{"Abbreviation":["PCE"],"Aliases":["N-Ethyl-1-phenylcyclohexylamine","Cyclohexanamine, N-ethyl-1-phenyl-","Ethylphencyclidine","N-ethyl-1-phenylcyclohexanamine","RefChem:139230","Cyclohexamine","Eticiclidina","Cyclohexylamine, N-ethyl-1-phenyl-","Eticyclidina","Eticyclidinum","(1-Phenylcyclohexyl)ethylamine","N-(1-Phenylcyclohexyl)ethylamine","CI 400","Wln: l6tj am2 ar","Ethyl-(1-phenyl-cyclohexyl)-amine","Cyclohexanamine, 1-phenyl, N-ethyl","C22716","4-12-00-02968"],"CAS":"2201-15-2","ChEMBL":"CHEMBL279924","ChemicalClasses":["arylcyclohexylamine"],"Chirality":"achiral","DEA no":7455,"Esters":[],"Formating":[],"HMDB ID":"HMDB0252096","HeavyAtomCount":15,"IUPACName":"N-ethyl-1-phenylcyclohexan-1-amine","InChI":"InChI=1S/C14H21N/c1-2-15-14(11-7-4-8-12-14)13-9-5-3-6-10-13/h3,5-6,9-10,15H,2,4,7-8,11-12H2,1H3","InChIKey":"IFYLVUHLOOCYBG-UHFFFAOYSA-N","Interactions":"The isolated perfused lung (IPL) of rats were used to examine the pulmonary disposition and metabolism of radiolabeled phencyclidine (PCP) and N-ethyl-1-phenylcyclohexylamine (PCE). The IPL removed PCP and PCE from the perfusate and converted them to free and conjugated metabolites. At the conclusion of a 1-hr perfusion, the lung accumulated at least 20% of the administered radioactivity and metabolized more than 30% of the added drug. Pretreatment of rats with 3-MC or cigarette smoke enhanced significantly PCP and PCE metabolism by the IPL. The concentration of conjugated PCE metabolite in the perfusate of the IPL was increased significantly by both 3-MC and cigarette smoke pretreatments whereas the concentration of conjugated PCP metabolite was not affected by cigarette smoke exposure and increased only slightly after 3-MC pretreatment. Pretreatment of rats with 3-MC or cigarette smoke also altered the amount of radioactivity accumulated by the lung tissue at the conclusion of a 1-hr perfusion. Inasmuch as PCP and PCE are often abused by humans via smoke inhalation, a significant amount of these drugs may be stored or metabolized by the lung.","MolecularFormula":"C\u003csub\u003e14\u003c/sub\u003eH\u003csub\u003e21\u003c/sub\u003eN","MolecularWeight":"203.32 g/mol","PubChemId":16622,"Record Description":["Wikipedia|List of designer drugs|Dissociatives|Arylcyclohexylamines"],"RefCount":4,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Eticyclidine","Name":"Eticyclidine","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q2365803","Name":"Eticyclidine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/16622","Name":"Eticyclidine","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL279924","Name":"Eticyclidine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=2201-15-2","Name":"Eticyclidine","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0252096","Name":"Eticyclidine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C22716","Name":"Eticyclidine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/O8I1LL6A89","Name":"Eticyclidine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID2062248","Name":"Eticyclidine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 16622, Eticyclidine. Accessed September 14, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/16622\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/16622\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Eticyclidine. UNII: O8I1LL6A89. Global Substance Registration System. Accessed September 14, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/O8I1LL6A89\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/O8I1LL6A89\u003c/a\u003e","Anvisa. RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. July 24, 2023. Accessed September 14, 2025. \u003ca href=https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-804-de-24-de-julho-de-2023-498447451\u003ehttps://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-804-de-24-de-julho-de-2023-498447451\u003c/a\u003e"],"SMILES":"CCNC1(CCCCC1)C2=CC=CC=C2","SaltData":[],"Salts":[],"Scheduling":[{"gov":"Australia","ref":[],"schedule":"S9 substance"},{"gov":"Brazil","ref":["3"],"schedule":"F2 substance"},{"gov":"Canada","ref":[],"schedule":"Schedule III substance"},{"gov":"Germany","ref":[],"schedule":"Anlage I substance"},{"act":"Controlled Substances Act (CSA)","gov":"United States","ref":[],"schedule":"Schedule I"},{"gov":"United Kingdom","ref":[],"schedule":"Class B substance"},{"act":"Convention on Psychotropic Substances 1971","gov":"United Nations","ref":[],"schedule":"Schedule I drug"}],"StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 52.243 70.224\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#3050f8\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h53v71H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m50.014 1.055-9.789 11.669M40.225 12.724l3.84 10.547M42.595 30.422l-6.949 8.283M35.646 38.705l13.191 7.616M48.837 46.321l-.004 15.24M48.833 61.561l-13.196 7.624M35.637 69.185 22.446 61.57M22.446 61.57l.005-15.24M35.646 38.705 22.451 46.33M35.646 38.705l-9.793-11.666\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m10.846 29.694 15.007-2.655M11.808 27.047l12.235-2.164\"/\u003e\u003c/g\u003e\u003cpath d=\"M10.846 29.694 1.053 18.028\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m6.267 3.708-5.214 14.32M8.077 5.864 3.826 17.539\"/\u003e\u003c/g\u003e\u003cpath d=\"m6.267 3.708 15.007-2.655\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M31.067 12.719 21.274 1.053M28.294 13.208 20.312 3.7\"/\u003e\u003c/g\u003e\u003cpath d=\"m25.853 27.039 5.214-14.32\" class=\"bond\"/\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M47.377 29.486h-.721l-2.619-4.066h-.03l.03.595q.024.358.024.733v2.738h-.566v-4.899h.715l2.607 4.054h.03l-.018-.328-.024-.476q-.006-.262-.006-.482v-2.768h.578zM51.683 29.486h-.619V27.2h-2.513v2.286h-.613v-4.899h.613v2.071h2.513v-2.071h.619z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"#3050f8\" d=\"m44.065 23.271-1.92-5.273M42.595 30.422l-3.475 4.141\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Title":"Eticyclidine","UNII":"O8I1LL6A89","Wikidata":"Q2365803","Wikipedia":"Eticyclidine","XLogP":3.3}