{"ATC Code":"C - Cardiovascular system","Abbreviation":[],"Aliases":["Mephenterdrine","Mephenterdrinum","Mefenterdrin","Mefentermin","Mephetedrine","Mephine","Vialin","N-Methylphentermine","Wyfentermina","Wyamine","Mefentermina","Mephenterminum","WY-585","2-Methylamino-2-methyl-1-phenylpropane","N-Methyl-omega-phenyl-t-butylamine","omega-Phenyl-tert-butyl-methylamine","N,α,α-Trimethylphenethylamine","N-Methyl-omega-phenyl-tert-butylamine","N,α,α-Trimethylbenzeneethanamine","Benzeneethanamine, N,α,α-trimethyl-","Phenethylamine, N,α,α-trimethyl-","methyl(2-methyl-1-phenylpropan-2-yl)amine","C01CA11","202-901-6","2-Methyl-2-methylamino-1-phenylpropane"],"Biological Half-Life":"17 to 18 hours.","CAS":"100-92-5","ChEBI":"CHEBI:6755","ChEMBL":"CHEMBL1201234","ChemicalClasses":["phentermine"],"Chirality":"achiral","Color/Form":"LIQUID","Drug Indication":"Used to maintain blood pressure in hypotensive states.","Drug Warnings":"Mephentermine may produce arrhythmias, including extrasystoles, and AV block and hypertension. Arrhythmias are most likely to occur in patients with heart disease or those receiving other drugs which may increase cardiac irritability such as cyclopropane or halogenated hydrocarbon general anesthetics. /Mephentermine sulfate/","EINECS":"202-901-6","Erowid Experience Reports":null,"Esters":[],"European Community (EC) Number":"202-901-6","Formating":[],"HMDB ID":"HMDB0015452","HeavyAtomCount":12,"Human Drugs":"Pharmaceuticals","IUPACName":"N,2-dimethyl-1-phenylpropan-2-amine","InChI":"InChI=1S/C11H17N/c1-11(2,12-3)9-10-7-5-4-6-8-10/h4-8,12H,9H2,1-3H3","InChIKey":"RXQCGGRTAILOIN-UHFFFAOYSA-N","Interactions":"IN ANESTHETIZED DOGS, RESERPINE POTENTIATED THE PRESSOR RESPONSE WHEN ADMIN AFTER MEPHENTERMINE.","LD50":[{"dosages":[{"amount":"85 mg/kg","route":"intraperitoneal"},{"amount":"13 mg/kg","route":"intravenous"}],"organism":"Rat"},{"dosages":[{"amount":"57 mg/kg","route":"oral"},{"amount":"89 mg/kg","route":"intraperitoneal"},{"amount":"43 mg/kg","route":"intravenous"}],"organism":"Mouse"}],"MeSH Pharmacological Classification":"Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.","Melting Point":"\u003c 25 °C","MolecularFormula":"C\u003csub\u003e11\u003c/sub\u003eH\u003csub\u003e17\u003c/sub\u003eN","MolecularWeight":"163.26 g/mol","Odor":"FISHY AMINE ODOR","Pharmacodynamics":"Mephentermine is a sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1248)","Physical Description":"Solid","PubChemId":3677,"RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Mephentermine","Name":"Mephentermine","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q6817800","Name":"Mephentermine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB01365","Name":"Mephentermine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/3677","Name":"Mephentermine","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201234","Name":"Mephentermine","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:6755","Name":"Mephentermine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=100-92-5","Name":"Mephentermine","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0015452","Name":"Mephentermine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C07889","Name":"Mephentermine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/TEZ91L71V4","Name":"Mephentermine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID4023256","Name":"Mephentermine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 3677, Mephentermine. Accessed August 19, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/3677\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/3677\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Mephentermine. UNII: TEZ91L71V4. Global Substance Registration System. Accessed August 19, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/TEZ91L71V4\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/TEZ91L71V4\u003c/a\u003e"],"SMILES":"CC(C)(CC1=CC=CC=C1)NC","SaltData":[{"AcidCount":1,"Amine":"Mephentermine","AmineCount":2,"Formula":"OS(=O)(=O)O","Name":"hemisulfate","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 136.56 44.819\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h137v45H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m65.059 29.67-9.796-11.674M55.263 17.996 45.467 29.67M55.263 17.996l-13.198-7.62M42.065 10.376l-13.199 7.62\" 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