{"Abbreviation":"","Aliases":["Airomate","Afloqualonum","Aflocualona","6-amino-2-(fluoromethyl)-3-(o-tolyl)-4(3H)-quinazolinone","6-Amino-2-fluoromethyl-3-(2-tolyl)-3H-quinazolin-4-one","Arofuto","Aroft","Afloqualon","4(3H)-Quinazolinone, 6-amino-2-(fluoromethyl)-3-(2-methylphenyl)-","Afloqualona","HQ 495","HQ-495","6-Amino-2-(fluoromethyl)-3-o-tolyl-4(3H)-chinazolinon","6-Amino-2-(fluoromethyl)-3-o-tolyl-4(3H)-quinazolinone","6-Amino-2-fluoromethyl-3-(o-tolyl)-4(3H)-quinazolinone","6-amino-2-(fluoromethyl)-3-(o-tolyl)quinazolin-4(3H)-one","6-amino-2-(fluoromethyl)-3-(2-methylphenyl)-4(3H)-Quinazolinone","6-Amino-3,4-dihydro-2-fluoromethyl-3-(2-methylphenyl)-4-chinazolinon","4(3H)-Quinazolinone, 6-amino-2-fluoromethyl-3-(o-tolyl)-","C16H14FN3O","6-Amino-2-(fluoromethyl)-3-(2-methylphenyl)-quinazolin-4-one","6-amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4(3H)-one","Mls006010086","HY-B1833R","HMS3885G19"],"CAS":"56287-74-2","ChEBI":"CHEBI:31177","ChEMBL":"CHEMBL2105918","ChemicalClasses":["quinazolinone"],"Chirality":"achiral","Classes":["Sedative"],"EliminationHalfLife":"","Erowid Experience Reports":[],"Esters":[],"European Community (EC) Number":"109-719-5","Formating":[],"HeavyAtomCount":21,"IUPACName":"6-amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4-one","InChI":"InChI=1S/C16H14FN3O/c1-10-4-2-3-5-14(10)20-15(9-17)19-13-7-6-11(18)8-12(13)16(20)21/h2-8H,9,18H2,1H3","InChIKey":"VDOSWXIDETXFET-UHFFFAOYSA-N","MeSH Pharmacological Classification":"A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358) (See all compounds classified as Muscle Relaxants, Central.)","MolecularFormula":"C\u003csub\u003e16\u003c/sub\u003eH\u003csub\u003e14\u003c/sub\u003eFN\u003csub\u003e3\u003c/sub\u003eO","MolecularWeight":"283.30 g/mol","PubChemId":2040,"Record Description":["Wikipedia|List of designer drugs|Sedatives|Methaqualone analogues"],"RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Afloqualone","Name":"Afloqualone","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q4689289","Name":"Afloqualone","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/2040","Name":"Afloqualone","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2105918","Name":"Afloqualone","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:31177","Name":"Afloqualone","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=56287-74-2","Name":"Afloqualone","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D01638","Name":"Afloqualone","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/CO4U2C8ORZ","Name":"Afloqualone","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022562","Name":"Afloqualone","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 2040, Afloqualone. Accessed July 13, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/2040\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/2040\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Afloqualone. UNII: CO4U2C8ORZ. Global Substance Registration System. Accessed July 13, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/CO4U2C8ORZ\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/CO4U2C8ORZ\u003c/a\u003e"],"SMILES":"CC1=CC=CC=C1N2C(=NC3=C(C2=O)C=C(C=C3)N)CF","SaltData":[],"Salts":[],"Scheduling":[{"gov":"United States","ref":[],"schedule":"Unscheduled substance"}],"StereoisomerData":[],"Stereoisomers":["(+)-Afloqualone","(-)-Afloqualone"],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 115.718 72.269\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#3050f8\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h116v73H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m101.316 25.873.124 15.239\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m114.511 48.549-13.071-7.437M112.088 49.976l-10.625-6.045\"/\u003e\u003c/g\u003e\u003cpath d=\"m114.511 48.549.168 15.059\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m101.777 71.229 12.902-7.621M101.726 68.427l10.499-6.202\"/\u003e\u003c/g\u003e\u003cpath d=\"m101.777 71.229-13.396-7.268\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m88.538 48.734-.157 15.227M90.962 50.134l-.128 12.384\"/\u003e\u003c/g\u003e\u003cpath d=\"m101.44 41.112-12.902 7.622M88.538 48.734l-10.044-5.801M75.341 37.262v-11.39\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m75.341 25.872-10.055-5.801M72.902 27.28l-8.834-5.097\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m65.286 20.071 5.028 2.9M64.068 22.183l4.417 2.549\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath d=\"m58.979 20.071-10.054 5.801\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M48.925 41.112v-15.24M46.486 39.703V27.28\"/\u003e\u003c/g\u003e\u003cpath d=\"m48.925 41.112 13.208 7.62M72.187 42.931l-10.054 5.801\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M63.352 48.028v12.023M60.913 48.028v12.023\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"M63.352 60.051V54.04M60.913 60.051V54.04\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath d=\"m48.925 41.112-13.208 7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m22.509 41.112 13.208 7.62M24.947 39.703l10.77 6.214\"/\u003e\u003c/g\u003e\u003cpath d=\"M22.509 41.112v-15.24\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m35.717 18.252-13.208 7.62M35.717 21.067l-10.77 6.213\"/\u003e\u003c/g\u003e\u003cpath d=\"m48.925 25.872-13.208-7.62M22.509 41.112l-10.044 5.801M75.341 25.872l13.197-7.622M88.538 18.25l-.002-12.175\" class=\"bond\"/\u003e\u003cpath stroke=\"none\" d=\"M77.281 43.562h-.72l-2.619-4.066h-.03l.03.595q.024.357.024.732v2.739H73.4v-4.9h.714l2.608 4.054h.03l-.018-.327-.024-.476q-.006-.262-.006-.483v-2.768h.577zM64.073 20.702h-.72l-2.619-4.066h-.03l.03.595q.024.357.024.732v2.739h-.566v-4.9h.714l2.608 4.054h.03l-.018-.327-.024-.476q-.006-.262-.006-.483v-2.768h.577z\" class=\"atom\"/\u003e\u003cpath fill=\"#ff0d0d\" stroke=\"none\" d=\"M64.392 63.969q0 .756-.256 1.327-.256.566-.756.881t-1.244.316q-.756 0-1.262-.316-.506-.315-.756-.887-.245-.571-.245-1.333 0-.75.245-1.31.25-.565.756-.881.506-.315 1.274-.315.732 0 1.232.315.5.31.756.875.256.566.256 1.328m-3.864 0q0 .923.387 1.458.393.53 1.221.53.839 0 1.22-.53.387-.535.387-1.458 0-.929-.387-1.453-.381-.524-1.208-.524-.834 0-1.227.524t-.393 1.453\" class=\"atom\"/\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M11.252 51.184h-.72l-2.619-4.066h-.03l.03.595q.024.357.024.732v2.739h-.566v-4.9h.714l2.608 4.054h.03l-.018-.327-.024-.476q-.006-.262-.006-.483v-2.768h.577zM4.305 51.184h-.62v-2.286H1.173v2.286H.56v-4.9h.613v2.072h2.512v-2.072h.62zM6.809 52.673H4.866v-.3l.772-.779q.221-.221.371-.392.154-.176.232-.34.079-.168.079-.364 0-.243-.147-.368-.142-.129-.371-.129-.214 0-.379.075-.16.075-.328.208l-.193-.243q.171-.147.393-.247.225-.1.507-.1.411 0 .65.207.239.208.239.575 0 .229-.096.433-.093.2-.264.396-.168.197-.393.418l-.615.604v.018h1.486z\"/\u003e\u003c/g\u003e\u003cpath fill=\"#90e050\" stroke=\"none\" d=\"M87.782 5.459h-.613V.56h2.733v.542h-2.12V2.84h1.994v.542h-1.994z\" class=\"atom\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m78.494 42.933 5.022 2.901M75.341 37.262v-5.695M58.979 20.071l-5.027 2.9M72.187 42.931l-5.027 2.9M12.465 46.913l5.022-2.9\" class=\"hi\"/\u003e\u003cpath stroke=\"#90e050\" d=\"m88.536 6.075.001 6.087\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Subjective Effects":null,"Title":"Afloqualone","UNII":"CO4U2C8ORZ","Wikidata":"Q4689289","Wikipedia":"Afloqualone","XLogP":2.2}