{"ATC Code":"QJ01AA02","Abbreviation":[],"Adverse Effects":"Common Reactions ","Aliases":["4-(Dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-3,4,4a,5,5a,6,12,12a-octahydrotetracene-2-carboximidic acid","7164-70-7","RefChem:1070088","Doxytetracycline","Vibramycin","Doxiciclina","Doxycyclinum","Monodox","Doxycycline anhydrous","6-Deoxytetracycline","Doxychel","Oracea","6α-Deoxy-5-oxytetracycline","Vibra-tabs","Doxycycline hyclate","5-Hydroxy-α-6-deoxytetracycline","Vibramycine","Anhydrous doxycycline","6-α-Deoxy-5-oxytetracycline","Doxycyclin","Jenacyclin","α-6-Deoxyoxytetracycline","α-6-Deoxy-5-hydroxytetracycline","Supracyclin","Liviatin"],"CAS":"564-25-0","ChEBI":"CHEBI:50845","ChEMBL":"CHEMBL1433","ChemicalClasses":["aniline"],"Chirality":"absolute","Classes":["Antibiotic"],"Drug Indication":"Treatment of periodontal disease in dogs. Periodontal pocket probing depths \u003e =4 mm are evidence of disease that may be responsive to treatment with the Doxirobe Gel. Use of this product as directed should result in attachment level gains, periodontal pocket depth reductions, local antimicrobial effect and improved gingival health. Noticeable improvements in these parameters should be evident within 2-4 weeks following treatment. The response in individual dogs is dependent on the severity of the condition and rigor of adjunctive therapy.","EINECS":"209-271-1","EliminationHalfLife":"10 – 22 hours","Esters":[],"European Community (EC) Number":"607-368-7","FDA Pharmacological Classification":"N12000U13O","Formating":[],"HeavyAtomCount":32,"Human Drugs":"Human drug -\u003e Prescription; Discontinued; Active ingredient (DOXYCYCLINE HYCLATE)","IUPACName":"(4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide","InChI":"InChI=1S/C22H24N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-7,10,14-15,17,25-27,30,32H,1-3H3,(H2,23,31)/t7-,10+,14+,15-,17-,22-/m0/s1","InChIKey":"SGKRLCUYIXIAHR-AKNGSSGZSA-N","LD50":[{"dosages":[{"amount":"\u0026gt;2 gm/kg","route":"oral"},{"amount":"378 mg/kg","route":"intraperitoneal"},{"amount":"228 mg/kg","route":"intravenous"}],"organism":"Rat"},{"dosages":[{"amount":"1870 mg/kg","route":"oral"},{"amount":"410 mg/kg","route":"intraperitoneal"},{"amount":"241 mg/kg","route":"intravenous"}],"organism":"Mouse"},{"dosages":[{"amount":"\u0026gt;500 mg/kg","route":"oral"},{"amount":"\u0026gt;100 mg/kg","route":"intravenous"}],"organism":"Dog"}],"MolecularFormula":"C\u003csub\u003e22\u003c/sub\u003eH\u003csub\u003e24\u003c/sub\u003eN\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e8\u003c/sub\u003e","MolecularWeight":"444.4 g/mol","Opticalactivity":"UNSPECIFIED","PubChemId":54671203,"RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Doxycycline","Name":"Doxycycline","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q422442","Name":"Doxycycline","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/54671203","Name":"Doxycycline","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1433","Name":"Doxycycline","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:50845","Name":"Doxycycline","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=564-25-0","Name":"Doxycycline","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D02129","Name":"Doxycycline","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/334895S862","Name":"Doxycycline","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID80992212","Name":"Doxycycline","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 54671203, Doxycycline. Accessed September 14, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/54671203\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/54671203\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Doxycycline. UNII: 334895S862. Global Substance Registration System. Accessed September 14, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/334895S862\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/334895S862\u003c/a\u003e"],"SMILES":"C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O","SaltData":[],"Salts":[],"Scheduling":[{"gov":"Australia","ref":[],"schedule":"S4 substance"},{"gov":"United Kingdom","ref":[],"schedule":"prescription only substance"},{"gov":"United States","ref":[],"schedule":"prescription only substance"}],"StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 96.827 120.479\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" 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