{"ATC Code":["C - Cardiovascular system","C01 - Cardiac therapy","C01C - Cardiac stimulants excl. cardiac glycosides","C01CA - Adrenergic and dopaminergic agents","C01CA11 - Mephentermine","QC - Cardiovascular system","QC01 - Cardiac therapy","QC01C - Cardiac stimulants excl. cardiac glycosides","QC01CA - Adrenergic and dopaminergic agents","QC01CA11 - Mephentermine"],"Absorption, Distribution and Excretion":"...MEPHENTERMINE.../IS/ WELL ABSORBED FROM DIGESTIVE TRACT. .../IT/ MAY BE ABSORBED TO A GREATER OR LESSER EXTENT FROM NASAL MUCOSA.","Aliases":["Mephenterdrine","Mephenterdrinum","Mefenterdrin","Mefentermin","Mephetedrine","Mephine","Vialin","N-Methylphentermine","Wyfentermina","Wyamine","Mefentermina","Mephenterminum","2-Methylamino-2-methyl-1-phenylpropane","WY-585","N,α,α-Trimethylbenzeneethanamine","N-Methyl-omega-phenyl-t-butylamine","omega-Phenyl-tert-butyl-methylamine","N,α,α-Trimethylphenethylamine","N-Methyl-omega-phenyl-tert-butylamine","Phenethylamine, N,α,α-trimethyl-","methyl(2-methyl-1-phenylpropan-2-yl)amine","Benzeneethanamine, N,α,α-trimethyl-","CHEBI:6755","Dtxsid4023256","Dtxcid603256","C01CA11","202-901-6","2-Methyl-2-methylamino-1-phenylpropane","(1,1-dimethyl-2-phenylethyl)methylamine","N,2-dimethyl-1-phenylpropan-2-amine;N,2-dimethyl-1-phenylpropan-2-amine","HSDB 2172","Ncgc00016570-01","Einecs 202-901-6","Cas-1212-72-2","Brn 1363850","Unii-tez91l71v4","Fentermin","Spectrum_001611","Prestwick0_000726","Prestwick1_000726","Prestwick2_000726","Prestwick3_000726","Spectrum2_000474","Spectrum3_001220","Spectrum4_000188","Spectrum5_001008","BSPBio_000652","BSPBio_002640","KBioGR_000735","KBioSS_002091","DivK1c_000229","Schembl121178","SPBio_000608","SPBio_002591","BPBio1_000718","GTPL7222","Chembl1201234","BDBM81455","KBio1_000229","KBio2_002091","KBio2_004659","KBio2_007227","KBio3_002140","Ninds_000229","CAS_3677","NSC_3677","SBB015072",".omega.-Phenyl-tert-butyl-methylamine","N-Methyl-.omega.-phenyl-t-butylamine","Akos006281398","DB01365","Idi1_000229","N,2-Dimethyl-1-phenyl-2-propanamine #","N-Methyl-.omega.-phenyl-tert-butylamine","Ncgc00016570-02","Ncgc00016570-03","ST075547","benzene, (2-methyl-2-methylamino)propyl-","Sbi-0051802.p002","AB00053662","NS00005281","C07889","D08180","Ab00053662_08","N,α,α-Trimethyl-β-phenethylamine","Brd-k18194590-065-05-6","Brd-k18194590-065-08-0"],"Biological Half-Life":"17 to 18 hours.","CAS":"100-92-5","ChemicalClasses":["phentermine"],"Chirality":"achiral","Color/Form":"LIQUID","Drug Indication":"Used to maintain blood pressure in hypotensive states.","Drug Warnings":"Mephentermine may produce arrhythmias, including extrasystoles, and AV block and hypertension. Arrhythmias are most likely to occur in patients with heart disease or those receiving other drugs which may increase cardiac irritability such as cyclopropane or halogenated hydrocarbon general anesthetics. /Mephentermine sulfate/","EliminationHalfLife":"","Erowid Experience Reports":[{"Author":"Vulcanblood","Id":14186,"Title":"One of the Best Crank Highs"},{"Author":"Peaceful Garden","Id":108083,"Title":"Obscure Pharmaco-speedball"}],"Esters":[],"European Community (EC) Number":"202-901-6","Formating":[],"HMDB ID":"HMDB0015452","HeavyAtomCount":12,"Human Drugs":"Pharmaceuticals","IUPACName":"N,2-dimethyl-1-phenylpropan-2-amine","InChI":"InChI=1S/C11H17N/c1-11(2,12-3)9-10-7-5-4-6-8-10/h4-8,12H,9H2,1-3H3","InChIKey":"RXQCGGRTAILOIN-UHFFFAOYSA-N","Interactions":"IN ANESTHETIZED DOGS, RESERPINE POTENTIATED THE PRESSOR RESPONSE WHEN ADMIN AFTER MEPHENTERMINE.","KEGG Entries":[{"Id":"D08180","Interactions":[],"Synonyms":["Mephentermine"]}],"MeSH Headers":[{"Id":"M0013430","Link":"https://id.nlm.nih.gov/mesh/M0013430.html","Name":"Mephentermine","Ref":43},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":45},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":65},{"Id":"M0020947","Link":"https://id.nlm.nih.gov/mesh/M0020947.html","Name":"Sympathomimetics","Ref":66},{"Id":"M0022551","Link":"https://id.nlm.nih.gov/mesh/M0022551.html","Name":"Vasoconstrictor Agents","Ref":67},{"Id":"M0543920","Link":"https://id.nlm.nih.gov/mesh/M0543920.html","Name":"Adrenergic alpha-1 Receptor Agonists","Ref":68}],"MeSH Pharmacological Classification":[{"Id":"M0020947","Link":"https://id.nlm.nih.gov/mesh/M0020947.html","Name":"Sympathomimetic","Ref":66},{"Id":"M0022551","Link":"https://id.nlm.nih.gov/mesh/M0022551.html","Name":"Vasoconstrictor Agent","Ref":67},{"Id":"M0543920","Link":"https://id.nlm.nih.gov/mesh/M0543920.html","Name":"Adrenergic alpha-1 Receptor Agonist","Ref":68}],"Mechanism of Action":"Mephentermine is an alpha adrenergic receptor agonist, but also acts indirectly by releasing endogenous norepinephrine. Cardiac output and systolic and diastolic pressures are usually increased. A change in heart rate is variable, depending on the degree of vagal tone. Sometimes the net vascular effect may be vasodilation. Large doses may depress the myocardium or produce central nervous system (CNS) effects.","Melting Point":"\u003c 25 °C","Metabolism/Metabolites":"Hepatic, by N-demethylation and then p-hydroxylation.","MolecularFormula":"C\u003csub\u003e11\u003c/sub\u003eH\u003csub\u003e17\u003c/sub\u003eN","MolecularWeight":"163.26 g/mol","Odor":"FISHY AMINE ODOR","Pharmacodynamics":"Mephentermine is a sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1248)","Physical Description":"Solid","PubChemId":3677,"Records":{"UNII":{"Impurities":[]}},"RefChem":"810992","RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Mephentermine","Name":"Mephentermine","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q6817800","Name":"Mephentermine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB01365","Name":"Mephentermine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/3677","Name":"Mephentermine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=100-92-5","Name":"Mephentermine","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0015452","Name":"Mephentermine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C07889","Name":"Mephentermine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/TEZ91L71V4","Name":"Mephentermine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID4023256","Name":"Mephentermine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 3677, Mephentermine. Accessed May 5, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/3677\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/3677\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Mephentermine. UNII: TEZ91L71V4. Global Substance Registration System. Accessed May 5, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/TEZ91L71V4\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/TEZ91L71V4\u003c/a\u003e"],"SMILES":"CC(C)(CC1=CC=CC=C1)NC","SaltData":[{"AcidCount":1,"Amine":"Mephentermine","AmineCount":2,"Formula":"OS(=O)(=O)O","Name":"hemisulfate","RName":"sulfate","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 136.56 44.819\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h137v45H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m45.467 29.67 9.796-11.674M55.263 17.996l9.796 11.674M55.263 17.996l-13.198-7.62M42.065 10.376l-13.199 7.62\" 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