{"Abbreviation":["4-MMC"],"Absorption, Distribution and Excretion":"The main routes of administration for mephedrone are reported as snorting (nasal insufflation) and swallowing (oral ingestion), sometimes after dissolving with water. As mephedrone is primarily available in powder form, injecting use is reported but appears to be rare.","Aliases":["Mephedrone","4-methylmethcathinone","Meow meow","4-MMC","M-CAT","4-methylephedrone","bk-4-methylmethamphetamine","β-keto-4-methylmethamphetamine","J2.756.280i","Chebi:59331","Dtxsid20891437","1-Propanone, 2-(methylamino)-1-(4-methylphenyl)-","MMCAT","Dtxcid30888999","663-408-3","Bubbles","Bounce","Chembl4094396","2-(Methylamino)-1-(4-methylphenyl)-1-propanone","88783-39-5","Unii-8ba8t27317","HSDB 7979","Schembl727913","DEA No. 1248","Bdbm50236718","2-methylamino-1-p-tolylpropane-1-one","DB13108","NS00000410","1-(4-methylphenyl)-2-methylaminopropan-1-one","2-Methylamino-1-(4-methylphenyl)propan-1-one","C22785","1-(4-Methylphenyl)-2-[methyl(phenylmethyl)amino]-1-propanone"],"CAS":"1189805-46-6","ChemicalClasses":["cathinone"],"Chirality":"racemic","Color/Form":"Fine-white to off-white or slightly colored powder ... also found in tablet or capsule form","DBI-IGS":["4-MMC"],"Dosing Info":[{"Method":"Insufflated","Tiers":{"Common":{"Entries":1145,"Lower":75.3,"Percentage":22.5,"Unit":"mg","Upper":90},"Extreme":{"Entries":498,"Lower":130,"Percentage":9.8,"Unit":"mg","Upper":130},"Heavy":{"Entries":726,"Lower":110,"Percentage":14.3,"Unit":"mg","Upper":130},"Light":{"Entries":1550,"Lower":75.3,"Percentage":30.5,"Unit":"mg","Upper":75.3},"Strong":{"Entries":1169,"Lower":90,"Percentage":23,"Unit":"mg","Upper":110}}},{"Method":"Intravenous","Tiers":{"Common":{"Entries":94,"Lower":47.6,"Percentage":32,"Unit":"mg","Upper":60},"Extreme":{"Entries":29,"Lower":100,"Percentage":9.9,"Unit":"mg","Upper":100},"Heavy":{"Entries":34,"Lower":80,"Percentage":11.6,"Unit":"mg","Upper":100},"Light":{"Entries":81,"Lower":47.6,"Percentage":27.6,"Unit":"mg","Upper":47.6},"Strong":{"Entries":56,"Lower":60,"Percentage":19,"Unit":"mg","Upper":80}}},{"Method":"Oral","Tiers":{"Common":{"Entries":69,"Lower":173.4,"Percentage":17.6,"Unit":"mg","Upper":200},"Extreme":{"Entries":43,"Lower":367.7,"Percentage":11,"Unit":"mg","Upper":367.7},"Heavy":{"Entries":43,"Lower":300,"Percentage":11,"Unit":"mg","Upper":367.7},"Light":{"Entries":146,"Lower":173.4,"Percentage":37.2,"Unit":"mg","Upper":173.4},"Strong":{"Entries":91,"Lower":200,"Percentage":23.2,"Unit":"mg","Upper":300}}},{"Method":"Intrarectal","Tiers":{"Common":{"Entries":5,"Lower":76.1,"Percentage":13.9,"Unit":"mg","Upper":98},"Extreme":{"Entries":7,"Lower":183.4,"Percentage":19.4,"Unit":"mg","Upper":183.4},"Heavy":{"Entries":2,"Lower":121.3,"Percentage":5.6,"Unit":"mg","Upper":183.4},"Light":{"Entries":13,"Lower":76.1,"Percentage":36.1,"Unit":"mg","Upper":76.1},"Strong":{"Entries":9,"Lower":98,"Percentage":25,"Unit":"mg","Upper":121.3}}},{"Method":"Vaporized","Tiers":{"Common":{"Entries":2,"Lower":8,"Percentage":18.2,"Unit":"mg","Upper":9},"Extreme":{"Entries":1,"Lower":13,"Percentage":9.1,"Unit":"mg","Upper":13},"Heavy":{"Entries":2,"Lower":11.5,"Percentage":18.2,"Unit":"mg","Upper":13},"Light":{"Entries":4,"Lower":8,"Percentage":36.4,"Unit":"mg","Upper":8},"Strong":{"Entries":2,"Lower":9,"Percentage":18.2,"Unit":"mg","Upper":11.5}}}],"DurationOfAction":"","EliminationHalfLife":"","Erowid Experience Reports":[{"Author":"Tabubue","Id":88665,"Title":"First Low Dosage Testing"},{"Author":"vitti...","Id":84452,"Title":"Did Nothing for Me Yet Worked for My Friends..."},{"Author":"julien","Id":79652,"Title":"No Advantage in Mixing These"},{"Author":"CW","Id":79404,"Title":"Testing It Out"},{"Author":"magical me123","Id":83629,"Title":"Good for Me, Bad for My C@ck"},{"Author":"Doomknot","Id":85916,"Title":"Looking Back"},{"Author":"Aurantiaca","Id":86157,"Title":"The Vasoconstriction is for Real"},{"Author":"bad","Id":86482,"Title":"A Night of Regret"},{"Author":"Anon","Id":86841,"Title":"Euphoria with Slight Vasoconstriction..."},{"Author":"boomer","Id":86995,"Title":"A Surrogate of Ecstasy, With Postrush Visions"},{"Author":"-that guy-","Id":87071,"Title":"Highly Addictive"},{"Author":"ChemicalMass","Id":87368,"Title":"Love Bonding Noseburn"},{"Author":"Tingles","Id":87656,"Title":"Definately Not a Drone State of Mind"},{"Author":"tricky dicky","Id":87989,"Title":"I'm Allergic to This Cat"},{"Author":"3eyeswise","Id":88054,"Title":"Amazing Stimulation and Euphoria"},{"Author":"Aurantiaca","Id":85440,"Title":"Effective when Smoked"},{"Author":"Uncle_bud","Id":85370,"Title":"Don't Ever Mix RC's"},{"Author":"katiescarlett","Id":83674,"Title":"Awfully Moreish Even for a Non-Addictive Type"},{"Author":"RA","Id":83806,"Title":"Nasty on the Nose!"},{"Author":"M_Bassy","Id":83822,"Title":"Impressive at First, Now Not So Sure"},{"Author":"Komodo","Id":83876,"Title":"Pleasant"},{"Author":"WEIRWOLF","Id":83881,"Title":"A Powder Whose Effects Last and Last"},{"Author":"The Masked Chemist","Id":83956,"Title":"Dangerously Pleasant"},{"Author":"rock*chick","Id":85298,"Title":"Lose Your Looks, Job, Friends \u0026 Mind!"},{"Author":"kewagi","Id":84545,"Title":"Pleasant Surprise"},{"Author":"Dave","Id":84596,"Title":"It's Pretty Ridiculous"}],"Esters":[],"European Community (EC) Number":"663-408-3","Formating":[],"HMDB ID":"HMDB0041923","HeavyAtomCount":13,"Human Drugs":"Pharmaceuticals","IUPACName":"2-(methylamino)-1-(4-methylphenyl)propan-1-one","InChI":"InChI=1S/C11H15NO/c1-8-4-6-10(7-5-8)11(13)9(2)12-3/h4-7,9,12H,1-3H3","InChIKey":"YELGFTGWJGBAQU-UHFFFAOYSA-N","MeSH Headers":[{"Id":"M0544970","Link":"https://id.nlm.nih.gov/mesh/M0544970.html","Name":"mephedrone","Ref":63},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":65},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":79}],"Mechanism of Action":"As with phenethylamines, in the absence of ring-substitution, cathinones behave predominantly as central nervous system (CNS) stimulants, although generally with a lower potency than the corresponding phenethylamine analogue. The lower potency is caused by the beta-keto group creating a more polar molecule with lower ability to cross the blood-brain barrier. In the presence of ring substitution, however, the properties are modified towards MDMA-like effects.","Metabolism/Metabolites":"Rats administered a single 20 mg/kg dose of mephedrone by gastric intubation and urine was collected over a 24-hour period after mephedrone administration. In addition to mephedrone, the following metabolites were detected: nor-mephedrone, nor-dihydro mephedrone, hydroxytolyl mephedrone and nor-hydroxytolyl mephedrone. In a human urine sample submitted by a mephedrone user, a further metabolite, 4-carboxy-dihydro mephedrone was also detected. /It was/ postulated that the overlapping metabolic pathways that were thought to be responsible for these metabolites were as follows:  N-demethylation to the primary amine (metabolites nor-mephedrone, nor-dihydro mephedrone and nor-hydroxytolyl mephedrone);  reduction of the keto moiety to the respective alcohol (metabolites nordihydro mephedrone and 4-carboxy-dihydro mephedrone);  oxidation of the tolyl moiety to the corresponding alcohol (metabolites hydroxytolyl mephedrone and nor-hydroxytolyl mephedrone). It is thought that the hydroxytolyl mephedrone and nor-hydroxytolyl mephedrone metabolites are partly excreted as glucuronides and sulfates.","MolecularFormula":"C\u003csub\u003e11\u003c/sub\u003eH\u003csub\u003e15\u003c/sub\u003eNO","MolecularWeight":"177.24 g/mol","Opticalactivity":"( + / - )","PubChemId":45266826,"Record Description":["Wikipedia|List of designer drugs|Stimulants|Cathinones"],"Records":{"UNII":{"Impurities":[".beta.-d-glucopyranosiduronic acid, 2-amino-3-(4-methylphenyl)-3-oxopropyl"]}},"RefChem":"5998","RefCount":4,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Mephedrone","Name":"Mephedrone","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q262613","Name":"Mephedrone","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB13108","Name":"Mephedrone","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/45266826","Name":"Mephedrone","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=1189805-46-6","Name":"Mephedrone","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0041923","Name":"Mephedrone","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C22785","Name":"Mephedrone","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/8BA8T27317","Name":"Mephedrone","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID20891437","Name":"Mephedrone","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 45266826, Mephedrone. Accessed May 4, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/45266826\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/45266826\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Mephedrone. UNII: 8BA8T27317. Global Substance Registration System. Accessed May 4, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/8BA8T27317\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/8BA8T27317\u003c/a\u003e","Anvisa. RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. July 24, 2023. Accessed May 4, 2026. \u003ca href=https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-804-de-24-de-julho-de-2023-498447451\u003ehttps://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-804-de-24-de-julho-de-2023-498447451\u003c/a\u003e"],"SMILES":"CC1=CC=C(C=C1)C(=O)C(C)NC","SaltData":[{"AcidCount":1,"Amine":"Mephedrone","AmineCount":1,"Formula":"Cl","Name":"hydrochloride","RName":"hydrochloride","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 117.372 49.848\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#1ff01f\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h118v50H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m1.038 48.801 13.198-7.62\" class=\"bond\"/\u003e\u003cg 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Nations","ref":[],"schedule":"Schedule II drug"}],"StereoisomerData":[{"ChemicalClasses":["cathinone"],"SMILES":"CN[C@@H](C)C(=O)C1=CC=C(C)C=C1","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 94.464 49.848\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#3050f8\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h95v50H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m93.426 25.941-10.045-5.799M77.074 20.142l-10.045 5.799\" class=\"bond\"/\u003e\u003cpath fill=\"#000\" stroke=\"none\" d=\"M67.379 25.941h-.7l-1.75 15.24h4.201z\" class=\"bond\"/\u003e\u003cpath d=\"m67.029 25.941-13.198-7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M52.612 19.025V7.002M55.05 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