{"ATC Code":"N - Nervous system","Abbreviation":"","Aliases":["Amylobarbitone","Isomytal","Amylobarbital","Barbamil","Barbamyl","Amytal","Amobarbitone","Amylbarbitone","Pentymal","Barbamyl acid","Binoctal","Dorlotyn","Dormytal","Mylodorm","Pentymalum","Schiwanox","Sednotic","Stadadorm","Amasust","Amital","Amospan","Amybal","Robarb","Somnal","Sumital"],"Biological Half-Life":"Following bolus iv administration, plasma concentrations of amobarbital decline in a biphasic manner with a half-life of about 40 minutes for the first phase and 20-25 hours for the second phase, although the second phase half-life has ranged from 14-42 hours in individual patients.","CAS":"57-43-2","ChEBI":"CHEBI:2673","ChEMBL":"CHEMBL267894","ChemicalClasses":["barbiturate"],"Chirality":"achiral","Color/Form":"Crystals","Decomposition":"When heated to decomposition, it emits toxic fumes of /nitric oxides/.","Drug Warnings":"Amobarbital (no longer commercially available in the US) and amobarbital sodium share the toxic potentials of the barbiturates, and the usual precautions of barbiturate administration should be observed.","EINECS":"200-330-7","EliminationHalfLife":"8 – 42 hours","Erowid Experience Reports":[],"Esters":[],"European Community (EC) Number":"200-330-7","Formating":[],"HMDB ID":"HMDB0015440","HeavyAtomCount":16,"Human Drugs":"Pharmaceuticals","IUPACName":"5-ethyl-5-(3-methylbutyl)-1,3-diazinane-2,4,6-trione","InChI":"InChI=1S/C11H18N2O3/c1-4-11(6-5-7(2)3)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16)","InChIKey":"VIROVYVQCGLCII-UHFFFAOYSA-N","MeSH Pharmacological Classification":"Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. (See all compounds classified as GABA Modulators.)","Melting Point":"313 to 316 °F (NTP, 1992)","MolecularFormula":"C\u003csub\u003e11\u003c/sub\u003eH\u003csub\u003e18\u003c/sub\u003eN\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e3\u003c/sub\u003e","MolecularWeight":"226.27 g/mol","Odor":"Odorless","Physical Description":"Amobarbital is a white crystalline solid with no odor and a slightly bitter taste. (NTP, 1992)","PubChemId":2164,"Record Description":["LiverTox|CNS|Sedative/Hypnotic|Barbiturate"],"RefCount":4,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Amobarbital","Name":"Amobarbital","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q415850","Name":"Amobarbital","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB01351","Name":"Amobarbital","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/2164","Name":"Amobarbital","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL267894","Name":"Amobarbital","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:2673","Name":"Amobarbital","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=57-43-2","Name":"Amobarbital","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0015440","Name":"Amobarbital","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D00555","Name":"Amobarbital","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/GWH6IJ239E","Name":"Amobarbital","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020081","Name":"Amobarbital","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 2164, Amobarbital. Accessed July 13, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/2164\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/2164\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Amobarbital. UNII: GWH6IJ239E. Global Substance Registration System. Accessed July 13, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/GWH6IJ239E\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/GWH6IJ239E\u003c/a\u003e","Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. March 31, 2023. Accessed July 13, 2025. \u003ca href=https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992\u003ehttps://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992\u003c/a\u003e"],"Reported Fatal Dose":"The toxic dose of barbiturates varies considerably but, in general, a severe reaction is likely to occur when the amount ingested is more than 10 times the usual oral hypnotic dose. Potentially lethal blood concentrations are those in excess of 80 ug/mL for phenobarbital, 50 ug/mL for amobarbital or butabarbital, and approximately 30 ug/mL for secobarbital or pentobarbital; however, some patients have survived much higher blood concentrations. /Barbiturates General Statement/","SMILES":"CCC1(C(=O)NC(=O)NC1=O)CCC(C)C","SaltData":[{"AcidCount":1,"AmineCount":1,"Formula":"[Na+]","Name":"sodium","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 83.41 101.816\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#3050f8\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h84v102H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m34.942 27.002 5.214 14.32M40.156 41.322l-9.795 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Barbiturate","Title":"Amobarbital","UNII":"GWH6IJ239E","Wikidata":"Q415850","Wikipedia":"Amobarbital","XLogP":2.1,"pH":"Solutions are acid to litmus"}