{"Abbreviation":"Ubenimex","Aliases":["Ubenimex","Ubenimexum","NK-421","NK 421","(3-Amino-2-hydroxy-4-phenylbutanoyl)-L-leucine","((2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl)-L-leucine","(S-(R*,S*))-N-(3-Amino-2-hydroxy-4-phenylbutyroyl)-L-leucine","Leucine, N-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-, (S-(R*,S*))-","([2S,3R]-3-Amino-2-hydroxy-4-phenylbutanoyl)-L-leucine","(2S)-2-(((2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl)amino)-4-methylpentanoic acid","3-amino-2-hydroxy-4-phenylbutyryl-L-leucine","2-((3-amino-2-hydroxy-4-phenylbutanoyl)amino)-4-methylpentanoic acid","(2R)-2-((2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido)-4-methylpentanoic acid","N-((2S,3R)-4-phenyl-3-amino-2-hydroxybutyryl)-L-leucine","(S-(R*,S*))-N-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-L-leucine","(2S)-2-(((2S,3R)-3-azaniumyl-2-hydroxy-4-phenylbutanoyl)amino)-4-methylpentanoate","(2S)-2-((2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoylamino)-4-methylpentanoic acid","261-529-2","2-((2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido)-4-methylpentanoic acid","N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine","N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutyl]-L-leucine","(2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanoic acid","Bestatin;Ubenimex","Leucine, N-[(2S,3R)-3-amino-2-hydroxy-1-oxo-4-phenylbutyl]-","2-(3-Amino-2-hydroxy-4-phenyl-butyrylamino)-4-methyl-pentanoic acid"],"CAS":"58970-76-6","ChEMBL":"CHEMBL29292","ChemicalClasses":["amino acid"],"Chirality":"achiral","ChiralityAminoAcid":true,"Classes":["Protease inhibitor"],"Drug Indication":"An adjuvant therapy used  for acute and chronic myelonous leukemia, lung cancer and nasopharyngeal cancer. It is also used to treat hypercholesterolaemia.","EINECS":"261-529-2","Erowid Experience Reports":null,"Esters":[],"European Community (EC) Number":"261-529-2","Formating":[],"HeavyAtomCount":22,"Human Drugs":"Rare disease (orphan) drug","IUPACName":"(2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid","InChI":"InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1","InChIKey":"VGGGPCQERPFHOB-RDBSUJKOSA-N","MeSH Pharmacological Classification":"Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund\u0026apos;s adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)","MolecularFormula":"C\u003csub\u003e16\u003c/sub\u003eH\u003csub\u003e24\u003c/sub\u003eN\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e","MolecularWeight":"308.37 g/mol","PubChemId":72172,"RefCount":2,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/6-Nitroquipazine","Name":"Bestatin","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB03424","Name":"Bestatin","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/72172","Name":"Bestatin","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL29292","Name":"Bestatin","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=58970-76-6","Name":"Bestatin","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/I0J33N5627","Name":"Bestatin","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID4048430","Name":"Bestatin","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 72172, Bestatin. 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