{"ATC Code":"M03BX01","Abbreviation":[],"Aliases":["Baclofen","baclofen","Lioresal","4-Amino-3-(4-chlorophenyl)butanoic acid","Baclon","Kemstro","Baclofene","Baclofeno","Baclofenum","Baclophen","Lioresal Intrathecal","BACLOFEN","β-(4-Chlorophenyl)gaba","4-Amino-3-(4-chlorophenyl)butyric acid","Gablofen","Ba-34647","Ciba 34,647-Ba","4-Amino-3-p-chlorophenylbutanoic acid","β-(Aminomethyl)-4-chlorobenzenepropanoic acid","Ba-34,647","C 34647Ba","β-(p-Chlorophenyl)-γ-aminobutyric acid","Ba 34647","β-(Aminomethyl)-p-chlorohydrocinnamic acid","γ-Amino-β-(p-chlorophenyl)butyric acid"],"Biological Half-Life":"The half-life is 2-6 hours after oral administration and 1-5 hours following intrathecal administration. The apparent elimination half-life of baclofen oral suspension or granules is about 5.6 hours.","CAS":"1134-47-0","ChEBI":"CHEBI:2972","ChEMBL":"CHEMBL701","ChemicalClasses":["gabapentinoid"],"Chirality":"racemic","Drug Classes":"Breast Feeding; Lactation; Milk, Human; GABA Agonists; Muscle Relaxants, Central","Drug Indication":"Oral baclofen is indicated for the treatment of spasticity resulting from multiple sclerosis and is particularly useful for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity. It may also be used to treat patients with spinal cord injuries and other spinal cord diseases. Baclofen should not be used to treat skeletal muscle spasms resulting from rheumatic disorders.  Intrathecal baclofen is also indicated for the management of severe spasticity of the cerebral or spinal original in patients 4 years of age and older. It is reserved for patients unresponsive to oral baclofen therapy, or those who experience intolerable central nervous system side effects at effective doses. For use in spasticity due to traumatic brain injury, baclofen should be considered after at least one year of injury.","EINECS":"214-486-9","Erowid Experience Reports":[{"Author":"Zack","Id":"100438","Title":"Too Much with Euphoria"},{"Author":"ozonelayer","Id":"104802","Title":"Like Alcohol but Without the Good Aspects"},{"Author":"Amara_V","Id":"106749","Title":"Euphoric Surprise"},{"Author":"Bear","Id":"113539","Title":"Helps With the Alcohol Withdrawals"},{"Author":"pillsguy","Id":"115205","Title":"Lasts Longer No Euphoria"},{"Author":"RexC","Id":"115987","Title":"Relaxation"},{"Author":"jmo","Id":"61520","Title":"A Variety of Effects"},{"Author":"Flowers","Id":"78730","Title":"Like Spinning in Circles for Hours"},{"Author":"Pallinard","Id":"92586","Title":"Limtless Addiction Healing"},{"Author":"Nicole ","Id":"92444","Title":"Long Euphoric High"},{"Author":"Yesterday","Id":"92881","Title":"The Addiction Saviour"},{"Author":"Blinds8","Id":"95934","Title":"Was the Right Choice"},{"Author":"Little Shulgin","Id":"97469","Title":"A Powerful Anti-Alcohol Therapeutic Agent"},{"Author":"Sir Gallahad","Id":"79539","Title":"Comparable to Alcohol"}],"Esters":[],"European Community (EC) Number":"214-486-9","FDA Pharmacological Classification":"H789N3FKE8","Formating":[],"HMDB ID":"HMDB0014327","HeavyAtomCount":14,"Human Drugs":"Breast Feeding; Lactation; Milk, Human; GABA Agonists; Muscle Relaxants, Central","IUPACName":"4-amino-3-(4-chlorophenyl)butanoic acid","InChI":"InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)","InChIKey":"KPYSYYIEGFHWSV-UHFFFAOYSA-N","MeSH Pharmacological Classification":"A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358)","Melting Point":"372 to 376 °F (NTP, 1992)","MolecularFormula":"C\u003csub\u003e10\u003c/sub\u003eH\u003csub\u003e12\u003c/sub\u003eClNO\u003csub\u003e2\u003c/sub\u003e","MolecularWeight":"213.66 g/mol","Pharmacodynamics":"Baclofen is an antispasmodic agent that induces muscle relaxation. It reduces the release of excitatory neurotransmitters in the pre-synaptic neurons and stimulates inhibitory neuronal signals in the post-synaptic neurons. Oral formulations of baclofen are the most commonly used form of the drug. In one cross-section study, intrathecal baclofen was more effective than oral baclofen in relieving spasticity directly at the level of the spinal cord. Baclofen has CNS depression properties and can cause sedation with tolerance, somnolence, ataxia, and respiratory and cardiovascular depression. Baclofen also mediates some antinociceptive effects and stimulates gastric acid secretion.  Baclofen exhibits anti-inflammatory and neuroprotective activities: it inhibits the release of pro-inflammatory cytokines from microglia and astrocytes, and decreases oxidative stress in rats.","Physical Description":"Baclofen appears as odorless or practically odorless white to off-white crystalline powder. (NTP, 1992)","PubChemId":2284,"RefCount":2,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Baclofen","Name":"Baclofen","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB00181","Name":"Baclofen","Sub":false},{"Link":"https://go.drugbank.com/drugs/DB12098","Name":"(S)-Baclofen","Sub":true},{"Link":"https://go.drugbank.com/drugs/DB08891","Name":"(R)-Baclofen","Sub":true}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/2284","Name":"Baclofen","Sub":false},{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/44600","Name":"(S)-Baclofen","Sub":true},{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/44602","Name":"(R)-Baclofen","Sub":true}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL701","Name":"Baclofen","Sub":false},{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL302213","Name":"(S)-Baclofen","Sub":true},{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL301742","Name":"(R)-Baclofen","Sub":true}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:2972","Name":"Baclofen","Sub":false},{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:190735","Name":"(R)-Baclofen","Sub":true}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=1134-47-0","Name":"Baclofen","Sub":false},{"Link":"https://commonchemistry.cas.org/detail?cas_rn=66514-99-6","Name":"(S)-Baclofen","Sub":true},{"Link":"https://commonchemistry.cas.org/detail?cas_rn=69308-37-8","Name":"(R)-Baclofen","Sub":true}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0014327","Name":"Baclofen","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D00241","Name":"Baclofen","Sub":false},{"Link":"https://www.kegg.jp/entry/C21605","Name":"(R)-Baclofen","Sub":true}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/H789N3FKE8","Name":"Baclofen","Sub":false},{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/3OHN4989XM","Name":"(S)-Baclofen","Sub":true},{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/NYU6UTW25B","Name":"(R)-Baclofen","Sub":true}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022641","Name":"Baclofen","Sub":false},{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID90219366","Name":"(R)-Baclofen","Sub":true}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 2284, Baclofen. Accessed August 6, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/2284\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/2284\u003c/a\u003e"],"SMILES":"C1=CC(=CC=C1C(CC(=O)O)CN)Cl","SaltData":[],"Salts":[],"Solubility":"less than 1 mg/mL at 64 °F (NTP, 1992)","StereoisomerData":[{"Aliases":["(S)-Baclofen","(S)-4-Amino-3-(4-chlorophenyl)butanoic acid","l-Baclofen","S(+)-Baclofen","L-(+)-Baclofen","(L)-Baclofen","Baclofen, (S)-","Baclofen, s-","Baclofen, s(+)-","Benzenepropanoic acid, β-(aminomethyl)-4-chloro-, (βS)-","Benzenepropanoic acid, β-(aminomethyl)-4-chloro-, (βs)-","(S) 4-Amino-3-(4-Chlorophenyl)Butanoic Acid","689-965-2","(+)-Baclofen; (L)-Baclofen","Cas-1134-47-0","Tocris-0417","Lopac-B-5399","orb1705303","DB12098","FB18126","Ncgc00015156-01","Ncgc00015156-02","Ncgc00015156-03","Ncgc00015156-09","Ncgc00015156-10"],"PubChemId":44600,"SMILES":"C1=CC(=CC=C1[C@H](CC(=O)O)CN)Cl","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" 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class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Title":"(S)-Baclofen","UNII":"3OHN4989XM"},{"Aliases":["(R)-Baclofen","Arbaclofen","(R)-4-Amino-3-(4-chlorophenyl)butanoic acid","d-Baclofen","(R)-(-)-Baclofen","R-(-)-Baclofen","STX209","Baclofen, r-","STX 209","Baclofen, (r)-","Baclofen, r(-)-","Arbaclofene","Arbaclofeno","STX-209","Baclofen (r)-form","p-chlorophenyl GABA","ARBACLOFEN","Benzenepropanoic acid, β-(aminomethyl)-4-chloro-, (R)-","Benzeneporopanoic acid, (β-(aminomethyl)-4-chloro-, (βR)-","(-)-(3R)-4-amino-3-(4-chlorophenyl)butanoic acid","Benzenepropanoic acid, β-(aminomethyl)-4-chloro-, (r)-","Benzenepropanoic acid, β-(aminomethyl)-4-chloro-, (βr)-","arbaclofenum","Baclofen R-","(R) 4-Amino-3-(4-Chlorophenyl)Butanoic Acid"],"PubChemId":44602,"SMILES":"C1=CC(=CC=C1[C@@H](CC(=O)O)CN)Cl","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 82.428 75.09\"\u003e\u003crect width=\"100%\" 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