{"Abbreviation":[],"Adverse Effects":"Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.","Aliases":["N-(Phosphonomethyl)glycine","Glyphosphate","N-Phosphomethylglycine","N-Phosphonomethylglycine","Pondmaster","Glyfos","Silglif","Glycine, N-(phosphonomethyl)-","Roundup Max","Folusen","Glialka","Herbatop","Phorsat","Forsat","Hockey","Rebel Garden","Glyphodin A","Glyphosate CT","Glialka 36","phosphonomethylglycine","MON 2139","Mon 6000","Lancer","CP 67573","Tumbleweed"],"Biological Half-Life":"Male and female Sprague-Dawley rats received single intraperitoneal injections of radiolabeled (14)C glyphosate. The dose level of glyphosate used for male and female rats was 1150 mg/kg. Blood samples were collected 0.25, 0.50, 1, 2, 4, 6 and 10 hours after injection. ... Assuming first order kinetics, the decrease in radioactivity in bone marrow occurred with a half-life of 7.6 and 4.2 hours for males and females, respectively. Similarly, the half-lives of the radioactivity in plasma were approximately 1 hour for both sexes.","CAS":"1071-83-6","ChEBI":"CHEBI:27744","ChEMBL":"CHEMBL95764","ChemicalClasses":["carboxylic acid"],"Chirality":"achiral","Color/Form":"White crystals","Decomposition":"When heated to decomposition it emits very toxic fumes of /nitrogen and phosphorus oxides/.","Density":"1.74 (NTP, 1992) - Denser than water; will sink g/cm\u003csup\u003e3\u003c/sup\u003e","EINECS":"213-997-4","Ecotoxicity Values":"LC50; Species: /Oncorhynchus mykiss/ (Rainbow trout) weight 0.8 g; Conditions: static bioassay without aeration, 12 °C, pH 7.2-7.5, water hardness 40-50 mg/L as calcium carbonate and alkalinity of 30-35 mg/L Concentration: 130 mg/L for 96 hr (95% confidence interval: 108-156 mg/L) /Technical material, 96.7%/","Esters":[],"European Community (EC) Number":"213-997-4","Formating":[],"HMDB ID":"HMDB0252891","HeavyAtomCount":10,"IUPACName":"2-(phosphonomethylamino)acetic acid","InChI":"InChI=1S/C3H8NO5P/c5-3(6)1-4-2-10(7,8)9/h4H,1-2H2,(H,5,6)(H2,7,8,9)","InChIKey":"XDDAORKBJWWYJS-UHFFFAOYSA-N","Interactions":"/This study/ investigated whether glyphosate influences the cellular toxicity of the surfactants TN-20 and LN-10 on the mouse fibroblast-like cells, alveolar epithelial cells, and a heart cell line. The cytotoxicity of TN-20 and LN-10 (0.4-100 uM), in the presence or absence of glyphosate was determined by assessing membrane integrity. TN-20 toxicity was significantly lower in the presence of 50 uM glyphosate for the fibroblast-like cell (6.25 uM; 3.9% +/- 3.4% vs -4.8%+/-0.7%), for the alveolar cells (0.78 uM; 5.7% +/- 0.9% vs 0.1% +/- 0.6%), and for the heart cell line (25.0 uM; 7.9% +/-3.0% vs 19.4% +/- 0.7%) compared to that of TN-20 alone. The cellular toxicity of LN-10 towards the fibroblast-like cells was found to be increased in the presence of 50 uM glyphosate when LN-10 concentrations of 50 uM (31.3% +/- 3.9% vs 19.2% +/-0.9%) and 100 uM (62.1% +/- 3.4% vs 39.0% +/- 0.7%) were compared to that of LN-10 alone. These results suggest that the mixture toxicity may be a factor in glyphosate-surfactant toxicity in patients with acute glyphosate herbicide intoxication.","LC50":[{"dosages":[{"amount":"\u0026gt;12200 mg/m3/4","route":"inhalation"}],"organism":"Rat"}],"LD50":[{"dosages":[{"amount":"4873 mg/kg","route":"oral"},{"amount":"235 mg/kg","route":"intraperitoneal"}],"organism":"Rat"},{"dosages":[{"amount":"1568 mg/kg","route":"oral"},{"amount":"130 mg/kg","route":"intraperitoneal"}],"organism":"Mouse"},{"dosages":[{"amount":"3800 mg/kg","route":"oral"},{"amount":"7940 mg/kg","route":"skin"}],"organism":"Rabbit"},{"dosages":[{"amount":"\u0026gt;4640 mg/kg","route":"oral"}],"organism":"Quail"}],"LDLo":[{"dosages":[{"amount":"2143 mg/kg","route":"oral"}],"organism":"Human - male"},{"dosages":[{"amount":"4 gm/kg","route":"oral"}],"organism":"Human - female"}],"Melting Point":"446 °","MolecularFormula":"C\u003csub\u003e3\u003c/sub\u003eH\u003csub\u003e8\u003c/sub\u003eNO\u003csub\u003e5\u003c/sub\u003eP","MolecularWeight":"169.07 g/mol","Non-Human Toxicity Values":"LD50 Rabbit percutaneous \u003e5000 mg/kg","Odor":"Odorless","Physical Description":"Glyphosate is an odorless white powder. Decomposition begins at approximately 419 °F (darkens). pH (1% solution in water) 2.5. (NTP, 1992)","PubChemId":3496,"RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Glyphosate","Name":"Glyphosate","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q407232","Name":"Glyphosate","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB04539","Name":"Glyphosate","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/3496","Name":"Glyphosate","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL95764","Name":"Glyphosate","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:27744","Name":"Glyphosate","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=1071-83-6","Name":"Glyphosate","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0252891","Name":"Glyphosate","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C01705","Name":"Glyphosate","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/4632WW1X5A","Name":"Glyphosate","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024122","Name":"Glyphosate","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 3496, Glyphosate. Accessed September 15, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/3496\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/3496\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Glyphosate. UNII: 4632WW1X5A. Global Substance Registration System. Accessed September 15, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/4632WW1X5A\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/4632WW1X5A\u003c/a\u003e"],"SMILES":"C(C(=O)O)NCP(=O)(O)O","SaltData":[],"Salts":[],"Solubility":"5 to 10 mg/mL at 64 °F (NTP, 1992)","Stability/Shelf Life":"Negligible volatility","StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 69.085 82.362\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h70v83H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m33.522 25.941-13.198-7.62\" class=\"bond\"/\u003e\u003cg 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