{"ATC Code":"H02AB09","Abbreviation":"","Aliases":["Cortisol","Acticort","Cetacort","Cortef","Hydrasson","Hydrocortisyl","Hydrocortone","Cobadex","Hytone","Cortenema"],"Biological Half-Life":"Total hydrocortisone via the oral route has a half life of 2.15h while the free fraction has a half life of 1.39h. A 20mg IV dose of hydrocortisone has a terminal half life of 1.9±0.4h.","CAS":"50-23-7","ChEBI":"CHEBI:17650","ChEMBL":"CHEMBL389621","ChemicalClasses":["steroid","steroid"],"Chirality":"absolute","Color/Form":"Plates from alc or iso-propyl alc","Dosing Info":[],"Drug Classes":"Breast Feeding; Lactation; Milk, Human; Corticosteroids, Systemic; Glucocorticoids; Anti-Inflammatory Agents","Drug Indication":"Otic solutions are indicated for infections of the external auditory canal caused by susceptible organisms and with inflammation. Hydrocortisone tablets are indicated for certain endocrine, rheumatic, collagen, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, and other conditions. A hydrocortisone enema is indicated for ulcerative colitis, a topical ointment with antibiotics is indicated for corticosteroid responsive dermatoses with infections, and a topical cream with [acyclovir] is indicated to treat cold sores. Oral granules of hydrocortisone are used as a replacement therapy for Adrenocortical Insufficiency (AI) in children under 17 years of age.","Drug Warnings":"It is not known whether rectal corticosteroids are distributed into breast milk. Systemic corticosteroids are distributed into breast milk and may cause unwanted effects, such as growth suppression, in the infant. Rectal corticosteroids are not recommended for use by breast-feeding mothers. /Corticosteroids, rectal/","DrugClasses":[],"EINECS":"200-020-1","Esters":["acetate","valerate","cypionate"],"European Community (EC) Number":"200-020-1","FDA Pharmacological Classification":"WI4X0X7BPJ","HMDB ID":"HMDB0000063","HeavyAtomCount":26,"Human Drugs":"Breast Feeding; Lactation; Milk, Human; Corticosteroids, Systemic; Glucocorticoids; Anti-Inflammatory Agents","IUPACName":"(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one","Impurities":["hydrocortisone-17-acetate","7.alpha.-hydroxyhydrocortisone","hydrocortisone acetate","6-dehydrocortisol","hydrocortisone 21-aldehyde","(11.beta.)-11,14,17,21-tetrahydroxypregn-4-ene-3,20-dione","6.beta.-hydroxycortisol","cortisone","prednisolone","11.beta.,17,21-trihydroxy-21-(11.beta.,17,21-trihydroxy-3,20-dioxopregn-4-en-21-yl)pregn-4-ene-3,20-dione","21-deoxycortisol","11-deoxycortisol 21-acetate","11-epihydrocortisone","cortodoxone"],"InChI":"InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1","InChIKey":"JYGXADMDTFJGBT-VWUMJDOOSA-N","MeSH Pharmacological Classification":"Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)","Melting Point":"217-220 °C with some decomposition","MolecularFormula":"C\u003csub\u003e21\u003c/sub\u003eH\u003csub\u003e30\u003c/sub\u003eO\u003csub\u003e5\u003c/sub\u003e","MolecularWeight":"362.5 g/mol","Odor":"Odorless","Opticalactivity":"UNSPECIFIED","Pharmacodynamics":"Hydrocortisone binds to the glucocorticoid receptor leading to downstream effects such as inhibition of phospholipase A2, NF-kappa B, other inflammatory transcription factors, and the promotion of anti-inflammatory genes. Hydrocortisone has a wide therapeutic index and a moderate duration of action. Patients should stop taking the medication if irritation or sensitization occurs.","Physical Description":"Solid","PrevSalts":[],"PubChemId":5754,"Record Description":["Cortisol is a 17alpha-hydroxy-C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the \"stress hormone\" as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses. It has a role as an anti-inflammatory drug, an anti-allergic agent, an anti-asthmatic drug, a human metabolite, a mouse metabolite and a drug allergen. It is a 21-hydroxy steroid, an 11beta-hydroxy steroid, a 20-oxo steroid, a 3-oxo-Delta(4) steroid, a primary alpha-hydroxy ketone, a tertiary alpha-hydroxy ketone, a 17alpha-hydroxy-C21-steroid and a glucocorticoid. It derives from a hydride of a pregnane.","Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions. It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.  Hydrocortisone was granted FDA approval on 5 August 1952.","Hydrocortisone is a Corticosteroid. The mechanism of action of hydrocortisone is as a Corticosteroid Hormone Receptor Agonist.","Hydrocortisone has been reported in Ganoderma boninense, Homo sapiens, and Phlomoides rotata with data available.","Therapeutic Hydrocortisone is a synthetic or semisynthetic analog of natural hydrocortisone hormone produced by the adrenal glands with primary glucocorticoid and minor mineralocorticoid effects. As a glucocorticoid receptor agonist, hydrocortisone promotes protein catabolism, gluconeogenesis, capillary wall stability, renal excretion of calcium, and suppresses immune and inflammatory responses. (NCI04)","HYDROCORTISONE is a small molecule drug with a maximum clinical trial phase of IV (across all indications) that was first approved in 1952 and has 35 approved and 62 investigational indications.","The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.","See also: Acetic acid, glacial; hydrocortisone (annotation moved to); Hydrocortisone Acetate (annotation moved to); Hydrocortisone; polymyxin B sulfate (annotation moved to) ... View More ...","Cortisol is a 17alpha-hydroxy-C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the \"stress hormone\" as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses. It has a role as an anti-inflammatory drug, an anti-allergic agent, an anti-asthmatic drug, a human metabolite, a mouse metabolite and a drug allergen. It is a 21-hydroxy steroid, an 11beta-hydroxy steroid, a 20-oxo steroid, a 3-oxo-Delta(4) steroid, a primary alpha-hydroxy ketone, a tertiary alpha-hydroxy ketone, a 17alpha-hydroxy-C21-steroid and a glucocorticoid. It derives from a hydride of a pregnane.","LiverTox|Endocrine|Hormone replacement|Corticosteroid"],"References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Hydrocortisone","Name":"Hydrocortisone","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q190875","Name":"Hydrocortisone","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB00741","Name":"Hydrocortisone","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/5754","Name":"Hydrocortisone","Sub":false}]},{"Name":"ChemSpider","Urls":[{"Link":"https://www.chemspider.com/Chemical-Structure.5551.html","Name":"Hydrocortisone","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL389621","Name":"Hydrocortisone","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:17650","Name":"Hydrocortisone","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=50-23-7","Name":"Hydrocortisone","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0000063","Name":"Hydrocortisone","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C00735","Name":"Hydrocortisone","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/WI4X0X7BPJ","Name":"Hydrocortisone","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020714","Name":"Hydrocortisone","Sub":false}]}],"SMILES":"C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O","Solubility":"Amorphous, hygroscopic, white powder. 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