{"ATC Code":"L01XX11","Abbreviation":"","Aliases":["Estramustinum","Estramustina","Estradiol 3-(N,N-bis(2-chloroethyl)carbamate)","17β-Estradiol 3-(bis(2-chloroethyl)carbamate)","Estradiol 3-[bis(2-chloroethyl)carbamate]","RO 21-8837","Ro 22-2296/000","Estradiol 3-(bis(2-chloroethyl)carbamate)","Ro-222296000","Ro-22-2296000"],"Biological Half-Life":"20 hours","CAS":"2998-57-4","ChEBI":"CHEBI:4868","ChEMBL":"CHEMBL1575","ChemicalClasses":[],"Chirality":"absolute","Dosing Info":[],"Drug Indication":"For the palliative treatment of patients with metastatic and/or progressive carcinoma of the prostate","DrugClasses":["hormone"],"EINECS":"221-076-3","EliminationHalfLife":"","European Community (EC) Number":"221-076-3","FDA Pharmacological Classification":"35LT29625A","HMDB ID":"HMDB0015327","HeavyAtomCount":29,"IUPACName":"[(8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] N,N-bis(2-chloroethyl)carbamate","InChI":"InChI=1S/C23H31Cl2NO3/c1-23-9-8-18-17-5-3-16(29-22(28)26(12-10-24)13-11-25)14-15(17)2-4-19(18)20(23)6-7-21(23)27/h3,5,14,18-21,27H,2,4,6-13H2,1H3/t18-,19-,20+,21+,23+/m1/s1","InChIKey":"FRPJXPJMRWBBIH-RBRWEJTLSA-N","MeSH Pharmacological Classification":"Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079) (See all compounds classified as Antineoplastic Agents, Hormonal.)","Melting Point":"104.5 °C","MolecularFormula":"C\u003csub\u003e23\u003c/sub\u003eH\u003csub\u003e31\u003c/sub\u003eCl\u003csub\u003e2\u003c/sub\u003eNO\u003csub\u003e3\u003c/sub\u003e","MolecularWeight":"440.4 g/mol","Opticalactivity":"UNSPECIFIED","Pharmacodynamics":"Estramustine is an antineoplastic agent indicated in the palliative treatment of patients with metastatic and/or progressive carcinoma of the prostate. Estramustine is a combination of estradiol with nitrogen mustard. In vivo, the nitrogen-mustard moiety becomes active and participates in alkylation of DNA or other cellular components.. This causes DNA damage in rapidly dividing cancerous cells leading to cell death and ideally, tumor shrinkage.","Physical Description":"Solid","PrevSalts":[],"PubChemId":259331,"Record Description":["Estramustine is a carbamate ester obtained by the formal condensation of the hydroxy group of 17beta-estradiol with the carboxy group of bis(2-chloroethyl)carbamic acid. It has a role as an antineoplastic agent, an alkylating agent and a radiation protective agent. It is a carbamate ester, a 17beta-hydroxy steroid and an organochlorine compound. It is functionally related to a 17beta-estradiol.","A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.","Estramustine is an Alkylating Drug. The mechanism of action of estramustine is as an Alkylating Activity.","Estramustine is a synthetic molecule combining estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects. (NCI04)","ESTRAMUSTINE is a small molecule drug with a maximum clinical trial phase of III (across all indications) and has 5 investigational indications.","A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.","See also: Estramustine Phosphate (is active moiety of); Estramustine Phosphate Sodium (active moiety of).","Estramustine is a carbamate ester obtained by the formal condensation of the hydroxy group of 17beta-estradiol with the carboxy group of bis(2-chloroethyl)carbamic acid. It has a role as an antineoplastic agent, an alkylating agent and a radiation protective agent. It is a carbamate ester, a 17beta-hydroxy steroid and an organochlorine compound. It is functionally related to a 17beta-estradiol.","LiverTox|Antineoplastic|Solid tumors, Prostate|Alkylating agent"],"References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Estramustine","Name":"Estramustine","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q412939","Name":"Estramustine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB01196","Name":"Estramustine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/259331","Name":"Estramustine","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1575","Name":"Estramustine","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:4868","Name":"Estramustine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=2998-57-4","Name":"Estramustine","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0015327","Name":"Estramustine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C11228","Name":"Estramustine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/35LT29625A","Name":"Estramustine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID8046458","Name":"Estramustine","Sub":false}]}],"SMILES":"C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)OC(=O)N(CCCl)CCCl","Scheduling":[],"Solubility":"3.85e-04 g/L","StoreUNII":["35LT29625A"],"StructureBase64":"<svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" height="109.257mm" version="1.2" viewBox="0 0 176.853 109.257" width="176.853mm">
      
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