{"ATC Code":["N - Nervous system","N06 - Psychoanaleptics","N06B - Psychostimulants, agents used for adhd and nootropics","N06BA - Centrally acting sympathomimetics","N06BA03 - Metamfetamine","QN - Nervous system","QN06 - Psychoanaleptics","QN06B - Psychostimulants, agents used for adhd and nootropics","QN06BA - Centrally acting sympathomimetics","QN06BA03 - Metamfetamine"],"Absorption, Distribution and Excretion":"Methamphetamine is rapidly absorbed from the gastrointestinal tract with peak methamphetamine concentrations occurring in 3.13 to 6.3 hours post ingestion. Moreover, when administered intranasally or as an inhalation, methamphetamine also demonstrates a high degree of absorption. It is distributed to most parts of the body. Because methamphetamine has a high lipophilicity it is distributed across the blood brain barrier and crosses the placenta.","Adverse Effects":"People who use methamphetamine feel an acute, powerful short rush for about 5 to 30 minutes, which varies based on different routes of use. The drug also causes an enhanced energy level, decreases appetite, and creates euphoria for a range of 6 to 12 hours.","Aliases":["Methamphetamine","Metamfetamine","Deoxyephedrine","Metamphetamine","Desoxyephedrine","Methylamphetamine","N-Methylamphetamine","Norodin","Phenylisopropylmethylamine","(S)-Methamphetamine","1-Phenyl-2-methylaminopropane","Metamfetamina","Stimulex","(+)-Deoxyephedrine","Methyl-β-phenylisopropylamine","Metamfetaminum","Metanfetamina","S-(+)-Methamphetamine","N,α-Dimethylbenzeneethanamine","N,α-dimethylphenethylamine","Methamphetaminum","2-(N-Methylamino)-1-phenylpropane","N-Methyl-β-phenylisopropylamine","N,α-Dimethylphenethylamine","N,α-Dimethyl-β-phenylethylamine","dextromethamphetamine","N-α-Dimethylphenethylamine","(αS)-N,α-dimethylbenzeneethanamine","(s)-phenylmethylaminopropane","NSC-25115","J6.362B","CHEBI:6809","Benzeneethanamine, N,α-dimethyl-, (S)-","Benzeneethanamine, N,α-dimethyl-, (+)-","Dtxsid8037128","Phenethylamine, N,α-dimethyl-, (S)-(+)-","methyl[(2S)-1-phenylpropan-2-yl]amine","methyl((2S)-1-phenylpropan-2-yl)amine","N Methylamphetamine","metamfetamine racemate","Dtxcid6017128","N06BA03","208-668-7","N-methyl-1-phenylpropan-2-amine","Desyphed","(+)-Methamphetamine","1-Phenyl-2-methylamino-propan","1-Phenyl-2-methylaminopropan","2S-(+)-Methamphetamine","Meth","N-Methyl-β-phenylisopropylamin","NSC 25115","N,α-Dimethylbenzeneethanoamine","(+)-N,α,dimethylphenethylamine","DEA No. 1105","Speed","Benzeneethanamine, N,α-dimethyl-, (αS)-","Crank","Crystal Meth","HSDB 3359","N-Methyl-1-phenyl-2-propanamine","(+ )-Methylamphetamine","Einecs 208-668-7","Phenethylamine, N,α-dimethyl-, (+)-","Unii-44ral3456c","B40","Epitope ID:178090","intra-venous methamphetamine","Benzeneethanamine,α-dimethyl-, (S)-","N,a-dimethylphenethylamine","Schembl42615","Phenethylamine,α-dimethyl-, (S)-(+)-","Chembl1201201","Wln: 1my1\u00261r -d","N,I+/--Dimethyl-phenethyl amine","Desyphed hydrochloride","NSC25115","N-Methyl-1-phenyl-2-propanamine #","Bdbm50359499","Pdsp1_001404","Pdsp1_001405","Pdsp2_001388","Pdsp2_001389","DB01577","Desoxyephedrine hydrochloride","Phenethylamine,α-dimethyl-, (+)-","Benzeneethanamine,α-dimethyl-, (+)-","NS00000412","C07164","D08187","N,α-Dimethylphenethylamine hydrochloride"],"Biological Half-Life":"The biological half-life has been reported in the range of 4 to 5 hours.","Boiling Point":"212 °C","CAS":"537-46-2","ChemicalClasses":["amphetamine"],"Chirality":"absolute","Classes":["Stimulant"],"Color/Form":"Clear, colorless liquid","DBI-IGS":["Methamphetamine"],"Decomposition":"When heated to decomposition it emits toxic vapors of Nitric oxides.","Dosing Info":[{"Method":"Insufflated","Tiers":{"Common":{"Entries":13,"Lower":15,"Percentage":15.9,"Unit":"mg","Upper":20},"Extreme":{"Entries":9,"Lower":31.8,"Percentage":11,"Unit":"mg","Upper":31.8},"Heavy":{"Entries":12,"Lower":27.3,"Percentage":14.6,"Unit":"mg","Upper":31.8},"Light":{"Entries":34,"Lower":15,"Percentage":41.5,"Unit":"mg","Upper":15},"Strong":{"Entries":14,"Lower":20,"Percentage":17.1,"Unit":"mg","Upper":27.3}}},{"Method":"Intravenous","Tiers":{"Common":{"Entries":2,"Lower":56.2,"Percentage":3.2,"Unit":"mg","Upper":130},"Extreme":{"Entries":3,"Lower":200,"Percentage":4.8,"Unit":"mg","Upper":200},"Heavy":{"Entries":6,"Lower":180,"Percentage":9.5,"Unit":"mg","Upper":200},"Light":{"Entries":30,"Lower":56.2,"Percentage":47.6,"Unit":"mg","Upper":56.2},"Strong":{"Entries":22,"Lower":130,"Percentage":34.9,"Unit":"mg","Upper":180}}},{"Method":"Oral","Tiers":{"Common":{"Entries":0,"Lower":20,"Percentage":0,"Unit":"mg","Upper":20},"Extreme":{"Entries":1,"Lower":22,"Percentage":16.7,"Unit":"mg","Upper":22},"Heavy":{"Entries":0,"Lower":20,"Percentage":0,"Unit":"mg","Upper":22},"Light":{"Entries":5,"Lower":20,"Percentage":83.3,"Unit":"mg","Upper":20},"Strong":{"Entries":0,"Lower":20,"Percentage":0,"Unit":"mg","Upper":20}}},{"Method":"Intrarectal","Tiers":{"Common":{"Entries":0,"Lower":51.2,"Percentage":0,"Unit":"mg","Upper":40},"Extreme":{"Entries":0,"Lower":300,"Percentage":0,"Unit":"mg","Upper":300},"Heavy":{"Entries":2,"Lower":200,"Percentage":28.6,"Unit":"mg","Upper":300},"Light":{"Entries":4,"Lower":51.2,"Percentage":57.1,"Unit":"mg","Upper":51.2},"Strong":{"Entries":1,"Lower":40,"Percentage":14.3,"Unit":"mg","Upper":200}}},{"Method":"Vaporized","Tiers":{"Common":{"Entries":0,"Lower":11.1,"Percentage":0,"Unit":"mg","Upper":10},"Extreme":{"Entries":1,"Lower":50,"Percentage":4.8,"Unit":"mg","Upper":50},"Heavy":{"Entries":4,"Lower":25,"Percentage":19,"Unit":"mg","Upper":50},"Light":{"Entries":12,"Lower":11.1,"Percentage":57.1,"Unit":"mg","Upper":11.1},"Strong":{"Entries":4,"Lower":10,"Percentage":19,"Unit":"mg","Upper":25}}}],"Drug Classes":["Breast Feeding","Lactation","Milk, Human","Street Drugs","Sympathomimetics","Dopamine Agents","Central Nervous System Stimulants","Adrenergic Agents","Wakefulness-Promoting Agents"],"Drug Indication":"For the treatment of Attention Deficit Disorder with Hyperactivity (ADHD) and exogenous obesity.","Drug Warnings":"BOXED WARNING: Methamphetamine has a high potential for abuse. It should thus be tried only in weight reduction programs for patients in whom alternative therapy has been ineffective. Administration of methamphetamine for prolonged periods of time in obesity may lead to drug dependence and must be avoided. Particular attention should be paid to the possibility of subjects obtaining methamphetamine for non-therapeutic use or distribution to others, and the drug should be prescribed or dispensed sparingly. Misuse of methamphetamine may cause sudden death and serious cardiovascular adverse events.","DurationOfAction":"8 – 12 hours\u003ca href='#cite_note-4'\u003e\u003csup\u003e[4]\u003c/sup\u003e\u003c/a\u003e","EliminationHalfLife":"9 – 12 hours (range 5 – 30 hours); irrespective of route","Esters":[],"European Community (EC) Number":"208-668-7","FDA Pharmacological Classification":[{"Name":"FDA UNII","ReferenceNumber":21,"Value":{"StringWithMarkup":[{"String":"44RAL3456C"}]}},{"Name":"Active Moiety","ReferenceNumber":21,"Value":{"StringWithMarkup":[{"String":"METHAMPHETAMINE"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":21,"Value":{"StringWithMarkup":[{"Markup":[{"Extra":"CID-3007","Length":11,"Start":40,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/Amphetamine"}],"String":"Established Pharmacologic Class [EPC] - Amphetamine Anorectic"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":21,"Value":{"StringWithMarkup":[{"String":"Chemical Structure [CS] - Amphetamines"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":21,"Value":{"StringWithMarkup":[{"String":"Physiologic Effects [PE] - Appetite Suppression"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":21,"Value":{"StringWithMarkup":[{"String":"Established Pharmacologic Class [EPC] - Central Nervous System Stimulant"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":21,"Value":{"StringWithMarkup":[{"String":"Physiologic Effects [PE] - Central Nervous System Stimulation"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":21,"Value":{"StringWithMarkup":[{"String":"Physiologic Effects [PE] - Increased Sympathetic Activity"}]}},{"Name":"FDA Pharmacology Summary","ReferenceNumber":21,"Value":{"StringWithMarkup":[{"Markup":[{"Extra":"CID-10836","Length":15,"Start":0,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/Methamphetamine"},{"Extra":"CID-3007","Length":11,"Start":22,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/Amphetamine"},{"Extra":"CID-10836","Length":15,"Start":108,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/methamphetamine"}],"String":"Methamphetamine is an Amphetamine Anorectic and Central Nervous System Stimulant. The physiologic effect of methamphetamine is by means of Appetite Suppression and Central Nervous System Stimulation and Increased Sympathetic Activity."}]}}],"Flash Point":"9.7 °C (49.5 °F) - closed cup","Formating":[],"HMDB ID":"HMDB0015517","Health Effects":"Using large amounts of these drugs can result in a condition known as amphetamine psychosis -- which can result in auditory, visual and tactile hallucinations, intense paranoia, irrational thoughts and beliefs, delusions, and mental confusion.","HeavyAtomCount":11,"Human Drugs":"Breast Feeding; Lactation; Milk, Human; Street Drugs; Sympathomimetics; Dopamine Agents; Central Nervous System Stimulants; Adrenergic Agents; Wakefulness-Promoting Agents","Human Toxicity Values":"Therapeutic or normal methamphetamine blood concentration: 20-60 ug/dL; Toxic methamphetamine blood concentration: 60-500 ug/dL; Lethal methamphetamine blood concentration: 1-4 mg/dL /From table/","IUPACName":"(2S)-N-methyl-1-phenylpropan-2-amine","Impurities":"Analysis of illicit preparations of methamphetamine ... revealed presence of significant quantities of zinc and minor amount of titantium.","InChI":"InChI=1S/C10H15N/c1-9(11-2)8-10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3/t9-/m0/s1","InChIKey":"MYWUZJCMWCOHBA-VIFPVBQESA-N","Interactions":"BACKGROUND: Methamphetamine addiction is a significant public health problem for which no Food and Drug Administration-approved pharmacotherapies exist. Preclinical drug vs. food choice procedures have been predictive of clinical medication efficacy in the treatment of opioid and cocaine addiction. Whether preclinical choice procedures are predictive of candidate medication effects for other abused drugs, such as methamphetamine, remains unclear. The present study aim was to determine continuous 7-day treatment effects with the monoamine releaser d-amphetamine and the monoamine uptake inhibitor methylphenidate on methamphetamine vs. food choice. In addition, 7-day cocaine treatment effects were also examined. METHODS: Behavior was maintained under a concurrent schedule of food delivery (1-g pellets, fixed-ratio 100 schedule) and methamphetamine injections (0-0.32mg/kg/injection, fixed-ratio 10 schedule) in male rhesus monkeys (n=4). Methamphetamine choice dose-effect functions were determined daily before and during 7-day periods of continuous intravenous treatment with d-amphetamine (0.01-0.1mg/kg/hr), methylphenidate (0.032-0.32mg/kg/hr), or cocaine (0.1-0.32mg/kg/hr). RESULTS: During saline treatment, increasing methamphetamine doses resulted in a corresponding increase in methamphetamine vs. food choice. Continuous 7-day treatments with d-amphetamine, methylphenidate or cocaine did not significantly attenuate methamphetamine vs. food choice up to doses that decreased rates of operant responding. However, 0.1mg/kg/hr d-amphetamine did eliminate methamphetamine choice in two monkeys. CONCLUSIONS: The present subchronic treatment results support the utility of preclinical methamphetamine choice to evaluate candidate medications for methamphetamine addiction. Furthermore, these results confirm and extend previous results demonstrating differential pharmacological mechanisms between cocaine choice and methamphetamine choice.","MeSH Headers":[{"Id":"M0013551","Link":"https://id.nlm.nih.gov/mesh/M0013551.html","Name":"Methamphetamine","Ref":85},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":87},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":113},{"Id":"M0001063","Link":"https://id.nlm.nih.gov/mesh/M0001063.html","Name":"Central Nervous System Stimulants","Ref":114},{"Id":"M0020947","Link":"https://id.nlm.nih.gov/mesh/M0020947.html","Name":"Sympathomimetics","Ref":115},{"Id":"M0023499","Link":"https://id.nlm.nih.gov/mesh/M0023499.html","Name":"Dopamine Agents","Ref":116},{"Id":"M0027961","Link":"https://id.nlm.nih.gov/mesh/M0027961.html","Name":"Adrenergic Agents","Ref":117},{"Id":"M0028095","Link":"https://id.nlm.nih.gov/mesh/M0028095.html","Name":"Adrenergic Uptake Inhibitors","Ref":118},{"Id":"M0028098","Link":"https://id.nlm.nih.gov/mesh/M0028098.html","Name":"Dopamine Uptake Inhibitors","Ref":119}],"MeSH Pharmacological Classification":[{"Id":"M0001063","Link":"https://id.nlm.nih.gov/mesh/M0001063.html","Name":"Central Nervous System Stimulant","Ref":114},{"Id":"M0020947","Link":"https://id.nlm.nih.gov/mesh/M0020947.html","Name":"Sympathomimetic","Ref":115},{"Id":"M0023499","Link":"https://id.nlm.nih.gov/mesh/M0023499.html","Name":"Dopamine Agent","Ref":116},{"Id":"M0027961","Link":"https://id.nlm.nih.gov/mesh/M0027961.html","Name":"Adrenergic Agent","Ref":117},{"Id":"M0028095","Link":"https://id.nlm.nih.gov/mesh/M0028095.html","Name":"Adrenergic Uptake Inhibitor","Ref":118},{"Id":"M0028098","Link":"https://id.nlm.nih.gov/mesh/M0028098.html","Name":"Dopamine Uptake Inhibitor","Ref":119}],"Mechanism of Action":"Methamphetamine enters the brain and triggers a cascading release of norepinephrine, dopamine and serotonin. To a lesser extent methamphetamine acts as a dopaminergic and adrenergic reuptake inhibitor and in high concentrations as a monamine oxidase inhibitor (MAOI). The mechanism of action involved in producing the beneficial behavioral changes seen in hyperkinetic children receiving methamphetamine is unknown.","Melting Point":"170-2 °C","Metabolism/Metabolites":"Hepatic. The primary site of metabolism is in the liver by aromatic hydroxylation, N-dealkylation and deamination. At least seven metabolites have been identified in the urine, with the main metabolites being amphetamine (active) and 4-hydroxymethamphetamine. Other minor metabolites include 4-hydroxyamphetamine, norephedrine, and 4-hydroxynorephedrine.","MolecularFormula":"C\u003csub\u003e10\u003c/sub\u003eH\u003csub\u003e15\u003c/sub\u003eN","MolecularWeight":"149.23 g/mol","Non-Human Toxicity Values":"LD50 Mouse intraperitoneal 70 mg/kg","Odor":"Characteristic odor resembling geranium leaves","Opticalactivity":"( + )","Pharmacodynamics":"Methamphetamine is a potent central nervous system stimulant which affects neurochemical mechanisms responsible for regulating heart rate, body temperature, blood pressure, appetite, attention, mood and responses associated with alertness or alarm conditions. The acute effects of the drug closely resemble the physiological and psychological effects of an epinephrine-provoked fight-or-flight response, including increased heart rate and blood pressure, vasoconstriction (constriction of the arterial walls), bronchodilation, and hyperglycemia (increased blood sugar). Users experience an increase in focus, increased mental alertness, and the elimination of fatigue, as well as a decrease in appetite.","Physical Description":"Solid","PubChemId":10836,"Record Description":["LiverTox|CNS|Stimulant|Sympathomimetic amine"],"Records":{"UNII":{"Impurities":["piperonal","ephedrine","apaa","apaan","mapa"]}},"RefChem":"6653","RefCount":5,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Methamphetamine","Name":"Dextromethamphetamine","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q191924","Name":"Dextromethamphetamine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB01577","Name":"Dextromethamphetamine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/10836","Name":"Dextromethamphetamine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=537-46-2","Name":"Dextromethamphetamine","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0015517","Name":"Dextromethamphetamine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C07164","Name":"Dextromethamphetamine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/44RAL3456C","Name":"Dextromethamphetamine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID8037128","Name":"Dextromethamphetamine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 10836, Methamphetamine. Accessed April 29, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/10836\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/10836\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Dextromethamphetamine. UNII: 44RAL3456C. Global Substance Registration System. Accessed April 29, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/44RAL3456C\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/44RAL3456C\u003c/a\u003e","Anvisa. RDC Nº 804 – Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. July 24, 2023. Accessed April 29, 2026. \u003ca href=https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-804-de-24-de-julho-de-2023-498447451\u003ehttps://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-804-de-24-de-julho-de-2023-498447451\u003c/a\u003e","Courtney KE, Ray LA. Methamphetamine: an update on epidemiology, pharmacology, clinical phenomenology, and treatment literature. Drug Alcohol Depend. October 1, 2014; 143():11–21."],"Reported Fatal Dose":"The minimal lethal amphetamine dose varies with age \u0026 animal species. Children appear more susceptible than adults. ... 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substance"},{"gov":"Germany","ref":[],"schedule":"Anlage II substance"},{"gov":"New Zealand","ref":[],"schedule":"Class A substance"},{"gov":"United Kingdom","ref":[],"schedule":"Class A substance"},{"act":"Controlled Substances Act (CSA)","gov":"United States","ref":[],"schedule":"Schedule I"},{"gov":"European Union","ref":[],"schedule":"prescription only substance"},{"gov":"United Nations","ref":[],"schedule":"Schedule II substance"}],"Slang":["ICE ","Crank ","Speed ","Crystal Meth "],"Solubility":"In water, 0.5 g/mL","Stability/Shelf Life":"Stable under recommended storage conditions.","StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 81.271 39.997\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#3050f8\" stroke=\"#000\" 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class=\"atom\"\u003e\u003cpath d=\"M68.975 10.921h-.72l-2.62-4.066h-.03l.03.595q.024.357.024.732v2.739h-.566v-4.9h.715l2.607 4.054h.03l-.018-.327-.024-.476q-.006-.262-.006-.483V6.021h.578zM68.838 5.459h-.619V3.173h-2.512v2.286h-.614V.56h.614v2.072h2.512V.56h.619z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"#3050f8\" d=\"m63.881 10.291-5.023 2.9M63.881 10.291l-5.023 2.9M70.187 10.291l5.022 2.9M70.187 10.291l5.022 2.9\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Subjective Effects":{"Cognitive Effects":["Analysis enhancement","Ego inflation","Focus enhancement","Increased music appreciation","Motivation enhancement","Thought acceleration","Wakefulness","Disinhibition","Suggestibility suppression","Cognitive euphoria","Compulsive redosing","Mania"],"Physical Effects":["Increased libido","Stamina enhancement","Stimulation","Appetite suppression","Dehydration","Dry mouth","Restless legs","Shakiness","Teeth grinding","Abnormal heartbeat","Increased blood pressure","Increased heart rate","Vasoconstriction"],"Visual Effects":[]},"Taste":"Bitter-tasting","Therapeutic Uses":"Adrenergic Agents; Adrenergic Uptake Inhibitors; Appetite Depressants; Central Nervous System Stimulants; Dopamine Agents; Dopamine Uptake Inhibitors; Sympathomimetics","Title":"Dextromethamphetamine","Treatment":"Management of acute methamphetamine intoxication is largely symptomatic and includes gastric evacuation, administration of activated charcoal, and sedation. Experience with hemodialysis or peritoneal dialysis is inadequate to permit recommendations in this regard. Acidification of urine increases methamphetamine excretion, but is believed to increase risk of acute renal failure if myoglobinuria is present. Intravenous phentolamine has been suggested for possible acute, severe hypertension, if this complicates methamphetamine overdosage. Usually a gradual drop in blood pressure will result when sufficient sedation has been achieved. Chlorpromazine has been reported to be useful in decreasing CNS stimulation and sympathomimetic effects. (L1712)","UNII":"44RAL3456C","Wikidata":"Q191924","Wikipedia":"Methamphetamine","XLogP":2.1,"pH":"A saturated soln in water is alkaline to litmus"}