{"Abbreviation":"","Aliases":["Dursban","Chlorpyriphos","Lorsban","Trichlorpyrphos","Coroban","Brodan","Chlorpyrifos-ethyl","Equity","Lentrek","Pyrinex"],"Biological Half-Life":"A dose of 50 mg/kg bw [(36)Cl] chlorpyrifos given orally to male Wistar rats by intubation ...The concentrations of residue were highest in liver and kidney 4 hr after dosing, but the half-life in these tissues was \u003c 20 hr. The longest half-time, 62 hr, was recorded in fat.","Boiling Point":"320 °","CAS":"2921-88-2","ChEBI":"CHEBI:34631","ChEMBL":"CHEMBL463210","ChemicalClasses":[],"Chirality":"achiral","Classes":["Neurotoxin"],"Color/Form":"White granular crystals","Decomposition":"Decomposition temperature: approx 160 °C","Density":"1.4 (Liquid at 110 °F) (NIOSH, 2024) - Denser than water; will sink g/cm\u003csup\u003e3\u003c/sup\u003e","Dosing Info":[],"DrugClasses":[],"EINECS":"220-864-4","European Community (EC) Number":"220-864-4","Flash Point":"82 °F (CLOSED CUP) /DURSBAN 4E/","HMDB ID":"HMDB0041856","HeavyAtomCount":18,"IUPACName":"diethoxy-sulfanylidene-(3,5,6-trichloropyridin-2-yl)oxy-lambda5-phosphane","InChI":"InChI=1S/C9H11Cl3NO3PS/c1-3-14-17(18,15-4-2)16-9-7(11)5-6(10)8(12)13-9/h5H,3-4H2,1-2H3","InChIKey":"SBPBAQFWLVIOKP-UHFFFAOYSA-N","MeSH Pharmacological Classification":"Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system. (See all compounds classified as Cholinesterase Inhibitors.)","Melting Point":"108 to 110 °F (NTP, 1992)","MolecularFormula":"C\u003csub\u003e9\u003c/sub\u003eH\u003csub\u003e11\u003c/sub\u003eCl\u003csub\u003e3\u003c/sub\u003eNO\u003csub\u003e3\u003c/sub\u003ePS","MolecularWeight":"350.6 g/mol","Odor":"Mild mercaptan odor","Physical Description":"Chlorpyrifos is a white crystalline or irregularly flaked solid. It has a very faint mercaptan-type odor. It is not soluble in water. It can cause slight irritation to the eye and skin.","PrevSalts":[],"PubChemId":2730,"Record Description":["Chlorpyrifos is an insecticide that is a white crystal-like solid with a strong odor. It does not mix well with water, so it is usually mixed with oily liquids before it is applied to crops or animals. It may also be applied to crops in a capsule form. Chlorpyrifos has been widely used in homes and on farms. In the home, it is used to control cockroaches, fleas, and termites; it is also used in some pet flea and tick collars. On the farm, it is used to control ticks on cattle and as a spray to control crop pests.","Chlorpyrifos can cause developmental toxicity according to an independent committee of scientific and health experts.","Chlorpyrifos is a white crystalline or irregularly flaked solid. It has a very faint mercaptan-type odor. It is not soluble in water. It can cause slight irritation to the eye and skin.","Chlorpyrifos is an organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an agrochemical, an EC 3.1.1.8 (cholinesterase) inhibitor, an environmental contaminant, a xenobiotic, an acaricide and an insecticide. It is an organic thiophosphate and a chloropyridine.","Chlorpyrifos is a synthetic organophosphate acetylcholinesterase inhibitor, reproduction toxicant, and neurotoxicant that is used as a pesticide. It is characterized as a highly toxic colorless, white, or light brown crystalline solid with a mild rotten egg odor, and exposure occurs by inhalation, ingestion, or contact.","Chlorpyrifos (IUPAC name: O,O-diethyl O-3,5,6-trichloropyridin-2-yl phosphorothioate) is a crystalline organophosphate insecticide. It was introduced in 1965 by Dow Chemical Company and is known by many trade names (see table), including Dursban and Lorsban. It acts on the nervous system of insects by inhibiting acetylcholinesterase. Chlorpyrifos is moderately toxic to humans, and exposure has been linked to neurological effects, persistent developmental disorders, and autoimmune disorders. Exposure during pregnancy retards the mental development of children, and most use in homes has been banned since 2001 in the U.S. In agriculture, it remains one of the most widely used organophosphate insecticides, according to the United States Environmental Protection Agency (EPA).","An organothiophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.","Chlorpyrifos can cause developmental toxicity according to an independent committee of scientific and health experts.","Chlorpyrifos is an organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an agrochemical, an EC 3.1.1.8 (cholinesterase) inhibitor, an environmental contaminant, a xenobiotic, an acaricide and an insecticide. It is an organic thiophosphate and a chloropyridine."],"References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Chlorpyrifos","Name":"Chlorpyrifos","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q414915","Name":"Chlorpyrifos","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/2730","Name":"Chlorpyrifos","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL463210","Name":"Chlorpyrifos","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:34631","Name":"Chlorpyrifos","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=2921-88-2","Name":"Chlorpyrifos","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0041856","Name":"Chlorpyrifos","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C14322","Name":"Chlorpyrifos","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/JCS58I644W","Name":"Chlorpyrifos","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020458","Name":"Chlorpyrifos","Sub":false}]}],"Reported Fatal Dose":"300 mg/kg for an adult human. 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