{"ATC Code":["N - Nervous system","N06 - Psychoanaleptics","N06B - Psychostimulants, agents used for adhd and nootropics","N06BA - Centrally acting sympathomimetics","N06BA11 - Dexmethylphenidate","QN - Nervous system","QN06 - Psychoanaleptics","QN06B - Psychostimulants, agents used for adhd and nootropics","QN06BA - Centrally acting sympathomimetics","QN06BA11 - Dexmethylphenidate"],"Abbreviation":["d-MPH"],"Absorption, Distribution and Excretion":"Taking dexmethylphenidate with or without food does not affect patients in a clinically relevant way. 90% of an oral dose is absorbed but as a result of hepatic first pass metabolism, oral bioavailability of dexmethylphenidate is 23% compared to l-methylphenidate with an oral bioavailability of 5%. Maximum concentration is generally reached in 1-1.5 hours.","Aliases":["threo-Methylphenidate","dexmetilfenidato","Attenade","TMP","dexmethylphenidatum","Chebi:51860","methyl (R)-phenyl[(R)-piperidin-2-yl]acetate","Dtxsid70893769","methyl (2R)-phenyl[(2R)-piperidin-2-yl]acetate","2-Piperidineacetic acid, α-phenyl-, methyl ester, (αR,2R)-","Methyl (2r)-phenyl((2r)-piperidin-2-yl)acetate","methyl (R)-phenyl((R)-piperidin-2-yl)acetate","methyl (2R)-2-phenyl-2-((2R)-piperidin-2-yl)acetate","Methylphenidate d-threo-","N06BA11","Dtxcid301323804","CHEMBL827","Methylphenidate d-threo-form","40572-71-2","Focalin XR","Methyl D-phenidate","Methylphenidate","Dex methylphenidate","MPH","Unii-m32rh9mfgp","threo-(+)-Methylphenidate","dex-methylphenidate","threo methylphenidate","A1D5U","Schembl34326","GTPL7554","Bdbm50062915","Pdsp1_000871","Pdsp1_000903","Pdsp2_000857","Pdsp2_000889","DB06701","FT28256","NS00121152","D07806","(2S,2'S)-(-)-threo-methyl a-phenyl-a-(2-piperidyl)acetate hydrochloride","2-Piperidineacetic acid, α-phenyl-, methyl ester, (αS,2S)-","2-Piperidineacetic acid, α-phenyl-, methyl ester, (αr,2r)-"],"Biological Half-Life":"The mean terminal half life is approximately 2.2 hours. However other studies have shown 3.8-3.9 hours, or 5.96 hours after intravenous administration and 5.69 hours following an oral dose.","CAS":"40431-64-9","ChemicalClasses":["phenidate"],"Chirality":"absolute","Classes":["Stimulant"],"DBI-IGS":["Methylphenidate"],"Dosing 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Love"},{"Author":"odonamon","Id":62163,"Title":"Midday Uplift"},{"Author":"Lilmikey1217","Id":13666,"Title":"Romance of Rap"},{"Author":"Hans-Alton","Id":67989,"Title":"Calm Study Night"},{"Author":"Sara","Id":34153,"Title":"A Waste of Time"}],"Esters":[],"FDA Pharmacological Classification":[{"Name":"FDA UNII","ReferenceNumber":16,"Value":{"StringWithMarkup":[{"String":"M32RH9MFGP"}]}},{"Name":"Active Moiety","ReferenceNumber":16,"Value":{"StringWithMarkup":[{"String":"DEXMETHYLPHENIDATE"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":16,"Value":{"StringWithMarkup":[{"String":"Established Pharmacologic Class [EPC] - Central Nervous System Stimulant"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":16,"Value":{"StringWithMarkup":[{"String":"Physiologic Effects [PE] - Central Nervous System Stimulation"}]}},{"Name":"FDA Pharmacology Summary","ReferenceNumber":16,"Value":{"StringWithMarkup":[{"Markup":[{"Extra":"CID-154101","Length":18,"Start":0,"Type":"PubChem Internal 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The physiologic effect of dexmethylphenidate is by means of Central Nervous System Stimulation."}]}}],"Formating":[],"HMDB ID":"HMDB0015647","HeavyAtomCount":17,"Human Drugs":"Breast Feeding; Lactation; Milk, Human; Adrenergic Agents; Central Nervous System Stimulants; Dopamine Agents; Sympathomimetics; Wakefulness-Promoting Agents","IUPACName":"methyl (2R)-2-phenyl-2-[(2R)-piperidin-2-yl]acetate","InChI":"InChI=1S/C14H19NO2/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3/t12-,13-/m1/s1","InChIKey":"DUGOZIWVEXMGBE-CHWSQXEVSA-N","KEGG Entries":[{"Id":"D03721","Interactions":[],"Synonyms":["Dexmethylphenidate hydrochloride","Focalin"]},{"Id":"D07806","Interactions":[],"Synonyms":["Dexmethylphenidate"]}],"MeSH Headers":[{"Id":"M000616897","Link":"https://id.nlm.nih.gov/mesh/M000616897.html","Name":"Dexmethylphenidate","Ref":37},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":38},{"Id":"M0001063","Link":"https://id.nlm.nih.gov/mesh/M0001063.html","Name":"Central Nervous System Stimulants","Ref":58},{"Id":"M0028098","Link":"https://id.nlm.nih.gov/mesh/M0028098.html","Name":"Dopamine Uptake Inhibitors","Ref":59}],"MeSH Pharmacological Classification":[{"Id":"M0001063","Link":"https://id.nlm.nih.gov/mesh/M0001063.html","Name":"Central Nervous System Stimulant","Ref":58},{"Id":"M0028098","Link":"https://id.nlm.nih.gov/mesh/M0028098.html","Name":"Dopamine Uptake Inhibitor","Ref":59}],"Mechanism of Action":"Methylphenidate inhibits dopamine and norepinephrine reuptake transporters in synapses, especially in the thalamus and striatum. One study shows no detectable difference in the caudal prefrontal cortex of treated or untreated monkeys, though multiple rat studies show activity on the prefrontal cortex. Imaging of human brains after administration of methylphenidate shows changes to blood flow of various regions of the brain including the striatum, supplementary motor area, and posterior parietal cortex.","Melting Point":"\u003e203","Metabolism/Metabolites":"Dexmethylphenidate is metabolised to the inactive metabolite ritalinic acid by carboxylesterase 1A1 in the liver. Other minor pathways metabolise dexmethylphenidate to the inactive metabolites 6-oxo-methylphenidate and p-hydroxy-methylphenidate which are de-esterified and conjugated into other unknown metabolites.","MolecularFormula":"C\u003csub\u003e14\u003c/sub\u003eH\u003csub\u003e19\u003c/sub\u003eNO\u003csub\u003e2\u003c/sub\u003e","MolecularWeight":"233.31 g/mol","Opticalactivity":"UNSPECIFIED","Pharmacodynamics":"Dexmethylphenidate is the d-enantiomer of methylphenidate. 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PubChem Compound Summary for CID 154101, Dexmethylphenidate. Accessed May 8, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/154101\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/154101\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Dexmethylphenidate. UNII: M32RH9MFGP. Global Substance Registration System. 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class=\"atom\"\u003e\u003cpath d=\"M68.985 41.464h-.721l-2.619-4.066h-.03l.03.595q.024.358.024.733v2.738h-.566v-4.899h.715l2.607 4.054h.03l-.018-.328-.024-.476q-.006-.262-.006-.482v-2.768h.578zM68.848 36.003h-.619v-2.286h-2.513v2.286h-.613v-4.899h.613v2.071h2.513v-2.071h.619z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m27.445 12.229.001-5.66M30.72 18.042l4.96 2.865\" class=\"hi\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m70.197 40.834 5.028 2.9M70.197 40.834l5.028 2.9\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Subjective Effects":{"Cognitive Effects":["Analysis enhancement","Ego inflation","Focus enhancement","Increased music appreciation","Motivation enhancement","Thought acceleration","Wakefulness","Disinhibition","Suggestibility suppression","Cognitive euphoria","Compulsive redosing","Mania"],"Physical Effects":["Increased libido","Stamina enhancement","Stimulation","Appetite suppression","Dehydration","Dry mouth","Restless legs","Shakiness","Teeth grinding","Abnormal heartbeat","Increased blood pressure","Increased heart rate","Vasoconstriction"],"Visual Effects":[]},"Title":"Dexmethylphenidate","Toxicity Data":"Oral, Mouse: LD\u003csub\u003e50\u003c/sub\u003e=190mg/kg","UNII":"M32RH9MFGP","Wikidata":"Q1207210","Wikipedia":"Dexmethylphenidate","XLogP":0.2}