{"Abbreviation":"","Aliases":["Gaboxadolum","MK-0928","4,5,6,7-Tetrahydroisoxazolo(5,4-c)pyridin-3-ol","Lu 02-030","4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol","Lu-02-030","4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one","LU-02030","Isoxazolo(5,4-c)pyridin-3(2H)-one, 4,5,6,7-tetrahydro-","2H,3H,4H,5H,6H,7H-[1,2]oxazolo[5,4-c]pyridin-3-one"],"CAS":"64603-91-4","ChEBI":"CHEBI:34373","ChEMBL":"CHEMBL312443","ChemicalClasses":[],"Chirality":"achiral","Dosing Info":[],"Drug Indication":"Investigated for use/treatment in sleep disorders and insomnia.","DrugClasses":[],"EINECS":"264-963-0","European Community (EC) Number":"264-963-0","FullSalts":["Gaboxadol monohydrate","Gaboxadol hydrochloride"],"HMDB ID":"HMDB0252570","HeavyAtomCount":10,"IUPACName":"4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-3-one","InChI":"InChI=1S/C6H8N2O2/c9-6-4-1-2-7-3-5(4)10-8-6/h7H,1-3H2,(H,8,9)","InChIKey":"ZXRVKCBLGJOCEE-UHFFFAOYSA-N","MeSH Pharmacological Classification":"Endogenous compounds and drugs that bind to and activate GAMMA-AMINOBUTYRIC ACID receptors (RECEPTORS, GABA). (See all compounds classified as GABA Agonists.)","MolecularFormula":"C\u003csub\u003e6\u003c/sub\u003eH\u003csub\u003e8\u003c/sub\u003eN\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e2\u003c/sub\u003e","MolecularWeight":"140.14 g/mol","PrevSalts":["monohydrate","hydrochloride"],"PubChemId":3448,"Record Description":["4,5,6,7-Tetrahydroisoxazolo(5,4-c)pyridin-3-ol is an oxazole.","Gaboxadol also known as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP) is an experimental sleep aid drug developed by Lundbeck and Merck, who reported increased deep sleep without the reinforcing effects of benzodiazepines. Development of Gaboxadol was stopped in March 2007 after concerns regarding safety and efficacy. It acts on the GABA system, but in a seemingly different way from benzodiazepines and other sedatives.","GABOXADOL is a small molecule drug with a maximum clinical trial phase of III (across all indications) and has 4 investigational indications.","4,5,6,7-Tetrahydroisoxazolo(5,4-c)pyridin-3-ol is an oxazole."],"References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Gaboxadol","Name":"Gaboxadol","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q4130924","Name":"Gaboxadol","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB06554","Name":"Gaboxadol","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/3448","Name":"Gaboxadol","Sub":false}]},{"Name":"ChemSpider","Urls":[{"Link":"https://www.chemspider.com/Chemical-Structure.3330.html","Name":"Gaboxadol","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL312443","Name":"Gaboxadol","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:34373","Name":"Gaboxadol","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=64603-91-4","Name":"Gaboxadol","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0252570","Name":"Gaboxadol","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D04282","Name":"Gaboxadol","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/K1M5RVL18S","Name":"Gaboxadol","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID0045206","Name":"Gaboxadol","Sub":false}]}],"SMILES":"C1CNCC2=C1C(=O)NO2","Salts":["monohydrate","hydrochloride"],"SaltsAcidCount":[0,1],"SaltsAmineCount":[1,1],"SaltsUNII":["91413J4SLI","478RVH3TVD"],"StoreUNII":["K1M5RVL18S"],"StructureBase64":"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