{"Aliases":["Dihydrodeoxymorphine","Permonid","Deoxydihydromorphine D","Dihydrodesoxymorphine D","Desomorfina","Krokodil","Dihydrodesoxymorphine-D","Desomorphinum","4,5-Epoxy-3-hydroxy-N-methylmorphinan","6-Deoxy-7,8-dihydromorphine","Morphine, 6-deoxy-7,8-dihydro-","IDS-ND-002","Ids-nd-002(sect.3)","Dtxcid20117881","Morphinan-3-ol, 4,5-epoxy-17-methyl-, (5α)-","(1S,5R,13S,17R)-4-methyl-12-oxa-4-azapentacyclo(9.6.1.01,13.0?,1?.0?,1?)octadeca-7,9,11(18)-trien-10-ol","207-045-7","Desomorfin","Chembl3228684","Einecs 207-045-7","DEA No. 9055","HSDB 8070","Morphinan-3-ol, 4,5-α-epoxy-17-methyl-","Schembl24969","Chembl2106274","Chebi:135119","Dihydrodeoxymorphine or 4,5-Epoxy-3-hydroxy-N-methylmorphinan","Bdbm50496883","Desomorphine, 1mg/ml in Acetonitrile","DB01531","17-Methyl-5α-4,5-epoxymorphinan-3-ol","NS00015682","D12670","Desomorphine (Dihydrodesoxymorphine; Krokodil) 1.0 mg/ml in Acetonitrile"],"Boiling Point":"Sublimes in high vacuum between 140 and 170 °C","CAS":"427-00-9","ChemicalClasses":["amphetamine","2-benzylpiperidine"],"Chirality":"absolute","Classes":["Opioid"],"Color/Form":"Rectangular plates from acetone-water","DTXSID":"10195390","Decomposition":"When heated to decomposition it emits toxic fumes of /oxides of nitrogen/.","Drug Warnings":"/Withdrawal symptoms were studied/ in 6 cases /and/ the drug being used, whether desomorphine or morphine, was withheld for 6-12 hours at about 10-day intervals throughout the course of the study. During these brief withdrawals observations for specific abstinence symptoms were made. Such signs of abstinence began to appear 10 days after the beginning of desomorphine administration. After the third week definite evidence of abstinence was seen if desomorphine was withheld for only 4 hours. No signs of addiction were observed during the short periods of withdrawal in the three patients receiving morphine. It must be remembered, however, that the dose of desomorphine had been increased more rapidly than that of morphine, and also that signs of abstinence from morphine are not ordinarily very apparent within the first 12 hours of withdrawal because of the longer duration of action of this drug.","Druglikeness":{"Lipinski":{"Passes":true,"Violations":0}},"DurationOfAction":"","EliminationHalfLife":"","Erowid Experience Reports":[],"Esters":[],"European Community (EC) Number":"207-045-7","Formating":[],"HeavyAtomCount":20,"IUPACName":"(4R,4aR,7aS,12bS)-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-9-ol","InChI":"InChI=1S/C17H21NO2/c1-18-8-7-17-11-3-2-4-14(17)20-16-13(19)6-5-10(15(16)17)9-12(11)18/h5-6,11-12,14,19H,2-4,7-9H2,1H3/t11-,12+,14-,17+/m0/s1","InChIKey":"LNNWVNGFPYWNQE-GMIGKAJZSA-N","MeSH Headers":[{"Id":"M000607853","Link":"https://id.nlm.nih.gov/mesh/M000607853.html","Name":"desomorphine","Ref":28},{"Id":"M000636844","Link":"https://id.nlm.nih.gov/mesh/M000636844.html","Name":"krokodil","Ref":30},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":31},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":44},{"Id":"M0001068","Link":"https://id.nlm.nih.gov/mesh/M0001068.html","Name":"Analgesics, Opioid","Ref":45}],"MeSH Pharmacological Classification":[{"Id":"M0001068","Link":"https://id.nlm.nih.gov/mesh/M0001068.html","Name":"Analgesics, Opioid","Ref":45}],"Mechanism of Action":"Morphine, codeine, dilaudid, and desomorphine inhibit the activity of cholinesterase from the following sources: human, dog or rabbit serum, and human or rabbit brain. The degree of inhibition varies with the source of the enzyme, which might account for the selective action of these drugs on physiological systems. The inhibition is in part competitive and in part non-competitive, judging by the relative reaction velocity at different substrate concentrations. The affinity of the alkaloids for the enzyme in human serum is as great (dilaudid) or greater (codeine, morphine and desomorphine) than the affinity of the enzyme for acetylcholine.","MolecularFormula":"C\u003csub\u003e17\u003c/sub\u003eH\u003csub\u003e21\u003c/sub\u003eNO\u003csub\u003e2\u003c/sub\u003e","MolecularWeight":"271.35 g/mol","Non-Human Toxicity Values":"LD50 Mouse intravenous 27 mg/kg","Opticalactivity":"UNSPECIFIED","Passes":true,"PubChemId":5362456,"PubChemTitle":"Desomorphine","Records":{"UNII":{"Impurities":[]}},"RefChem":"132272","RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Desomorphine","Name":"Desomorphine","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q422163","Name":"Desomorphine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB01531","Name":"Desomorphine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/5362456","Name":"Desomorphine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=427-00-9","Name":"Desomorphine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D12670","Name":"Desomorphine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/7OP86J5E33","Name":"Desomorphine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID10195390","Name":"Desomorphine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 5362456, Desomorphine. Accessed June 14, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/5362456\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/5362456\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Desomorphine. UNII: 7OP86J5E33. Global Substance Registration System. Accessed June 14, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/7OP86J5E33\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/7OP86J5E33\u003c/a\u003e"],"SMILES":"CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3CCC4","SaltData":[{"AcidCount":1,"Amine":"Desomorphine","AmineCount":1,"Formula":"Br","Name":"hydrobromide","RName":"hydrobromide","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 111.13 70.654\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".8\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h112v71H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m27.049.972.331 11.133\" class=\"bond\"/\u003e\u003cpath stroke=\"none\" d=\"M40.69 24.217a.4.4 0 0 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substance"},{"gov":"Canada","ref":[],"schedule":"Schedule I substance"},{"gov":"United Kingdom","ref":[],"schedule":"Class A substance"},{"act":"Controlled Substances Act (CSA)","gov":"United States","ref":[],"schedule":"Schedule I"},{"gov":"Germany","ref":[],"schedule":"Anlage I substance"}],"Slang":["Krokodil ","Crocodile "],"Solubility":"Soluble in acetone, ethyl acetate","StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 86.395 70.654\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".8\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h87v71H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m27.049.972.331 11.133\" class=\"bond\"/\u003e\u003cpath 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