{"ATC Code":"A01AB12","Abbreviation":"","Aliases":["Oraldene","Sterisil","Glypesin","Elsix","Sterilate","Triocil","Triscol","Collu hextril","Duranil Aerosol","Hexetidina"],"Boiling Point":"160 °C","CAS":"141-94-6","ChEBI":"CHEBI:94339","ChEMBL":"CHEMBL144673","ChemicalClasses":[],"Chirality":"mixed","Classes":null,"Color/Form":"Liquid","Density":"0.8889 at 20 °C g/cm\u003csup\u003e3\u003c/sup\u003e","Drug Warnings":"Oral disinfectants containing chlorhexidine or hexetidine are able to produce disturbances of taste, as demonstrated by Krarup's electrogustometric method and the gustometric method of Harris and Kalmus. Hypo- and dysgeusia are characterized by dissociated disturbances, the most prominent of which concerns the sweet perception. The bitter taste is least affected, whereas the effects on salty and acidic tastes range between that for sweet and bitter. Taste disturbances which include ageusia for 48 hr were observed when the tongue was touched with a 20% solution of chlorhexidine. Not only the disinfectants themselves provoked dysgeusia but also other \"taste improving\" agents (particularly, the volatile /oils/). In addition to dysgeusia, the authors found disturbances of the mucous membrane sensitivity caused by the test substances.","DrugClasses":[],"EINECS":"205-513-5","EliminationHalfLife":"","Erowid Experience Reports":[],"European Community (EC) Number":"205-513-5","HMDB ID":"HMDB0253159","HeavyAtomCount":24,"IUPACName":"1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine","Impurities":["dehydrohexetidine","hexedine","1,5-naphthalenedisulfonic acid","propoctamine"],"InChI":"InChI=1S/C21H45N3/c1-6-10-12-19(8-3)14-23-16-21(5,22)17-24(18-23)15-20(9-4)13-11-7-2/h19-20H,6-18,22H2,1-5H3","InChIKey":"DTOUUUZOYKYHEP-UHFFFAOYSA-N","MeSH Pharmacological Classification":"Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)","Melting Point":"Freezing point = 70 °C","MolecularFormula":"C\u003csub\u003e21\u003c/sub\u003eH\u003csub\u003e45\u003c/sub\u003eN\u003csub\u003e3\u003c/sub\u003e","MolecularWeight":"339.6 g/mol","Opticalactivity":"UNSPECIFIED","PrevSalts":[],"PubChemId":3607,"Record Description":["1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine is an organonitrogen heterocyclic compound and an organic heteromonocyclic compound.","A bactericidal and fungicidal antiseptic. It is used as a 0.1% mouthwash for local infections and oral hygiene.","HEXETIDINE is a small molecule drug with a maximum clinical trial phase of IV and is indicated for infection.","A bactericidal and fungicidal antiseptic. It is used as a 0.1% mouthwash for local infections and oral hygiene. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)","1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine is an organonitrogen heterocyclic compound and an organic heteromonocyclic compound."],"RefCount":3,"References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Hexetidine","Name":"Hexetidine","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q419749","Name":"Hexetidine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB08958","Name":"Hexetidine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/3607","Name":"Hexetidine","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL144673","Name":"Hexetidine","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:94339","Name":"Hexetidine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=141-94-6","Name":"Hexetidine","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0253159","Name":"Hexetidine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D07068","Name":"Hexetidine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/852A84Y8LS","Name":"Hexetidine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID1045297","Name":"Hexetidine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 3607, Hexetidine. Accessed June 27, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/3607\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/3607\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Hexetidine. UNII: 852A84Y8LS. Global Substance Registration System. Accessed June 27, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/852A84Y8LS\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/852A84Y8LS\u003c/a\u003e"],"SMILES":"CCCCC(CC)CN1CC(CN(C1)CC(CC)CCCC)(C)N","Scheduling":[],"Solubility":"Soluble in petroleum ether, methanol, benzene, acetone, ethanol, n-hexane, chloroform","StoreUNII":["852A84Y8LS"],"StructureBase64":"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","Subjective Effects":null,"Therapeutic Uses":"A bactericidal and fungicidal antiseptic. It is used as a 0.1% mouthwash for local infections and oral hygiene.","Title":"Hexetidine","UNII":"852A84Y8LS","Wikidata":"Q419749","Wikipedia":"Hexetidine","XLogP":5.7}