptors.","Melting Point":"56 °","Metabolism/Metabolites":"Mitochondrial aldehyde dehydrogenase 2 (ALDH2) promotes the bioactivation of nitroglycerin. Nitroglycerin is metabolized to nitrite; 1,2-glyceryl dinitrate; and 1,3 glyceryl dinitrate. Nitrite is further metabolized to nitric oxide. 1,2- and 1,3-dinitroglycerols are less biologically active than nitroglycerin but they have longer half-lives, which explains some prolonged effects of nitrates. Both dinitrates are finally metabolized to glycerol, carbon dioxide, and mononitrates that do not have vasodilatory actions.  Nitroglycerin can also chemically react with a thiol to generate an intermediate S-nitrosothiol, which resulted in further production of nitric oxide.","MolecularFormula":"C\u003csub\u003e3\u003c/sub\u003eH\u003csub\u003e5\u003c/sub\u003eN\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e9\u003c/sub\u003e","MolecularWeight":"227.09 g/mol","Non-Human Toxicity Values":"LD50 Rat oral (male) 822 mg/kg","Pharmacodynamics":"Nitroglycerin causes the relaxation of vascular smooth muscles, causing arteriolar and venous dilatation. It increases blood flow to the myocardium and reduces cardiac preload and afterload, decreasing myocardial wall stress and ameliorating anginal symptoms. Nitroglycerin also reduces coronary artery spasm, decreasing systemic vascular resistance as well as systolic and diastolic blood pressure.  Like other organic nitrates, repeated and prolonged administration of nitroglycerin can lead to the development of tolerance or desensitization of vascular smooth muscle to further nitroglycerin-induced vasorelaxation. This loss of efficacy may be associated with the inhibition of mitochondrial aldehyde dehydrogenase, which is an important enzyme involved in the bioactivation of nitroglycerin. Nitroglycerin tolerance may be accompanied by pro-oxidant effects, endothelial dysfunction, and increased sensitivity to vasoconstrictors.","Physical Description":"Glyceryl trinitrate solution appears as a colorless solution of glyceryl trinitrate (nitroglycerin) in water. If allowed to dry out, the remaining nitroglycerin is explosive.","PubChemId":4510,"Record Description":["LiverTox|Cardiac|Angina|Nitrate"],"Records":{"UNII":{"Impurities":["glyceryl 1-nitrate","glyceryl 1,3-dinitrate","glyceryl 1,2-dinitrate","glyceryl 2-nitrate"]}},"RefChem":"6474","RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Nitroglycerine","Name":"Nitroglycerine","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q162867","Name":"Nitroglycerine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB00727","Name":"Nitroglycerine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/4510","Name":"Nitroglycerine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=55-63-0","Name":"Nitroglycerine","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0014865","Name":"Nitroglycerine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C07455","Name":"Nitroglycerine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/G59M7S0WS3","Name":"Nitroglycerine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021407","Name":"Nitroglycerine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 4510, Nitroglycerin. Accessed February 17, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/4510\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/4510\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Nitroglycerine. UNII: G59M7S0WS3. Global Substance Registration System. Accessed February 17, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/G59M7S0WS3\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/G59M7S0WS3\u003c/a\u003e"],"SMILES":"C(C(CO[N+](=O)[O-])O[N+](=O)[O-])O[N+](=O)[O-]","SaltData":[],"Salts":[],"Solubility":"0.1 % (NIOSH, 2024)","Stability/Shelf Life":"Tablets of nitorglycerin are stable but should be dispensed in glass containers and protected from moisture, light and extremes of temperature.","StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 111.224 67.269\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h112v68H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m42.414 18.468 13.198 7.62M55.612 26.088l13.198-7.62M68.81 18.468l9.915 5.724M85.287 24.195l6.766-3.907\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m99.505 19.541 6.226 3.595M98.286 21.653l6.226 3.595\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m99.505 19.541 3.113 1.797M99.505 19.541l3.113 1.797\" class=\"hi\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m105.731 23.136-3.113-1.798\" class=\"hi\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m98.286 21.653 3.113 1.797M98.286 21.653l3.113 1.797\" class=\"hi\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m104.512 25.248-3.113-1.798\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath d=\"M95.207 14.251V7.149M55.612 26.088v11.318M52.331 43.222l-4.27 2.465\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M43.633 52.797v7.469M41.195 52.797v7.469\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"M43.633 52.797v3.734M43.633 52.797v3.734\" class=\"hi\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"M43.633 60.266v-3.735\" class=\"hi\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"M41.195 52.797v3.734\" class=\"hi\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"M41.195 60.266v-3.735\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath d=\"m39.261 47.127-6.77-3.908M42.414 18.468l-9.92 5.727M25.932 24.192l-6.226-3.595\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m13.474 21.344-6.767 3.907M12.255 19.232l-6.767 3.907\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m13.474 21.344-3.383 1.953\" class=\"hi\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m6.707 25.251 3.384-1.954\" class=\"hi\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m12.255 19.232-3.383 1.953\" class=\"hi\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m5.488 23.139 3.384-1.954\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath d=\"M16.017 14.251V7.149\" class=\"bond\"/\u003e\u003cpath stroke=\"none\" d=\"M84.268 26.085q0 .756-.256 1.327-.256.566-.756.881t-1.244.316q-.756 0-1.263-.316-.506-.315-.756-.887-.244-.571-.244-1.333 0-.75.244-1.31.25-.566.756-.881.507-.316 1.274-.316.733 0 1.233.316.5.31.756.875.256.566.256 1.328m-3.864 0q0 .922.387 1.458.393.53 1.221.53.839 0 1.22-.53.387-.536.387-1.458 0-.929-.387-1.453-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.453\" class=\"atom\"/\u003e\u003cg fill=\"#3050f8\" stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M97.148 20.917h-.721l-2.619-4.066h-.03l.03.596q.024.357.024.732v2.738h-.566v-4.899h.714l2.608 4.054h.03l-.018-.327-.024-.477q-.006-.262-.006-.482v-2.768h.578zM98.824 15.873h.818v.293h-.818v.847h-.297v-.847h-.818v-.293h.818v-.85h.297z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"none\" d=\"M110.664 26.085q0 .756-.256 1.327-.256.566-.756.881t-1.244.316q-.756 0-1.262-.316-.506-.315-.756-.887-.244-.571-.244-1.333 0-.75.244-1.31.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.31.756.875.256.566.256 1.328m-3.863 0q0 .922.387 1.458.393.53 1.22.53.839 0 1.22-.53.387-.536.387-1.458 0-.929-.387-1.453-.381-.524-1.208-.524-.834 0-1.226.524-.393.524-.393 1.453\" class=\"atom\"/\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M97.466 3.225q0 .756-.256 1.327-.256.566-.756.881t-1.244.316q-.756 0-1.262-.316-.506-.315-.756-.887-.244-.571-.244-1.333 0-.75.244-1.31.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.31.756.875.256.566.256 1.328m-3.864 0q0 .922.387 1.458.393.53 1.221.53.839 0 1.22-.53.387-.536.387-1.458 0-.929-.387-1.453-.381-.524-1.208-.524-.834 0-1.227.524t-.393 1.453M99.96.56v.293h-1.932V.56z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"none\" d=\"M57.871 41.325q0 .756-.256 1.327-.256.566-.756.881t-1.244.316q-.756 0-1.262-.316-.506-.315-.756-.887-.244-.571-.244-1.333 0-.75.244-1.31.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.31.756.875.256.566.256 1.328m-3.863 0q0 .922.387 1.458.393.53 1.22.53.839 0 1.22-.53.387-.536.387-1.458 0-.929-.387-1.453-.381-.524-1.208-.524-.833 0-1.226.524t-.393 1.453\" class=\"atom\"/\u003e\u003cg fill=\"#3050f8\" stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M44.355 51.397h-.721l-2.619-4.066h-.03l.03.596q.024.357.024.732v2.738h-.566v-4.899h.715l2.607 4.054h.03l-.018-.327-.024-.477q-.006-.262-.006-.482v-2.768h.578zM46.031 46.353h.818v.293h-.818v.847h-.297v-.847h-.818v-.293h.818v-.85h.297z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"none\" d=\"M44.673 64.185q0 .756-.256 1.327-.256.566-.756.881t-1.244.316q-.756 0-1.262-.316-.506-.315-.756-.887-.244-.571-.244-1.333 0-.75.244-1.31.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.31.756.875.256.566.256 1.328m-3.863 0q0 .922.386 1.458.393.53 1.221.53.839 0 1.22-.53.387-.536.387-1.458 0-.929-.387-1.453-.381-.524-1.208-.524-.834 0-1.227.524-.392.524-.392 1.453\" class=\"atom\"/\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M31.475 41.325q0 .756-.256 1.327-.256.566-.756.881t-1.244.316q-.756 0-1.262-.316-.506-.315-.756-.887-.245-.571-.245-1.333 0-.75.245-1.31.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.31.756.875.256.566.256 1.328m-3.864 0q0 .922.387 1.458.393.53 1.221.53.839 0 1.22-.53.387-.536.387-1.458 0-.929-.387-1.453-.381-.524-1.208-.524-.834 0-1.227.524t-.393 1.453M26.395 38.66v.293h-1.933v-.293z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"none\" d=\"M31.475 26.085q0 .756-.256 1.327-.256.566-.756.881t-1.244.316q-.756 0-1.262-.316-.506-.315-.756-.887-.245-.571-.245-1.333 0-.75.245-1.31.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.31.756.875.256.566.256 1.328m-3.864 0q0 .922.387 1.458.393.53 1.221.53.839 0 1.22-.53.387-.536.387-1.458 0-.929-.387-1.453-.381-.524-1.208-.524-.834 0-1.227.524t-.393 1.453\" class=\"atom\"/\u003e\u003cg fill=\"#3050f8\" stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M17.958 20.917h-.72l-2.62-4.066h-.029l.029.596q.024.357.024.732v2.738h-.565v-4.899h.714l2.608 4.054h.029l-.018-.327-.023-.477q-.006-.262-.006-.482v-2.768h.577zM19.634 15.873h.818v.293h-.818v.847h-.296v-.847h-.818v-.293h.818v-.85h.296z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"none\" d=\"M5.078 26.085q0 .756-.256 1.327-.256.566-.756.881t-1.244.316q-.756 0-1.262-.316-.506-.315-.756-.887-.244-.571-.244-1.333 0-.75.244-1.31.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.31.756.875.256.566.256 1.328m-3.863 0q0 .922.387 1.458.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.458 0-.929-.387-1.453-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.453\" class=\"atom\"/\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M18.277 3.225q0 .756-.256 1.327-.256.566-.756.881t-1.245.316q-.756 0-1.262-.316-.506-.315-.756-.887-.244-.571-.244-1.333 0-.75.244-1.31.25-.566.756-.881t1.274-.316q.733 0 1.233.316.5.31.756.875.256.566.256 1.328m-3.864 0q0 .922.387 1.458.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.458 0-.929-.387-1.453-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.453M20.771.56v.293h-1.933V.56z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m78.725 24.192-4.958-2.862M85.287 24.195l3.383-1.953\" class=\"hi\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m92.053 20.288-3.383 1.954M95.207 14.251V10.7M95.207 14.251V10.7\" class=\"hi\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"M95.207 7.149V10.7M55.612 37.406v-5.659M52.331 43.222l-2.135 1.232\" class=\"hi\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m48.061 45.687 2.135-1.233M48.061 45.687l2.135-1.233M39.261 47.127l-3.385-1.954M39.261 47.127l-3.385-1.954\" class=\"hi\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m32.491 43.219 3.385 1.954M32.491 43.219l3.385 1.954M32.494 24.195l4.96-2.864M25.932 24.192l-3.113-1.797\" class=\"hi\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m19.706 20.597 3.113 1.798M19.706 20.597l3.113 1.798M16.017 14.251V10.7M16.017 14.251V10.7\" class=\"hi\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"M16.017 7.149V10.7\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Taste":"Sweet, burning taste","Therapeutic Uses":"Vasodilator Agents","Title":"Nitroglycerine","UNII":"G59M7S0WS3","Wikidata":"Q162867","Wikipedia":"Nitroglycerine","XLogP":1.6}