{"ATC Code":"N05CD06","Abbreviation":"","Aliases":["Lorazepam","Lormetazepam","Methyllorazepam","N-Methyllorazepam","Loramet","Noctamid","Lormetazepamum","Chlorotemazepam","Ergocalm","Noctamide","WY-4082","Ro 5-5516","7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one","7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one","Dormagen","7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one","()-Lorazepam","2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-","2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(o-chlorophenyl)-3-hydroxy-1-methyl-","7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one","7-Chloro-1,3-dihydro-5-(o-chlorophenyl)-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one","N05CD06","7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-1h-1,4-benzodiazepin-2(3h)-one","212-700-5","WY 4082"],"Biological Half-Life":"The terminal phase half life is 11 h.","CAS":"848-75-9","ChEBI":"CHEBI:52993","ChEMBL":"CHEMBL22097","ChemicalClasses":["benzodiazepine"],"Chirality":"racemic","DEA no":2774,"Drug Classes":"Breast Feeding; Lactation; Milk, Human; Hypnotics and Sedatives; Anti-Anxiety Agents; Benzodiazepines","Drug Indication":"For the treatment of short-term insomnia","EINECS":"212-700-5","EliminationHalfLife":"10 – 12 hours","Esters":[],"European Community (EC) Number":"212-700-5","Formating":[],"HMDB ID":"HMDB0041919","HeavyAtomCount":22,"Human Drugs":"Breast Feeding; Lactation; Milk, Human; Hypnotics and Sedatives; Anti-Anxiety Agents; Benzodiazepines","IUPACName":"7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-3H-1,4-benzodiazepin-2-one","InChI":"InChI=1S/C16H12Cl2N2O2/c1-20-13-7-6-9(17)8-11(13)14(19-15(21)16(20)22)10-4-2-3-5-12(10)18/h2-8,15,21H,1H3","InChIKey":"FJIKWRGCXUCUIG-UHFFFAOYSA-N","MeSH Pharmacological Classification":"Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. (See all compounds classified as Hypnotics and Sedatives.)","Melting Point":"206 °C","MolecularFormula":"C\u003csub\u003e16\u003c/sub\u003eH\u003csub\u003e12\u003c/sub\u003eCl\u003csub\u003e2\u003c/sub\u003eN\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e2\u003c/sub\u003e","MolecularWeight":"335.2 g/mol","Opticalactivity":"( + / - )","Pharmacodynamics":"Lormetazepam is a benzodiazepine which reduces central nervous system (CNS) activity. It produces anxiolytic, muscle relaxant, sedative and hypnotic effects. Because it is a short-acting benzodiapine, it does not produce significant sedation after waking.","Physical Description":"Solid","PubChemId":13314,"RefCount":4,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Lormetazepam","Name":"Lorazepam","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q186257","Name":"Lorazepam","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB13872","Name":"Lorazepam","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/13314","Name":"Lorazepam","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL22097","Name":"Lorazepam","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:52993","Name":"Lorazepam","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=848-75-9","Name":"Lorazepam","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0041919","Name":"Lorazepam","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D01657","Name":"Lorazepam","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/GU56C842ZA","Name":"Lorazepam","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID40862442","Name":"Lorazepam","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 13314, Lorazepam. Accessed July 11, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/13314\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/13314\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Lorazepam. UNII: GU56C842ZA. Global Substance Registration System. Accessed July 11, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/GU56C842ZA\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/GU56C842ZA\u003c/a\u003e","Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. March 31, 2023. Accessed July 11, 2025. \u003ca href=https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992\u003ehttps://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992\u003c/a\u003e"],"SMILES":"CN1C2=C(C=C(C=C2)Cl)C(=NC(C1=O)O)C3=CC=CC=C3Cl","SaltData":[],"Salts":[],"Scheduling":[{"gov":"Brazil","ref":["3"],"schedule":"B1 substance"},{"gov":"Canada","ref":[],"schedule":"Schedule IV substance"},{"gov":"Germany","ref":[],"schedule":"prescription only/Anlage III substance"},{"act":"Controlled Substances Act (CSA)","gov":"United States","ref":[],"schedule":"Schedule I"}],"StereoisomerData":[{"Aliases":["(S)-lorazepam","Lorazepam, (S)-","2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-, (3S)-","2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-, 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0-1.238.53-.452.524-.452 1.447 0 .91.417 1.446.422.53 1.268.53.321 0 .607-.054.291-.059.565-.142v.535q-.274.101-.565.149-.292.054-.697.054-.744 0-1.25-.31-.5-.309-.75-.875-.25-.571-.25-1.339 0-.745.268-1.31.274-.566.804-.881.529-.322 1.279-.322.78 0 1.352.286l-.244.524q-.227-.101-.506-.185-.274-.083-.608-.083m2.757 4.423h-.601v-5.215h.601z\" class=\"atom\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m73.482 38.696 2.409-5.002M60.166 12.29l5.764 1.343M60.166 12.29l5.764 1.343M53.83 13.957l-4.427 3.557M53.83 13.957l-4.427 3.557\" class=\"hi\"/\u003e\u003cpath stroke=\"#1ff01f\" d=\"m6.875 43.059 5.842-3.374M75.987 67.494l-5.677 1.783\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Title":"(+)-Lorazepam","UNII":"0VMC8E4D2Y"},{"Aliases":["(R)-Lorazepam","Lorazepam, (R)-","2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-, (3R)-","2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-, 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