{"ATC Code":"N - Nervous system","Abbreviation":"","Aliases":["Allypropymal","Alurate","Allylpropymal","Aprobarbitone","Allonal","Allional","Aprozal","Numal","Allylisopropylmalonylurea","5-Allyl-5-isopropylbarbituric acid","Alurate elixir verdum","Allylisopropylbarbituric acid","Isopropylallylbarbituric acid","5-Isopropyl-5-allylbarbituric acid","Aprobarbitalum","Barbituric acid, 5-allyl-5-isopropyl-","5-(1-Methylethyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione","5-allyl-5-isopropylpyrimidine-2,4,6(1H,3H,5H)-trione","5-(prop-2-en-1-yl)-5-(propan-2-yl)-1,3-diazinane-2,4,6-trione","N05CA05","200-997-4","Aprobarbita","Allypropymalum","Isonal","Aprobarbitale"],"Biological Half-Life":"APROBARBITAL DOSE 0.75 G ORAL REACHED CONCN 2.3 MG% IN 3-9 HR; T/2 WAS 24-36 HR. /FROM TABLE/","CAS":"77-02-1","ChEBI":"CHEBI:2791","ChEMBL":"CHEMBL7863","ChemicalClasses":["barbiturate"],"Chirality":"achiral","Color/Form":"CRYSTALS","Decomposition":"When heated to decomp it emits toxic fumes of oxides of nitrogen. /Aprobarbital sodium/","Drug Warnings":"May be habit forming.","EINECS":"200-997-4","EliminationHalfLife":"","Erowid Experience Reports":[],"Esters":[],"European Community (EC) Number":"200-997-4","Formating":[],"HMDB ID":"HMDB0015441","HeavyAtomCount":15,"IUPACName":"5-propan-2-yl-5-prop-2-enyl-1,3-diazinane-2,4,6-trione","InChI":"InChI=1S/C10H14N2O3/c1-4-5-10(6(2)3)7(13)11-9(15)12-8(10)14/h4,6H,1,5H2,2-3H3,(H2,11,12,13,14,15)","InChIKey":"UORJNBVJVRLXMQ-UHFFFAOYSA-N","Melting Point":"140-141.5 °C","MolecularFormula":"C\u003csub\u003e10\u003c/sub\u003eH\u003csub\u003e14\u003c/sub\u003eN\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e3\u003c/sub\u003e","MolecularWeight":"210.23 g/mol","Physical Description":"Solid","PubChemId":6464,"RefCount":4,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Aprobarbital","Name":"Aprobarbital","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q411940","Name":"Aprobarbital","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB01352","Name":"Aprobarbital","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/6464","Name":"Aprobarbital","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL7863","Name":"Aprobarbital","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:2791","Name":"Aprobarbital","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=77-02-1","Name":"Aprobarbital","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0015441","Name":"Aprobarbital","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C07826","Name":"Aprobarbital","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/Q0YKG9L6RF","Name":"Aprobarbital","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID8022616","Name":"Aprobarbital","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 6464, Aprobarbital. Accessed July 13, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/6464\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/6464\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Aprobarbital. UNII: Q0YKG9L6RF. Global Substance Registration System. Accessed July 13, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/Q0YKG9L6RF\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/Q0YKG9L6RF\u003c/a\u003e","Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. March 31, 2023. Accessed July 13, 2025. \u003ca href=https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992\u003ehttps://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992\u003c/a\u003e"],"SMILES":"CC(C)C1(C(=O)NC(=O)NC1=O)CC=C","SaltData":[],"Salts":[],"Scheduling":[{"gov":"Brazil","ref":["3"],"schedule":"B1 substance"},{"gov":"Canada","ref":[],"schedule":"Schedule IV substance"}],"Solubility":"POWDER; HYGROSCOPIC; SLIGHTLY BITTER TASTE; VERY SOL IN WATER; SLIGHTLY SOL IN ALC; PRACTICALLY INSOL IN ETHER; AQ SOLN ARE ALKALINE TO LITMUS /APROBARBITAL SODIUM SALT/","Stability/Shelf Life":"STABLE IN AIR","StereoisomerData":[],"Stereoisomers":["(+)-Aprobarbital","(-)-Aprobarbital"],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 58.437 87.538\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#3050f8\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h59v88H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m33.801 12.724 5.214 14.32M39.015 27.044l15.009 2.645M39.015 27.044 29.221 38.72M29.221 38.72l-13.204 7.629\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m16.017 47.756-10.532-6.08M17.236 45.644l-10.532-6.08\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m5.485 41.676 5.266 3.04M6.704 39.564l5.266 3.04\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath d=\"m16.017 46.349-.003 11.398M19.166 63.418l10.045 5.799\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m30.43 68.513.002 12.022M27.991 68.513l.002 12.023\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m30.432 80.535-.001-6.011M27.993 80.536l-.001-6.011\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath d=\"m29.211 69.217 10.05-5.807M42.415 57.739l.004-11.399M29.221 38.72l13.198 7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m41.199 45.636 10.529-6.076M42.418 47.748l10.529-6.076\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m51.728 39.56-5.265 3.038M52.947 41.672l-5.264 3.038\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath d=\"m29.221 38.72-9.799-11.672M19.422 27.048l5.209-14.322\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M24.631 12.726 14.833 1.053M21.859 13.215 12.965 2.621\"/\u003e\u003c/g\u003e\u003cpath fill=\"#ff0d0d\" stroke=\"none\" d=\"M5.078 38.726q0 .756-.256 1.327-.256.566-.756.881t-1.244.316q-.756 0-1.262-.316-.506-.315-.756-.887-.244-.571-.244-1.333 0-.75.244-1.31.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.309.756.875t.256 1.328m-3.863 0q0 .922.387 1.458.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.458 0-.929-.387-1.453-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.453\" class=\"atom\"/\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M17.953 64.047h-.72l-2.619-4.066h-.03l.03.595q.023.357.023.732v2.739h-.565v-4.9h.714l2.608 4.054h.029l-.017-.327-.024-.476q-.006-.262-.006-.483v-2.768h.577zM13.51 64.047h-.619v-2.286h-2.512v2.286h-.613v-4.9h.613v2.072h2.512v-2.072h.619z\"/\u003e\u003c/g\u003e\u003cpath fill=\"#ff0d0d\" stroke=\"none\" d=\"M31.472 84.454q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.31.25-.565.756-.881.506-.315 1.274-.315.732 0 1.232.315.5.31.756.875.256.566.256 1.328m-3.863 0q0 .923.387 1.459.393.529 1.22.529.84 0 1.221-.529.387-.536.387-1.459 0-.929-.387-1.453-.381-.523-1.209-.523-.833 0-1.226.523-.393.524-.393 1.453\" class=\"atom\"/\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M44.355 64.038h-.721l-2.619-4.066h-.03l.03.596q.024.357.024.732v2.738h-.566v-4.899h.715l2.607 4.054h.03l-.018-.328-.024-.476q-.006-.262-.006-.482v-2.768h.578zM48.661 64.038h-.619v-2.286h-2.513v2.286h-.613v-4.899h.613v2.071h2.513v-2.071h.619z\"/\u003e\u003c/g\u003e\u003cpath fill=\"#ff0d0d\" stroke=\"none\" d=\"M57.877 38.719q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.309.756.875.256.565.256 1.327m-3.863 0q0 .923.387 1.459.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.459 0-.929-.387-1.452-.381-.524-1.209-.524-.833 0-1.226.524-.393.523-.393 1.452\" class=\"atom\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m16.014 57.747.001-5.699M16.014 57.747l.001-5.699M19.166 63.418l5.022 2.899M19.166 63.418l5.022 2.899M39.261 63.41l-5.025 2.904M42.415 57.739l.002-5.699\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Taste":"SLIGHTLY BITTER","Therapeutic Uses":"BARBITURATES MAY BE USED FOR PREANESTHETIC MEDICATION \u0026 TO PRODUCE BASAL ANESTHESIA. ... BARBITURATES ARE EMPLOYED AS DIAGNOSTIC \u0026 THERAPEUTIC AIDS IN PSYCHIATRY, IN NARCOANALYSIS \u0026 NARCOTHERAPY. /BARBITURATES/","Title":"Aprobarbital","UNII":"Q0YKG9L6RF","Wikidata":"Q411940","Wikipedia":"Aprobarbital","XLogP":1.1,"pH":"A SATURATED AQUEOUS SOLN IS ACID TO LITMUS"}