{"Adverse Effects":"As an anticoagulant, the main risk of LMWH is bleeding. Less common adverse effects include heparin-induced thrombocytopenia, osteoporosis, spontaneous fractures, hypoaldosteronism, and hypersensitivity reactions. In assessing the need for anticoagulant medication, clinicians must consider the risks posed by bleeding versus the risks of clotting.","Aliases":["2-O-Sulfohexopyranuronosyl-(1-\u003e4)-2-deoxy-3-O-sulfo-2-(sulfoamino)hexopyranosyl-(1-\u003e4)-2-O-sulfohexopyranuronosyl-(1-\u003e4)-2-acetamido-2-deoxy-6-O-sulfohexopyranose","2-o-sulfohexopyranuronosyl-(1-\u003e4)-2-deoxy-3-o-sulfo-2-(sulfoamino)hexopyranosyl-(1-\u003e4)-2-o-sulfohexopyranuronosyl-(1-\u003e4)-2-acetamido-2-deoxy-6-o-sulfohexopyranose","GlyTouCan:G90061MS","Dtxcid50820351","G90061MS","Clexane","Parvoparin","α-Heparin","LMWH","Sandoparin","Pabyrin","Subeparin","Triofiban","Fragmin A","Fragmin B","Vitrum AB","Eparina","Heparin","Adomiparin","Heparin CY 216","PK-10169","Heparine","Heparinum","Heparina","Semuloparin","Schembl543122","GTPL6811","M 118REH","orb1705503","Cy 222","HSDB 3094","AVE-5026","Einecs 232-681-7","FR 860","KB 101","OP 386","OP 622","Akos032944890","NS00003059","Q416516","Brd-a83644949-236-01-6","6-[6-[6-[5-acetamido-4,6-dihydroxy-2-(sulfooxymethyl)tetrahydropyran-3-yl]oxy-2-carboxy-4-hydroxy-5-sulfooxy-tetrahydropyran-3-yl]oxy-2-(hydroxymethyl)-5-(sulfoamino)-4-sulfooxy-tetrahydropyran-3-yl]oxy-3,4-dihydroxy-5-sulfooxy-tetrahydropyran-2-carboxylic acid"],"CAS":"9005-49-6","ChemicalClasses":[],"Classes":["Anticoagulant"],"DTXSID":"80872762","Drug Indication":"Low-molecular-weight heparins (LMWHs), such as dalteparin, enoxaparin, and tinzaparin, are anticoagulants. Tinzaparin has not been available in the United States since the voluntary recall. These drugs are administered as prophylaxis of venous thromboembolic disease (VTE) on acute or elective admission to the hospital, and they are used in the treatment of deep vein thromboses (DVT) and pulmonary embolism (PE).","EliminationHalfLife":"3 – 5 hours subcutaneous; 2.1 – 2.3 hours IV","Esters":[],"Formating":[],"HMDB ID":"HMDB0014551","HeavyAtomCount":70,"IUPACName":"6-[6-[6-[5-acetamido-4,6-dihydroxy-2-(sulfooxymethyl)oxan-3-yl]oxy-2-carboxy-4-hydroxy-5-sulfooxyoxan-3-yl]oxy-2-(hydroxymethyl)-5-(sulfoamino)-4-sulfooxyoxan-3-yl]oxy-3,4-dihydroxy-5-sulfooxyoxane-2-carboxylic acid","InChI":"InChI=1S/C26H42N2O37S5/c1-4(30)27-7-9(31)13(6(56-23(7)39)3-55-67(43,44)45)58-26-19(65-70(52,53)54)12(34)16(20(62-26)22(37)38)60-24-8(28-66(40,41)42)15(63-68(46,47)48)14(5(2-29)57-24)59-25-18(64-69(49,50)51)11(33)10(32)17(61-25)21(35)36/h5-20,23-26,28-29,31-34,39H,2-3H2,1H3,(H,27,30)(H,35,36)(H,37,38)(H,40,41,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54)","InChIKey":"HTTJABKRGRZYRN-UHFFFAOYSA-N","MeSH Headers":[],"Medical Side Effects":{"ATC Codes":["B01AB04","B01AB06","B01AB07","B01AB08","B01AB10","B01AB12"],"Canonical Name":"Dalteparin","Confidence Score":95,"Drug Name":"Dalteparin","Indications":[{"name":"Angina unstable","umls_cui":"C0002965"},{"name":"Angiopathy","umls_cui":"C0042373"},{"name":"Atrial fibrillation","umls_cui":"C0004238"},{"name":"Chronic renal insufficiency","umls_cui":"C0403447"},{"name":"Clotting","umls_cui":"C0005778"},{"name":"Coagulopathy","umls_cui":"C0005779"},{"name":"Coronary artery disease","umls_cui":"C1956346"},{"name":"Deep vein thrombosis","umls_cui":"C0149871"},{"name":"Deep vein thrombosis postoperative","umls_cui":"C0589110"},{"name":"Disseminated intravascular coagulation","umls_cui":"C0012739"},{"name":"Electrocardiogram ST segment elevation","umls_cui":"C0520886"},{"name":"Embolism arterial","umls_cui":"C0549124"},{"name":"Function kidney decreased","umls_cui":"C0232807"},{"name":"Haematoma","umls_cui":"C0018944"},{"name":"Haemorrhage","umls_cui":"C0019080"},{"name":"Major bleed","umls_cui":"C3160769"},{"name":"Myocardial infarction","umls_cui":"C0027051"},{"name":"Neoplasm malignant","umls_cui":"C0006826"},{"name":"Pulmonary embolism","umls_cui":"C0034065"},{"name":"Renal failure acute","umls_cui":"C0022660"},{"name":"Solid tumour","umls_cui":"C0280100"},{"name":"Thromboembolism","umls_cui":"C0040038"},{"name":"Thrombophlebitis","umls_cui":"C0040046"},{"name":"Trauma","umls_cui":"C0043251"},{"name":"Venous thromboembolism","umls_cui":"C1861172"},{"name":"Venous thrombosis","umls_cui":"C0042487"}],"Resolved Alias":"Dalteparin","Side Effects":[{"name":"Angiopathy","umls_cui":"C0042373"},{"name":"Hepatobiliary disease","umls_cui":"C0267792"},{"name":"Urinary tract infection","umls_cui":"C0042029"},{"name":"Pulmonary embolism","umls_cui":"C0034065"},{"name":"Chest pain","umls_cui":"C0008031"},{"name":"Haemorrhage","umls_cui":"C0019080"},{"name":"Hemorrhage symptom","umls_cui":"C0858540"},{"name":"Haemoglobin","umls_cui":"C0518015"},{"name":"Nausea","umls_cui":"C0027497"},{"name":"Body temperature increased","umls_cui":"C0015967"},{"name":"Reaction febrile","umls_cui":"C0235723"},{"name":"Headache","umls_cui":"C0018681"},{"name":"Epistaxis","umls_cui":"C0014591"},{"name":"Constipation","umls_cui":"C0009806"},{"name":"Pain","umls_cui":"C0030193"},{"name":"Dyspnoea","umls_cui":"C0013404"},{"name":"Dermatitis","umls_cui":"C0011603"},{"name":"Rash","umls_cui":"C0015230"},{"name":"Eruption","umls_cui":"C0302295"},{"name":"Vomiting","umls_cui":"C0042963"},{"name":"Haematuria","umls_cui":"C0018965"},{"name":"Back pain","umls_cui":"C0004604"},{"name":"Abdominal pain","umls_cui":"C0000737"},{"name":"Gastrointestinal pain","umls_cui":"C0687713"},{"name":"Diarrhoea","umls_cui":"C0011991"},{"name":"Anaemia","umls_cui":"C0002871"},{"name":"Connective tissue disorder","umls_cui":"C0009782"},{"name":"Endocrine disorder","umls_cui":"C0014130"},{"name":"Skin disorder","umls_cui":"C0037274"},{"name":"Wound haematoma","umls_cui":"C0281860"},{"name":"Alopecia","umls_cui":"C0002170"},{"name":"Haematoma","umls_cui":"C0018944"},{"name":"Skin necrosis","umls_cui":"C0151799"},{"name":"Skin exfoliation","umls_cui":"C0237849"},{"name":"Paralysis","umls_cui":"C0522224"},{"name":"Spinal haematoma","umls_cui":"C0856150"},{"name":"Congenital anomaly","umls_cui":"C0000768"},{"name":"Developmental delay","umls_cui":"C0424605"},{"name":"Abscess","umls_cui":"C0000833"},{"name":"Agranulocytosis","umls_cui":"C0001824"},{"name":"Anaphylactic shock","umls_cui":"C0002792"},{"name":"Anaphylactoid reaction","umls_cui":"C0340865"},{"name":"Angina pectoris","umls_cui":"C0002962"},{"name":"Angioedema","umls_cui":"C0002994"},{"name":"Arrhythmia","umls_cui":"C0003811"},{"name":"Asthenia","umls_cui":"C0004093"},{"name":"Asthma","umls_cui":"C0004096"},{"name":"Mental disorder","umls_cui":"C0004936"},{"name":"Calcinosis","umls_cui":"C0006663"},{"name":"Cardiovascular disorder","umls_cui":"C0007222"},{"name":"Cellulitis","umls_cui":"C0007642"},{"name":"Coma","umls_cui":"C0009421"},{"name":"Infection","umls_cui":"C0009450"},{"name":"Confusional state","umls_cui":"C0009676"},{"name":"Feeling abnormal","umls_cui":"C1443060"},{"name":"Coronary artery thrombosis","umls_cui":"C0010072"},{"name":"Cyanosis","umls_cui":"C0010520"},{"name":"Dizziness","umls_cui":"C0012833"},{"name":"Dyspepsia","umls_cui":"C0013395"},{"name":"Dysuria","umls_cui":"C0013428"},{"name":"Ecchymosis","umls_cui":"C0013491"},{"name":"Eosinophilia","umls_cui":"C0014457"},{"name":"Hypereosinophilia","umls_cui":"C0745091"},{"name":"Eye haemorrhage","umls_cui":"C0015402"},{"name":"Foetal death","umls_cui":"C0015927"},{"name":"Foetal distress syndrome","umls_cui":"C0015930"},{"name":"Flatulence","umls_cui":"C0016204"},{"name":"Gangrene","umls_cui":"C0017086"},{"name":"Gastrointestinal disorder","umls_cui":"C0017178"},{"name":"Gastrointestinal haemorrhage","umls_cui":"C0017181"},{"name":"Cardiac disorder","umls_cui":"C0018799"},{"name":"Haemarthrosis","umls_cui":"C0018924"},{"name":"Haematemesis","umls_cui":"C0018926"},{"name":"Subdural haematoma","umls_cui":"C0018946"},{"name":"Pericardial haemorrhage","umls_cui":"C0019064"},{"name":"Haemoptysis","umls_cui":"C0019079"},{"name":"Hyperkalaemia","umls_cui":"C0020461"},{"name":"Hyperlipidaemia","umls_cui":"C0020473"},{"name":"Hypersensitivity","umls_cui":"C0020517"},{"name":"Systemic allergic reaction","umls_cui":"C1736167"},{"name":"Hypertension","umls_cui":"C0020538"},{"name":"Hypoaldosteronism","umls_cui":"C0020595"},{"name":"Hyponatraemia","umls_cui":"C0020625"},{"name":"Hypotension","umls_cui":"C0020649"},{"name":"Immune system disorder","umls_cui":"C0021053"},{"name":"Renal failure chronic","umls_cui":"C0022661"},{"name":"Melaena","umls_cui":"C0025222"},{"name":"Necrosis","umls_cui":"C0027540"},{"name":"Neoplasm","umls_cui":"C0027651"},{"name":"Nervous system disorder","umls_cui":"C0027765"},{"name":"Neurological 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accident","umls_cui":"C0038454"},{"name":"Subarachnoid haemorrhage","umls_cui":"C0038525"},{"name":"Swelling","umls_cui":"C0038999"},{"name":"Tachycardia","umls_cui":"C0039231"},{"name":"Thrombocytopenia","umls_cui":"C0040034"},{"name":"Thrombosis","umls_cui":"C0040053"},{"name":"Ulcer","umls_cui":"C0041582"},{"name":"Erythema","umls_cui":"C0041834"},{"name":"Urethral disorder","umls_cui":"C0041969"},{"name":"Urinary tract disorder","umls_cui":"C0042075"},{"name":"Urticaria","umls_cui":"C0042109"},{"name":"Wound","umls_cui":"C0043250"},{"name":"Procedural haemorrhage","umls_cui":"C3203457"},{"name":"Urinary retention","umls_cui":"C0080274"},{"name":"Chills","umls_cui":"C0085593"},{"name":"Hepatitis cholestatic","umls_cui":"C0149904"},{"name":"Adrenocortical insufficiency acute","umls_cui":"C0151467"},{"name":"Coagulation time prolonged","umls_cui":"C0151563"},{"name":"Toxic epidermal necrolysis","umls_cui":"C0014518"},{"name":"Impaired healing","umls_cui":"C0151692"},{"name":"Adrenal haemorrhage","umls_cui":"C0151693"},{"name":"Injection site haemorrhage","umls_cui":"C0151698"},{"name":"Haemorrhage intracranial","umls_cui":"C0151699"},{"name":"Retroperitoneal haemorrhage","umls_cui":"C0151705"},{"name":"Injection site reaction","umls_cui":"C0151735"},{"name":"Hepatocellular injury","umls_cui":"C0151763"},{"name":"Liver injury","umls_cui":"C0160390"},{"name":"Injection site pain","umls_cui":"C0151828"},{"name":"Aspartate aminotransferase increased","umls_cui":"C0151904"},{"name":"Alanine aminotransferase increased","umls_cui":"C0151905"},{"name":"Malaise","umls_cui":"C0231218"},{"name":"Rash erythematous","umls_cui":"C0234913"},{"name":"Gravitational oedema","umls_cui":"C0235437"},{"name":"Peripheral ischaemia","umls_cui":"C0235490"},{"name":"Haemorrhage urinary tract","umls_cui":"C0235620"},{"name":"Dermatitis bullous","umls_cui":"C0085932"},{"name":"Intra-abdominal haemorrhage","umls_cui":"C0236178"},{"name":"Epidural 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infarction","umls_cui":"C0027051"},{"name":"Spinal epidural haematoma","umls_cui":"C0877172"},{"name":"Insomnia","umls_cui":"C0917801"},{"name":"Death","umls_cui":"C1306577"},{"name":"Hypotonia neonatal","umls_cui":"C2267233"},{"name":"Vaginal haemorrhage","umls_cui":"C2979982"}],"Source":"SIDER","URL":"http://sideeffects.embl.de/drugs/9812414/pt"},"MolecularFormula":"C\u003csub\u003e26\u003c/sub\u003eH\u003csub\u003e42\u003c/sub\u003eN\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e37\u003c/sub\u003eS\u003csub\u003e5\u003c/sub\u003e","MolecularWeight":"1134.9 g/mol","Physical Description":"Solid","PubChemId":772,"PubChemTitle":"2-O-Sulfohexopyranuronosyl-(1-\u003e4)-2-deoxy-3-O-sulfo-2-(sulfoamino)hexopyranosyl-(1-\u003e4)-2-O-sulfohexopyranuronosyl-(1-\u003e4)-2-acetamido-2-deoxy-6-O-sulfohexopyranose","RefChem":"935558","RefCount":2,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Dalteparin sodium","Name":"Dalteparin","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q105969973","Name":"Dalteparin","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/772","Name":"Dalteparin","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=9005-49-6","Name":"Dalteparin","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0014551","Name":"Dalteparin","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID80872762","Name":"Dalteparin","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 772, Dalteparin. 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