{"ATC Code":["M - Musculo-skeletal system","M03 - Muscle relaxants","M03B - Muscle relaxants, centrally acting agents","M03BA - Carbamic acid esters","M03BA02 - Carisoprodol","QM - Musculo-skeletal system","QM03 - Muscle relaxants","QM03B - Muscle relaxants, centrally acting agents","QM03BA - Carbamic acid esters","QM03BA02 - Carisoprodol"],"Absorption, Distribution and Excretion":"The absolute bioavailability of carisoprodol has not yet been established. The mean time to peak plasma concentrations (Tmax) of this drug was about 1.5-2 hours in clinical studies. Co-administration of a fatty meal with carisoprodol (350 mg tablet) had no impact on carisoprodol pharmacokinetics.","Adverse Effects":"The most common adverse drug reactions of carisoprodol include drowsiness, headache, and dizziness. According to the product labeling, up to 17% of patients experienced sedation after receiving carisoprodol compared to 6% of patients who were administered a placebo. This adverse drug reaction can impair the mental and physical capabilities required to perform potentially hazardous work, such as driving or working with heavy machinery. Post-marketing reports have indicated motor vehicle accidents linked to carisoprodol usage. The potential for misuse, abuse, physical dependence, and withdrawal is apparent if carisoprodol is used indiscriminately. In March 2007, Norwegian medical regulatory authorities reviewed carisoprodol, leading the Committee for Medicinal Products for Human Use and the European Medicines Agency. They concluded that the benefits of carisoprodol no longer outweigh their associated risks. Consequently, all marketing authorizations for carisoprodol were suspended throughout Europe. Another potentially significant reported adverse effect is seizures. In Indonesia, in September 2017, close to 100 people suffered seizures with at least 1 fatality when PCC, standing for \"paracetamol-caffeine-carisoprodol,\" was mixed into student's drinks.","Aliases":["Carisoprodol","Isomeprobamate","Carisoprodate","SOMA","Carisoprodatum","Carisoma","Isobamate","Isoprothane","Sanoma","Flexartal","Isoprotane","Miolisodal","Atonalyt","Isopropyl meprobamate","Nospasm","Relasom","Skutamil","Somalgit","Somanil","Apesan","Mioril","Caprodat","Isoprotan","Izoprotan","Somadril","Arusal","Carisol","Diolene","Domarax","Flexal","RELA","Carlsoma","Carlsoprol","Carsodal","Mediquil","Stialgin","Brianil","Calenfa","Carisoprodolum","Carsodol","Listaflex","Tonolyt isopropyl meprobamate","Isopropylmeprobamate","NCI-C56235","Carisoprodol civ","SCH 7307","CB 8019","2-Methyl-2-propyl-1,3-propanediol carbamate isopropylcarbamate","Dtxsid8024733","NSC-172124","(1-Methylethyl)carbamic acid 2-(((aminocarbonyl)oxy)methyl)-2-methylpentyl ester","Isopropylcarbamic acid, ester with 2-(hydroxymethyl)-2-methylpentyl carbamate","N-Isopropyl-2-methyl-2-propyl-1,3-propanediol dicarbamate","Carbamic acid, ester with 2-methyl-2-propyl-1,3-propanediol isopropylcarbamate","Carbamic acid, isopropyl-, 2-(hydroxymethyl)-2-methylpentyl ester carbamate","Carbamic acid, (1-methylethyl)-, 2-(((aminocarbonyl)oxy)methyl)-2-methylpentyl ester","CHEBI:3419","Dtxcid904733","Carbamic acid, ester with 2-(hydroxymethyl)-2-methylpentyl isopropylcarbamate","NSC172124","2-methyl-2-propyltrimethylene carbamate isopropylcarbamate","N-isopropy-2-methyl-2-propyl-1,3-propanediol dicarbamate","Carbamic acid 2-isopropylcarbamoyloxymethyl-2-methyl-pentyl ester","Carbamic acid, (1-methylethyl)-, 2-[[(aminocarbonyl)oxy]methyl]-2-methylpentyl ester","(2-(carbamoyloxymethyl)-2-methylpentyl) N-propan-2-ylcarbamate","2-(((aminocarbonyl)oxy)methyl)-2-methylpentyl isopropylcarbamate","2-{[(aminocarbonyl)oxy]methyl}-2-methylpentyl isopropylcarbamate","Carisoprodol Tablets","M03BA02","Carisoprodol Tablets, USP, 350 mg","2-((carbamoyloxy)methyl)-2-methylpentyl N-(propan-2-yl)carbamate","201-118-7","Mioratrina","Carlsodol","Mioriodol","Miolisodol","Flexartel","Mls000028401","Artifar","Caridolin","Chinchen","Fibrosona","Flexagilt","Flexagit","Flexidon","Meprodat","Neotica","Muslax","Scutamil-C","Mfcd00057661","2-((Carbamoyloxy)methyl)-2-methylpentyl isopropylcarbamate","Ncgc00015278-09","Smr000058433","Carisoprodolo","Prazolamine","2-[(carbamoyloxy)methyl]-2-methylpentyl propan-2-ylcarbamate","2-methyl-2-propyl-1,3-propanediol carbamate isopropylcarbamate","Carbamic acid, ester with 2-(hydroxymethyl)-2-methylpentylisopropyl carbamate","CCRIS 4764","HSDB 3021","Sr-01000000076","Einecs 201-118-7","NSC 172124","Brn 1791537","2-[(Carbamoyloxy)methyl]-2-methylpentyl isopropylcarbamate","Cas-78-44-4","Prestwick_50","Unii-21925k482h","Soma","Spectrum_000102","Opera_ID_1100","Prestwick0_000423","Prestwick1_000423","Prestwick2_000423","Prestwick3_000423","Spectrum2_001153","Spectrum3_000328","Spectrum4_000265","Spectrum5_000661","1,3-Propanediol, 2-methyl-2-propyl-, carbamate isopropylcarbamate","CHEMBL1233","Lopac0_000319","Schembl33286","BSPBio_000406","BSPBio_001935","KBioGR_000730","KBioSS_000542","Mls001148409","Mls002454391","orb341972","DivK1c_000816","Spectrum1500162","SPBio_001105","SPBio_002345","BPBio1_000448","GTPL7610","DEA No. 8192","HMS502I18","KBio1_000816","KBio2_000542","KBio2_003110","KBio2_005678","KBio3_001155","Carisoprodol, 1mg/ml in Methanol","Ninds_000816","[2-(carbamoyloxymethyl)-2-methyl-pentyl] N-isopropylcarbamate","HMS1569E08","HMS1920K03","HMS2091A06","HMS2096E08","HMS2234F13","HMS3259O15","HMS3372H19","HMS3713E08","Pharmakon1600-01500162","HY-B1380","QYB60282","TYB91170","Carisoprodol 1.0 mg/ml in Methanol","Tox21_110122","Tox21_200623","AC-212","CCG-40092","NSC756671","Akos015842914","Tox21_110122_1","Wln: zvo1x3\u00261\u00261ovmy1\u00261","CS-4819","DB00395","FM19816","LP00319","NC00502","NSC-756671","Sdccgsbi-0050307.p005","Idi1_000816","Ncgc00015278-03","Ncgc00015278-04","Ncgc00015278-05","Ncgc00015278-06","Ncgc00015278-07","Ncgc00015278-08","Ncgc00015278-11","Ncgc00015278-12","Ncgc00015278-14","Ncgc00015278-15","Ncgc00089734-02","Ncgc00089734-03","Ncgc00089734-04","Ncgc00089734-05","Ncgc00089734-06","Ncgc00089734-07","Ncgc00258177-01","Sbi-0050307.p004","Soma compound component carisoprodol","AB00051932","C3573","EU-0100319","NS00008741","ST51037205","Carbamic acid,3-propanediol isopropylcarbamate","C 8759","D00768","N-Isopropyl-2-methyl-2-propyl-1, dicarbamate","Ab00051932_15","Carisoprodol compound component carisoprodol","Sr-01000000076-2","Sr-01000000076-4","Sr-01000000076-6","W-104280","1, 2-methyl-2-propyl-, carbamate isopropylcarbamate","Brd-a99939097-001-24-2","N-Isopropyl-2-methyl-2-propyl-1,3-propanediol, dicarbamate","Carisoprodol, European Pharmacopoeia (EP) Reference Standard","2-methyl-2-{[N-(methylethyl)carbamoyloxy]methyl}pentyl aminooate","Carisoprodol, United States Pharmacopeia (USP) Reference Standard","1-Methylethylcarbamic acid 2-{[(aminocarbonyl)oxy]methyl}-2 -methylpentyl ester","Carbamic acid, isopropyl-, 2-(hydroxymethyl)-2-methylpentyl ester, carbamate","Carisoprodol;Domarax;N-Isopropyl-2-methyl-2-propyl-1,3-propanediol dicarbamate","N-Isopropyl 2-methyl-2-propyl-1,3-propanediol dicarbamate; Isopropylcarbamic acid ester with 2-(hydroxymethyl)-2-methylpentyl carbamate"],"Biological Half-Life":"The terminal half-life is approximately 2 hours.","CAS":"78-44-4","Chemical Classes":"Pharmaceutical","ChemicalClasses":[],"Chirality":"racemic","Color/Form":"Crystals","DBI-IGS":["Carisoprodol"],"Dosing Info":[{"Method":"Oral","Tiers":{"Common":{"Entries":0,"Lower":125,"Percentage":0,"Unit":"mg","Upper":125},"Extreme":{"Entries":1,"Lower":290,"Percentage":20,"Unit":"mg","Upper":290},"Heavy":{"Entries":0,"Lower":125,"Percentage":0,"Unit":"mg","Upper":290},"Light":{"Entries":4,"Lower":125,"Percentage":80,"Unit":"mg","Upper":125},"Strong":{"Entries":0,"Lower":125,"Percentage":0,"Unit":"mg","Upper":125}}},{"Method":"Intrarectal","Tiers":{"Common":{"Entries":0,"Lower":125,"Percentage":0,"Unit":"mg","Upper":125},"Extreme":{"Entries":2,"Lower":156.5,"Percentage":12.5,"Unit":"mg","Upper":156.5},"Heavy":{"Entries":0,"Lower":125,"Percentage":0,"Unit":"mg","Upper":156.5},"Light":{"Entries":14,"Lower":125,"Percentage":87.5,"Unit":"mg","Upper":125},"Strong":{"Entries":0,"Lower":125,"Percentage":0,"Unit":"mg","Upper":125}}}],"Drug Classes":["Breast Feeding","Lactation","Milk, Human","Muscle Relaxants, Central"],"Drug Indication":"Carisoprodol is indicated for the relief of discomfort related to acute, painful musculoskeletal conditions.   **Important limitations of use**:  • Should only be used for acute treatment periods up to two or three weeks   • Adequate evidence of effectiveness for more prolonged use has not been established   • Not recommended in pediatric patients less than 16 years of age","Drug Warnings":"Occasionally, patients may have allergic or idiosyncratic reactions to carisoprodol. In patients who have not received carisoprodol previously, these reactions are usually evident by the time of the fourth dose of the drug. Idiosyncratic reactions may be characterized by extreme weakness, transient quadriplegia, dizziness, ataxia, temporary loss of vision, diplopia, mydriasis, dysarthria, agitation, euphoria, confusion, and disorientation. These symptoms usually subside within several hours; however, symptomatic and supportive therapy, including hospitalization, may be necessary in some patients. Rash, erythema multiforme, pruritus, urticaria, eosinophilia, and fixed drug eruption have occurred in patients receiving carisoprodol who previously had similar reactions to meprobamate. Severe allergic reactions have been characterized by asthmatic episodes, fever, weakness, dizziness, angioedema, smarting eyes, hypotension, and anaphylactic shock.","DurationOfAction":"","EliminationHalfLife":"2.5 hours [12 hours{-{refn|group=nb|At least 25% of the carisoprodol in the body is transformed by the liver into meprobamate, its main active metabolite, which in turn has a half-life of 10 hours.}-}]","Esters":[],"European Community (EC) Number":"201-118-7","FDA Pharmacological Classification":[{"Name":"FDA UNII","ReferenceNumber":32,"Value":{"StringWithMarkup":[{"String":"21925K482H"}]}},{"Name":"Active Moiety","ReferenceNumber":32,"Value":{"StringWithMarkup":[{"String":"CARISOPRODOL"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":32,"Value":{"StringWithMarkup":[{"String":"Physiologic Effects [PE] - Centrally-mediated Muscle Relaxation"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":32,"Value":{"StringWithMarkup":[{"String":"Established Pharmacologic Class [EPC] - Muscle Relaxant"}]}},{"Name":"FDA Pharmacology Summary","ReferenceNumber":32,"Value":{"StringWithMarkup":[{"Markup":[{"Extra":"CID-2576","Length":12,"Start":0,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/Carisoprodol"},{"Extra":"CID-2576","Length":12,"Start":61,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/carisoprodol"}],"String":"Carisoprodol is a Muscle Relaxant. The physiologic effect of carisoprodol is by means of Centrally-mediated Muscle Relaxation."}]}},{"Name":"Non-Proprietary Name","ReferenceNumber":66,"Value":{"StringWithMarkup":[{"String":"CARISOPRODOL"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":66,"Value":{"StringWithMarkup":[{"String":"Centrally-mediated Muscle Relaxation [PE]; Muscle Relaxant [EPC]"}]}}],"Formating":[],"HMDB ID":"HMDB0014539","HeavyAtomCount":18,"Human Drugs":"Breast Feeding; Lactation; Milk, Human; Muscle Relaxants, Central","IUPACName":"[2-(carbamoyloxymethyl)-2-methylpentyl] N-propan-2-ylcarbamate","Impurities":"Impurities: (2RS)-2-(hydroxymethyl)-2-methylpentyl (1-methylethyl)carbamate; 5-methyl-5-propyl-1,3-dioxan-2-one; 2-methyl-2-propylpropane-1,3-diol; meprobamate","InChI":"InChI=1S/C12H24N2O4/c1-5-6-12(4,7-17-10(13)15)8-18-11(16)14-9(2)3/h9H,5-8H2,1-4H3,(H2,13,15)(H,14,16)","InChIKey":"OFZCIYFFPZCNJE-UHFFFAOYSA-N","Interactions":"Additive CNS depression may occur when carisoprodol is administered concomitantly with other CNS depressants, including alcohol. If carisoprodol is used concomitantly with other depressant drugs, caution should be used to avoid overdosage.","KEGG Entries":[{"Id":"D00768","Interactions":[{"Action":"inhibition","Target":"CYP2C19"},{"Action":"induction","Target":"CYP2C19"}],"Synonyms":["Carisoprodol","Soma"]},{"Id":"D00768","Interactions":[{"Action":"inhibition","Target":"CYP2C19"},{"Action":"induction","Target":"CYP2C19"}],"Synonyms":["Carisoprodol","Soma"]},{"Id":"D00768","Interactions":[{"Action":"inhibition","Target":"CYP2C19"},{"Action":"induction","Target":"CYP2C19"}],"Synonyms":["Carisoprodol","Soma"]}],"MeSH Headers":[{"Id":"M0003488","Link":"https://id.nlm.nih.gov/mesh/M0003488.html","Name":"Carisoprodol","Ref":94},{"Id":"M0477278","Link":"https://id.nlm.nih.gov/mesh/M0477278.html","Name":"Carisoma","Ref":96},{"Id":"M0477279","Link":"https://id.nlm.nih.gov/mesh/M0477279.html","Name":"Somalgit","Ref":97},{"Id":"M0477280","Link":"https://id.nlm.nih.gov/mesh/M0477280.html","Name":"Soma","Ref":98},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":99},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":127},{"Id":"M0014240","Link":"https://id.nlm.nih.gov/mesh/M0014240.html","Name":"Muscle Relaxants, Central","Ref":128}],"MeSH Pharmacological Classification":[{"Id":"M0014240","Link":"https://id.nlm.nih.gov/mesh/M0014240.html","Name":"Muscle Relaxants, Central","Ref":128}],"Mechanism of Action":"The mechanism of action of carisoprodol in relieving discomfort associated with acute painful musculoskeletal conditions has not been confirmed. In studies using animal models, the muscle relaxation that is induced by carisoprodol is associated with a change in the interneuronal activity of the spinal cord and of the descending reticular formation, located in the brain.   The abuse potential of this drug is attributed to its ability to alter GABAA function. This drug has been shown to modulate a variety of GABAA receptor subunits.  GABAA receptor modulation can lead to anxiolysis due to inhibitory effects on neurotransmission.","Melting Point":"198 to 199 °F (NTP, 1992)","Metabolism/Metabolites":"The main pathway of carisoprodol is liver metabolism is by the cytochrome enzyme CYP2C19 to form meprobamate. This enzyme exhibits genetic polymorphism, which may affect the metabolism of this drug.","MolecularFormula":"C\u003csub\u003e12\u003c/sub\u003eH\u003csub\u003e24\u003c/sub\u003eN\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e","MolecularWeight":"260.33 g/mol","Opticalactivity":"( + / - )","Pharmacodynamics":"Carisoprodol is a centrally acting skeletal muscle relaxant that does not act directly on skeletal muscle but acts directly on the central nervous system (CNS).  This drug relieves the painful effects of muscle spasm. A metabolite of carisoprodol, _meprobamate_, possesses both anxiolytic and sedative properties. Clinical studies have shown that this drug causes impairment of psychomotor performance in neuropsychological tests.","Physical Description":"Carisoprodol is a white powder. (NTP, 1992)","PubChemId":2576,"Record Description":["LiverTox|CNS|Muscle relaxant|Carbamate derivative"],"Records":{"UNII":{"Impurities":["2-hydroxymethyl-2-methylpentyl isopropylcarbamate","5-methyl-5-propyl-1,3-dioxan-2-one","2-(hydroxymethyl)-2-methylpentyl carbamate","meprobamate"]}},"RefChem":"54722","RefCount":5,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Carisoprodol","Name":"Carisoprodol","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q416905","Name":"Carisoprodol","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB00395","Name":"Carisoprodol","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/2576","Name":"Carisoprodol","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=78-44-4","Name":"Carisoprodol","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0014539","Name":"Carisoprodol","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C07927","Name":"Carisoprodol","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/21925K482H","Name":"Carisoprodol","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024733","Name":"Carisoprodol","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 2576, Carisoprodol. Accessed April 16, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/2576\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/2576\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Carisoprodol. UNII: 21925K482H. Global Substance Registration System. Accessed April 16, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/21925K482H\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/21925K482H\u003c/a\u003e","Soma Product information. March 14, 2003. Accessed April 16, 2026. \u003ca href=https://health-products.canada.ca/dpd-bdpp/info?lang=eng\u0026code=205\u003ehttps://health-products.canada.ca/dpd-bdpp/info?lang=eng\u0026code=205\u003c/a\u003e","Notice of consultation: Removing carisoprodol from the Prescription Drug List (PDL). February 18, 2025. Accessed April 16, 2026. \u003ca href=https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/prescription-drug-list/notices-changes/consultation-removal-carisoprodol.html\u003ehttps://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/prescription-drug-list/notices-changes/consultation-removal-carisoprodol.html\u003c/a\u003e"],"SMILES":"CCCC(C)(COC(=O)N)COC(=O)NC(C)C","SaltData":[],"Salts":[],"Scheduling":[{"gov":"Australia","ref":[],"schedule":"S4 substance"},{"gov":"Canada","ref":["3","4"],"schedule":"Schedule IV substance"},{"act":"Controlled Substances Act (CSA)","gov":"United States","ref":[],"schedule":"Schedule I"}],"Solubility":"less than 1 mg/mL at 67.1 °F (NTP, 1992)","Stability/Shelf Life":"STABLE IN DIL ACIDS \u0026 ALKALIES.","StereoisomerData":[{"ChemicalClasses":[],"SMILES":"CCC[C@](C)(COC(N)=O)COC(=O)NC(C)C","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" 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