{"Abbreviation":"","Aliases":["(-)-Etafedrine","(1r,2s)-2-[ethyl(methyl)amino]-1-phenylpropan-1-ol","1-N-Ethylephedrine","Novedrin","(1R,2S)-N-Ethylephedrine","Etafedrine, (-)-","Menetryl","α-(1-(Ethylmethylamino)ethyl)benzyl alcohol","Etafedrina","Etafedrinum"],"Biological Half-Life":"It has a plasma half-life ranging from 3 to 6 hours depending on urinary pH.","CAS":"48141-64-6","ChemicalClasses":["phenylethanolamine"],"Chirality":"absolute","Classes":["Sympathomimetic"],"Dosing Info":[],"Drug Indication":"Conditions characterized by bronchial congestion and bronchospasm when an expectorant or bronchodilator action is required, such as acute bronchitis, acute episodes of chronic bronchitis and bronchial asthma,.","DrugClasses":[],"EINECS":"256-359-0","EliminationHalfLife":"","European Community (EC) Number":"256-359-0","HeavyAtomCount":14,"Human Drugs":"Pharmaceuticals","IUPACName":"(1R,2S)-2-[ethyl(methyl)amino]-1-phenylpropan-1-ol","InChI":"InChI=1S/C12H19NO/c1-4-13(3)10(2)12(14)11-8-6-5-7-9-11/h5-10,12,14H,4H2,1-3H3/t10-,12-/m0/s1","InChIKey":"IRVLBORJKFZWMI-JQWIXIFHSA-N","Melting Point":"108-110","MolecularFormula":"C\u003csub\u003e12\u003c/sub\u003eH\u003csub\u003e19\u003c/sub\u003eNO","MolecularWeight":"193.28 g/mol","Opticalactivity":"UNSPECIFIED","Pharmacodynamics":"Etafedrine helps to control the cough which is associated with irritation of the mouth and throat that is not alleviated by cough medications that are less strong.  The results of one study in 48 individuals showed that lung FEV1 (forced expiratory volume) and lung VC (vital capacity) were significantly improved with etafedrine, sleep improved, and patients showed improved appetite in addition to the suppression of cough.","PrevSalts":[],"PubChemId":94532,"Record Description":["Etafedrine (INN) or ethylephedrine is a long-acting bronchodilator and has been an ingredient combined with other drugs in the brand names Nethaprin and Dalmacol. It was previously available as both the free base and as the hydrochloride salt manufactured by Sanofi-Aventis (now Sanofi) has been discontinued.  Ethylephedrine is be formed by alkylating ephedrine with ethyl iodide. The hydrochloride is be prepared by passing hydrogen chloride through a solution of ethylephedrine in diethyl ether.  This belongs to the family of medications called decongestants. It acts by narrowing blood vessels in the nasal passages, helping to relieve nasal congestion."],"References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Etafedrine","Name":"Etafedrine","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q5402378","Name":"Etafedrine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB11587","Name":"Etafedrine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/94532","Name":"Etafedrine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=48141-64-6","Name":"Etafedrine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/2Y6VQU63E8","Name":"Etafedrine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID201016521","Name":"Etafedrine","Sub":false}]}],"SMILES":"CCN(C)[C@@H](C)[C@@H](C1=CC=CC=C1)O","Scheduling":[{"gov":"Australia","schedule":"S2 substance"},{"gov":"Brazil","schedule":"D1 substance"}],"StoreUNII":["2Y6VQU63E8"],"StructureBase64":"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