{"ATC Code":["M02AA10","M - Musculo-skeletal system","M01 - Antiinflammatory and antirheumatic products","M01A - Antiinflammatory and antirheumatic products, non-steroids","M01AE - Propionic acid derivatives","M01AE03 - Ketoprofen","M - Musculo-skeletal system","M02 - Topical products for joint and muscular pain","M02A - Topical products for joint and muscular pain","M02AA - Antiinflammatory preparations, non-steroids for topical use","M02AA10 - Ketoprofen","QM - Musculo-skeletal system","QM02 - Topical products for joint and muscular pain","QM02A - Topical products for joint and muscular pain","QM02AA - Antiinflammatory preparations, non-steroids for topical use","QM02AA10 - Ketoprofen","QM - Musculo-skeletal system","QM01 - Antiinflammatory and antirheumatic products","QM01A - Antiinflammatory and antirheumatic products, non-steroids","QM01AE - Propionic acid derivatives","QM01AE03 - Ketoprofen"],"Absorption, Distribution and Excretion":"Ketoprofen is rapidly and well-absorbed orally, with peak plasma levels occurring within 0.5 to 2 hours.","Aliases":["Ketoprofen","22071-15-4","2-(3-Benzoylphenyl)propanoic acid","2-(3-Benzoylphenyl)propionic acid","Orudis","Oruvail","Capisten","Actron","Alrheumat","Ketoprofene","Aneol","m-Benzoylhydratropic acid","3-Benzoylhydratropic acid","Iso-K","Ketoprofeno","Orudis KT","RP-19583","Sector","Ketoprofenum","Ketorin","(rs)-ketoprofen","Actron ketoprofen","3-Benzoyl-α-methylbenzeneacetic acid","Dtxsid6020771","Benzeneacetic acid, 3-benzoyl-α-methyl-","Hydratropic acid, m-benzoyl-","NSC-758144","19583RP","NEXCEDE","CHEBI:6128","IDEA-033","90Y4QC304K","R.p. 19,583","RU-4733","Dtxcid40771","R.P. 19583","(2RS)-2-(3-Benzoylphenyl)propanoic acid","Benzoylhydratropic Acid","RP19583","ketonal","Ketofen","Ketovail","Kiprofen","Larafen","Powergel","Tiloket","Axorid","KetoMed","Jomethid xl","Larafen cr","Oruvail im","Tiloket cr","RP, 19,583","Ketotard 200 xl","Ketozip 200 xl","Fenoket 200","Ketocid 200","KETOPHENE","Oruvail 100","Oruvail 150","Oruvail 200","Valket 200 retard","Orudis 100","M01AE03","M02AA10","244-759-8","Alrheumun","Profenid","Epatec","Ketoprophene","2-(m-Benzoylphenyl)propionic acid","rac Ketoprofen","Racemic ketoprofen","2-[3-(phenylcarbonyl)phenyl]propanoic acid","RU 4733","Mfcd00055790","CHEMBL571","Propionic acid, 2-(3-benzoylphenyl)-","19583 RP","Mls000079024","Kefenid","Menamin","Lertus","1189508-77-7","Ketopron","Meprofen","Orugesic","Oscorel","Smr000040181","Fastum","Ketoprofen 100 microg/mL in Acetonitrile","Toprec","Toprek","Dexal","racemic-Ketoprofen","RP 19583","Ketoprofen;Dexketoprofen","Sr-01000075949","Alrheumat;","CCRIS 4508","Oruvail;","Ketoprofen CRS","Orudis;","(+) ketoprofen","Ncgc00016757-01","Acide (benzoyl-3-phenyl)-2-propionique","Prestwick_617","Einecs 244-759-8","2-[3-(benzoyl)phenyl]propanoic acid","Cas-22071-15-4","2-(3-benzoylphenyl)-propionic acid","Hydratropic acid, m-benzoyl-, (+-)-","Spectrum_001309","Opera_ID_509","L'Acide (benzoyl-3-phenyl)-2-propionique","Prestwick0_000219","Prestwick1_000219","Prestwick2_000219","Prestwick3_000219","Spectrum2_000956","Spectrum3_001479","Spectrum4_000028","Spectrum5_001254","m-benzoyl-hydratropic acid","Epitope ID:131783","K 1751","Schembl2896","Lopac0_000686","Oprea1_117113","BSPBio_000237","BSPBio_003037","KBioGR_000435","KBioSS_001789","22161-86-0","Mls000028446","Mls001201752","Mls001306444","Mls002548889","Mls006011967","Bidd:gt0443","DivK1c_000598","Schembl679920","Spectrum1501215","Unii-90y4qc304k","SPBio_000952","SPBio_002158","Benzeneacetic acid, 3-benzoyl-α-methyl-, (+-)-","BPBio1_000261","GTPL4795","Ketoprofen - 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Cyclooxygenase Inhibitors"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":39,"Value":{"StringWithMarkup":[{"String":"Chemical Structure [CS] - Anti-Inflammatory Agents, Non-Steroidal"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":39,"Value":{"StringWithMarkup":[{"String":"Established Pharmacologic Class [EPC] - Nonsteroidal Anti-inflammatory Drug"}]}},{"Name":"FDA Pharmacology Summary","ReferenceNumber":39,"Value":{"StringWithMarkup":[{"Markup":[{"Extra":"CID-3825","Length":10,"Start":0,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/Ketoprofen"},{"Extra":"CID-3825","Length":10,"Start":80,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/ketoprofen"}],"String":"Ketoprofen is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of ketoprofen is as a Cyclooxygenase Inhibitor."}]}},{"Name":"Non-Proprietary Name","ReferenceNumber":124,"Value":{"StringWithMarkup":[{"String":"KETOPROFEN"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":124,"Value":{"StringWithMarkup":[{"String":"Anti-Inflammatory Agents, Non-Steroidal [CS]; Cyclooxygenase Inhibitors [MoA]; Nonsteroidal Anti-inflammatory Drug [EPC]"}]}}],"Formating":[],"HMDB ID":"HMDB0015144","HeavyAtomCount":19,"Human Drugs":"Breast Feeding; Lactation; Milk, Human; Analgesic Agents; Anti-inflammatory Agents, Nonsteroidal","IUPACName":"2-(3-benzoylphenyl)propanoic acid","InChI":"InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)","InChIKey":"DKYWVDODHFEZIM-UHFFFAOYSA-N","MeSH Headers":[{"Id":"M0011996","Link":"https://id.nlm.nih.gov/mesh/M0011996.html","Name":"Ketoprofen","Ref":162},{"Id":"M0011998","Link":"https://id.nlm.nih.gov/mesh/M0011998.html","Name":"Orudis","Ref":164},{"Id":"M0352656","Link":"https://id.nlm.nih.gov/mesh/M0352656.html","Name":"Alrheumat","Ref":165},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":166},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":200},{"Id":"M0001335","Link":"https://id.nlm.nih.gov/mesh/M0001335.html","Name":"Anti-Inflammatory Agents, Non-Steroidal","Ref":201},{"Id":"M0025664","Link":"https://id.nlm.nih.gov/mesh/M0025664.html","Name":"Cyclooxygenase Inhibitors","Ref":202}],"MeSH Pharmacological Classification":[{"Id":"M0001335","Link":"https://id.nlm.nih.gov/mesh/M0001335.html","Name":"Anti-Inflammatory Agents, Non-Steroidal","Ref":201},{"Id":"M0025664","Link":"https://id.nlm.nih.gov/mesh/M0025664.html","Name":"Cyclooxygenase Inhibitor","Ref":202}],"Mechanism of Action":"The anti-inflammatory effects of ketoprofen are believed to be due to inhibition cylooxygenase-2 (COX-2), an enzyme involved in prostaglandin synthesis via the arachidonic acid pathway. This results in decreased levels of prostaglandins that mediate pain, fever and inflammation. Ketoprofen is a non-specific cyclooxygenase inhibitor and inhibition of COX-1 is thought to confer some of its side effects, such as GI upset and ulceration. Ketoprofen is thought to have anti-bradykinin activity, as well as lysosomal membrane-stabilizing action. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.","Melting Point":"94 °C","Metabolism/Metabolites":"Rapidly and extensively metabolized in the liver, primarily via conjugation to glucuronic acid. No active metabolites have been identified.","MolecularFormula":"C\u003csub\u003e16\u003c/sub\u003eH\u003csub\u003e14\u003c/sub\u003eO\u003csub\u003e3\u003c/sub\u003e","MolecularWeight":"254.28 g/mol","Opticalactivity":"( + / - )","Pharmacodynamics":"Ketoprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. Ketoprofen has pharmacologic actions similar to those of other prototypical NSAIDs, which inhibit prostaglandin synthesis. Ketoprofen is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and alleviate moderate pain.","Physical Description":"Solid","PubChemId":3825,"Record Description":["LiverTox|Analgesic|Mild-Moderate Pain|NSAID"],"Records":{"UNII":{"Impurities":["3-(cyanomethyl)benzoic acid","2-(3-benzoylphenyl)propionitrile","2-(3-(2,4,5-trimethylbenzoyl)phenyl)propanoic acid, (±)-","3-acetylbenzophenone","3-(1-cyanoethyl)benzoic acid","ketoprofen amide","2-(3-(4-methylbenzoyl)phenyl)propanoic acid","(3-benzoylphenyl)acetic acid","3-(1-carboxyethyl)benzoic acid, (±)-","2-(3-(2(5),3,4-trimethylbenzoyl)phenyl)propanoic acid, (±)-","2-(3-(2,4-dimethylbenzoyl)phenyl)propanoic acid, (±)-","(3-benzoylphenyl)ethanenitrile","methyl-2-(3-benzoylphenyl)propanoate, (s)-","3-benzoylbenzoic acid"]}},"RefChem":"5933","RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Ketoprofen","Name":"Ketoprofen","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q409192","Name":"Ketoprofen","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB01009","Name":"Ketoprofen","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/3825","Name":"Ketoprofen","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=22071-15-4","Name":"Ketoprofen","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0015144","Name":"Ketoprofen","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C01716","Name":"Ketoprofen","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/90Y4QC304K","Name":"Ketoprofen","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020771","Name":"Ketoprofen","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 3825, Ketoprofen. Accessed April 2, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/3825\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/3825\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Ketoprofen. UNII: 90Y4QC304K. Global Substance Registration System. 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class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Subjective Effects":null,"Title":"Ketoprofen","UNII":"90Y4QC304K","Wikidata":"Q409192","Wikipedia":"Ketoprofen","XLogP":3.1}