{"Abbreviation":"E4","Aliases":["Estetrol anhydrous","estetrolum","oestetrol","Donesta","15.α.-hydroxyestriol","15α-hydroxyestriol","15 α-hydroxyestriol","estra-1(10),2,4-triene-3,15α,16α,17β-tetrol","estra-1,3,5(10)-triene-3,15α,16α,17β-tetrol","3,15α,16α,17β-tetrahydroxyestra-1,3,5(10)-triene"],"Biological Half-Life":"The elimination half-life of estetrol is approximately 27 hours. Half-life may range between 19-40 hours.","Boiling Point":"491.9±45.0","CAS":"15183-37-6","ChEBI":"CHEBI:142773","ChEMBL":"CHEMBL1230314","ChemicalClasses":["steroid"],"Chirality":"absolute","Dosing Info":[],"Drug Indication":"Estetrol is indicated in combination with drospirenone for the prevention of pregnancy.","DrugClasses":[],"European Community (EC) Number":"840-340-4","FDA Pharmacological Classification":"ENB39R14VF","HMDB ID":"HMDB0304837","HeavyAtomCount":22,"Human Drugs":"Human drug -\u003e Active ingredient (ESTETROL)","IUPACName":"(8R,9S,13S,14S,15R,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,15,16,17-tetrol","InChI":"InChI=1S/C18H24O4/c1-18-7-6-12-11-5-3-10(19)8-9(11)2-4-13(12)14(18)15(20)16(21)17(18)22/h3,5,8,12-17,19-22H,2,4,6-7H2,1H3/t12-,13-,14-,15-,16-,17+,18+/m1/s1","InChIKey":"AJIPIJNNOJSSQC-NYLIRDPKSA-N","Melting Point":"233-236","MolecularFormula":"C\u003csub\u003e18\u003c/sub\u003eH\u003csub\u003e24\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e","MolecularWeight":"304.4 g/mol","Opticalactivity":"UNSPECIFIED","Pharmacodynamics":"Estetrol prevents pregnancy by suppressing ovulation.","PrevSalts":[],"PubChemId":27125,"Record Description":["Estetrol is a 3-hydroxy steroid that is 17beta-estradiol which has been substituted at the 15alpha and 16alpha positions by two additional hydroxy groups. It is a natural estrogen produced exclusively during pregnancy by the fetal liver. It has a role as an estrogen, an estrogen receptor agonist, a human metabolite, a human xenobiotic metabolite and an oral contraceptive. It is a 3-hydroxy steroid, a 17beta-hydroxy steroid, a 16alpha-hydroxy steroid, a 15alpha-hydroxy steroid and a steroid hormone. It derives from a hydride of an estrane.","Naturally or synthetically produced steroid estrogens have a wide range of pharmaceutical uses ranging from hormonal contraception to the treatment of menopausal symptoms. Estetrol (E4) is a native estrogen occurring naturally during pregnancy, but can be synthesized from a plant source and used for contraception. It is more potent and is safer than the synthetic estrogen ethinylestradiol (EE2) found in 97% of oral contraceptive pills, reducing the environmental accumulation of unwanted endocrine disrupting chemicals (EDCs) that often lead to harmful epigenetic effects.   On April 15 2021, Mayne Pharma Group Limited and Mithra Pharmaceuticals were granted FDA approval for the oral contraceptive Estelle/Nextstellis, a combination of [drospirenone] and estetrol. Estetrol is the first new estrogen introduced to the USA in over 50 years and is the first approved estetrol product in the world. The combination of drospirenone and estetrol offers a new choice with a favourable safety profile for women seeking contraceptive therapy. In Canada, Nextstellis was approved for use in March 2021; it was developed by Mithra and is marketed by Searchlight Pharma.","Estetrol anhydrous is an Estrogen. The mechanism of action of estetrol anhydrous is as an Estrogen Receptor Agonist.","Therapeutic Estetrol is a synthetic steroid similar or identical to endogenous estetrol, a short-acting estrogen with both agonistic and antagonistic estrogen receptor activity. Administered orally, therapeutic estetrol binds to the estrogen receptor and as a selective estrogen receptor modulator (SERM) exhibits estrogen agonism in certain tissues and estrogen antagonism in others. Displaying weak estrogen activity in the uterus, estetrol acts as an estrogen antagonist in breast tissue. Produced solely by the human fetal liver, endogenous estetrol is the primary estrogen metabolite of estrogen biosynthesis in the human fetal liver.","ESTETROL is a small molecule drug with a maximum clinical trial phase of IV (across all indications) that was first approved in 2021 and is indicated for pregnancy and has 8 investigational indications.","A metabolite of ESTRIOL with a 15-alpha-hydroxyl group. Estetrol can be converted from estriol sulfate or DEHYDROEPIANDROSTERONE SULFATE by the fetal-placental unit.","See also: Drospirenone; estetrol (component of).","Estetrol is a 3-hydroxy steroid that is 17beta-estradiol which has been substituted at the 15alpha and 16alpha positions by two additional hydroxy groups. It is a natural estrogen produced exclusively during pregnancy by the fetal liver. It has a role as an estrogen, an estrogen receptor agonist, a human metabolite, a human xenobiotic metabolite and an oral contraceptive. It is a 3-hydroxy steroid, a 17beta-hydroxy steroid, a 16alpha-hydroxy steroid, a 15alpha-hydroxy steroid and a steroid hormone. It derives from a hydride of an estrane."],"References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Estetrol","Name":"Estetrol","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q5401078","Name":"Estetrol","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB12235","Name":"Estetrol","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/27125","Name":"Estetrol","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1230314","Name":"Estetrol","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:142773","Name":"Estetrol","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=15183-37-6","Name":"Estetrol","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0304837","Name":"Estetrol","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D11513","Name":"Estetrol","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/ENB39R14VF","Name":"Estetrol","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID50164888","Name":"Estetrol","Sub":false}]}],"SMILES":"C[C@]12CC[C@H]3[C@H]([C@@H]1[C@H]([C@H]([C@@H]2O)O)O)CCC4=C3C=CC(=C4)O","StoreUNII":["ENB39R14VF"],"StructureBase64":"<svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" height="71.046mm" version="1.2" viewBox="0 0 128.281 71.046" width="128.281mm">
      
    <desc>Generated by the Chemistry Development Kit (http://github.com/cdk)</desc>
      
    <g fill="#FF0D0D" stroke="#000000" stroke-linecap="round" stroke-linejoin="round" stroke-width=".7">
            
        <rect fill="#FFFFFF" height="72.0" stroke="none" width="129.0" x=".0" y=".0"/>
            
        <g class="mol" id="mol1">
                  
            <path class="bond" d="M86.026 22.146l.673 .194l5.901 -14.16l-2.018 -.581l-2.018 -.582z" fill="#000000" id="mol1bnd1" stroke="none"/>
                  
            <line class="bond" id="mol1bnd2" x1="86.362" x2="73.154" y1="22.243" y2="14.623"/>
                  
            <line class="bond" id="mol1bnd3" x1="73.154" x2="59.946" y1="14.623" y2="22.243"/>
                  
            <line class="bond" id="mol1bnd4" x1="59.946" x2="59.946" y1="22.243" y2="37.483"/>
                  
            <line class="bond" id="mol1bnd5" x1="59.946" x2="73.154" y1="37.483" y2="45.103"/>
                  
            <line class="bond" id="mol1bnd6" x1="73.154" x2="86.362" y1="45.103" y2="37.483"/>
                  
            <line class="bond" id="mol1bnd7" x1="86.362" x2="86.362" y1="22.243" y2="37.483"/>
                  
            <line class="bond" id="mol1bnd8" x1="86.362" x2="100.891" y1="37.483" y2="42.157"/>
                  
            <line class="bond" id="mol1bnd9" x1="100.891" x2="109.832" y1="42.157" y2="29.863"/>
                  
            <line class="bond" id="mol1bnd10" x1="109.832" x2="100.891" y1="29.863" y2="17.569"/>
                  
            <line class="bond" id="mol1bnd11" x1="86.362" x2="100.891" y1="22.243" y2="17.569"/>
                  
            <path class="bond" d="M100.558 17.461l.666 .217l4.708 -10.272l-1.559 -.509l-1.558 -.508z" fill="#000000" id="mol1bnd12" stroke="none"/>
                  
            <line class="bond" id="mol1bnd13" x1="109.832" x2="118.255" y1="29.863" y2="37.45"/>
                  
            <g class="bond" id="mol1bnd14">
                        
                <line stroke="#000000" x1="101.211" x2="100.571" y1="42.298" y2="42.015"/>
                        
                <line stroke="#FF0D0D" x1="100.558" x2="99.461" y1="44.39" y2="43.904"/>
                        
                <line stroke="#FF0D0D" x1="99.905" x2="98.35" y1="46.482" y2="45.793"/>
                        
                <line stroke="#FF0D0D" x1="99.251" x2="97.24" y1="48.574" y2="47.683"/>
                        
                <line stroke="#FF0D0D" x1="98.598" x2="96.129" y1="50.666" y2="49.572"/>
                        
                <line stroke="#FF0D0D" x1="97.944" x2="95.018" y1="52.757" y2="51.461"/>
                      
            </g>
                  
            <line class="bond" id="mol1bnd15" x1="73.154" x2="73.154" y1="45.103" y2="60.343"/>
                  
            <line class="bond" id="mol1bnd16" x1="73.154" x2="59.946" y1="60.343" y2="67.963"/>
                  
            <line class="bond" id="mol1bnd17" x1="59.946" x2="46.738" y1="67.963" y2="60.343"/>
                  
            <g class="bond" id="mol1bnd18">
                        
                <line x1="46.738" x2="46.738" y1="60.343" y2="45.103"/>
                        
                <line x1="44.3" x2="44.3" y1="58.935" y2="46.511"/>
                      
            </g>
                  
            <line class="bond" id="mol1bnd19" x1="59.946" x2="46.738" y1="37.483" y2="45.103"/>
                  
            <line class="bond" id="mol1bnd20" x1="46.738" x2="33.53" y1="45.103" y2="37.483"/>
                  
            <g class="bond" id="mol1bnd21">
                        
                <line x1="33.53" x2="20.322" y1="37.483" y2="45.103"/>
                        
                <line x1="33.53" x2="22.761" y1="40.298" y2="46.511"/>
                      
            </g>
                  
            <line class="bond" id="mol1bnd22" x1="20.322" x2="20.322" y1="45.103" y2="60.343"/>
                  
            <g class="bond" id="mol1bnd23">
                        
                <line x1="20.322" x2="33.53" y1="60.343" y2="67.963"/>
                        
                <line x1="22.761" x2="33.53" y1="58.935" y2="65.148"/>
                      
            </g>
                  
            <line class="bond" id="mol1bnd24" x1="46.738" x2="33.53" y1="60.343" y2="67.963"/>
                  
            <line class="bond" id="mol1bnd25" x1="20.322" x2="10.403" y1="60.343" y2="66.072"/>
                  
            <g class="bond" id="mol1bnd26">
                        
                <line x1="60.296" x2="59.596" y1="37.483" y2="37.483"/>
                        
                <line x1="60.546" x2="59.346" y1="39.66" y2="39.66"/>
                        
                <line x1="60.797" x2="59.096" y1="41.837" y2="41.837"/>
                        
                <line x1="61.047" x2="58.846" y1="44.014" y2="44.014"/>
                        
                <line x1="61.297" x2="58.596" y1="46.192" y2="46.192"/>
                        
                <line x1="61.547" x2="58.346" y1="48.369" y2="48.369"/>
                      
            </g>
                  
            <path class="bond" d="M72.804 45.103h.7l1.309 -11.39h-1.659h-1.658z" fill="#000000" id="mol1bnd27" stroke="none"/>
                  
            <g class="bond" id="mol1bnd28">
                        
                <line x1="86.712" x2="86.012" y1="37.483" y2="37.483"/>
                        
                <line x1="86.962" x2="85.762" y1="39.66" y2="39.66"/>
                        
                <line x1="87.213" x2="85.512" y1="41.837" y2="41.837"/>
                        
                <line x1="87.463" x2="85.262" y1="44.014" y2="44.014"/>
                        
                <line x1="87.713" x2="85.012" y1="46.192" y2="46.192"/>
                        
                <line x1="87.963" x2="84.762" y1="48.369" y2="48.369"/>
                      
            </g>
                  
            <g class="atom" id="mol1atm11">
                        
                <path d="M107.878 3.078q-.0 .756 -.256 1.328q-.256 .565 -.756 .881q-.5 .315 -1.245 .315q-.756 .0 -1.262 -.315q-.506 -.316 -.756 -.887q-.244 -.572 -.244 -1.334q.0 -.75 .244 -1.309q.25 -.566 .756 -.881q.506 -.316 1.274 -.316q.733 .0 1.233 .316q.5 .309 .756 .875q.256 .565 .256 1.327zM104.014 3.078q.0 .923 .387 1.459q.393 .53 1.22 .53q.84 -.0 1.221 -.53q.387 -.536 .387 -1.459q-.0 -.929 -.387 -1.452q-.381 -.524 -1.209 -.524q-.833 -.0 -1.226 .524q-.393 .523 -.393 1.452z" stroke="none"/>
                        
                <path d="M112.184 5.531h-.619v-2.286h-2.513v2.286h-.613v-4.9h.613v2.072h2.513v-2.072h.619v4.9z" stroke="none"/>
                      
            </g>
                  
            <g class="atom" id="mol1atm12">
                        
                <path d="M123.415 40.059q.0 .756 -.256 1.328q-.256 .566 -.756 .881q-.5 .316 -1.244 .316q-.756 -.0 -1.262 -.316q-.506 -.315 -.756 -.887q-.244 -.571 -.244 -1.333q-.0 -.751 .244 -1.31q.25 -.566 .756 -.881q.506 -.316 1.274 -.316q.732 .0 1.232 .316q.5 .309 .756 .875q.256 .565 .256 1.327zM119.552 40.059q-.0 .923 .386 1.459q.393 .53 1.221 .53q.839 -.0 1.22 -.53q.387 -.536 .387 -1.459q.0 -.928 -.387 -1.452q-.381 -.524 -1.208 -.524q-.834 -.0 -1.227 .524q-.392 .524 -.392 1.452z" stroke="none"/>
                        
                <path d="M127.721 42.512h-.619v-2.286h-2.512v2.286h-.613v-4.899h.613v2.071h2.512v-2.071h.619v4.899z" stroke="none"/>
                      
            </g>
                  
            <g class="atom" id="mol1atm13">
                        
                <path d="M96.977 56.087q-.0 .756 -.256 1.328q-.256 .565 -.756 .881q-.5 .315 -1.244 .315q-.756 .0 -1.263 -.315q-.506 -.316 -.756 -.887q-.244 -.572 -.244 -1.334q.0 -.75 .244 -1.309q.25 -.566 .756 -.881q.507 -.316 1.274 -.316q.733 .0 1.233 .316q.5 .309 .756 .875q.256 .565 .256 1.327zM93.113 56.087q.0 .923 .387 1.459q.393 .53 1.221 .53q.839 -.0 1.22 -.53q.387 -.536 .387 -1.459q-.0 -.928 -.387 -1.452q-.381 -.524 -1.209 -.524q-.833 -.0 -1.226 .524q-.393 .524 -.393 1.452z" stroke="none"/>
                        
                <path d="M91.897 58.54h-.619v-2.286h-2.513v2.286h-.613v-4.9h.613v2.072h2.513v-2.072h.619v4.9z" stroke="none"/>
                      
            </g>
                  
            <g class="atom" id="mol1atm22">
                        
                <path d="M9.385 67.962q-.0 .756 -.256 1.328q-.256 .565 -.756 .881q-.5 .315 -1.245 .315q-.756 .0 -1.262 -.315q-.506 -.316 -.756 -.887q-.244 -.572 -.244 -1.334q.0 -.75 .244 -1.309q.25 -.566 .756 -.881q.506 -.316 1.274 -.316q.733 .0 1.233 .316q.5 .309 .756 .875q.256 .565 .256 1.327zM5.521 67.962q.0 .923 .387 1.459q.393 .53 1.22 .53q.84 -.0 1.221 -.53q.387 -.536 .387 -1.459q-.0 -.928 -.387 -1.452q-.381 -.524 -1.209 -.524q-.833 -.0 -1.226 .524q-.393 .524 -.393 1.452z" stroke="none"/>
                        
                <path d="M4.305 70.415h-.62v-2.286h-2.512v2.286h-.613v-4.9h.613v2.072h2.512v-2.072h.62v4.9z" stroke="none"/>
                      
            </g>
                  
            <path class="atom" d="M61.819 55.173h-.619v-2.286h-2.513v2.286h-.613v-4.9h.613v2.072h2.513v-2.072h.619v4.9z" fill="#000000" id="mol1atm23" stroke="none"/>
                  
            <path class="atom" d="M75.027 32.313h-.619v-2.286h-2.513v2.286h-.613v-4.9h.613v2.072h2.513v-2.072h.619v4.9z" fill="#000000" id="mol1atm24" stroke="none"/>
                  
            <path class="atom" d="M88.235 55.173h-.619v-2.286h-2.513v2.286h-.613v-4.9h.613v2.072h2.513v-2.072h.619v4.9z" fill="#000000" id="mol1atm25" stroke="none"/>
                
            <line class="hi" id="mol1bnd13" stroke="#FF0D0D" x1="118.255" x2="114.0435" y1="37.45" y2="33.6565"/>
            <line class="hi" id="mol1bnd25" stroke="#FF0D0D" x1="10.403" x2="15.3625" y1="66.072" y2="63.2075"/>
            <line class="hi" id="mol1bnd25" stroke="#FF0D0D" x1="10.403" x2="15.3625" y1="66.072" y2="63.2075"/>
        </g>
          
    </g>
    
</svg>
","Title":"Estetrol","UNII":"ENB39R14VF","Wikidata":"Q5401078","Wikipedia":"Estetrol","XLogP":1.5}