{"Abbreviation":"","Aliases":["MET-enkephalin","H-Tyr-Gly-Gly-Phe-Met-OH","Methionine enkephalin","Tyr-Gly-Gly-Phe-Met-OH","Metenkefalin","Tyr-gly-gly-phe-met","(Met5)-enkephalin","[Met]enkephalin","Opioid growth factor","Enkephalin, methionine"],"Biological Half-Life":"The half life of metenkefalin is 4.2-39 minutes.","CAS":"58569-55-4","ChEBI":"CHEBI:6618","ChEMBL":"CHEMBL13786","ChemicalClasses":["amino acid"],"Chirality":"absolute","ChiralityAminoAcid":true,"Dosing Info":[],"Drug Indication":"Metenkefalin is indicated in Bosnia for the treatment of relapsing-remitting multiple sclerosis.","DrugClasses":[],"EINECS":"261-335-8","European Community (EC) Number":"261-335-8","FullSalts":["Met-enkephalin acetate"],"HeavyAtomCount":40,"IUPACName":"(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid","InChI":"InChI=1S/C27H35N5O7S/c1-40-12-11-21(27(38)39)32-26(37)22(14-17-5-3-2-4-6-17)31-24(35)16-29-23(34)15-30-25(36)20(28)13-18-7-9-19(33)10-8-18/h2-10,20-22,33H,11-16,28H2,1H3,(H,29,34)(H,30,36)(H,31,35)(H,32,37)(H,38,39)/t20-,21-,22-/m0/s1","InChIKey":"YFGBQHOOROIVKG-FKBYEOEOSA-N","MeSH Pharmacological Classification":"Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function. (See all compounds classified as Neurotransmitter Agents.)","MolecularFormula":"C\u003csub\u003e27\u003c/sub\u003eH\u003csub\u003e35\u003c/sub\u003eN\u003csub\u003e5\u003c/sub\u003eO\u003csub\u003e7\u003c/sub\u003eS","MolecularWeight":"573.7 g/mol","Opticalactivity":"UNSPECIFIED","PrevSalts":["acetate"],"PubChemId":443363,"Record Description":["Metenkefalin  is an endogenous opioid and beta-endorphin. It has been shown to reduce chromosomal abberations in patients with multiple sclerosis. Metenkefalin, along with [tridecactide], are under investigation as an immunomodulatory therapy for moderate to severe COVID-19.","MET-enkephalin has been reported in Mytilus edulis and Apis cerana with data available.","Metenkefalin is a synthetic form of the naturally occurring, endogenous opioid peptide, metenkephalin, and agonist of the zeta- and delta-opioid receptor and, to a lesser extent the mu-opioid receptor, with potential analgesic, neuromodulatory, immunomodulatory, anti-inflammatory, antinociceptive/analgesic, antidepressant, and gastrointestinal (GI) motility modulating activities. Upon administration, metenkefalin mimics its endogenous ligand and targets, binds to and activates the opioid receptors. This leads to an analgesic effect, inhibits neuropathic pain, and inhibits GI muscle contractility. Binding to the opioid growth factor receptor (OGFR; zeta-opioid receptor), enhances tissue growth and regeneration. In addition, activation of delta-opioid receptors located on a variety of immune cells may modulate the inflammatory immune response. This may inhibit the secretion of pro-inflammatory cytokines and the proliferation of leukocytes.","Opioid Growth Factor is an endogenous pentapeptide with potential antineoplastic and antiangiogenic activities. Opioid growth factor (OGF) binds to and activates the OGF receptor, present on some tumor cells and vascular cells, thereby inhibiting tumor cell proliferation and angiogenesis. (NCI05)","Met-Enkephalin is a Protein drug.","One of the endogenous pentapeptides with morphine-like activity. It differs from LEU-ENKEPHALIN by the amino acid METHIONINE in position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN."],"References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Met-enkephalin","Name":"Met-enkephalin","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q1960495","Name":"Met-enkephalin","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB12668","Name":"Met-enkephalin","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/443363","Name":"Met-enkephalin","Sub":false}]},{"Name":"ChemSpider","Urls":[{"Link":"https://www.chemspider.com/Chemical-Structure.4932480.html","Name":"Met-enkephalin","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL13786","Name":"Met-enkephalin","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:6618","Name":"Met-enkephalin","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=58569-55-4","Name":"Met-enkephalin","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C11684","Name":"Met-enkephalin","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/9JEZ9OD3AS","Name":"Met-enkephalin","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID80332078","Name":"Met-enkephalin","Sub":false}]}],"SMILES":"CSCC[C@@H](C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)[C@H](CC2=CC=C(C=C2)O)N","Salts":["acetate"],"SaltsAcidCount":[0],"SaltsAmineCount":[1],"SaltsUNII":["RBM01752JM"],"StoreUNII":["9JEZ9OD3AS"],"StructureBase64":"<svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" height="211.79mm" version="1.2" viewBox="0 0 193.225 211.79" width="193.225mm">
      
    <desc>Generated by the Chemistry Development Kit (http://github.com/cdk)</desc>
      
    <g fill="#3050F8" stroke="#000000" stroke-linecap="round" stroke-linejoin="round" stroke-width=".7">
            
        <rect fill="#FFFFFF" height="212.0" stroke="none" width="194.0" x=".0" y=".0"/>
            
        <g class="mol" id="mol1">
                  
            <line class="bond" id="mol1bnd1" x1="1.038" x2="11.493" y1="25.941" y2="19.905"/>
                  
            <line class="bond" id="mol1bnd2" x1="16.994" x2="27.435" y1="19.913" y2="25.941"/>
                  
            <line class="bond" id="mol1bnd3" x1="27.435" x2="40.633" y1="25.941" y2="18.321"/>
                  
            <line class="bond" id="mol1bnd4" x1="40.633" x2="53.831" y1="18.321" y2="25.941"/>
                  
            <line class="bond" id="mol1bnd5" x1="53.831" x2="67.029" y1="25.941" y2="18.321"/>
                  
            <g class="bond" id="mol1bnd6">
                        
                <line x1="65.81" x2="65.81" y1="19.025" y2="7.002"/>
                        
                <line x1="68.249" x2="68.249" y1="19.025" y2="7.002"/>
                      
                <line class="hi" stroke="#FF0D0D" x1="65.81" x2="65.81" y1="7.001999999999999" y2="13.013499999999999"/>
                <line class="hi" stroke="#FF0D0D" x1="68.249" x2="68.249" y1="7.001999999999999" y2="13.013499999999999"/>
            </g>
                  
            <line class="bond" id="mol1bnd7" x1="67.029" x2="76.944" y1="18.321" y2="24.045"/>
                  
            <path class="bond" d="M54.181 25.941h-.7l-1.308 11.39h1.658h1.658z" fill="#000000" id="mol1bnd8" stroke="none"/>
                  
            <line class="bond" id="mol1bnd9" x1="56.984" x2="67.029" y1="43.002" y2="48.801"/>
                  
            <g class="bond" id="mol1bnd10">
                        
                <line x1="65.81" x2="76.337" y1="48.097" y2="42.02"/>
                        
                <line x1="67.029" x2="77.556" y1="50.209" y2="44.131"/>
                      
                <line class="hi" stroke="#FF0D0D" x1="76.337" x2="71.0735" y1="42.02" y2="45.0585"/>
                <line class="hi" stroke="#FF0D0D" x1="77.556" x2="72.29249999999999" y1="44.131" y2="47.17"/>
            </g>
                  
            <line class="bond" id="mol1bnd11" x1="67.029" x2="67.029" y1="48.801" y2="64.041"/>
                  
            <line class="bond" id="mol1bnd12" x1="67.029" x2="53.831" y1="64.041" y2="71.661"/>
                  
            <line class="bond" id="mol1bnd13" x1="53.831" x2="40.633" y1="71.661" y2="64.041"/>
                  
            <g class="bond" id="mol1bnd14">
                        
                <line x1="27.43" x2="40.633" y1="71.67" y2="64.041"/>
                        
                <line x1="27.429" x2="38.195" y1="68.854" y2="62.634"/>
                      
            </g>
                  
            <line class="bond" id="mol1bnd15" x1="27.43" x2="14.232" y1="71.67" y2="64.05"/>
                  
            <g class="bond" id="mol1bnd16">
                        
                <line x1="14.236" x2="14.232" y1="48.801" y2="64.05"/>
                        
                <line x1="16.674" x2="16.67" y1="50.209" y2="62.642"/>
                      
            </g>
                  
            <line class="bond" id="mol1bnd17" x1="14.236" x2="27.44" y1="48.801" y2="41.173"/>
                  
            <g class="bond" id="mol1bnd18">
                        
                <line x1="40.638" x2="27.44" y1="48.793" y2="41.173"/>
                        
                <line x1="38.199" x2="27.44" y1="50.2" y2="43.989"/>
                      
            </g>
                  
            <line class="bond" id="mol1bnd19" x1="40.633" x2="40.638" y1="64.041" y2="48.793"/>
                  
            <path class="bond" d="M67.204 63.738l-.35 .606l9.379 6.953l.841 -1.456l.841 -1.457z" fill="#000000" id="mol1bnd20" stroke="none"/>
                  
            <line class="bond" id="mol1bnd21" x1="80.228" x2="80.228" y1="75.511" y2="86.901"/>
                  
            <g class="bond" id="mol1bnd22">
                        
                <line x1="81.447" x2="70.917" y1="87.605" y2="93.684"/>
                        
                <line x1="80.228" x2="69.698" y1="85.493" y2="91.573"/>
                      
                <line class="hi" stroke="#FF0D0D" x1="70.917" x2="76.182" y1="93.684" y2="90.6445"/>
                <line class="hi" stroke="#FF0D0D" x1="69.698" x2="74.963" y1="91.573" y2="88.53299999999999"/>
            </g>
                  
            <line class="bond" id="mol1bnd23" x1="80.228" x2="93.426" y1="86.901" y2="94.521"/>
                  
            <line class="bond" id="mol1bnd24" x1="93.426" x2="93.426" y1="94.521" y2="105.911"/>
                  
            <line class="bond" id="mol1bnd25" x1="96.579" x2="106.624" y1="111.582" y2="117.381"/>
                  
            <g class="bond" id="mol1bnd26">
                        
                <line x1="105.405" x2="115.932" y1="116.677" y2="110.6"/>
                        
                <line x1="106.624" x2="117.151" y1="118.789" y2="112.711"/>
                      
                <line class="hi" stroke="#FF0D0D" x1="115.932" x2="110.6685" y1="110.6" y2="113.6385"/>
                <line class="hi" stroke="#FF0D0D" x1="117.151" x2="111.88749999999999" y1="112.711" y2="115.75"/>
            </g>
                  
            <line class="bond" id="mol1bnd27" x1="106.624" x2="106.624" y1="117.381" y2="132.621"/>
                  
            <line class="bond" id="mol1bnd28" x1="106.624" x2="116.669" y1="132.621" y2="138.421"/>
                  
            <line class="bond" id="mol1bnd29" x1="119.822" x2="119.822" y1="144.091" y2="155.481"/>
                  
            <g class="bond" id="mol1bnd30">
                        
                <line x1="121.041" x2="110.512" y1="156.185" y2="162.264"/>
                        
                <line x1="119.822" x2="109.293" y1="154.073" y2="160.153"/>
                      
                <line class="hi" stroke="#FF0D0D" x1="110.512" x2="115.7765" y1="162.264" y2="159.2245"/>
                <line class="hi" stroke="#FF0D0D" x1="109.293" x2="114.5575" y1="160.153" y2="157.113"/>
            </g>
                  
            <line class="bond" id="mol1bnd31" x1="119.822" x2="133.02" y1="155.481" y2="163.101"/>
                  
            <line class="bond" id="mol1bnd32" x1="133.02" x2="133.02" y1="163.101" y2="178.341"/>
                  
            <line class="bond" id="mol1bnd33" x1="133.02" x2="146.219" y1="178.341" y2="185.961"/>
                  
            <g class="bond" id="mol1bnd34">
                        
                <line x1="159.379" x2="146.219" y1="178.276" y2="185.961"/>
                        
                <line x1="159.407" x2="148.65" y1="181.084" y2="187.365"/>
                      
            </g>
                  
            <line class="bond" id="mol1bnd35" x1="159.379" x2="172.466" y1="178.276" y2="185.576"/>
                  
            <g class="bond" id="mol1bnd36">
                        
                <line x1="172.802" x2="172.466" y1="201.263" y2="185.576"/>
                        
                <line x1="170.334" x2="170.058" y1="199.881" y2="187.025"/>
                      
            </g>
                  
            <line class="bond" id="mol1bnd37" x1="172.802" x2="159.642" y1="201.263" y2="208.948"/>
                  
            <g class="bond" id="mol1bnd38">
                        
                <line x1="146.145" x2="159.642" y1="200.946" y2="208.948"/>
                        
                <line x1="148.59" x2="159.651" y1="199.561" y2="206.119"/>
                      
            </g>
                  
            <line class="bond" id="mol1bnd39" x1="146.219" x2="146.145" y1="185.961" y2="200.946"/>
                  
            <line class="bond" id="mol1bnd40" x1="172.802" x2="182.794" y1="201.263" y2="206.858"/>
                  
            <path class="bond" d="M132.845 162.798l.35 .606l10.711 -4.646l-.841 -1.456l-.841 -1.457z" fill="#000000" id="mol1bnd41" stroke="none"/>
                  
            <path class="atom" d="M15.781 19.458q.0 .649 -.476 1.018q-.47 .363 -1.268 .363q-.417 .0 -.768 -.065q-.345 -.06 -.577 -.173v-.589q.244 .113 .607 .202q.369 .09 .762 .09q.547 -.0 .827 -.215q.28 -.214 .28 -.577q.0 -.238 -.107 -.399q-.101 -.167 -.351 -.31q-.25 -.143 -.697 -.297q-.625 -.227 -.946 -.554q-.316 -.333 -.316 -.899q.0 -.393 .197 -.667q.202 -.279 .553 -.428q.357 -.155 .816 -.155q.405 -.0 .738 .077q.339 .072 .613 .197l-.196 .53q-.25 -.113 -.548 -.185q-.298 -.077 -.625 -.077q-.458 -.0 -.691 .196q-.232 .197 -.232 .518q.0 .244 .101 .411q.108 .167 .34 .298q.232 .125 .631 .279q.428 .155 .726 .34q.298 .178 .452 .434q.155 .25 .155 .637z" fill="#C6C62C" id="mol1atm2" stroke="none"/>
                  
            <path class="atom" d="M69.289 3.078q-.0 .756 -.256 1.328q-.256 .565 -.757 .881q-.5 .315 -1.244 .315q-.756 .0 -1.262 -.315q-.506 -.316 -.756 -.887q-.244 -.572 -.244 -1.334q.0 -.75 .244 -1.309q.25 -.566 .756 -.881q.506 -.316 1.274 -.316q.732 .0 1.232 .316q.501 .309 .757 .875q.256 .565 .256 1.327zM65.425 3.078q-.0 .923 .387 1.459q.393 .53 1.22 .53q.84 -.0 1.221 -.53q.387 -.536 .387 -1.459q-.0 -.929 -.387 -1.452q-.381 -.524 -1.209 -.524q-.833 -.0 -1.226 .524q-.393 .523 -.393 1.452z" fill="#FF0D0D" id="mol1atm7" stroke="none"/>
                  
            <g class="atom" id="mol1atm8">
                        
                <path d="M82.487 25.938q-.0 .756 -.256 1.328q-.256 .565 -.756 .881q-.5 .315 -1.244 .315q-.757 .0 -1.263 -.315q-.506 -.316 -.756 -.887q-.244 -.572 -.244 -1.334q.0 -.75 .244 -1.309q.25 -.566 .756 -.881q.506 -.316 1.274 -.316q.733 .0 1.233 .316q.5 .309 .756 .875q.256 .565 .256 1.327zM78.623 25.938q.0 .923 .387 1.459q.393 .53 1.221 .53q.839 -.0 1.22 -.53q.387 -.536 .387 -1.459q-.0 -.929 -.387 -1.452q-.381 -.524 -1.209 -.524q-.833 -.0 -1.226 .524q-.393 .523 -.393 1.452z" fill="#FF0D0D" stroke="none"/>
                        
                <path d="M86.793 28.391h-.619v-2.286h-2.512v2.286h-.614v-4.9h.614v2.072h2.512v-2.072h.619v4.9z" fill="#FF0D0D" stroke="none"/>
                      
            </g>
                  
            <g class="atom" id="mol1atm9">
                        
                <path d="M55.772 43.631h-.721l-2.619 -4.066h-.03q.012 .238 .03 .595q.024 .357 .024 .732v2.739h-.566v-4.9h.715l2.607 4.055h.03q-.006 -.108 -.018 -.328q-.012 -.22 -.024 -.476q-.006 -.262 -.006 -.482v-2.769h.578v4.9z" stroke="none"/>
                        
                <path d="M51.329 43.631h-.619v-2.286h-2.513v2.286h-.613v-4.9h.613v2.072h2.513v-2.072h.619v4.9z" stroke="none"/>
                      
            </g>
                  
            <path class="atom" d="M82.487 41.178q-.0 .756 -.256 1.328q-.256 .565 -.756 .881q-.5 .315 -1.244 .315q-.757 .0 -1.263 -.315q-.506 -.316 -.756 -.887q-.244 -.572 -.244 -1.334q.0 -.75 .244 -1.309q.25 -.566 .756 -.881q.506 -.316 1.274 -.316q.733 .0 1.233 .316q.5 .309 .756 .875q.256 .565 .256 1.327zM78.623 41.178q.0 .923 .387 1.459q.393 .53 1.221 .53q.839 -.0 1.22 -.53q.387 -.536 .387 -1.459q-.0 -.929 -.387 -1.452q-.381 -.524 -1.209 -.524q-.833 -.0 -1.226 .524q-.393 .523 -.393 1.452z" fill="#FF0D0D" id="mol1atm11" stroke="none"/>
                  
            <g class="atom" id="mol1atm20">
                        
                <path d="M82.168 74.111h-.72l-2.619 -4.066h-.03q.012 .238 .03 .595q.023 .357 .023 .732v2.739h-.565v-4.9h.714l2.608 4.055h.029q-.006 -.108 -.017 -.328q-.012 -.22 -.024 -.476q-.006 -.262 -.006 -.482v-2.769h.577v4.9z" stroke="none"/>
                        
                <path d="M86.474 74.111h-.619v-2.286h-2.512v2.286h-.613v-4.9h.613v2.072h2.512v-2.072h.619v4.9z" stroke="none"/>
                      
            </g>
                  
            <path class="atom" d="M69.289 94.518q-.0 .756 -.256 1.328q-.256 .565 -.757 .881q-.5 .315 -1.244 .315q-.756 .0 -1.262 -.315q-.506 -.316 -.756 -.887q-.244 -.572 -.244 -1.334q.0 -.75 .244 -1.309q.25 -.566 .756 -.881q.506 -.316 1.274 -.316q.732 .0 1.232 .316q.501 .309 .757 .875q.256 .565 .256 1.327zM65.425 94.518q-.0 .923 .387 1.459q.393 .53 1.22 .53q.84 -.0 1.221 -.53q.387 -.536 .387 -1.459q-.0 -.929 -.387 -1.452q-.381 -.524 -1.209 -.524q-.833 -.0 -1.226 .524q-.393 .523 -.393 1.452z" fill="#FF0D0D" id="mol1atm22" stroke="none"/>
                  
            <g class="atom" id="mol1atm24">
                        
                <path d="M95.366 112.211h-.72l-2.619 -4.066h-.03q.012 .238 .03 .595q.024 .357 .024 .732v2.739h-.566v-4.9h.714l2.608 4.055h.03q-.006 -.108 -.018 -.328q-.012 -.22 -.024 -.476q-.006 -.262 -.006 -.482v-2.769h.577v4.9z" stroke="none"/>
                        
                <path d="M90.923 112.211h-.619v-2.286h-2.512v2.286h-.613v-4.9h.613v2.072h2.512v-2.072h.619v4.9z" stroke="none"/>
                      
            </g>
                  
            <path class="atom" d="M122.081 109.758q.0 .756 -.256 1.328q-.256 .565 -.756 .881q-.5 .315 -1.244 .315q-.756 .0 -1.262 -.315q-.506 -.316 -.756 -.887q-.244 -.572 -.244 -1.334q.0 -.75 .244 -1.309q.25 -.566 .756 -.881q.506 -.316 1.274 -.316q.732 .0 1.232 .316q.5 .309 .756 .875q.256 .565 .256 1.327zM118.218 109.758q-.0 .923 .387 1.459q.393 .53 1.22 .53q.84 -.0 1.221 -.53q.387 -.536 .387 -1.459q-.0 -.929 -.387 -1.452q-.381 -.524 -1.209 -.524q-.833 -.0 -1.226 .524q-.393 .523 -.393 1.452z" fill="#FF0D0D" id="mol1atm26" stroke="none"/>
                  
            <g class="atom" id="mol1atm28">
                        
                <path d="M121.763 142.691h-.72l-2.62 -4.066h-.03q.012 .238 .03 .595q.024 .357 .024 .732v2.739h-.566v-4.9h.715l2.607 4.055h.03q-.006 -.108 -.018 -.328q-.012 -.22 -.024 -.476q-.006 -.262 -.006 -.482v-2.769h.578v4.9z" stroke="none"/>
                        
                <path d="M126.069 142.691h-.619v-2.286h-2.512v2.286h-.613v-4.9h.613v2.072h2.512v-2.072h.619v4.9z" stroke="none"/>
                      
            </g>
                  
            <path class="atom" d="M108.883 163.098q.0 .756 -.256 1.328q-.256 .565 -.756 .881q-.5 .315 -1.244 .315q-.756 .0 -1.262 -.315q-.506 -.316 -.756 -.887q-.244 -.572 -.244 -1.334q-.0 -.75 .244 -1.309q.25 -.566 .756 -.881q.506 -.316 1.274 -.316q.732 .0 1.232 .316q.5 .309 .756 .875q.256 .565 .256 1.327zM105.02 163.098q-.0 .923 .387 1.459q.392 .53 1.22 .53q.839 -.0 1.22 -.53q.387 -.536 .387 -1.459q.0 -.929 -.387 -1.452q-.381 -.524 -1.208 -.524q-.834 -.0 -1.226 .524q-.393 .523 -.393 1.452z" fill="#FF0D0D" id="mol1atm30" stroke="none"/>
                  
            <g class="atom" id="mol1atm39">
                        
                <path d="M188.359 208.706q-.0 .756 -.256 1.327q-.256 .566 -.756 .882q-.5 .315 -1.244 .315q-.756 .0 -1.263 -.315q-.506 -.316 -.756 -.887q-.244 -.572 -.244 -1.334q.0 -.75 .244 -1.31q.25 -.565 .756 -.881q.507 -.315 1.274 -.315q.733 -.0 1.233 .315q.5 .31 .756 .875q.256 .566 .256 1.328zM184.495 208.706q.0 .923 .387 1.458q.393 .53 1.221 .53q.839 .0 1.22 -.53q.387 -.535 .387 -1.458q-.0 -.929 -.387 -1.453q-.381 -.524 -1.209 -.524q-.833 .0 -1.226 .524q-.393 .524 -.393 1.453z" fill="#FF0D0D" stroke="none"/>
                        
                <path d="M192.665 211.159h-.619v-2.286h-2.512v2.286h-.614v-4.9h.614v2.072h2.512v-2.072h.619v4.9z" fill="#FF0D0D" stroke="none"/>
                      
            </g>
                  
            <g class="atom" id="mol1atm40">
                        
                <path d="M148.159 157.931h-.72l-2.619 -4.066h-.03q.012 .238 .03 .595q.023 .357 .023 .732v2.739h-.565v-4.9h.714l2.608 4.055h.03q-.006 -.108 -.018 -.328q-.012 -.22 -.024 -.476q-.006 -.262 -.006 -.482v-2.769h.577v4.9z" stroke="none"/>
                        
                <path d="M152.466 157.931h-.62v-2.286h-2.512v2.286h-.613v-4.9h.613v2.072h2.512v-2.072h.62v4.9z" stroke="none"/>
                        
                <path d="M154.97 159.42h-1.943v-.3l.772 -.778q.221 -.222 .371 -.393q.154 -.175 .232 -.34q.079 -.167 .079 -.364q.0 -.243 -.146 -.368q-.143 -.128 -.372 -.128q-.214 -.0 -.379 .075q-.16 .075 -.328 .207l-.193 -.243q.171 -.147 .393 -.247q.225 -.1 .507 -.1q.411 .0 .65 .208q.239 .207 .239 .575q.0 .228 -.096 .432q-.093 .2 -.264 .396q-.168 .197 -.393 .418l-.615 .604v.018h1.486v.328z" stroke="none"/>
                      
            </g>
                
            <line class="hi" id="mol1bnd1" stroke="#C6C62C" x1="11.493" x2="6.2655" y1="19.905" y2="22.923000000000002"/>
            <line class="hi" id="mol1bnd2" stroke="#C6C62C" x1="16.994" x2="22.2145" y1="19.913" y2="22.927"/>
            <line class="hi" id="mol1bnd7" stroke="#FF0D0D" x1="76.944" x2="71.9865" y1="24.045" y2="21.183"/>
            <line class="hi" id="mol1bnd9" stroke="#3050F8" x1="56.984" x2="62.0065" y1="43.002" y2="45.9015"/>
            <line class="hi" id="mol1bnd9" stroke="#3050F8" x1="56.984" x2="62.0065" y1="43.002" y2="45.9015"/>
            <line class="hi" id="mol1bnd21" stroke="#3050F8" x1="80.228" x2="80.228" y1="75.511" y2="81.20599999999999"/>
            <line class="hi" id="mol1bnd21" stroke="#3050F8" x1="80.228" x2="80.228" y1="75.511" y2="81.20599999999999"/>
            <line class="hi" id="mol1bnd24" stroke="#3050F8" x1="93.426" x2="93.426" y1="105.911" y2="100.21600000000001"/>
            <line class="hi" id="mol1bnd24" stroke="#3050F8" x1="93.426" x2="93.426" y1="105.911" y2="100.21600000000001"/>
            <line class="hi" id="mol1bnd25" stroke="#3050F8" x1="96.579" x2="101.60149999999999" y1="111.582" y2="114.4815"/>
            <line class="hi" id="mol1bnd25" stroke="#3050F8" x1="96.579" x2="101.60149999999999" y1="111.582" y2="114.4815"/>
            <line class="hi" id="mol1bnd28" stroke="#3050F8" x1="116.669" x2="111.6465" y1="138.421" y2="135.52100000000002"/>
            <line class="hi" id="mol1bnd29" stroke="#3050F8" x1="119.822" x2="119.822" y1="144.091" y2="149.786"/>
            <line class="hi" id="mol1bnd29" stroke="#3050F8" x1="119.822" x2="119.822" y1="144.091" y2="149.786"/>
            <line class="hi" id="mol1bnd40" stroke="#FF0D0D" x1="182.794" x2="177.798" y1="206.858" y2="204.0605"/>
        </g>
          
    </g>
    
</svg>
","Title":"Met-enkephalin","UNII":"9JEZ9OD3AS","Wikidata":"Q1960495","XLogP":-2.1}