{"Abbreviation":[],"Aliases":["Creatin","Kreatin","N-amidinosarcosine","Krebiozon","N-methyl-N-guanylglycine","Glycine, N-(aminoiminomethyl)-N-methyl-","methylglycocyamine","(α-Methylguanido)acetic acid","Pyrolysate","2-(1-methylcarbamimidamido)acetic acid","Cosmocair C 100","N-carbamimidoyl-N-methylglycine","Kreatinum","Neotine","α-Methylguanidino acetic acid","N-(aminoiminomethyl)-N-methylglycine","(N-methylcarbamimidamido)acetic acid","((amino(imino)methyl)(methyl)amino)acetic acid","N-[(e)-amino(imino)methyl]-n-methylglycine","2-(carbamimidoyl(methyl)amino)acetic acid","[[Amino(imino)methyl](methyl)amino]acetic acid","N-((e)-amino(imino)methyl)-n-methylglycine","200-306-6","2-(1-Methylguanidino)acetic acid","Creatine, anhydrous"],"Biological Half-Life":"3 hours","CAS":"57-00-1","ChEBI":"CHEBI:16919","ChEMBL":"CHEMBL283800","ChemicalClasses":["carboxylic acid"],"Chirality":"achiral","Density":"1.33 at 25 °C g/cm\u003csup\u003e3\u003c/sup\u003e","Drug Classes":"Breast Feeding; Lactation; Milk, Human; Amino Acids; Complementary Therapies","Drug Indication":"For nutritional supplementation, also for treating dietary shortage or imbalance.","Drug Warnings":"Phosphocreatine inhibits enzymes in the glycolitic pathway, including glyceraldehydes-3-phosphate dehydrogenase, phosphofructokinase and pyruvate kinase.","EINECS":"200-306-6","Erowid Experience Reports":null,"Esters":[],"European Community (EC) Number":"200-306-6","Formating":[],"HMDB ID":"HMDB0000064","HeavyAtomCount":9,"Human Drugs":"Breast Feeding; Lactation; Milk, Human; Amino Acids; Complementary Therapies","IUPACName":"2-[carbamimidoyl(methyl)amino]acetic acid","Impurities":["dihydrotriazine"],"InChI":"InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9)","InChIKey":"CVSVTCORWBXHQV-UHFFFAOYSA-N","Melting Point":"Decomposes at 303 °C","MolecularFormula":"C\u003csub\u003e4\u003c/sub\u003eH\u003csub\u003e9\u003c/sub\u003eN\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e2\u003c/sub\u003e","MolecularWeight":"131.13 g/mol","Pharmacodynamics":"Creatine is a essential, non-proteinaceous amino acid derivative found in all animals. It is synthesized in the kidney, liver, and pancreas from L-arginine, glycine and L-methionine. Following its biosynthesis, creatine is transported to the skeletal muscle, heart, brain and other tissues. Most of the creatine is metabolized in these tissues to phosphocreatine (creatine phosphate). Phosphocreatine is a major energy storage form in the body. Supplemental creatine may have an energy-generating action during anaerobic exercise and may also have neuroprotective and cardioprotective actions.","Physical Description":"Solid; [Merck Index] White powder; [Alfa Aesar MSDS]","PubChemId":586,"RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Creatine","Name":"Creatine","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q106345487","Name":"Creatine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB00148","Name":"Creatine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/586","Name":"Creatine","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL283800","Name":"Creatine","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:16919","Name":"Creatine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=57-00-1","Name":"Creatine","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0000064","Name":"Creatine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C00300","Name":"Creatine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/MU72812GK0","Name":"Creatine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID1040451","Name":"Creatine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 586, Creatine. Accessed August 19, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/586\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/586\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Creatine. UNII: MU72812GK0. Global Substance Registration System. Accessed August 19, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/MU72812GK0\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/MU72812GK0\u003c/a\u003e"],"SMILES":"CN(CC(=O)O)C(=N)N","SaltData":[{"AcidCount":1,"Amine":"Creatine","AmineCount":1,"Formula":"O","Name":"monohydrate","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 91.555 68.54\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h92v69H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m20.324 48.801 10.045-5.799M33.522 37.331v-11.39M33.522 25.941l-13.198-7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M19.104 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