{"Aliases":["(1R,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine","(1R,4S)-trans-Norsertraline","Norsertraline, (1R,4S)-trans-","Dasotralina","SEP-225289","Dtxsid20217855","Sep-225,289","1-Naphthalenamine, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-, (1r,4s)-","dasotralinum","Dtxcid70140346","C16H15Cl2N","Unii-4d28ey0l5t","Sertraline Impurity 37","Schembl263142","Dasotraline; SEP 225289","GTPL8308","Chembl3301595","Schembl29690290","EX-A2622","DB12305","Dasotraline(SEP-225289) free base?","AC-36184","DA-72569","HY-12850","CS-0012724","NS00069019","D10700","T60607","(1R,4S)-4-(3,4-dichlorophenyl)tetralin-1-amine"],"CAS":"675126-05-3","ChemicalClasses":["benzylamine"],"Chirality":"absolute","Classes":["Serotonin reuptake inhibitor"],"EliminationHalfLife":"47 – 77 hours","Erowid Experience Reports":[],"Esters":[],"Formating":[],"HeavyAtomCount":19,"IUPACName":"(1R,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine","InChI":"InChI=1S/C16H15Cl2N/c17-14-7-5-10(9-15(14)18)11-6-8-16(19)13-4-2-1-3-12(11)13/h1-5,7,9,11,16H,6,8,19H2/t11-,16+/m0/s1","InChIKey":"SRPXSILJHWNFMK-MEDUHNTESA-N","KEGG Entries":[{"Id":"D10700","Interactions":[],"Synonyms":["Dasotraline"]},{"Id":"D10870","Interactions":[],"Synonyms":["Dasotraline hydrochloride"]}],"MeSH Headers":[],"Mechanism of Action":"Dasotraline has been shown in preclinical studies to be a potent and balanced reuptake inhibitor of serotonin, norepinephrine and dopamine (SNDRI). Serotonin, norepinephrine and dopamine are neurotransmitters associated with depression. There are currently no marketed treatments for depression that inhibit reuptake of all three neurotransmitters.","MolecularFormula":"C\u003csub\u003e16\u003c/sub\u003eH\u003csub\u003e15\u003c/sub\u003eCl\u003csub\u003e2\u003c/sub\u003eN","MolecularWeight":"292.2 g/mol","Opticalactivity":"UNSPECIFIED","PubChemId":9947999,"Records":{"UNII":{"Impurities":[]}},"RefChem":"585202","RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Dasotraline","Name":"Dasotraline","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q27076989","Name":"Dasotraline","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB12305","Name":"Dasotraline","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/9947999","Name":"Dasotraline","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=675126-05-3","Name":"Dasotraline","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D10700","Name":"Dasotraline","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/4D28EY0L5T","Name":"Dasotraline","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID20217855","Name":"Dasotraline","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 9947999, Dasotraline. Accessed May 9, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/9947999\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/9947999\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Dasotraline. UNII: 4D28EY0L5T. Global Substance Registration System. Accessed May 9, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/4D28EY0L5T\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/4D28EY0L5T\u003c/a\u003e"],"SMILES":"C1C[C@H](C2=CC=CC=C2[C@@H]1C3=CC(=C(C=C3)Cl)Cl)N","SaltData":[{"AcidCount":1,"Amine":"Dasotraline","AmineCount":1,"Formula":"Cl","Name":"hydrochloride","RName":"hydrochloride","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 93.803 112.785\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#1ff01f\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h94v113H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m53.841 41.105-.005-15.239M53.836 25.866 40.637 18.25M40.637 18.25 27.44 25.87\" 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Effects":null,"Title":"Dasotraline","UNII":"4D28EY0L5T","Wikidata":"Q27076989","Wikipedia":"Dasotraline","XLogP":4.3}