{"ATC Code":"QG03CA04","Abbreviation":"E3","Aliases":["Trihydroxyestrin","Aacifemine","Estratriol","Ovestrion","Destriol","Theelol","Tridestrin","Oestratriol","Orestin","Ortho-Gynest"],"CAS":"50-27-1","ChEBI":"CHEBI:27974","ChEMBL":"CHEMBL193482","ChemicalClasses":["steroid"],"Chirality":"absolute","Color/Form":"Leaflets from alcohol","Decomposition":"When heated to decomposition it emits acrid smoke and irritating fumes.","Density":"1.27 g/cu cm at 25 °C g/cm\u003csup\u003e3\u003c/sup\u003e","Dosing Info":[],"Drug Indication":"Used as a test to determine the general health of an unborn fetus.","Drug Warnings":"Gynest Cream is not indicated during pregnancy. If pregnancy occurs during use of Gynest Cream, treatment should be withdrawn immediately.","DrugClasses":["hormone"],"EINECS":"200-022-2","Esters":["propionate","dipropionate"],"European Community (EC) Number":"200-022-2","HMDB ID":"HMDB0000153","HeavyAtomCount":21,"IUPACName":"(8R,9S,13S,14S,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol","Impurities":["9(11)-didehydroestriol"],"InChI":"InChI=1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1","InChIKey":"PROQIPRRNZUXQM-ZXXIGWHRSA-N","Melting Point":"82-86","MolecularFormula":"C\u003csub\u003e18\u003c/sub\u003eH\u003csub\u003e24\u003c/sub\u003eO\u003csub\u003e3\u003c/sub\u003e","MolecularWeight":"288.4 g/mol","Odor":"Odorless","Opticalactivity":"UNSPECIFIED","Pharmacodynamics":"Estriol (also oestriol) is one of the three main estrogens produced by the human body. It is only produced in significant amounts during pregnancy as it is made by the placenta. In pregnant women with multiple sclerosis (MS), estriol reduces the disease's symptoms noticeably, according to researchers at UCLA's Geffen Medical School.","Physical Description":"Solid","PrevSalts":[],"PubChemId":5756,"Record Description":["Estriol is a 3-hydroxy steroid that is estra-1,3,5(10)-trien-3-ol substituted by additional hydroxy groups at positions 16 and 17 (16alpha,17beta-stereoisomer). It has a role as an estrogen, a human metabolite, a human xenobiotic metabolite and a mouse metabolite. It is a 3-hydroxy steroid, a 16alpha-hydroxy steroid and a 17beta-hydroxy steroid. It derives from a hydride of an estrane.","A hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada. It is however available in the United States by prescription filled only by compounding pharmacies. It has also been approved and marketed throughout Europe and Asia for approximately 40 years for the treatment of post-menopausal hot flashes.","Estriol has been reported in Arabidopsis thaliana, Homo sapiens, and Sarcophaga bullata with data available.","Estriol is a synthetic form of the endogenous human estriol, a weak oestrogen and natural metabolite of estradiol, that can be used for hormone replacement. Upon administration, estriol maintains adequate levels of estrogen, binds to estrogen receptors, and relieves symptoms caused by estrogen deficiency.","ESTRIOL is a small molecule drug with a maximum clinical trial phase of IV (across all indications) that was first approved in 2000 and has 6 investigational indications.","A hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada. It is however available in the United States by prescription filled only by compounding pharmacies. It has also been approved and marketed throughout Europe and Asia for approximately 40 years for the treatment of post-menopausal hot flashes.","A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol.","See also: Estriol Succinate (is active moiety of); Estradiol; estriol (component of).","Estriol is a 3-hydroxy steroid that is estra-1,3,5(10)-trien-3-ol substituted by additional hydroxy groups at positions 16 and 17 (16alpha,17beta-stereoisomer). It has a role as an estrogen, a human metabolite, a human xenobiotic metabolite and a mouse metabolite. It is a 3-hydroxy steroid, a 16alpha-hydroxy steroid and a 17beta-hydroxy steroid. It derives from a hydride of an estrane.","LiverTox|Endocrine|Birth control|Estrogen"],"References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Estriol","Name":"Estriol","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q409721","Name":"Estriol","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB04573","Name":"Estriol","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/5756","Name":"Estriol","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL193482","Name":"Estriol","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:27974","Name":"Estriol","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=50-27-1","Name":"Estriol","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0000153","Name":"Estriol","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C05141","Name":"Estriol","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/FB33469R8E","Name":"Estriol","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022366","Name":"Estriol","Sub":false}]}],"SMILES":"C[C@]12CC[C@H]3[C@H]([C@@H]1C[C@H]([C@@H]2O)O)CCC4=C3C=CC(=C4)O","Solubility":"Slightly soluble in ethyl ether, benzene, trifluoroacetic acid; very soluble in pyridine","StoreUNII":["FB33469R8E"],"StructureBase64":"<svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" height="71.046mm" version="1.2" viewBox="0 0 128.281 71.046" width="128.281mm">
      
    <desc>Generated by the Chemistry Development Kit (http://github.com/cdk)</desc>
      
    <g fill="#000000" stroke="#000000" stroke-linecap="round" stroke-linejoin="round" stroke-width=".7">
            
        <rect fill="#FFFFFF" height="72.0" stroke="none" width="129.0" x=".0" y=".0"/>
            
        <g class="mol" id="mol1">
                  
            <path class="bond" d="M86.026 22.146l.673 .194l5.901 -14.16l-2.018 -.581l-2.018 -.582z" id="mol1bnd1" stroke="none"/>
                  
            <line class="bond" id="mol1bnd2" x1="86.362" x2="73.154" y1="22.243" y2="14.623"/>
                  
            <line class="bond" id="mol1bnd3" x1="73.154" x2="59.946" y1="14.623" y2="22.243"/>
                  
            <line class="bond" id="mol1bnd4" x1="59.946" x2="59.946" y1="22.243" y2="37.483"/>
                  
            <line class="bond" id="mol1bnd5" x1="59.946" x2="73.154" y1="37.483" y2="45.103"/>
                  
            <line class="bond" id="mol1bnd6" x1="73.154" x2="86.362" y1="45.103" y2="37.483"/>
                  
            <line class="bond" id="mol1bnd7" x1="86.362" x2="86.362" y1="22.243" y2="37.483"/>
                  
            <line class="bond" id="mol1bnd8" x1="86.362" x2="100.891" y1="37.483" y2="42.157"/>
                  
            <g class="bond" id="mol1bnd9">
                        
                <line x1="109.499" x2="110.165" y1="29.756" y2="29.97"/>
                        
                <line x1="107.731" x2="108.953" y1="31.715" y2="32.109"/>
                        
                <line x1="105.963" x2="107.74" y1="33.675" y2="34.247"/>
                        
                <line x1="104.195" x2="106.528" y1="35.635" y2="36.385"/>
                        
                <line x1="102.427" x2="105.315" y1="37.594" y2="38.523"/>
                        
                <line x1="100.66" x2="104.103" y1="39.554" y2="40.662"/>
                        
                <line x1="98.892" x2="102.891" y1="41.514" y2="42.8"/>
                      
            </g>
                  
            <line class="bond" id="mol1bnd10" x1="109.832" x2="100.891" y1="29.863" y2="17.569"/>
                  
            <line class="bond" id="mol1bnd11" x1="86.362" x2="100.891" y1="22.243" y2="17.569"/>
                  
            <path class="bond" d="M100.558 17.461l.666 .217l4.708 -10.272l-1.559 -.509l-1.558 -.508z" id="mol1bnd12" stroke="none"/>
                  
            <line class="bond" id="mol1bnd13" x1="109.832" x2="118.255" y1="29.863" y2="37.45"/>
                  
            <line class="bond" id="mol1bnd14" x1="73.154" x2="73.154" y1="45.103" y2="60.343"/>
                  
            <line class="bond" id="mol1bnd15" x1="73.154" x2="59.946" y1="60.343" y2="67.963"/>
                  
            <line class="bond" id="mol1bnd16" x1="59.946" x2="46.738" y1="67.963" y2="60.343"/>
                  
            <g class="bond" id="mol1bnd17">
                        
                <line x1="46.738" x2="46.738" y1="60.343" y2="45.103"/>
                        
                <line x1="44.3" x2="44.3" y1="58.935" y2="46.511"/>
                      
            </g>
                  
            <line class="bond" id="mol1bnd18" x1="59.946" x2="46.738" y1="37.483" y2="45.103"/>
                  
            <line class="bond" id="mol1bnd19" x1="46.738" x2="33.53" y1="45.103" y2="37.483"/>
                  
            <g class="bond" id="mol1bnd20">
                        
                <line x1="33.53" x2="20.322" y1="37.483" y2="45.103"/>
                        
                <line x1="33.53" x2="22.761" y1="40.298" y2="46.511"/>
                      
            </g>
                  
            <line class="bond" id="mol1bnd21" x1="20.322" x2="20.322" y1="45.103" y2="60.343"/>
                  
            <g class="bond" id="mol1bnd22">
                        
                <line x1="20.322" x2="33.53" y1="60.343" y2="67.963"/>
                        
                <line x1="22.761" x2="33.53" y1="58.935" y2="65.148"/>
                      
            </g>
                  
            <line class="bond" id="mol1bnd23" x1="46.738" x2="33.53" y1="60.343" y2="67.963"/>
                  
            <line class="bond" id="mol1bnd24" x1="20.322" x2="10.403" y1="60.343" y2="66.072"/>
                  
            <g class="bond" id="mol1bnd25">
                        
                <line x1="60.296" x2="59.596" y1="37.483" y2="37.483"/>
                        
                <line x1="60.546" x2="59.346" y1="39.66" y2="39.66"/>
                        
                <line x1="60.797" x2="59.096" y1="41.837" y2="41.837"/>
                        
                <line x1="61.047" x2="58.846" y1="44.014" y2="44.014"/>
                        
                <line x1="61.297" x2="58.596" y1="46.192" y2="46.192"/>
                        
                <line x1="61.547" x2="58.346" y1="48.369" y2="48.369"/>
                      
            </g>
                  
            <path class="bond" d="M72.804 45.103h.7l1.309 -11.39h-1.659h-1.658z" id="mol1bnd26" stroke="none"/>
                  
            <g class="bond" id="mol1bnd27">
                        
                <line x1="86.712" x2="86.012" y1="37.483" y2="37.483"/>
                        
                <line x1="86.962" x2="85.762" y1="39.66" y2="39.66"/>
                        
                <line x1="87.213" x2="85.512" y1="41.837" y2="41.837"/>
                        
                <line x1="87.463" x2="85.262" y1="44.014" y2="44.014"/>
                        
                <line x1="87.713" x2="85.012" y1="46.192" y2="46.192"/>
                        
                <line x1="87.963" x2="84.762" y1="48.369" y2="48.369"/>
                      
            </g>
                  
            <g class="atom" id="mol1atm11">
                        
                <path d="M107.878 3.078q-.0 .756 -.256 1.328q-.256 .565 -.756 .881q-.5 .315 -1.245 .315q-.756 .0 -1.262 -.315q-.506 -.316 -.756 -.887q-.244 -.572 -.244 -1.334q.0 -.75 .244 -1.309q.25 -.566 .756 -.881q.506 -.316 1.274 -.316q.733 .0 1.233 .316q.5 .309 .756 .875q.256 .565 .256 1.327zM104.014 3.078q.0 .923 .387 1.459q.393 .53 1.22 .53q.84 -.0 1.221 -.53q.387 -.536 .387 -1.459q-.0 -.929 -.387 -1.452q-.381 -.524 -1.209 -.524q-.833 -.0 -1.226 .524q-.393 .523 -.393 1.452z" fill="#FF0D0D" stroke="none"/>
                        
                <path d="M112.184 5.531h-.619v-2.286h-2.513v2.286h-.613v-4.9h.613v2.072h2.513v-2.072h.619v4.9z" fill="#FF0D0D" stroke="none"/>
                      
            </g>
                  
            <g class="atom" id="mol1atm12">
                        
                <path d="M123.415 40.059q.0 .756 -.256 1.328q-.256 .566 -.756 .881q-.5 .316 -1.244 .316q-.756 -.0 -1.262 -.316q-.506 -.315 -.756 -.887q-.244 -.571 -.244 -1.333q-.0 -.751 .244 -1.31q.25 -.566 .756 -.881q.506 -.316 1.274 -.316q.732 .0 1.232 .316q.5 .309 .756 .875q.256 .565 .256 1.327zM119.552 40.059q-.0 .923 .386 1.459q.393 .53 1.221 .53q.839 -.0 1.22 -.53q.387 -.536 .387 -1.459q.0 -.928 -.387 -1.452q-.381 -.524 -1.208 -.524q-.834 -.0 -1.227 .524q-.392 .524 -.392 1.452z" fill="#FF0D0D" stroke="none"/>
                        
                <path d="M127.721 42.512h-.619v-2.286h-2.512v2.286h-.613v-4.899h.613v2.071h2.512v-2.071h.619v4.899z" fill="#FF0D0D" stroke="none"/>
                      
            </g>
                  
            <g class="atom" id="mol1atm21">
                        
                <path d="M9.385 67.962q-.0 .756 -.256 1.328q-.256 .565 -.756 .881q-.5 .315 -1.245 .315q-.756 .0 -1.262 -.315q-.506 -.316 -.756 -.887q-.244 -.572 -.244 -1.334q.0 -.75 .244 -1.309q.25 -.566 .756 -.881q.506 -.316 1.274 -.316q.733 .0 1.233 .316q.5 .309 .756 .875q.256 .565 .256 1.327zM5.521 67.962q.0 .923 .387 1.459q.393 .53 1.22 .53q.84 -.0 1.221 -.53q.387 -.536 .387 -1.459q-.0 -.928 -.387 -1.452q-.381 -.524 -1.209 -.524q-.833 -.0 -1.226 .524q-.393 .524 -.393 1.452z" fill="#FF0D0D" stroke="none"/>
                        
                <path d="M4.305 70.415h-.62v-2.286h-2.512v2.286h-.613v-4.9h.613v2.072h2.512v-2.072h.62v4.9z" fill="#FF0D0D" stroke="none"/>
                      
            </g>
                  
            <path class="atom" d="M61.819 55.173h-.619v-2.286h-2.513v2.286h-.613v-4.9h.613v2.072h2.513v-2.072h.619v4.9z" id="mol1atm22" stroke="none"/>
                  
            <path class="atom" d="M75.027 32.313h-.619v-2.286h-2.513v2.286h-.613v-4.9h.613v2.072h2.513v-2.072h.619v4.9z" id="mol1atm23" stroke="none"/>
                  
            <path class="atom" d="M88.235 55.173h-.619v-2.286h-2.513v2.286h-.613v-4.9h.613v2.072h2.513v-2.072h.619v4.9z" id="mol1atm24" stroke="none"/>
                
            <line class="hi" id="mol1bnd13" stroke="#FF0D0D" x1="118.255" x2="114.0435" y1="37.45" y2="33.6565"/>
            <line class="hi" id="mol1bnd24" stroke="#FF0D0D" x1="10.403" x2="15.3625" y1="66.072" y2="63.2075"/>
            <line class="hi" id="mol1bnd24" stroke="#FF0D0D" x1="10.403" x2="15.3625" y1="66.072" y2="63.2075"/>
        </g>
          
    </g>
    
</svg>
","Therapeutic Uses":"/Estriol is indicated as/ hormone replacement therapy for treatment of atrophic vaginitis and kraurosis in post-menopausal women.","Title":"Estriol","UNII":"FB33469R8E","Wikidata":"Q409721","Wikipedia":"Estriol","XLogP":2.5}