{"Abbreviation":["DMT","N,N-DMT"],"Absorption, Distribution and Excretion":"(14)C-DMT accumulates in rat brain cortical slices incubated at 37 °C.  ... Most of the accumulated (14)C-DMT was associated with the cytoplasmic fraction. Of the portion associated with the crude mitochondrial fraction, 54.4% was associated with nerve-ending fraction.","Aliases":["N,N-Dimethyltryptamine","N,n-dimethyltryptamine","Dimethyltryptamine","2-(3-Indolyl)ethyldimethylamine","3-(2-Dimethylaminoethyl)indole","1H-Indole-3-ethanamine, N,N-dimethyl-","N,N-Dimethyl-1H-indole-3-ethylamine","2-(1H-Indol-3-yl)-N,N-dimethylethanamine","DEA No. 7435","3-[2-(dimethylamino)ethyl]indole","NSC-63795","Dtxsid60110053","Chebi:28969","[2-(1H-indol-3-yl)ethyl]dimethylamine","3-(2-(Dimethylamino)ethyl)indole","(2-(1H-indol-3-yl)ethyl)dimethylamine","N,N Dimethyltryptamine","Dtxcid4065313","200-508-4","DMT","N,N-dimethyl-1H-Indole-3-ethanamine","2-(1H-indol-3-yl)-n,n-dimethyl-ethanamine","Chembl12420","(2-Indol-3-ylethyl)dimethylamine","Indole, 3-(2-(dimethylamino)ethyl)-","Indole, 3-[2-(dimethylamino)ethyl]-","A1AFV","2-(1H-Indol-3-yl)-N,N-dimethylethan-1-amine","(psychogenic)","Einecs 200-508-4","Unii-wub601bhaa","NSC 63795","Brn 0138259","HSDB 8017","NN-Dimethyltryptamine","1H-Indole-3-ethanamine,N,N-dimethyl-","Dimethyltryptamine(DMT)","dimethyltryptamine","(N,N)-Dimethyltryptamine","N-dimethyltryptamine","VLS01","GTPL141","3-(dimethylaminoethyl)-indole","Schembl335710","[2-(1H-indol-3-yl)-ethyl]-dimethyl-amine","Schembl4035596","Schembl9232580","VLS-01","Methyl-(2-(1h-indol-3-yl)-ethyl)-methylamine","Schembl23723328","Schembl29261888","Schembl29350959","N,N-Dimethyltryptamine, free base","NSC63795","Wln: t56 bmj d2n1\u00261","3-(2-(dimethylamino)ethyl)-Indole","Bdbm50026868","Mfcd00055989","STK370594","3-[2- (dimethylamino)ethyl]-Indole","Akos005446117","DB01488","MB00483","3-(2-Dimethylaminoethyl) indole","2-(1H-indol-3-yl)-ethyl-dimethyl-amine","AS-47089","N,N-Dimethyltryptamine, \u003e=97%","2-(1H-indol-3-yl)-N,N-dimethylethylamine","DB-308391","N,N-Dimethyltryptamine, 1mg/ml in Methanol","1H-indole-3-ethanamine,n,n-dimethyl","NS00005525","2-(1H-Indol-3-yl)-N,N-dimethylethanamine #","C08302","5500","D13141","L001288","N-(2-(1H-indol-3-yl)ethyl)-N,N-dimethylamine","InChI=1/C12H16N2/c1-14(2)8-7-10-9-13-12-6-4-3-5-11(10)12/h3-6,9,13H,7-8H2,1-2H"],"Boiling Point":"60-80 °C","CAS":"61-50-7","Chemical Classes":"Indoles","ChemicalClasses":["tryptamine"],"Chirality":"achiral","Classes":["Psychedelic"],"Color/Form":"Crystals ... also reported as plates from ethanol and light petroleum","DBI-IGS":["DMT"],"Decomposition":"When heated to decomposition if emits toxic fumes of /nitrogen oxides/.","Dosing Info":[{"Method":"Insufflated","Tiers":{"Common":{"Entries":0,"Lower":62.5,"Percentage":0,"Unit":"mg","Upper":75},"Extreme":{"Entries":1,"Lower":95,"Percentage":50,"Unit":"mg","Upper":95},"Heavy":{"Entries":0,"Lower":87.5,"Percentage":0,"Unit":"mg","Upper":95},"Light":{"Entries":1,"Lower":62.5,"Percentage":50,"Unit":"mg","Upper":62.5},"Strong":{"Entries":0,"Lower":75,"Percentage":0,"Unit":"mg","Upper":87.5}}},{"Method":"Oral","Tiers":{"Common":{"Entries":0,"Lower":65.1,"Percentage":0,"Unit":"mg","Upper":130.1},"Extreme":{"Entries":1,"Lower":234,"Percentage":50,"Unit":"mg","Upper":234},"Heavy":{"Entries":0,"Lower":195,"Percentage":0,"Unit":"mg","Upper":234},"Light":{"Entries":1,"Lower":65.1,"Percentage":50,"Unit":"mg","Upper":65.1},"Strong":{"Entries":0,"Lower":130.1,"Percentage":0,"Unit":"mg","Upper":195}}},{"Method":"Vaporized","Tiers":{"Common":{"Entries":1,"Lower":21.9,"Percentage":20,"Unit":"mg","Upper":30},"Extreme":{"Entries":1,"Lower":48,"Percentage":20,"Unit":"mg","Upper":48},"Heavy":{"Entries":0,"Lower":45,"Percentage":0,"Unit":"mg","Upper":48},"Light":{"Entries":2,"Lower":21.9,"Percentage":40,"Unit":"mg","Upper":21.9},"Strong":{"Entries":1,"Lower":30,"Percentage":20,"Unit":"mg","Upper":45}}}],"Drug Indication":"Some people use this compound as a psychedelic inducing agent.","DurationOfAction":"* Inhalation: ≤15 min\n* Intravenous: ≤30 min\u003ca href='#cite_note-5'\u003e\u003csup\u003e[5]\u003c/sup\u003e\u003c/a\u003e\n* Intramuscular injection|Intramuscular: 30 – 60 min\n* Oral administration|Oral with monoamine oxidase inhibitor: 4 – 6 hours","EliminationHalfLife":"* Alone: 5 – 19 min\u003ca href='#cite_note-4'\u003e\u003csup\u003e[4]\u003c/sup\u003e\u003c/a\u003e\n* With monoamine oxidase inhibitor: 1 – 4 hours","Erowid Experience Reports":[{"Author":"norman","Id":61908,"Title":"What Happened?"},{"Author":"Enesi/Xenonsion","Id":70238,"Title":"Using DMSO for Transdermal Administration"},{"Author":"mike","Id":101748,"Title":"These Drugs Used to Have an Effect on Me"},{"Author":"Kellykellyjelly6","Id":115096,"Title":"Have No Effect"},{"Author":"Explorer of Life","Id":24076,"Title":"A Healthy Reminder"},{"Author":"oliversion","Id":28636,"Title":"Kinda Disappointed..."},{"Author":"Tmaxx","Id":28809,"Title":"Swirling Colors and Rotating Energy"},{"Author":"Zeroismore","Id":31694,"Title":"Worst Trip Ever"},{"Author":"FlowGnome","Id":34614,"Title":"Velveteen Liquid Dreams"},{"Author":"Scalliwag","Id":41323,"Title":"An Attempt to Squelch the DMT Hyperbole"},{"Author":"nanobrain","Id":44849,"Title":"Breathing Better With the Letter B"},{"Author":"Caius Augustus","Id":48312,"Title":"Oh, I liked DMT, I just didnt like...The DMT"},{"Author":"Loki","Id":60939,"Title":"IV Trial"},{"Author":"I love you","Id":66551,"Title":"A Serene and Perfect Place"},{"Author":"Wreckin Crew","Id":69732,"Title":"The Best Trip ever... Ruined by Cops"},{"Author":"mabel","Id":72148,"Title":"Taste Sensation"},{"Author":"D-Day","Id":74368,"Title":"My Pants Look Like Jazz Album Covers!"},{"Author":"Sam","Id":74571,"Title":"HPPD and Me"},{"Author":"1108","Id":76862,"Title":"Threshold Oral Experience"},{"Author":"Visionary","Id":76976,"Title":"I Purchased a Vaporizer Today"},{"Author":"Mantrayana","Id":78233,"Title":"Seeing What The Fuss Was About"},{"Author":"Chen Cho Dorge","Id":85066,"Title":"A Strawberry Solstice"},{"Author":"ELK","Id":92292,"Title":"Tears of Joy"},{"Author":"PippUK","Id":95087,"Title":"Non-Critical Mass"},{"Author":"ASG13","Id":95231,"Title":"Seeing the Window: A Threshold Experience"},{"Author":"Zed","Id":96569,"Title":"Short and Pleasant"}],"Esters":[],"European Community (EC) Number":"200-508-4","Formating":[],"HMDB ID":"HMDB0005973","HeavyAtomCount":14,"Human Drugs":"Pharmaceuticals","IUPACName":"2-(1H-indol-3-yl)-N,N-dimethylethanamine","InChI":"InChI=1S/C12H16N2/c1-14(2)8-7-10-9-13-12-6-4-3-5-11(10)12/h3-6,9,13H,7-8H2,1-2H3","InChIKey":"DMULVCHRPCFFGV-UHFFFAOYSA-N","Interactions":"... The effects of the monamine oxidase inhibitor iproniazid phosphate on DMT metabolism were also studied. Iproniazid inhibited the formation of IAA from DMT by 83 per cent. However, the formation of NMT and DMT-NO was inhibited by 90 per cent under these conditions. Thus, the reported extension of half-life and potentiation of DMT behavioral effects by iproniazid may be due to inhibition of NMT and DMT-NO formation rather than inhibition of monoamine oxidase. A cyclic pathway for the synthesis and metabolism of DMT in brain tissue is proposed.","KEGG Entries":[{"Id":"D13141","Interactions":[],"Synonyms":["Dimethyltryptamine"]},{"Id":"D13141","Interactions":[],"Synonyms":["Dimethyltryptamine"]}],"MeSH Headers":[{"Id":"M0006467","Link":"https://id.nlm.nih.gov/mesh/M0006467.html","Name":"N,N-Dimethyltryptamine","Ref":65},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":67},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":88},{"Id":"M0009763","Link":"https://id.nlm.nih.gov/mesh/M0009763.html","Name":"Hallucinogens","Ref":89},{"Id":"M0019685","Link":"https://id.nlm.nih.gov/mesh/M0019685.html","Name":"Serotonin Antagonists","Ref":90},{"Id":"M0026371","Link":"https://id.nlm.nih.gov/mesh/M0026371.html","Name":"Serotonin Receptor Agonists","Ref":91}],"MeSH Pharmacological Classification":[{"Id":"M0009763","Link":"https://id.nlm.nih.gov/mesh/M0009763.html","Name":"Hallucinogen","Ref":89},{"Id":"M0019685","Link":"https://id.nlm.nih.gov/mesh/M0019685.html","Name":"Serotonin Antagonist","Ref":90},{"Id":"M0026371","Link":"https://id.nlm.nih.gov/mesh/M0026371.html","Name":"Serotonin Receptor Agonist","Ref":91}],"Mechanism of Action":"DMT acts as a non-selective agonist at most or all of the serotonin receptors.","Melting Point":"46 °C","Metabolism/Metabolites":"Following intraperitoneal administration, 5-methoxy-N,N-dimethyltryptamine and N,N-dimethyltryptamine are subject to both a very rapid uptake into, and clearance from, all tissues examined. The current studies in vivo confirm previous in vitro observations that the routes involved in the metabolism of these compounds include oxidative deamination, N-demethylation, O-demethylation, and N-oxidation. The analysis of metabolic profiles in various tissues led to the identification of the N-oxides as major metabolites...","MolecularFormula":"C\u003csub\u003e12\u003c/sub\u003eH\u003csub\u003e16\u003c/sub\u003eN\u003csub\u003e2\u003c/sub\u003e","MolecularWeight":"188.27 g/mol","Non-Human Toxicity Values":"LD50 Mouse iv 32 mg/kg","Physical Description":"Solid","PubChemId":6089,"Record Description":["Wikipedia|TiHKAL|Tryptamines"],"Records":{"UNII":{"Impurities":[]}},"RefChem":"34942","RefCount":6,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/N,N-Dimethyltryptamine","Name":"Dimethyltryptamine","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q407217","Name":"Dimethyltryptamine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB01488","Name":"Dimethyltryptamine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/6089","Name":"Dimethyltryptamine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=61-50-7","Name":"Dimethyltryptamine","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0005973","Name":"Dimethyltryptamine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C08302","Name":"Dimethyltryptamine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/WUB601BHAA","Name":"Dimethyltryptamine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID60110053","Name":"Dimethyltryptamine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 6089, N,N-Dimethyltryptamine. Accessed May 4, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/6089\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/6089\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Dimethyltryptamine. UNII: WUB601BHAA. Global Substance Registration System. Accessed May 4, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/WUB601BHAA\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/WUB601BHAA\u003c/a\u003e","Anvisa. RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. July 24, 2023. Accessed May 4, 2026. \u003ca href=https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-804-de-24-de-julho-de-2023-498447451\u003ehttps://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-804-de-24-de-julho-de-2023-498447451\u003c/a\u003e","Vollebregt R, Storm AE, Lucassen PJ, Somers M. Psychedelic Experiences Elicited by Serotonergic Psychedelics; Molecular Mechanisms and Functional Connectivity Changes in /the Brain. Neurosci Biobehav Rev. December 1, 2025; 181()","Barker SA. Administration of N,N-dimethyltryptamine (DMT) in psychedelic therapeutics and research and the study of endogenous DMT. Psychopharmacology (Berl). June 1, 2022; 239(6):1749–1763."],"SMILES":"CN(C)CCC1=CNC2=CC=CC=C21","SaltData":[{"AcidCount":1,"Amine":"Dimethyltryptamine","AmineCount":1,"Formula":"C(=C/C(=O)O)\\C(=O)O","Name":"fumarate","RName":"fumarate","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 186.954 46.26\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h187v47H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m97.6 25.043-10.036-5.811M84.416 13.557l.014-11.39M81.257 19.223l-10.053 5.788M71.204 25.011l-13.189-7.636M58.015 17.375l-13.208 7.604\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m43.225 40.097 1.582-15.118M40.985 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