{"ATC Code":"C - Cardiovascular system","Abbreviation":["DA"],"Adverse Effects":"Dopamine administration can adversely affect kidney function, causing increased urinary flow and irregular heartbeat. Excessive administration may cause deleterious conditions such as cerebrovascular accidents due to elevated blood pressure in the brain.","Aliases":["4-(2-Aminoethyl)benzene-1,2-diol","3-Hydroxytyramine","Oxytyramine","Hydroxytyramin","Dopamin","3,4-dihydroxyphenethylamine","hydroxytyramine","4-(2-Aminoethyl)catechol","2-(3,4-dihydroxyphenyl)ethylamine","Dopamina","Dopaminum","4-(2-Aminoethyl)pyrocatechol","3,4-Dihydroxyphenylethylamine","4-(2-Aminoethyl)-1,2-benzenediol","ASL 279","1,2-Benzenediol, 4-(2-aminoethyl)-","Dobutamine a","A-dopamine","α-(3,4-Dihydroxyphenyl)-β-aminoethane","Revivan","3,4 Dihydroxyphenethylamine","Dopamine 1515","RefChem:6423","200-110-0","Medopa"],"Biological Half-Life":"2 minutes","CAS":"51-61-6","ChEBI":"CHEBI:18243","ChEMBL":"CHEMBL59","ChemicalClasses":["phenethylamine"],"Chirality":"achiral","Classes":["Neurotransmitter"],"Color/Form":"Stout prisms","Decomposition":"When heated to decomposition it emits toxic fumes of /nitrous oxides/.","Drug Classes":"Breast Feeding; Lactation; Milk, Human; Cardiotonic Agents; Catecholamines; Dopamine Agents; Sympathomimetics","Drug Indication":"For the correction of hemodynamic imbalances present in the shock syndrome due to myocardial infarction, trauma, endotoxic septicemia, open-heart surgery, renal failure, and chronic cardiac decompensation as in congestive failure","Drug Warnings":"Dopamine should be used with caution in patients with ischemic heart disease. The drug is contraindicated in patients with pheochromocytoma and in patients with uncorrected tachyarrhythmias or ventricular fibrillation.","EINECS":"200-110-0","Esters":[],"European Community (EC) Number":"200-110-0","FDA Pharmacological Classification":"VTD58H1Z2X","Formating":[],"HMDB ID":"HMDB0000073","Health Effects":"Chronically high levels of dopamine are associated with at least 2 inborn errors of metabolism including: Aromatic L-Amino acid Decarboxylase Deficiency and Norepinephrine deficiency.","HeavyAtomCount":11,"Human Drugs":"Breast Feeding; Lactation; Milk, Human; Cardiotonic Agents; Catecholamines; Dopamine Agents; Sympathomimetics","IUPACName":"4-(2-aminoethyl)benzene-1,2-diol","InChI":"InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2","InChIKey":"VYFYYTLLBUKUHU-UHFFFAOYSA-N","Interactions":"Monoamine oxidase inhibition by furazolidone ... exposes pt to hazards of potential hypertensive crisis if ... other amine-releasing agents /dopamine/ are taken concurrently.","LD50":[{"dosages":[{"amount":"163 mg/kg","route":"intraperitoneal"}],"organism":"Rat"},{"dosages":[{"amount":"950 mg/kg","route":"intraperitoneal"},{"amount":"59 mg/kg","route":"intravenous"},{"amount":"74 mg/kg","route":"intracervical"}],"organism":"Mouse"}],"MeSH Pharmacological Classification":"Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).","Melting Point":"128 °C","MolecularFormula":"C\u003csub\u003e8\u003c/sub\u003eH\u003csub\u003e11\u003c/sub\u003eNO\u003csub\u003e2\u003c/sub\u003e","MolecularWeight":"153.18 g/mol","Non-Human Toxicity Values":"LD50 Rat ip 163 mg/kg","Pharmacodynamics":"Dopamine is a natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine (DOPA). It is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in a few peripheral sympathetic nerves. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sympathetic nerve endings.","Physical Description":"Solid","PubChemId":681,"RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Dopamine","Name":"Dopamine","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q170304","Name":"Dopamine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB00988","Name":"Dopamine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/681","Name":"Dopamine","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL59","Name":"Dopamine","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:18243","Name":"Dopamine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=51-61-6","Name":"Dopamine","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0000073","Name":"Dopamine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C03758","Name":"Dopamine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/VTD58H1Z2X","Name":"Dopamine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022420","Name":"Dopamine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 681, Dopamine. Accessed September 13, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/681\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/681\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Dopamine. UNII: VTD58H1Z2X. Global Substance Registration System. Accessed September 13, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/VTD58H1Z2X\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/VTD58H1Z2X\u003c/a\u003e"],"SMILES":"C1=CC(=C(C=C1CCN)O)O","SaltData":[{"AcidCount":1,"Amine":"Dopamine","AmineCount":1,"Formula":"Cl","Name":"hydrochloride","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 118.541 36.649\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h119v37H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m33.533 33.576 13.198-7.62M33.533 30.76l10.759-6.212\"/\u003e\u003c/g\u003e\u003cpath d=\"M33.533 33.576 20.33 25.947\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m20.325 10.699.005 15.248M22.764 12.107l.004 12.433\"/\u003e\u003c/g\u003e\u003cpath d=\"m20.325 10.699 13.198-7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M46.726 10.707 33.523 3.079M44.288 12.115l-10.765-6.22\"/\u003e\u003c/g\u003e\u003cpath d=\"m46.731 25.956-.005-15.249M46.726 10.707l13.198-7.62M59.924 3.087l13.199 7.62M73.123 10.707l10.045-5.799M20.325 10.699l-9.924-5.727M20.33 25.947l-9.92 5.728\" class=\"bond\"/\u003e\u003cg fill=\"#3050f8\" stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M88.262 5.537h-.721l-2.619-4.066h-.03l.03.596q.024.357.024.732v2.738h-.566V.638h.715l2.607 4.054h.03l-.018-.328-.024-.476q-.006-.262-.006-.482V.638h.578zM92.568 5.537h-.619V3.251h-2.513v2.286h-.613V.638h.613v2.071h2.513V.638h.619zM95.073 7.027h-1.944v-.3l.772-.779q.221-.221.371-.393.154-.175.233-.339.078-.168.078-.365 0-.242-.146-.367-.143-.129-.372-.129-.214 0-.378.075-.161.075-.329.207l-.193-.243q.172-.146.393-.246.225-.1.507-.1.411 0 .65.207t.24.575q0 .229-.097.432-.093.2-.264.397-.168.196-.393.418l-.614.603v.018h1.486z\"/\u003e\u003c/g\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M9.385 3.078q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.245.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881T7.14.56q.733 0 1.233.316.5.309.756.875.256.565.256 1.327m-3.864 0q0 .923.387 1.459.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.459 0-.929-.387-1.452-.381-.524-1.209-.524-.833 0-1.226.524-.393.523-.393 1.452M4.305 5.531h-.62V3.245H1.173v2.286H.56v-4.9h.613v2.072h2.512V.631h.62z\"/\u003e\u003c/g\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M9.391 33.565q0 .756-.256 1.327-.256.566-.756.881t-1.245.316q-.756 0-1.262-.316-.506-.315-.756-.887-.244-.571-.244-1.333 0-.75.244-1.31.25-.566.756-.881t1.274-.316q.733 0 1.233.316.5.309.756.875t.256 1.328m-3.864 0q0 .922.387 1.458.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.458 0-.929-.387-1.453-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.453M4.311 36.017h-.62v-2.286H1.179v2.286H.566v-4.899h.613v2.071h2.512v-2.071h.62z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"#3050f8\" d=\"m83.168 4.908-5.023 2.9\" class=\"hi\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m10.401 4.972 4.962 2.863M10.401 4.972l4.962 2.863M10.41 31.675l4.96-2.864M10.41 31.675l4.96-2.864\" class=\"hi\"/\u003e\u003c/g\u003e\u003cg class=\"mol\"\u003e\u003cg fill=\"#1ff01f\" stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M115.224 16.473q-.786 0-1.238.53-.452.524-.452 1.446 0 .911.416 1.447.423.53 1.268.53.322 0 .608-.054.291-.059.565-.143v.536q-.274.101-.565.149-.292.054-.697.054-.744 0-1.25-.31-.5-.31-.75-.875-.25-.572-.25-1.34 0-.744.268-1.309.273-.566.803-.881.53-.322 1.28-.322.78 0 1.352.286l-.244.524q-.227-.101-.506-.185-.274-.083-.608-.083m2.757 4.423h-.601v-5.215h.601zM112.317 20.896h-.619V18.61h-2.512v2.286h-.613v-4.899h.613v2.071h2.512v-2.071h.619z\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Title":"Dopamine hydrochloride","UNII":"7L3E358N9L"}],"Salts":["hydrochloride"],"Scheduling":[],"Solubility":"Freely sol in water; sol in methanol, in hot 95% ethanol, in aq soln of alkali hydroxides; practically insol in petroleum ether, ether, benzene, chloroform, toluene /Hydrochloride/","Stability/Shelf Life":"Highly sensitive to oxygen; discolors quickly","StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 95.633 36.649\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h96v37H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m33.533 33.576 13.198-7.62M33.533 30.76l10.759-6.212\"/\u003e\u003c/g\u003e\u003cpath d=\"M33.533 33.576 20.33 25.947\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m20.325 10.699.005 15.248M22.764 12.107l.004 12.433\"/\u003e\u003c/g\u003e\u003cpath d=\"m20.325 10.699 13.198-7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M46.726 10.707 33.523 3.079M44.288 12.115l-10.765-6.22\"/\u003e\u003c/g\u003e\u003cpath d=\"m46.731 25.956-.005-15.249M46.726 10.707l13.198-7.62M59.924 3.087l13.199 7.62M73.123 10.707l10.045-5.799M20.325 10.699l-9.924-5.727M20.33 25.947l-9.92 5.728\" class=\"bond\"/\u003e\u003cg fill=\"#3050f8\" stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M88.262 5.537h-.721l-2.619-4.066h-.03l.03.596q.024.357.024.732v2.738h-.566V.638h.715l2.607 4.054h.03l-.018-.328-.024-.476q-.006-.262-.006-.482V.638h.578zM92.568 5.537h-.619V3.251h-2.513v2.286h-.613V.638h.613v2.071h2.513V.638h.619zM95.073 7.027h-1.944v-.3l.772-.779q.221-.221.371-.393.154-.175.233-.339.078-.168.078-.365 0-.242-.146-.367-.143-.129-.372-.129-.214 0-.378.075-.161.075-.329.207l-.193-.243q.172-.146.393-.246.225-.1.507-.1.411 0 .65.207t.24.575q0 .229-.097.432-.093.2-.264.397-.168.196-.393.418l-.614.603v.018h1.486z\"/\u003e\u003c/g\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M9.385 3.078q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.245.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881T7.14.56q.733 0 1.233.316.5.309.756.875.256.565.256 1.327m-3.864 0q0 .923.387 1.459.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.459 0-.929-.387-1.452-.381-.524-1.209-.524-.833 0-1.226.524-.393.523-.393 1.452M4.305 5.531h-.62V3.245H1.173v2.286H.56v-4.9h.613v2.072h2.512V.631h.62z\"/\u003e\u003c/g\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M9.391 33.565q0 .756-.256 1.327-.256.566-.756.881t-1.245.316q-.756 0-1.262-.316-.506-.315-.756-.887-.244-.571-.244-1.333 0-.75.244-1.31.25-.566.756-.881t1.274-.316q.733 0 1.233.316.5.309.756.875t.256 1.328m-3.864 0q0 .922.387 1.458.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.458 0-.929-.387-1.453-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.453M4.311 36.017h-.62v-2.286H1.179v2.286H.566v-4.899h.613v2.071h2.512v-2.071h.62z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"#3050f8\" d=\"m83.168 4.908-5.023 2.9\" class=\"hi\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m10.401 4.972 4.962 2.863M10.401 4.972l4.962 2.863M10.41 31.675l4.96-2.864M10.41 31.675l4.96-2.864\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Subjective Effects":null,"Therapeutic Uses":"Cardiotonic Agents","Title":"Dopamine","Toxicity Data":"LD\u003csub\u003e50\u003c/sub\u003e oral mice = 1460 mg/kg, LD\u003csub\u003e50\u003c/sub\u003e oral rats = 1780 mg/kg","UNII":"VTD58H1Z2X","Wikidata":"Q170304","Wikipedia":"Dopamine","XLogP":-1}