{"ATC Code":"G - Genito urinary system and sex hormones","Abbreviation":[],"Aliases":["Ergometrine","Ergobasine","Ergotocine","Ergostetrine","Margonovine","Ergometrin","Ergometrina","Ergoklinine","Ergometrinum","Secacornin","Secometrin","Lysergic acid-L-propanolamide","Lysergic acid propanolamide","Lysergic acid 1-hydroxymethylethylamide","N-(α-(Hydroxymethyl)ethyl)-D-lysergamide","Lysergic-L(β-hydroxyisopropylamide)","N-(1-(Hydroxymethyl)ethyl)-D-lysergamide","N-(2-Hydroxy-1-methylethyl)-D(+)-lysergamide","9,10-Didehydro-N-(2-hydroxy-1-methylethyl)-6-methylergoline-8β(S)-carboxamide","9,10-Didehydro-N-(α-(hydroxymethyl)ethyl)-6-methylergoline-8-β-carboxamide","N-(2-Hydroxy-1-methylethyl)-D-(+)-lysergamide","[8β(S)]-9,10-didehydro-N-(2-hydroxy-1-methylethyl)-6-methylergoline-8-carboxamide","Ergoline-8-β-carboxamide, 9,10-didehydro-N-((S)-2-hydroxy-1-methylethyl)-6-methyl-","(6aR,9R)-7-Methyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinoline-9-carboxylic acid ((S)-2-hydroxy-1-methyl-ethyl)-amide","(8β(S))-9,10-Didehydro-N-(2-hydroxy-1-methylethyl)-6-methylergoline-8-carboxamide"],"Biological Half-Life":"t\u003csub\u003e1/2 \u0026alpha;\u003c/sub\u003e=10 minutes; t\u003csub\u003e1/2 \u0026beta;\u003c/sub\u003e=2 hours","CAS":"60-79-7","ChEBI":"CHEBI:4822","ChEMBL":"CHEMBL119443","ChemicalClasses":["lysergamide"],"Chirality":"absolute","Color/Form":"Plates or needles","DEA no":8675,"Decomposition":"When heated to decomposition it emits toxic fumes of /nitrogen oxides/.","Drug Classes":"Breast Feeding; Lactation; Milk, Human; Ergot Alkaloids; Oxytocics","Drug Indication":"Used to treat postpartum haemorrhage and postabortion haemorrhage in patients with uterine atony.","Drug Warnings":"When administered in correct doses to carefully selected patients who are closely monitored, there is little risk of serious adverse systemic effects in patients receiving ergonovine or methylergonovine.","EINECS":"200-485-0","EliminationHalfLife":"2-phase (10 min; 2 hours)","Esters":[],"European Community (EC) Number":"200-485-0","Formating":[],"HMDB ID":"HMDB0015383","Health Effects":"Ingestion of ergoline alkaloids is known to cause the disease ergotism. Ergotism occurs in two forms, gangrenous and convulsive, likely depending on the different kinds and amounts of ergoline alkaloids present. (A2913)","HeavyAtomCount":24,"Human Drugs":"Breast Feeding; Lactation; Milk, Human; Ergot Alkaloids; Oxytocics","IUPACName":"(6aR,9R)-N-[(2S)-1-hydroxypropan-2-yl]-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide","InChI":"InChI=1S/C19H23N3O2/c1-11(10-23)21-19(24)13-6-15-14-4-3-5-16-18(14)12(8-20-16)7-17(15)22(2)9-13/h3-6,8,11,13,17,20,23H,7,9-10H2,1-2H3,(H,21,24)/t11-,13+,17+/m0/s1","InChIKey":"WVVSZNPYNCNODU-XTQGRXLLSA-N","Interactions":"Concomitant use of ergot alkaloids and human immunodeficiency virus (HIV) protease inhibitors, delavirdine, or nevirapine is contraindicated.","LD50":[{"dosages":[{"amount":"144 mg/kg","route":"intravenous"}],"organism":"Mouse"}],"LDLo":[{"dosages":[{"amount":"500 mg/kg","route":"subcutaneous"}],"organism":"Rat"},{"dosages":[{"amount":"6 mg/kg","route":"intravenous"}],"organism":"Rabbit"},{"dosages":[{"amount":"80 mg/kg","route":"intravenous"}],"organism":"Guinea pig"}],"MeSH Pharmacological Classification":"Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157)","Melting Point":"162 °C","MolecularFormula":"C\u003csub\u003e19\u003c/sub\u003eH\u003csub\u003e23\u003c/sub\u003eN\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e2\u003c/sub\u003e","MolecularWeight":"325.4 g/mol","Opticalactivity":"UNSPECIFIED","Pharmacodynamics":"Ergonovine belongs to the group of medicines known as ergot alkaloids. These medicines are usually given to stop excessive bleeding that sometimes occurs after abortion or a baby is delivered. They work by causing the muscle of the uterus to contract.","Physical Description":"Solid","PubChemId":443884,"RefCount":4,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Ergonovine","Name":"Ergonovine","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q424508","Name":"Ergonovine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB01253","Name":"Ergonovine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/443884","Name":"Ergonovine","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL119443","Name":"Ergonovine","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:4822","Name":"Ergonovine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=60-79-7","Name":"Ergonovine","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0015383","Name":"Ergonovine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C07543","Name":"Ergonovine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/WH41D8433D","Name":"Ergonovine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID8046323","Name":"Ergonovine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 443884, Ergonovine. Accessed October 13, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/443884\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/443884\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Ergonovine. UNII: WH41D8433D. Global Substance Registration System. Accessed October 13, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/WH41D8433D\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/WH41D8433D\u003c/a\u003e","Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. March 31, 2023. Accessed October 13, 2025. \u003ca href=https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992\u003ehttps://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992\u003c/a\u003e"],"Reported Fatal Dose":"4 OR 5. 4= VERY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 50-500 MG/KG; BETWEEN 1 TEASPOON \u0026 1 OZ FOR 70 KG PERSON (150 LB). 5= EXTREMELY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 5-50 MG/KG; BETWEEN 7 DROPS \u0026 1 TEASPOON FOR 70 KG PERSON (150 LB). /ERGOT/","SMILES":"C[C@@H](CO)NC(=O)[C@H]1CN([C@@H]2CC3=CNC4=CC=CC(=C34)C2=C1)C","SaltData":[{"AcidCount":1,"Amine":"Ergonovine","AmineCount":2,"Formula":"O=C(O)C(O)C(O)C(=O)O","Name":"hemitartrate","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 169.527 140.607\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h170v141H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath fill=\"#000\" stroke=\"none\" d=\"m68.297 28.153.35-.606-12.326-9.133-1.049 1.819-1.05 1.82z\" class=\"bond\"/\u003e\u003cpath d=\"m68.472 27.85 13.196-7.624M81.668 20.226l-.003-11.319M68.472 27.85l.003 11.39M65.323 44.911 55.28 50.713\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m55.28 50.713-9.924-5.726M55.279 47.898l-8.704-5.023\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m45.356 44.987 4.962 2.863M46.575 42.875l4.352 2.511\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath fill=\"#000\" stroke=\"none\" d=\"M54.934 65.953h.7l1.895-16.539-2.249 1.299-2.25-1.298z\" class=\"bond\"/\u003e\u003cpath d=\"m55.284 65.953 13.2 7.615M68.484 73.568l.005 11.389\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m55.122 96.132.35.606\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m57.175 94.609.642 1.111M59.228 93.085l.934 1.616M61.28 91.561l1.227 2.121M63.333 90.037l1.519 2.626\"/\u003e\u003c/g\u003e\u003cpath d=\"M55.297 96.435v15.24M55.297 111.675 40.2 121.88\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M33.996 135.799 40.2 121.88M32.49 133.189l4.762-10.684\"/\u003e\u003c/g\u003e\u003cpath d=\"m33.996 135.799-11.821-1.245M18.03 130.383l-2.357-11.088\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m2.465 111.675 13.208 7.62M4.903 110.267l10.77 6.213\"/\u003e\u003c/g\u003e\u003cpath d=\"M2.465 111.675v-15.24\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m15.673 88.815-13.208 7.62M15.673 91.631l-10.77 6.213\"/\u003e\u003c/g\u003e\u003cpath d=\"m15.673 88.815 13.208 7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M28.881 111.675v-15.24M26.443 110.267V97.844\"/\u003e\u003c/g\u003e\u003cpath d=\"m40.2 121.88-11.319-10.205M15.673 119.295l13.208-7.62M28.881 96.435l13.208-7.62M55.297 96.435l-13.208-7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M42.089 73.576v15.239M44.527 74.983v12.424\"/\u003e\u003c/g\u003e\u003cpath d=\"m55.284 65.953-13.195 7.623M71.644 90.626l10.048 5.794\" class=\"bond\"/\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M83.923 4.983q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.309.756.875.256.565.256 1.327m-3.863 0q0 .923.387 1.459.393.53 1.22.53.84 0 1.221-.53.386-.536.386-1.459 0-.929-.386-1.452-.381-.524-1.209-.524-.833 0-1.226.524-.393.523-.393 1.452M88.23 7.436h-.62V5.15h-2.512v2.286h-.613v-4.9h.613v2.072h2.512V2.536h.62z\"/\u003e\u003c/g\u003e\u003cg fill=\"#3050f8\" stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M70.417 45.539h-.72l-2.62-4.066h-.029l.029.596q.024.357.024.732v2.738h-.565V40.64h.714l2.607 4.054h.03l-.018-.327q-.012-.221-.023-.477-.006-.262-.006-.482V40.64h.577zM74.723 45.539h-.619v-2.286h-2.512v2.286h-.613V40.64h.613v2.072h2.512V40.64h.619z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"none\" d=\"M44.948 42.038q0 .756-.256 1.327-.256.566-.756.882-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.31.25-.565.756-.881.506-.315 1.274-.315.732 0 1.232.315.5.31.756.875.256.566.256 1.328m-3.863 0q0 .923.387 1.458.393.53 1.22.53.84 0 1.221-.53.386-.535.386-1.458 0-.929-.386-1.453-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.453\" class=\"atom\"/\u003e\u003cpath fill=\"#3050f8\" stroke=\"none\" d=\"M70.431 91.257h-.72l-2.62-4.066h-.03l.03.595q.024.357.024.732v2.739h-.566v-4.9h.715l2.607 4.055h.03l-.018-.328-.024-.476q-.006-.262-.006-.482v-2.769h.578z\" class=\"atom\"/\u003e\u003cg fill=\"#3050f8\" stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M20.782 136.652h-.72l-2.619-4.066h-.03l.03.596q.024.357.024.732v2.738h-.566v-4.899h.714l2.608 4.054h.03l-.018-.328-.024-.476q-.006-.262-.006-.482v-2.768h.577zM16.339 136.652h-.619v-2.286h-2.512v2.286h-.613v-4.899h.613v2.071h2.512v-2.071h.619z\"/\u003e\u003c/g\u003e\u003cpath fill=\"none\" d=\"M3.303 138.557H.56V.56h2.743m84.088 137.997h2.744V.56h-2.744\"/\u003e\u003cpath fill=\"#000\" stroke=\"none\" d=\"M93.849 140.047h-1.943v-.3l.772-.779q.221-.222.371-.393.154-.175.232-.339.079-.168.079-.365 0-.243-.146-.368-.143-.128-.372-.128-.214 0-.379.075-.16.075-.328.207l-.193-.243q.171-.146.393-.246.225-.1.507-.1.411 0 .65.207t.239.575q0 .229-.096.432-.093.2-.264.397-.168.196-.393.418l-.615.603v.018h1.486z\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m81.665 8.907.002 5.659M81.665 8.907l.002 5.659\" class=\"hi\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m68.475 39.24-.001-5.695M65.323 44.911l-5.022 2.901M68.489 84.957l-.002-5.695M22.175 134.554l5.911.623M22.175 134.554l5.911.623M18.03 130.383l-1.178-5.544M18.03 130.383l-1.178-5.544M71.644 90.626l5.024 2.897\" class=\"hi\"/\u003e\u003c/g\u003e\u003cg class=\"mol\"\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M147.984 96.862V84.839M150.422 96.862V84.839\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"M147.984 96.862V90.85M150.422 96.862V90.85\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath d=\"m149.203 85.543 9.918-5.725M149.203 85.543l-13.198-7.62M136.005 77.923l-9.92 5.728M136.005 77.923v-15.24M136.005 62.683l9.917-5.725M136.005 62.683l-13.198-7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m124.026 55.767-10.53 6.079M122.807 53.656l-10.53 6.079\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m113.496 61.846 5.265-3.04M112.277 59.735l5.265-3.04\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath d=\"M122.807 55.063V43.745\" class=\"bond\"/\u003e\u003cpath stroke=\"none\" d=\"M151.462 100.78q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.309.756.875.256.565.256 1.327m-3.863 0q0 .923.387 1.459.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.459 0-.928-.387-1.452-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.452\" class=\"atom\"/\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M164.661 77.92q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.245.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881t1.274-.316q.733 0 1.233.316.5.309.756.875.256.565.256 1.327m-3.864 0q0 .923.387 1.459.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.459 0-.928-.387-1.452-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.452M168.967 80.373h-.619v-2.286h-2.513v2.286h-.613v-4.899h.613v2.071h2.513v-2.071h.619z\"/\u003e\u003c/g\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M125.066 85.54q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.309.756.875.256.565.256 1.327m-3.864 0q0 .923.387 1.459.393.53 1.221.53.839 0 1.22-.53.387-.536.387-1.459 0-.928-.387-1.452-.381-.524-1.208-.524-.834 0-1.227.524t-.393 1.452M119.986 87.993h-.619v-2.286h-2.512v2.286h-.614v-4.899h.614v2.071h2.512v-2.071h.619z\"/\u003e\u003c/g\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M151.462 55.06q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.309.756.875.256.565.256 1.327m-3.863 0q0 .923.387 1.459.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.459 0-.928-.387-1.452-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.452M155.769 57.513h-.62v-2.286h-2.512v2.286h-.613v-4.899h.613v2.071h2.512v-2.071h.62z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"none\" d=\"M111.868 62.68q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.245.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881t1.274-.316q.733 0 1.233.316.5.309.756.875.256.565.256 1.327m-3.864 0q0 .923.387 1.459.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.459 0-.928-.387-1.452-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.452\" class=\"atom\"/\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M125.066 39.82q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.309.756.875.256.565.256 1.327m-3.864 0q0 .923.387 1.459.393.53 1.221.53.839 0 1.22-.53.387-.536.387-1.459 0-.928-.387-1.452-.381-.524-1.208-.524-.834 0-1.227.524t-.393 1.452M129.372 42.273h-.619v-2.286h-2.512v2.286h-.613v-4.899h.613v2.071h2.512v-2.071h.619z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m159.121 79.818-4.959 2.862M126.085 83.651l4.96-2.864M126.085 83.651l4.96-2.864M145.922 56.958l-4.958 2.862M122.807 43.745v5.659M122.807 43.745v5.659\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Title":"Ergonovine hemitartrate","UNII":"54E5P4SD4U"},{"AcidCount":1,"Amine":"Ergonovine","AmineCount":1,"Formula":"O=C(O)CC(O)C(=O)O","Name":"maleate","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 175.678 135.307\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h176v136H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath fill=\"#000\" stroke=\"none\" d=\"m66.87 26.248.35-.606-12.325-9.133-1.05 1.819-1.05 1.82z\" class=\"bond\"/\u003e\u003cpath d=\"m67.045 25.945 13.196-7.624M80.241 18.321l-.003-11.319M67.045 25.945l.003 11.39M63.896 43.006l-10.043 5.802\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m53.853 48.808-9.924-5.726M53.853 45.993l-8.705-5.023\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m43.929 43.082 4.962 2.863M45.148 40.97l4.353 2.511\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath fill=\"#000\" stroke=\"none\" d=\"M53.507 64.048h.7l1.895-16.539-2.249 1.299-2.249-1.298z\" class=\"bond\"/\u003e\u003cpath d=\"m53.857 64.048 13.2 7.615M67.057 71.663l.005 11.389\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m53.695 94.227.35.606\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m55.748 92.704.642 1.111M57.801 91.18l.934 1.616M59.853 89.656l1.227 2.121M61.906 88.132l1.519 2.626\"/\u003e\u003c/g\u003e\u003cpath d=\"M53.87 94.53v15.24M53.87 109.77l-15.097 10.205\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m32.57 133.894 6.203-13.919M31.063 131.284l4.762-10.684\"/\u003e\u003c/g\u003e\u003cpath d=\"m32.57 133.894-11.822-1.245M16.603 128.478l-2.357-11.088\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m1.038 109.77 13.208 7.62M3.477 108.362l10.769 6.213\"/\u003e\u003c/g\u003e\u003cpath d=\"M1.038 109.77V94.53\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M14.246 86.91 1.038 94.53M14.246 89.726 3.477 95.939\"/\u003e\u003c/g\u003e\u003cpath d=\"m14.246 86.91 13.208 7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M27.454 109.77V94.53M25.016 108.362V95.939\"/\u003e\u003c/g\u003e\u003cpath d=\"M38.773 119.975 27.454 109.77M14.246 117.39l13.208-7.62M27.454 94.53l13.208-7.62M53.87 94.53l-13.208-7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M40.662 71.671V86.91M43.1 73.078l.001 12.424\"/\u003e\u003c/g\u003e\u003cpath d=\"m53.857 64.048-13.195 7.623M70.217 88.721l10.049 5.794\" class=\"bond\"/\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M82.496 3.078q0 .756-.255 1.328-.256.565-.757.881-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881T80.252.56q.732 0 1.232.316.501.309.757.875.255.565.255 1.327m-3.863 0q0 .923.387 1.459.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.459 0-.929-.387-1.452-.381-.524-1.209-.524-.833 0-1.226.524-.393.523-.393 1.452M86.803 5.531h-.619V3.245h-2.513v2.286h-.613v-4.9h.613v2.072h2.513V.631h.619z\"/\u003e\u003c/g\u003e\u003cg fill=\"#3050f8\" stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M68.99 43.634h-.72l-2.62-4.066h-.029l.029.596q.024.357.024.732v2.738h-.565v-4.899h.714l2.608 4.054h.029l-.018-.327-.023-.477q-.006-.262-.006-.482v-2.768h.577zM73.296 43.634h-.619v-2.286h-2.512v2.286h-.613v-4.899h.613v2.072h2.512v-2.072h.619z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"none\" d=\"M43.521 40.133q0 .756-.255 1.327-.256.566-.757.882-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.31.25-.565.756-.881.506-.315 1.274-.315.732 0 1.232.315.501.31.757.875.255.566.255 1.328m-3.863 0q0 .923.387 1.458.393.53 1.22.53.84 0 1.221-.53.387-.535.387-1.458 0-.929-.387-1.453-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.453\" class=\"atom\"/\u003e\u003cpath fill=\"#3050f8\" stroke=\"none\" d=\"M69.004 89.352h-.72l-2.62-4.066h-.029l.029.595q.024.357.024.732v2.739h-.565v-4.9h.714l2.607 4.055h.03l-.018-.328q-.012-.22-.023-.476-.006-.262-.006-.482v-2.769h.577z\" class=\"atom\"/\u003e\u003cg fill=\"#3050f8\" stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M19.356 134.747h-.721l-2.619-4.066h-.03l.03.596q.024.357.024.732v2.738h-.566v-4.899h.715l2.607 4.054h.03l-.018-.328-.024-.476q-.006-.262-.006-.482v-2.768h.578zM14.912 134.747h-.619v-2.286h-2.512v2.286h-.613v-4.899h.613v2.071h2.512v-2.071h.619z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m80.238 7.002.001 5.66M80.238 7.002l.001 5.66\" class=\"hi\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m67.048 37.335-.001-5.695M63.896 43.006l-5.022 2.901M67.062 83.052l-.003-5.694M20.748 132.649l5.911.623M20.748 132.649l5.911.623M16.603 128.478l-1.178-5.544M16.603 128.478l-1.178-5.544M70.217 88.721l5.025 2.897\" class=\"hi\"/\u003e\u003c/g\u003e\u003cg class=\"mol\"\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m168.966 70.624-10.524-6.077M170.185 68.512l-10.524-6.076\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m168.966 70.624-5.262-3.039M170.185 68.512l-5.262-3.038\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath d=\"M159.661 63.844V52.525M159.661 63.844l-13.198 7.62M146.463 71.464l-13.198-7.62M133.265 63.844V52.525M133.265 63.844l-13.199 7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M121.286 70.76v12.022M118.847 70.76v12.022\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"M121.286 82.782v-6.011M118.847 82.782v-6.011\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath d=\"m120.066 71.464-9.922-5.729\" class=\"bond\"/\u003e\u003cpath stroke=\"none\" d=\"M175.118 71.461q0 .756-.256 1.327-.256.566-.756.881t-1.244.316q-.756 0-1.262-.316-.506-.315-.756-.887-.244-.571-.244-1.333 0-.75.244-1.31.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.31.756.875.256.566.256 1.328m-3.863 0q0 .922.387 1.458.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.458 0-.929-.387-1.453-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.453\" class=\"atom\"/\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M161.92 48.601q0 .756-.256 1.327-.256.566-.756.881t-1.244.316q-.756 0-1.262-.316-.506-.315-.756-.887-.244-.571-.244-1.333 0-.75.244-1.31.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.31.756.875.256.566.256 1.328m-3.863 0q0 .922.387 1.458.392.53 1.22.53.839 0 1.22-.53.387-.536.387-1.458 0-.929-.387-1.453-.381-.524-1.208-.524-.834 0-1.226.524-.393.524-.393 1.453M166.226 51.053h-.619v-2.286h-2.512v2.286h-.613v-4.899h.613v2.072h2.512v-2.072h.619z\"/\u003e\u003c/g\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M135.524 48.601q0 .756-.256 1.327-.256.566-.756.881t-1.244.316q-.757 0-1.263-.316-.506-.315-.756-.887-.244-.571-.244-1.333 0-.75.244-1.31.25-.566.756-.881t1.274-.316q.733 0 1.233.316.5.31.756.875.256.566.256 1.328m-3.864 0q0 .922.387 1.458.393.53 1.221.53.839 0 1.22-.53.387-.536.387-1.458 0-.929-.387-1.453-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.453M139.83 51.053h-.619v-2.286h-2.512v2.286h-.614v-4.899h.614v2.072h2.512v-2.072h.619z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"none\" d=\"M122.326 86.701q0 .756-.256 1.327-.256.566-.757.881-.5.316-1.244.316-.756 0-1.262-.316-.506-.315-.756-.887-.244-.571-.244-1.333 0-.75.244-1.31.25-.566.756-.881t1.274-.316q.732 0 1.232.316.501.31.757.875.256.566.256 1.328m-3.864 0q0 .922.387 1.458.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.458 0-.929-.387-1.453-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.453\" class=\"atom\"/\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M109.127 63.841q0 .756-.256 1.327-.256.566-.756.881t-1.244.316q-.756 0-1.262-.316-.506-.315-.756-.887-.244-.571-.244-1.333 0-.75.244-1.31.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.31.756.875.256.566.256 1.328m-3.863 0q0 .922.387 1.458.393.53 1.22.53.839 0 1.22-.53.387-.536.387-1.458 0-.929-.387-1.453-.381-.524-1.208-.524-.833 0-1.226.524t-.393 1.453M104.047 66.293h-.619v-2.286h-2.512v2.286h-.613v-4.899h.613v2.072h2.512v-2.072h.619z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"#ff0d0d\" d=\"M159.661 52.525v5.659M159.661 52.525v5.659M133.265 52.525v5.659M133.265 52.525v5.659M110.144 65.735l4.961 2.865M110.144 65.735l4.961 2.865\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Title":"Ergonovine maleate","UNII":"YMH3D0ZJWV"}],"Salts":["hemitartrate","maleate"],"Scheduling":[{"gov":"Brazil","ref":["3"],"schedule":"D1 substance"},{"gov":"Canada","ref":[],"schedule":"Schedule VI substance"},{"gov":"United States","ref":[],"schedule":"Rx only substance"}],"Solubility":"Freely soluble in lower alcohols, ethyl acetate, acetone; more soluble in water than other principal alkaloids of ergot; slightly soluble in chloroform","Stability/Shelf Life":"Ergonovine maleate darkens with age and on exposure to light.","StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 87.363 135.307\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#3050f8\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h88v136H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath fill=\"#000\" stroke=\"none\" d=\"m66.87 26.248.35-.606-12.325-9.133-1.05 1.819-1.05 1.82z\" class=\"bond\"/\u003e\u003cpath d=\"m67.045 25.945 13.196-7.624M80.241 18.321l-.003-11.319M67.045 25.945l.003 11.39M63.896 43.006l-10.043 5.802\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m53.853 48.808-9.924-5.726M53.853 45.993l-8.705-5.023\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m43.929 43.082 4.962 2.863M45.148 40.97l4.353 2.511\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath fill=\"#000\" stroke=\"none\" d=\"M53.507 64.048h.7l1.895-16.539-2.249 1.299-2.249-1.298z\" class=\"bond\"/\u003e\u003cpath d=\"m53.857 64.048 13.2 7.615M67.057 71.663l.005 11.389\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m53.695 94.227.35.606\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m55.748 92.704.642 1.111M57.801 91.18l.934 1.616M59.853 89.656l1.227 2.121M61.906 88.132l1.519 2.626\"/\u003e\u003c/g\u003e\u003cpath d=\"M53.87 94.53v15.24M53.87 109.77l-15.097 10.205\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m32.57 133.894 6.203-13.919M31.063 131.284l4.762-10.684\"/\u003e\u003c/g\u003e\u003cpath d=\"m32.57 133.894-11.822-1.245M16.603 128.478l-2.357-11.088\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m1.038 109.77 13.208 7.62M3.477 108.362l10.769 6.213\"/\u003e\u003c/g\u003e\u003cpath d=\"M1.038 109.77V94.53\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M14.246 86.91 1.038 94.53M14.246 89.726 3.477 95.939\"/\u003e\u003c/g\u003e\u003cpath d=\"m14.246 86.91 13.208 7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M27.454 109.77V94.53M25.016 108.362V95.939\"/\u003e\u003c/g\u003e\u003cpath d=\"M38.773 119.975 27.454 109.77M14.246 117.39l13.208-7.62M27.454 94.53l13.208-7.62M53.87 94.53l-13.208-7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M40.662 71.671V86.91M43.1 73.078l.001 12.424\"/\u003e\u003c/g\u003e\u003cpath d=\"m53.857 64.048-13.195 7.623M70.217 88.721l10.049 5.794\" class=\"bond\"/\u003e\u003cg fill=\"#ff0d0d\" stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M82.496 3.078q0 .756-.255 1.328-.256.565-.757.881-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881T80.252.56q.732 0 1.232.316.501.309.757.875.255.565.255 1.327m-3.863 0q0 .923.387 1.459.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.459 0-.929-.387-1.452-.381-.524-1.209-.524-.833 0-1.226.524-.393.523-.393 1.452M86.803 5.531h-.619V3.245h-2.513v2.286h-.613v-4.9h.613v2.072h2.513V.631h.619z\"/\u003e\u003c/g\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M68.99 43.634h-.72l-2.62-4.066h-.029l.029.596q.024.357.024.732v2.738h-.565v-4.899h.714l2.608 4.054h.029l-.018-.327-.023-.477q-.006-.262-.006-.482v-2.768h.577zM73.296 43.634h-.619v-2.286h-2.512v2.286h-.613v-4.899h.613v2.072h2.512v-2.072h.619z\"/\u003e\u003c/g\u003e\u003cpath fill=\"#ff0d0d\" stroke=\"none\" d=\"M43.521 40.133q0 .756-.255 1.327-.256.566-.757.882-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.31.25-.565.756-.881.506-.315 1.274-.315.732 0 1.232.315.501.31.757.875.255.566.255 1.328m-3.863 0q0 .923.387 1.458.393.53 1.22.53.84 0 1.221-.53.387-.535.387-1.458 0-.929-.387-1.453-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.453\" class=\"atom\"/\u003e\u003cpath stroke=\"none\" d=\"M69.004 89.352h-.72l-2.62-4.066h-.029l.029.595q.024.357.024.732v2.739h-.565v-4.9h.714l2.607 4.055h.03l-.018-.328q-.012-.22-.023-.476-.006-.262-.006-.482v-2.769h.577z\" class=\"atom\"/\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M19.356 134.747h-.721l-2.619-4.066h-.03l.03.596q.024.357.024.732v2.738h-.566v-4.899h.715l2.607 4.054h.03l-.018-.328-.024-.476q-.006-.262-.006-.482v-2.768h.578zM14.912 134.747h-.619v-2.286h-2.512v2.286h-.613v-4.899h.613v2.071h2.512v-2.071h.619z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m80.238 7.002.001 5.66M80.238 7.002l.001 5.66\" class=\"hi\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m67.048 37.335-.001-5.695M63.896 43.006l-5.022 2.901M67.062 83.052l-.003-5.694M20.748 132.649l5.911.623M20.748 132.649l5.911.623M16.603 128.478l-1.178-5.544M16.603 128.478l-1.178-5.544M70.217 88.721l5.025 2.897\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","TDLo":[{"dosages":[{"amount":"93 mg/kg","route":"intramuscular"},{"amount":"138 mg/kg","route":"intramuscular"}],"organism":"Human - infant"}],"Therapeutic Uses":"Oxytocics","Title":"Ergonovine","Treatment":"Treatment for ergotism consists of vasodilators, anticoagulants and low molecular weight dextrans. If necessary, a sympathetic nerve blockade may be carried out, such as brachial plexus blockade. Temporary sedation (e.g. haloperidol) will be necessary in hallucination and diazepam is used for convulsions. There is no specific antidote. (L1921)","UNII":"WH41D8433D","Wikidata":"Q424508","Wikipedia":"Ergonovine","XLogP":1.8}