{"ATC Code":"N03","Abbreviation":"","Aliases":["Fenfluramine","fenfluramine","Obedrex","Rotondin","Pesos","Ponderax PA","Fenfluramina","Acino","Fenfluraminum","Fenfluramin","Phenfluramine","Brabafen","Ponderax","ZX008","2-Ethylamino-1-(3-trifluoromethylphenyl)propane","1-(meta-Trifluoromethyl-phenyl)-2 ethylaminopropane","N-Ethyl-α-methyl-3-trifluoromethylphenethylamine","S 768","3-(Trifluoromethyl)-N-ethyl-α-methylphenethylamine","N-Ethyl-α-methyl-m-(trifluoromethyl)phenethylamine","N-Ethyl-α-methyl-3-(trifluoromethyl)benzeneethanamine","Benzeneethanamine, N-ethyl-α-methyl-3-(trifluoromethyl)-","ZX-008","J5.760F","Z008"],"Biological Half-Life":"Fenfluramine has an elimination half-life of 20 hours in healthy subjects.","Boiling Point":"108-112","CAS":"458-24-2","ChEBI":"CHEBI:5000","ChEMBL":"CHEMBL87493","ChemicalClasses":["amphetamine"],"Chirality":"racemic","DEA no":1670,"Decomposition":"When heated to decomp it emits very toxic fumes of fluoride ion and oxides of nitrogen.","Drug Indication":"Fenfluramine is indicated for the treatment of seizures associated with Dravet syndrome and  Lennox-Gastaut syndrome in patients aged two years and older.","Drug Warnings":"Temporal association between use of fenfluramine (Pondimin) or dexfenfluramine (Redux) and the development of unusual mitral, aortic, tricuspid, and/or pulmonary valvular (usually multivalvular) and echocardiographic abnormalities (that sometimes occurred concomitantly with pulmonary hypertension, occasionally required open heart surgery, and rarely were fatal) resulted in the withdrawal of /this/ anorexigenic agents from the US market in 1997.","EINECS":"207-276-3","Erowid Experience Reports":null,"Esters":[],"European Community (EC) Number":"207-276-3","Formating":[],"HMDB ID":"HMDB0252200","HeavyAtomCount":16,"Human Drugs":"Human drug -\u003e Prescription","IUPACName":"N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine","InChI":"InChI=1S/C12H16F3N/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15/h4-6,8-9,16H,3,7H2,1-2H3","InChIKey":"DBGIVFWFUFKIQN-UHFFFAOYSA-N","MeSH Pharmacological Classification":"Drugs used for their effects on serotonergic systems. Among these are drugs that affect serotonin receptors, the life cycle of serotonin, and the survival of serotonergic neurons. (See all compounds classified as Serotonin Agents.)","Melting Point":"160-170","MolecularFormula":"C\u003csub\u003e12\u003c/sub\u003eH\u003csub\u003e16\u003c/sub\u003eF\u003csub\u003e3\u003c/sub\u003eN","MolecularWeight":"231.26 g/mol","Pharmacodynamics":"Fenfluramine increases extracellular serotonin levels, and also acts as both a serotonergic 5-HT\u003csub\u003e2\u003c/sub\u003e receptor agonist and σ1 receptor antagonist. These activities, through an incompletely understood mechanism, lead to anti-epileptiform activity and therapeutic benefit. This modulation has other effects such as decreased appetite, weight loss, sedation, lethargy, increased blood pressure, and mood alteration including possible suicidal ideation. There is a risk of glaucoma and potentially fatal serotonin syndrome. Fenfluramine should be gradually withdrawn following treatment alteration or cessation.","PubChemId":3337,"RefCount":2,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Fenfluramine","Name":"Fenfluramine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB00574","Name":"Fenfluramine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/3337","Name":"Fenfluramine","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL87493","Name":"Fenfluramine","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:5000","Name":"Fenfluramine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=458-24-2","Name":"Fenfluramine","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0252200","Name":"Fenfluramine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C06996","Name":"Fenfluramine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/2DS058H2CF","Name":"Fenfluramine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID4023044","Name":"Fenfluramine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 3337, Fenfluramine. Accessed July 25, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/3337\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/3337\u003c/a\u003e"],"Reported Fatal Dose":"The lowest reported fatal dose of fenfluramine hydrochloride was 400 mg in a small child and the highest reported nonfatal dose was 1.8 g in an adult.","SMILES":"CCNC(C)CC1=CC(=CC=C1)C(F)(F)F","SaltData":[],"Salts":[],"Stability/Shelf Life":"Generally stable under ordinary conditions in light, air, \u0026 heat /Hydrochloride/","StereoisomerData":[{"Aliases":null,"PubChemId":null,"SMILES":"CCN[C@H](C)Cc1cccc(C(F)(F)F)c1","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 97.391 72.449\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#90e050\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" 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2.776-4.81M4.168 9.885l5.479 3.162M20.677 6.59l-2.776 4.809\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Therapeutic Uses":"The Food and Drug Administration, acting on ... evidence about significant side-effects associated with fenfluramine and dexfenfluramine, has asked the manufacturers to voluntarily withdraw both treatments for obesity from the market. ...  Both companies have agreed to voluntarily withdraw their drugs. The FDA is not requesting the withdrawal of phentermine, the third widely used medication for obesity.  The action is based on ... findings from doctors who have evaluated patients taking these two drugs with echocardiograms, a special procedure that can test the functioning of heart valves. These findings indicate that approximately 30 percent of patients who were evaluated had abnormal echocardiograms, even though they had no symptoms. This is a much higher than expected percentage of abnormal test results.","Title":"Fenfluramine","UNII":"2DS058H2CF","Wikipedia":"Fenfluramine","XLogP":3.4}