{"Abbreviation":[],"Aliases":["Metamizol","Methamizole","Novamine sulfone","Methamizole-","(antipyrinylmethylamino)methanesulfonic acid","Methanesulfonic acid, (antipyrinylmethylamino)-","N-Methyl-N-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl)aminomethanesulfosaeure","[(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl)amino]methanesulfonic acid","Methanesulfonic acid, ((2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino)-","N-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl)-N-methylaminomethanesulfonic acid","[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulfonic acid","Methanesulfonic acid, [(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]-","Dolemicin","((2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino)methanesulfonic acid","((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl)amino)methanesulfonic acid","256-627-7","Metamizolum","pyridone","Metamizole sodium ;Analgin","((2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino)methanesulphonic acid","Analgin","[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulphonic acid","Metamizole free","KBio2_004729","Melubrin, methyl-"],"Biological Half-Life":"_In vitro_, the half-life of metamizole is 16 minutes. The half-life of 4-methyl-amino-antipyrine (MAA), its active metabolite, ranges from 2.6 to 3.5 hours.","CAS":"50567-35-6","ChEBI":"CHEBI:62088","ChEMBL":"CHEMBL461522","ChemicalClasses":["aniline"],"Chirality":"achiral","Classes":["Analgesic","Antipyretics","CYP3A4 inducer"],"Drug Classes":"Breast Feeding; Lactation; Milk, Human; Analgesic Agents; Anti-inflammatory Agents, Nonsteroidal","Drug Indication":"Metamizole is banned in several countries, where it was previously used as a powerful analgesic and fever reducer. In countries where it is still available, metamizole is indicated for acute severe pain after injuries or surgeries, colic, tumor pain, and acute or severe pain symptoms, as well as high fever if other treatments are unsuccessful.","EINECS":"256-627-7","Erowid Experience Reports":null,"Esters":[],"European Community (EC) Number":"256-627-7","Formating":[],"HMDB ID":"HMDB0254502","HeavyAtomCount":21,"Human Drugs":"Breast Feeding; Lactation; Milk, Human; Analgesic Agents; Anti-inflammatory Agents, Nonsteroidal","IUPACName":"[(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-methylamino]methanesulfonic acid","InChI":"InChI=1S/C13H17N3O4S/c1-10-12(14(2)9-21(18,19)20)13(17)16(15(10)3)11-7-5-4-6-8-11/h4-8H,9H2,1-3H3,(H,18,19,20)","InChIKey":"LVWZTYCIRDMTEY-UHFFFAOYSA-N","MolecularFormula":"C\u003csub\u003e13\u003c/sub\u003eH\u003csub\u003e17\u003c/sub\u003eN\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003eS","MolecularWeight":"311.36 g/mol","Pharmacodynamics":"Metamizole is a strong analgesic and antipyretic with spasmolytic properties. It has weak anti-inflammatory or antithrombotic properties and does not follow the same mechanism of action as conventional non-steroidal anti-inflammatory drugs (NSAIDs). Metamizole can lead to agranulocytosis, a life-threatening side effect where a patient’s neutrophil count falls below 500 cells per microliter. It has been shown that metamizole-induced agranulocytosis is caused by the development of drug-dependent anti-neutrophil antibodies requiring covalent binding of neutrophils to metamizole and its metabolites.","PubChemId":3111,"RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Metamizole","Name":"Metamizole","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB04817","Name":"Metamizole","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/3111","Name":"Metamizole","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL461522","Name":"Metamizole","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:62088","Name":"Metamizole","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=50567-35-6","Name":"Metamizole","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0254502","Name":"Metamizole","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D08188","Name":"Metamizole","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/934T64RMNJ","Name":"Metamizole","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID6044143","Name":"Metamizole","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 3111, Metamizole. Accessed August 14, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/3111\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/3111\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Metamizole. UNII: 934T64RMNJ. Global Substance Registration System. Accessed August 14, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/934T64RMNJ\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/934T64RMNJ\u003c/a\u003e"],"SMILES":"CC1=C(C(=O)N(N1C)C2=CC=CC=C2)N(C)CS(=O)(=O)O","SaltData":[{"AcidCount":1,"Amine":"Metamizole","AmineCount":1,"Formula":"[Na+]","Name":"sodium","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 125.27 96.317\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h126v97H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m79.929 61.254-15.156-1.599\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m64.773 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