{"ATC Code":"R06AB54","Abbreviation":["CP","CPM"],"Absorption, Distribution and Excretion":"Well absorbed in the gastrointestinal tract.","Aliases":["Chlorpheniramine","chlorpheniramine","Chlorphenamine","132-22-9","Chlorophenylpyridamine","Haynon","Clorfeniramina","Allergican","Allergisan","Clorfenamina","Histadur","Chloropheniramine","Chlorprophenpyridamine","Chloroprophenpyridamine","Chlorpheniraminum","Chlorphenaminum","4-Chloropheniramine","Clofeniramina","Chlorphenamin","1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane","3-(p-Chlorophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine","γ-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine","γ-(4-Chlorophenyl)-γ-(2-pyridyl)propyldimethylamine","1-(p-Chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpropylamine","3U6IO1965U","3-(4-chlorophenyl)-N,N-dimethyl-3-(2-pyridyl)propan-1-amine","2-(p-Chloro-α-(2-(dimethylamino)ethyl)benzyl)pyridine","Dtxsid0022804","Chebi:52010","Pyridine, 2-(p-chloro-α-(2-(dimethylamino)ethyl)benzyl)-","Hayon","Tuzistra componenet of chlorpheniramine","2-[p-chloro-α-[2-(dimethylamino)ethyl]benzyl]pyridine","(3-(4-chlorophenyl)-3-(pyridin-2-yl)propyl)dimethylamine","[3-(4-chlorophenyl)-3-(pyridin-2-yl)propyl]dimethylamine","Cloro-Trimeton","Tannate, Chlorpheniramine","Dtxcid402804","R06AB04","205-054-0","Chloropheniramine-d4","Teldrin","Polaronil","3-(4-chlorophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine","Chlorpheniramine polistirex","2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-","CHEMBL505","Dexchlorpheniramine free base","Chloropiril","25523-97-1","Chloropheniramine maleate","Telachlor","Aller-Chlor","HSDB 3032","Einecs 205-054-0","[3-(4-Chlorophenyl)-3-(2-pyridyl)propyl]dimethylamine","PiriIton","Unii-3u6io1965u","Chlor-Pro","[3H]Chlorphenamine","[3H]Chlorpheniramine","chlorpheniaramine maleate","S-(+)-Chlorpheniramine","Prestwick0_000117","Prestwick1_000117","Prestwick2_000117","Prestwick3_000117","Ncgc00015227-04","5-Ht,n-acetyl","Schembl4219","Lopac0_000261","Oprea1_779072","BSPBio_000134","DivK1c_000596","SPBio_002073","BPBio1_000148","GTPL6976","orb1689526","Schembl29687335","BDBM35938","KBio1_000596","Chlorpheniramine-d6see c424303","Ninds_000596","783AHI015X","HMS2090M21","HMS3428J07","HBA18809","HY-B0286","BBL012285","EBC-26398","Mfcd00053581","SBB017260","STK736174","Akos001650136","Akos022060794","CCG-108982","DB01114","SB19135","Sdccgsbi-0050249.p002","Idi1_000596","Ncgc00015227-03","Ncgc00015227-05","Ncgc00015227-06","Ncgc00015227-09","Ncgc00015227-19","Ncgc00162108-01","Ncgc00162108-02","DA-62286","ST076791","CS-0009285","NS00010179","C06905","D07398","En300-708772","G77687","L000003","Q420133","Brd-a04553218-050-03-0","Brd-a04553218-050-08-9","Brd-a04553218-050-16-2","pyridine, 2-[p-chloro-α-(2-dimethylaminoethyl)benzyl]-","Brompheniramine Maleate EP Impurity A; Chlorpheniramine Maleate","2-(P-chloro-α-(2-(dimethylamino)ethyl)benzyl)pyridine","N-[3-(4-Chlorophenyl)-3-(2-pyridinyl)propyl]-N,N-dimethylamine #","n.-Propanamine, 3-(4-chlorophenyl)-3-(2-pyridyl)-N,N-dimethyl-","2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (S)-","Pyridine, 2-[p-chloro-α-[2-(dimethylamino)ethyl]benzyl]-, (S)-(+)-"],"Biological Half-Life":"21-27 hours","Boiling Point":"142 °C","CAS":"25523-97-1","Chemical Classes":"Pharmaceutical","ChemicalClasses":["phenethylamine"],"Chirality":"racemic","Color/Form":"OILY LIQUID","Drug Classes":["Breast Feeding","Lactation","Milk, Human","Antihistamines"],"Drug Indication":"For the treatment of rhinitis, urticaria, allergy, common cold, asthma and hay fever.","Drug Warnings":"Use is not recommended in newborn or premature infants because this age group has an increased susceptibility to anticholinergic side effects, such as central nervous system excitation, and an increased tendency toward convulsions. A paradoxical reaction characterized by hyperexcitability may occur in children taking antihistamines. /Antihistamines/","EliminationHalfLife":"13.9 – 43.4 hours","Esters":[],"European Community (EC) Number":"205-054-0","FDA Pharmacological Classification":"3U6IO1965U","Formating":[],"HMDB ID":"HMDB0001944","Health Effects":"Chlorpheniramine posesses serotonergic and norepinephrinergic effects. It has been shown to work as a serotonin-norepinephrine reuptake inhibitor or SNRI. [Wikipedia]","HeavyAtomCount":19,"Human Drugs":"Breast Feeding; Lactation; Milk, Human; Antihistamines","IUPACName":"3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine","InChI":"InChI=1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3","InChIKey":"SOYKEARSMXGVTM-UHFFFAOYSA-N","Interactions":"Concurrent use /of ototoxic medications/ with antihistamines may mask the symptoms of ototoxicity such as tinnitus, dizziness, or vertigo. /Antihistamines/","MeSH Pharmacological Classification":"Agents, usually topical, that relieve itching (pruritus).","Mechanism of Action":"Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.","Melting Point":"130 - 135 °C","Metabolism/Metabolites":"Primarily hepatic via Cytochrome P450 (CYP450) enzymes.","MolecularFormula":"C\u003csub\u003e16\u003c/sub\u003eH\u003csub\u003e19\u003c/sub\u003eClN\u003csub\u003e2\u003c/sub\u003e","MolecularWeight":"274.79 g/mol","Opticalactivity":"( + / - )","Pharmacodynamics":"In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H\u003csub\u003e1\u003c/sub\u003e-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Chlorpheniramine, is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It competes with histamine for the normal H\u003csub\u003e1\u003c/sub\u003e-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.","Physical Description":"Solid","PubChemId":2725,"Record Description":["LiverTox|Respiratory|Allergy symptoms|Antihistamine"],"Records":{"UNII":{"Impurities":["n-nitroso-desmethyl-chlorpheniramine"]}},"RefChem":"390707","RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Chlorphenamine","Name":"Chlorphenamine","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q420133","Name":"Chlorphenamine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB01114","Name":"Chlorphenamine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/2725","Name":"Chlorphenamine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=25523-97-1","Name":"Chlorphenamine","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0001944","Name":"Chlorphenamine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C06905","Name":"Chlorphenamine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/3U6IO1965U","Name":"Chlorphenamine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID0022804","Name":"Chlorphenamine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 2725, Chlorpheniramine. Accessed January 13, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/2725\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/2725\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Chlorphenamine. UNII: 3U6IO1965U. Global Substance Registration System. 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