{"Abbreviation":"","Aliases":["1H-Imidazole-4-ethanamine","Ergamine","Ergotidine","2-(4-Imidazolyl)ethylamine","5-Imidazoleethylamine","Eramin","Theramine","Free histamine","2-(1H-Imidazol-4-yl)ethanamine","β-Aminoethylimidazole"],"Boiling Point":"209-210 °C @ 18 MM HG","CAS":"51-45-6","ChEBI":"CHEBI:18295","ChEMBL":"CHEMBL90","ChemicalClasses":["arylethylamine"],"Chirality":"achiral","Classes":["Neurotransmitters"],"Color/Form":"NEEDLES FROM CHLOROFORM","Dosing Info":[],"Drug Indication":"Histamine phosphate is indicated as a diagnostic aid for the evaluation of gastric acid secretory function.","Drug Warnings":"/WHEN HISTAMINE IS EMPLOYED TOPICALLY TO EYE IN CONCN FROM 0.1 TO 10% IT CAUSES/ VASODILATION \u0026 EDEMA OF CONJUNCTIVA.","DrugClasses":[],"EINECS":"200-100-6","European Community (EC) Number":"200-100-6","FullSalts":["Histamine phosphate"],"HMDB ID":"HMDB0000870","HeavyAtomCount":8,"IUPACName":"2-(1H-imidazol-5-yl)ethanamine","InChI":"InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)","InChIKey":"NTYJJOPFIAHURM-UHFFFAOYSA-N","MeSH Pharmacological Classification":"Drugs that bind to and activate histamine receptors. Although they have been suggested for a variety of clinical applications histamine agonists have so far been more widely used in research than therapeutically. (See all compounds classified as Histamine Agonists.)","Melting Point":"83-84 °C","MolecularFormula":"C\u003csub\u003e5\u003c/sub\u003eH\u003csub\u003e9\u003c/sub\u003eN\u003csub\u003e3\u003c/sub\u003e","MolecularWeight":"111.15 g/mol","Pharmacodynamics":"Histamine stimulates gastric gland secretion, causing an increased secretion of gastric juice of high acidity. This action is probably due mainly to a direct action on parietal and chief gland cells.","Physical Description":"Solid","PrevSalts":["phosphate"],"PubChemId":774,"Record Description":["Histamine is a member of the class of imidazoles that is 1H-imidazole substituted at position C-4 by a 2-aminoethyl group. It has a role as a human metabolite, a mouse metabolite and a neurotransmitter. It is an aralkylamino compound and a member of imidazoles. It is a conjugate base of a histaminium.","A depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.","Histamine has been reported in Cynanchum caudatum, Phytolacca japonica, and other organisms with data available.","HISTAMINE is a small molecule drug with a maximum clinical trial phase of IV (across all indications) that was first approved in 1939 and is indicated for neoplasm and acute myeloid leukemia and has 12 investigational indications. This drug has a black box warning from the FDA.","Histamine is a metabolite found in or produced by Saccharomyces cerevisiae.","An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.","See also: Histamine Dihydrochloride (has salt form); Histamine Phosphate (has salt form); Acetylcholine Chloride; Histamine; Serotonin (component of) ... View More ...","Histamine is a member of the class of imidazoles that is 1H-imidazole substituted at position C-4 by a 2-aminoethyl group. It has a role as a human metabolite, a mouse metabolite and a neurotransmitter. It is an aralkylamino compound and a member of imidazoles. It is a conjugate base of a histaminium."],"References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Histamine","Name":"Histamine","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q61233","Name":"Histamine","Sub":false},{"Link":"https://www.wikidata.org/wiki/Q27077043","Name":"(+)-Histamine","Sub":true}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB05381","Name":"Histamine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/774","Name":"Histamine","Sub":false},{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/71083","Name":"(+)-Histamine","Sub":true}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL90","Name":"Histamine","Sub":false},{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL104875","Name":"(+)-Histamine","Sub":true}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:18295","Name":"Histamine","Sub":false},{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:27947","Name":"(+)-Histamine","Sub":true}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=51-45-6","Name":"Histamine","Sub":false},{"Link":"https://commonchemistry.cas.org/detail?cas_rn=351-50-8","Name":"(+)-Histamine","Sub":true}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0000870","Name":"Histamine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C00388","Name":"Histamine","Sub":false},{"Link":"https://www.kegg.jp/entry/C06419","Name":"(+)-Histamine","Sub":true}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/820484N8I3","Name":"Histamine","Sub":false},{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/4JE5HRM5CH","Name":"(+)-Histamine","Sub":true}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID4023125","Name":"Histamine","Sub":false},{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID70889344","Name":"(+)-Histamine","Sub":true}]}],"SMILES":"C1=C(NC=N1)CCN","Salts":["phosphate"],"SaltsAcidCount":[2],"SaltsAmineCount":[1],"SaltsUNII":["QWB37T4WZZ"],"Solubility":"14.1 [ug/mL] (The mean of the results at pH 7.4)","Stability/Shelf Life":"STABLE IN AIR BUT IS AFFECTED BY LIGHT /PHOSPHATE/","Stereoisomers":["(+)-Histamine","(-)-Histamine"],"StereoisomersUNII":["4JE5HRM5CH",""],"StoreUNII":["820484N8I3"],"StructureBase64":"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Uses":"EXPTL USE: IN VET MEDICINE PRIMARILY FOR EXPTL PRODN OF ULCERS IN DOGS \u0026 HOGS, \u0026 OCCASIONALLY TO DETERMINE STATUS OF HYDROCHLORIC ACID SECRETION IN STOMACH OF DOGS BY USE OF \"DIAGNEX BLUE-TEST\" OR \"GASTRO-TEST\"...","Title":"Histamine","UNII":"820484N8I3","Wikidata":"Q61233","Wikipedia":"Histamine","XLogP":-0.7}