{"Abbreviation":[],"Aliases":["Cyclohexanamine","Aminocyclohexane","Hexahydroaniline","Hexahydrobenzenamine","Aminohexahydrobenzene","1-Cyclohexylamine","1-Aminocyclohexane","Aniline, hexahydro-","Benzenamine, hexahydro-","203-629-0","Cyclohexyl amine","cyclohexyl-amine","1-Amino-cyclohexane","cyclohexaneamine","157973-60-9","Cyclohexylamine.HCl","Aminocylcohexane","cyclohexane, amino-","Cyclohexylamine [UN2357] ","CCRIS 3645","Cas-108-91-8","HAI","UN2357","cylohexylamine","cyclohexylarnine"],"Biological Half-Life":"Cyclohexylamine showed dose dependent kinetics after administration of single oral doses of 35, 200 or 500 mg/kg in mice, with a reduction in plasma clearance from 61 to 53 ml/min/kg, an increase in apparent half-life from 1.4 to 3.5 hr, and an increased area under the testicular concentration vs time curve. During chronic dietary administration the concentrations of cyclohexylamine in the plasma and testes showed little diurna variation. The steady state plasma clearance was 65 ml/min/kg. The concentrations of cyclohexylamine in the plasma and testes of the mice showed a linear relationship to dietary intake, even at the highest intake, about 900 mg/kg/day.","Boiling Point":"274.1 °","CAS":"108-91-8","ChEBI":"CHEBI:15773","ChEMBL":"CHEMBL1794762","ChemicalClasses":["cyclohexylamine"],"Chirality":"achiral","Classes":["Trace amine-associated receptor 1 agonist"],"Color/Form":"Colorless or yellow liquid.","Decomposition":"When heated to decomposition it emits toxic fumes of NOx /nitrogen oxides/.","Density":"0.8647 at 77 °F (EPA, 1998) - Less dense than water; will float g/cm\u003csup\u003e3\u003c/sup\u003e","EINECS":"203-629-0","Erowid Experience Reports":[],"Esters":[],"European Community (EC) Number":"203-629-0","Flash Point":"88 °F (EPA, 1998)","Formating":[],"HMDB ID":"HMDB0031404","HeavyAtomCount":7,"IUPACName":"cyclohexanamine","InChI":"InChI=1S/C6H13N/c7-6-4-2-1-3-5-6/h6H,1-5,7H2","InChIKey":"PAFZNILMFXTMIY-UHFFFAOYSA-N","Melting Point":"0.1 °","MolecularFormula":"C\u003csub\u003e6\u003c/sub\u003eH\u003csub\u003e13\u003c/sub\u003eN","MolecularWeight":"99.17 g/mol","Odor":"Strong, fishy, amine odor.","Physical Description":"Cyclohexylamine appears as a clear colorless to yellow liquid with an odor of ammonia. Flash point 90 °F. Irritates the eyes and respiratory system. Skin contact may cause burns. Less dense than water. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion.","PubChemId":7965,"RefCount":2,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Cyclohexylamine","Name":"Cyclohexylamine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/7965","Name":"Cyclohexylamine","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1794762","Name":"Cyclohexylamine","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:15773","Name":"Cyclohexylamine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=108-91-8","Name":"Cyclohexylamine","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0031404","Name":"Cyclohexylamine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C00571","Name":"Cyclohexylamine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/I6GH4W7AEG","Name":"Cyclohexylamine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID1023996","Name":"Cyclohexylamine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 7965, Cyclohexylamine. Accessed July 27, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/7965\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/7965\u003c/a\u003e"],"Reported Fatal Dose":"4. 4= VERY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 50-500 MG/KG; BETWEEN 1 TEASPOON \u0026 1 OZ FOR 70 KG PERSON (150 LB).","SMILES":"C1CCC(CC1)N","SaltData":[],"Salts":[],"Solubility":"Very soluble (NTP, 1992)","StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 49.927 34.519\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#3050f8\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h50v35H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m1.043 25.857 13.196 7.624M14.239 33.481l13.191-7.616M27.43 25.865l-.005-15.24M27.425 10.625 14.229 3.001M14.229 3.001 1.038 10.617M1.043 25.857l-.005-15.24M27.425 10.625 37.462 4.83\" class=\"bond\"/\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M42.556 5.459h-.72l-2.619-4.066h-.03l.03.596q.024.357.024.732v2.738h-.566V.56h.714l2.608 4.054h.03l-.018-.327-.024-.477q-.006-.262-.006-.482V.56h.577zM46.863 5.459h-.619V3.173h-2.513v2.286h-.613V.56h.613v2.072h2.513V.56h.619zM49.367 6.949h-1.943v-.3l.772-.779q.221-.221.371-.393.154-.175.233-.339.078-.168.078-.364 0-.243-.146-.368-.143-.129-.372-.129-.214 0-.378.075-.161.075-.329.207l-.193-.243q.172-.146.393-.246.225-.1.507-.1.411 0 .65.207t.24.575q0 .229-.097.432-.093.2-.264.397-.168.196-.393.418l-.614.603v.018h1.485z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"#3050f8\" d=\"m37.462 4.83-5.018 2.898\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Subjective Effects":null,"Title":"Cyclohexylamine","UNII":"I6GH4W7AEG","Wikipedia":"Cyclohexylamine","XLogP":1.5,"pH":"STRONG BASE"}