{"ATC Code":"A - Alimentary tract and metabolism","Abbreviation":[],"Actives":["Ethcathinone"],"Aliases":["Amfepramone","Diethylpropione","Amfepramon","Amphepramone","Nopropiophenone","Adiposon","Amphepramon","Frekentine","Danylen","Magrene","Tylinal","Diethylcathinone","α-Benzoyltriethylamine","Amfepramonum","Anfepramona","Cegramine","Obesitex","Derfon","Neobes","Silutin","α-Diethylaminopropiophenone","2-(Diethylamino)propiophenone","1-Propanone, 2-(diethylamino)-1-phenyl-","2-(Diethylamino)-1-phenyl-1-propanone","1-Phenyl-2-diethylamino-1-propanone"],"Biological Half-Life":"Using a phosphorescence assay that is specific for basic compounds containing benzoyl group, the plasma half-life of the aminoketone metabolites is estimated to be between 4 to 6 hours.","CAS":"90-84-6","ChEBI":"CHEBI:4530","ChEMBL":"CHEMBL1194666","ChemicalClasses":["amphetamine"],"Chirality":"racemic","Classes":["Prodrug","Stimulant"],"DEA no":1610,"Decomposition":"When heated to decomp it emits very toxic fumes of /hydrogen chloride and nitrogen oxides./ /Diethylpropion hydrochloride/","Drug Classes":"Weight Loss Agents","Drug Indication":"Used in the management of exogenous obesity as a short-term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction.","Drug Warnings":"Because of their stimulant effects on the cardiovascular system auorexiants with adrenergic activity should not be prescribed for individuals with ischemic heart disease, hyperthyroidism or advanced arteriosclerosis.","EINECS":"202-019-1","Esters":[],"European Community (EC) Number":"202-019-1","FDA Pharmacological Classification":"Q94YYU22B8","Formating":[],"HMDB ID":"HMDB0015072","Health Effects":"Using large amounts of these drugs can result in a condition known as amphetamine psychosis -- which can result in auditory, visual and tactile hallucinations, intense paranoia, irrational thoughts and beliefs, delusions, and mental confusion.","HeavyAtomCount":15,"Human Drugs":"Human drug -\u003e Discontinued","IUPACName":"2-(diethylamino)-1-phenylpropan-1-one","InChI":"InChI=1S/C13H19NO/c1-4-14(5-2)11(3)13(15)12-9-7-6-8-10-12/h6-11H,4-5H2,1-3H3","InChIKey":"XXEPPPIWZFICOJ-UHFFFAOYSA-N","Interactions":"An increased prevalence of abnormal cardiac valve function, primarily aortic regurgitation, was found on echocardiographic evaluation in patients receiving phentermine in combination with either dexfenfluramine or fenfluramine, both of which act to suppress appetite by increasing serotonergic function; however, an increased prevalence of abnormal cardiac valve function also has been found in patients receiving dexfenfluramine or fenfluramine alone, and the role of phentermine in producing the cardiotoxic effect is uncertain; because of the severity of these cardiovascular effects and because the safety and efficacy of other appetite suppressant combinations have not been established, combined use is not recommended; also, the safety and efficacy of combining as selective serotonin reuptake inhibitor (SSRI), which enhances serotonergic function, with a sympathomimetic appetite suppressant have not been established and combined use is not recommended. /Appetite suppressants, sympathomimetic/","LD50":[{"dosages":[{"amount":"\u0026gt;400 mg/kg","route":"oral"}],"organism":"Rat"},{"dosages":[{"amount":"160 mg/kg","route":"oral"},{"amount":"24 mg/kg","route":"intraperitoneal"}],"organism":"Mouse"}],"MeSH Pharmacological Classification":"Agents that are used to suppress appetite.","MolecularFormula":"C\u003csub\u003e13\u003c/sub\u003eH\u003csub\u003e19\u003c/sub\u003eNO","MolecularWeight":"205.30 g/mol","Opticalactivity":"( + / - )","Pharmacodynamics":"Diethylpropion is a sympathomimetic stimulant drug marketed as an appetite suppressant. Chemically, it is the N,N-diethyl analog of cathinone. Its mechanism of action is similar to other appetite suppressants such as sibutramine, phentermine and dextroamphetamine.","Physical Description":"Solid","PubChemId":7029,"Record Description":["LiverTox|Weight loss agent|Obesity|Sympathomimetic amine"],"RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Amfepramone","Name":"Diethylpropion","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q2356505","Name":"Diethylpropion","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB00937","Name":"Diethylpropion","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/7029","Name":"Diethylpropion","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1194666","Name":"Diethylpropion","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:4530","Name":"Diethylpropion","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=90-84-6","Name":"Diethylpropion","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0015072","Name":"Diethylpropion","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C06954","Name":"Diethylpropion","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/Q94YYU22B8","Name":"Diethylpropion","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022929","Name":"Diethylpropion","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 7029, Diethylpropion. Accessed August 31, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/7029\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/7029\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Diethylpropion. UNII: Q94YYU22B8. Global Substance Registration System. Accessed August 31, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/Q94YYU22B8\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/Q94YYU22B8\u003c/a\u003e"],"SMILES":"CCN(CC)C(C)C(=O)C1=CC=CC=C1","SaltData":[{"AcidCount":1,"Amine":"Diethylpropion","AmineCount":1,"Formula":"Cl","Name":"hydrochloride","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 117.377 55.425\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#1ff01f\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h118v56H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m93.431 23.898-13.199 7.62M80.232 31.518l-10.045-5.799M67.034 20.048V8.658M67.034 8.658l13.198-7.62M63.881 25.719l-10.045 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26.348h-.72l-2.62-4.066h-.03l.03.595q.024.357.024.732v2.739h-.566v-4.9h.715l2.607 4.055h.03l-.018-.328-.024-.476q-.006-.262-.006-.482v-2.769h.578z\" class=\"atom\"/\u003e\u003cpath fill=\"#ff0d0d\" stroke=\"none\" d=\"M42.897 8.655q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.309.756.875.256.565.256 1.327m-3.864 0q0 .923.387 1.459.393.53 1.221.53.839 0 1.22-.53.387-.536.387-1.459 0-.928-.387-1.452-.381-.524-1.208-.524-.834 0-1.227.524t-.393 1.452\" class=\"atom\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m70.187 25.719 5.022 2.9M67.034 20.048v-5.695M63.881 25.719l-5.023 2.9\" class=\"hi\"/\u003e\u003c/g\u003e\u003cg class=\"mol\"\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M114.061 25.861q-.786 0-1.239.53-.452.524-.452 1.446 0 .911.417 1.447.422.53 1.268.53.321 0 .607-.054.292-.059.565-.143v.536q-.273.101-.565.149-.292.054-.697.054-.744 0-1.25-.31-.5-.31-.75-.875-.25-.572-.25-1.34 0-.744.268-1.309.274-.566.804-.881.529-.322 1.279-.322.78 0 1.352.286l-.244.524q-.226-.101-.506-.185-.274-.083-.607-.083m2.756 4.423h-.601v-5.215h.601zM111.153 30.284h-.619v-2.286h-2.512v2.286h-.613v-4.899h.613v2.071h2.512v-2.071h.619z\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Title":"Diethylpropion hydrochloride","UNII":"19V2PL39NG"}],"Salts":["hydrochloride"],"Solubility":"White or creamy white, small crystals or crystalline powder; characteristic, mildly aromatic odor; 1 g sol in: about 0.6 mL water, about 0.6 ml chloroform, 1 ml absolute methanol, 1 ml alcohol; practically insoluble in ether /Diethylpropion hydrochloride/","Stability/Shelf Life":"Stable in dry air /Diethylpropion hydrochloride/","StereoisomerData":[{"Aliases":null,"PubChemId":null,"SMILES":"CCN(CC)[C@H](C)C(=O)C1=CC=CC=C1","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 94.469 55.425\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h95v56H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m93.431 23.898-13.199 7.62M80.232 31.518l-10.045-5.799M67.034 20.048V8.658M67.034 8.658l13.198-7.62M63.881 25.719l-10.045 5.799\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M54.186 31.518h-.7M54.436 33.695h-1.2M54.686 35.872h-1.7M54.936 38.05h-2.2M55.186 40.227h-2.7M55.436 42.404h-3.2M55.686 44.581h-3.7M55.936 46.758h-4.2\"/\u003e\u003c/g\u003e\u003cpath d=\"m53.836 31.518-13.198-7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M39.419 24.602V12.579M41.857 24.602V12.579\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"M39.419 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1.328-.256.565-.756.881-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.309.756.875.256.565.256 1.327m-3.864 0q0 .923.387 1.459.393.53 1.221.53.839 0 1.22-.53.387-.536.387-1.459 0-.928-.387-1.452-.381-.524-1.208-.524-.834 0-1.227.524t-.393 1.452\" class=\"atom\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m70.187 25.719 5.022 2.9M67.034 20.048v-5.695M63.881 25.719l-5.023 2.9\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Title":"(R)-Diethylpropion","UNII":null},{"Aliases":null,"PubChemId":null,"SMILES":"CCN(CC)[C@@H](C)C(=O)C1=CC=CC=C1","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 94.469 55.425\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h95v56H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m93.431 23.898-13.199 7.62M80.232 31.518l-10.045-5.799M67.034 20.048V8.658M67.034 8.658l13.198-7.62M63.881 25.719l-10.045 5.799\" class=\"bond\"/\u003e\u003cpath stroke=\"none\" d=\"M54.186 31.518h-.7l-1.75 15.24h4.2z\" class=\"bond\"/\u003e\u003cpath d=\"m53.836 31.518-13.198-7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M39.419 24.602V12.579M41.857 24.602V12.579\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"M39.419 12.579v6.011M41.857 12.579v6.011\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath d=\"m40.638 23.898-13.198 7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M27.44 31.518 14.236 23.89M25.002 32.926l-10.766-6.22\"/\u003e\u003c/g\u003e\u003cpath d=\"M14.236 23.89 1.038 31.51\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m1.038 31.51.005 15.248M3.477 32.917l.004 12.434\"/\u003e\u003c/g\u003e\u003cpath d=\"m1.043 46.758 13.203 7.629\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m14.246 54.387 13.198-7.62M14.247 51.571l10.759-6.212\"/\u003e\u003c/g\u003e\u003cpath d=\"m27.44 31.518.004 15.249\" class=\"bond\"/\u003e\u003cpath fill=\"#3050f8\" stroke=\"none\" d=\"M68.975 26.348h-.72l-2.62-4.066h-.03l.03.595q.024.357.024.732v2.739h-.566v-4.9h.715l2.607 4.055h.03l-.018-.328-.024-.476q-.006-.262-.006-.482v-2.769h.578z\" class=\"atom\"/\u003e\u003cpath fill=\"#ff0d0d\" stroke=\"none\" d=\"M42.897 8.655q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.309.756.875.256.565.256 1.327m-3.864 0q0 .923.387 1.459.393.53 1.221.53.839 0 1.22-.53.387-.536.387-1.459 0-.928-.387-1.452-.381-.524-1.208-.524-.834 0-1.227.524t-.393 1.452\" class=\"atom\"/\u003e\u003cpath stroke=\"#3050f8\" 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class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M39.419 24.602V12.579M41.857 24.602V12.579\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"M39.419 12.579v6.011M41.857 12.579v6.011\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath d=\"m40.638 23.898-13.198 7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M27.44 31.518 14.236 23.89M25.002 32.926l-10.766-6.22\"/\u003e\u003c/g\u003e\u003cpath d=\"M14.236 23.89 1.038 31.51\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m1.038 31.51.005 15.248M3.477 32.917l.004 12.434\"/\u003e\u003c/g\u003e\u003cpath d=\"m1.043 46.758 13.203 7.629\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m14.246 54.387 13.198-7.62M14.247 51.571l10.759-6.212\"/\u003e\u003c/g\u003e\u003cpath d=\"m27.44 31.518.004 15.249\" class=\"bond\"/\u003e\u003cpath fill=\"#3050f8\" stroke=\"none\" d=\"M68.975 26.348h-.72l-2.62-4.066h-.03l.03.595q.024.357.024.732v2.739h-.566v-4.9h.715l2.607 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libido","Stamina enhancement","Stimulation","Appetite suppression","Dehydration","Dry mouth","Restless legs","Shakiness","Teeth grinding","Abnormal heartbeat","Increased blood pressure","Increased heart rate","Vasoconstriction"],"Visual Effects":[]},"TDLo":[{"dosages":[{"amount":"11 mg/kg","route":"oral"}],"organism":"Human - male"}],"Therapeutic Uses":"Appetite Depressants","Title":"Diethylpropion","Toxicity Data":"LD50: 600 mg/kg (Oral, Mouse) (A308)\nLD50: 50 mg/kg (Oral, Rat) (A308)\nLD50: 225 mg/kg (Oral, Dog) (A308)","Treatment":"Management of acute diethylpropion hydrochloride intoxication is largely symptomatic and includes lavage and sedation with a barbiturate. Experience with hemodialysis or peritoneal dialysis is inadequate to permit recommendation in this regard. Intravenous phentolamine (Regitine","UNII":"Q94YYU22B8","Wikidata":"Q2356505","Wikipedia":"Amfepramone","XLogP":2.8}