{"Abbreviation":"","Aliases":["Clorfentermina","Desopimon","Teramine","Effox","Lucofen SA","Chlorphenterminum","1-(p-Chlorophenyl)-2-methyl-2-aminopropane","α,α-Dimethyl-p-chlorophenethylamine","p-Chloro-α,α-dimethylphenethylamine","4-Chloro-α,α-dimethylphenethylamine","4-Chloro-α,α-dimethylbenzeneethanamine","Benzeneethanamine, 4-chloro-α,α-dimethyl-","β-(p-Chlorophenyl)-α,α-dimethylethylamine","1-(p-Chlorophenyl)-2-methyl-2-propylamine","Phenethylamine, p-chloro-α,α-dimethyl-","207-314-9","Chlorophentermine","Chlorphenteramine","2-(4-Chloro-phenyl)-1,1-dimethyl-ethylamine","Lucofen","a,a-Dimethyl-p-chlorophenethylamine","4-12-00-02823","4-Chloro-a,a-dimethylphenethylamine","4-Chloro-a,a-dimethylbenzeneethanamine","Benzeneethanamine, 4-chloro-α,α-dimethyl"],"Biological Half-Life":"40 hours","Boiling Point":"100-102 °C at 2.00E+00 mm Hg","CAS":"461-78-9","ChEBI":"CHEBI:3646","ChEMBL":"CHEMBL1201269","ChemicalClasses":["phentermine"],"Chirality":"achiral","Color/Form":"LIQUID","DEA no":1645,"Decomposition":"When heated to decomp it emits very toxic fumes of /hydrogen chloride and nitrogen oxides/.","Drug Indication":"Used as an appetite suppressant.","Drug Warnings":"DESPITE ABSENCE OF REPORTS OF ABUSE, IT IS POSSIBLE THAT LONG-TERM USE, ESP OF LARGER THAN USUAL THERAPEUTIC DOSES, MAY RESULT IN PSYCHIC \u0026 PHYSICAL DEPENDENCE. /CHLORPHENTERMINE HYDROCHLORIDE/","EINECS":"207-314-9","EliminationHalfLife":"40 hours\u003ca href='#cite_note-4'\u003e\u003csup\u003e[4]\u003c/sup\u003e\u003c/a\u003e–5 days","Erowid Experience Reports":[],"Esters":[],"European Community (EC) Number":"207-314-9","Formating":[],"HMDB ID":"HMDB0250132","HeavyAtomCount":12,"Human Drugs":"Pharmaceuticals","IUPACName":"1-(4-chlorophenyl)-2-methylpropan-2-amine","InChI":"InChI=1S/C10H14ClN/c1-10(2,12)7-8-3-5-9(11)6-4-8/h3-6H,7,12H2,1-2H3","InChIKey":"ZCKAMNXUHHNZLN-UHFFFAOYSA-N","MeSH Pharmacological Classification":"Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)","MolecularFormula":"C\u003csub\u003e10\u003c/sub\u003eH\u003csub\u003e14\u003c/sub\u003eClN","MolecularWeight":"183.68 g/mol","Pharmacodynamics":"Chlorphentermine is a relatively weak stimulant with little abuse potential. It presents a prominent serotonergic profile leading to pulmonary hypertension and cardiac fibrosis after prolonged use. Thus, this drug is no longer used.","PubChemId":10007,"RefCount":5,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Chlorphentermine","Name":"Chlorphentermine","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q5103230","Name":"Chlorphentermine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB01556","Name":"Chlorphentermine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/10007","Name":"Chlorphentermine","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201269","Name":"Chlorphentermine","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:3646","Name":"Chlorphentermine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=461-78-9","Name":"Chlorphentermine","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0250132","Name":"Chlorphentermine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C07559","Name":"Chlorphentermine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/NHW07912O7","Name":"Chlorphentermine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID0022806","Name":"Chlorphentermine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 10007, Chlorphentermine. Accessed July 13, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/10007\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/10007\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Chlorphentermine. UNII: NHW07912O7. Global Substance Registration System. Accessed July 13, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/NHW07912O7\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/NHW07912O7\u003c/a\u003e","Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. March 31, 2023. Accessed July 13, 2025. \u003ca href=https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992\u003ehttps://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992\u003c/a\u003e","Chlorphentermine: Uses, Interactions, Mechanism of Action. July 31, 2007. Accessed July 13, 2025. \u003ca href=https://go.drugbank.com/drugs/DB01556\u003ehttps://go.drugbank.com/drugs/DB01556\u003c/a\u003e"],"SMILES":"CC(C)(CC1=CC=C(C=C1)Cl)N","SaltData":[{"AcidCount":1,"AmineCount":1,"Formula":"Cl","Name":"hydrochloride","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 116.771 36.729\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#1ff01f\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h117v37H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"M81.149 22.304 71.353 10.63M71.353 10.63l-9.796 11.674M71.353 10.63 58.154 3.01M58.154 3.01l-13.198 7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M44.956 10.63 31.753 3.001M42.518 12.037l-10.765-6.22\"/\u003e\u003c/g\u003e\u003cpath d=\"m31.753 3.001-13.198 7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m18.555 10.621.005 15.249M20.994 12.029l.004 12.433\"/\u003e\u003c/g\u003e\u003cpath d=\"m18.56 25.87 13.203 7.628\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m31.763 33.498 13.198-7.62M31.763 30.682l10.759-6.211\"/\u003e\u003c/g\u003e\u003cpath d=\"m44.956 10.63.005 15.248M18.56 25.87 6.875 32.616M71.353 10.63l10.045-5.8\" class=\"bond\"/\u003e\u003cpath stroke=\"none\" d=\"M2.906 31.674q-.786 0-1.239.53-.452.524-.452 1.446 0 .911.417 1.447.422.53 1.268.53.321 0 .607-.054.292-.059.565-.143v.536q-.273.101-.565.149-.292.054-.697.054-.744 0-1.25-.31-.5-.31-.75-.875-.25-.572-.25-1.34 0-.744.268-1.309.274-.566.804-.881.529-.322 1.279-.322.78 0 1.352.286l-.244.524q-.226-.101-.506-.185-.274-.083-.607-.083m2.756 4.423h-.601v-5.215h.601z\" class=\"atom\"/\u003e\u003cg fill=\"#3050f8\" stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M86.492 5.459h-.721l-2.619-4.066h-.03l.03.596q.024.357.024.732v2.738h-.566V.56h.715l2.607 4.054h.03l-.018-.327-.024-.477q-.006-.262-.006-.482V.56h.578zM90.798 5.459h-.619V3.173h-2.513v2.286h-.613V.56h.613v2.072h2.513V.56h.619zM93.303 6.949H91.36v-.3l.771-.779q.221-.221.372-.393.153-.175.232-.339.078-.168.078-.364 0-.243-.146-.368-.143-.129-.372-.129-.214 0-.378.075-.161.075-.329.207l-.193-.243q.172-.146.393-.246.225-.1.507-.1.411 0 .65.207t.24.575q0 .229-.097.432-.093.2-.264.397-.168.196-.393.418l-.614.603v.018h1.486z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"#1ff01f\" d=\"m6.875 32.616 5.842-3.373\" class=\"hi\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m81.398 4.83-5.023 2.9\" class=\"hi\"/\u003e\u003c/g\u003e\u003cg class=\"mol\"\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M113.454 16.513q-.785 0-1.238.53-.452.524-.452 1.446 0 .911.416 1.447.423.53 1.268.53.322 0 .608-.054.291-.059.565-.143v.536q-.274.101-.565.149-.292.053-.697.053-.744 0-1.25-.309-.5-.31-.75-.875-.25-.572-.25-1.34 0-.744.268-1.309.274-.566.803-.881.53-.322 1.28-.322.78 0 1.352.286l-.244.524q-.227-.101-.506-.185-.274-.083-.608-.083m2.757 4.423h-.601v-5.215h.601zM110.547 20.936h-.619V18.65h-2.512v2.286h-.613v-4.899h.613v2.071h2.512v-2.071h.619z\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Title":"Chlorphentermine hydrochloride","UNII":"RL11HOJ7DM"}],"Salts":["hydrochloride"],"Scheduling":[{"gov":"Brazil","ref":["3"],"schedule":"A3 substance"},{"act":"Controlled Substances Act (CSA)","gov":"United States","ref":[],"schedule":"Schedule I"},{"gov":"Canada","ref":[],"schedule":"Schedule IV substance"},{"gov":"United Kingdom","ref":[],"schedule":"Class C substance"}],"Solubility":"WHITE TO OFF-WHITE POWDER; ODORLESS \u0026 HAS BITTER TASTE; FREELY SOL IN WATER \u0026 ALC; SPARINGLY SOL IN CHLOROFORM; PRACTICALLY INSOL IN ETHER /CHLORPHENTERMINE HYDROCHLORIDE/","Stability/Shelf Life":"STABLE IN LIGHT \u0026 AIR /CHLORPHENTERMINE HYDROCHLORIDE/","StereoisomerData":[],"Stereoisomers":["(+)-Chlorphentermine","(-)-Chlorphentermine"],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 93.863 36.729\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#3050f8\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h94v37H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"M81.149 22.304 71.353 10.63M71.353 10.63l-9.796 11.674M71.353 10.63 58.154 3.01M58.154 3.01l-13.198 7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M44.956 10.63 31.753 3.001M42.518 12.037l-10.765-6.22\"/\u003e\u003c/g\u003e\u003cpath d=\"m31.753 3.001-13.198 7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m18.555 10.621.005 15.249M20.994 12.029l.004 12.433\"/\u003e\u003c/g\u003e\u003cpath d=\"m18.56 25.87 13.203 7.628\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m31.763 33.498 13.198-7.62M31.763 30.682l10.759-6.211\"/\u003e\u003c/g\u003e\u003cpath d=\"m44.956 10.63.005 15.248M18.56 25.87 6.875 32.616M71.353 10.63l10.045-5.8\" class=\"bond\"/\u003e\u003cpath fill=\"#1ff01f\" stroke=\"none\" d=\"M2.906 31.674q-.786 0-1.239.53-.452.524-.452 1.446 0 .911.417 1.447.422.53 1.268.53.321 0 .607-.054.292-.059.565-.143v.536q-.273.101-.565.149-.292.054-.697.054-.744 0-1.25-.31-.5-.31-.75-.875-.25-.572-.25-1.34 0-.744.268-1.309.274-.566.804-.881.529-.322 1.279-.322.78 0 1.352.286l-.244.524q-.226-.101-.506-.185-.274-.083-.607-.083m2.756 4.423h-.601v-5.215h.601z\" class=\"atom\"/\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M86.492 5.459h-.721l-2.619-4.066h-.03l.03.596q.024.357.024.732v2.738h-.566V.56h.715l2.607 4.054h.03l-.018-.327-.024-.477q-.006-.262-.006-.482V.56h.578zM90.798 5.459h-.619V3.173h-2.513v2.286h-.613V.56h.613v2.072h2.513V.56h.619zM93.303 6.949H91.36v-.3l.771-.779q.221-.221.372-.393.153-.175.232-.339.078-.168.078-.364 0-.243-.146-.368-.143-.129-.372-.129-.214 0-.378.075-.161.075-.329.207l-.193-.243q.172-.146.393-.246.225-.1.507-.1.411 0 .65.207t.24.575q0 .229-.097.432-.093.2-.264.397-.168.196-.393.418l-.614.603v.018h1.486z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"#1ff01f\" d=\"m6.875 32.616 5.842-3.373\" class=\"hi\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m81.398 4.83-5.023 2.9\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Therapeutic Uses":"Sympathomimetics","Title":"Chlorphentermine","UNII":"NHW07912O7","Wikidata":"Q5103230","Wikipedia":"Chlorphentermine","XLogP":2.6}