{"Abbreviation":["2M2B"],"Adverse Effects":"Neurotoxin - Acute solvent syndrome","Aliases":["tert-Amyl alcohol","2-Methylbutan-2-ol","Amylene hydrate","tert-Pentyl alcohol","tert-Pentanol","t-Amyl alcohol","2-Butanol, 2-methyl-","Dimethylethylcarbinol","Ethyldimethylcarbinol","t-Pentyl alcohol","tert-Isoamyl alcohol","1,1-Dimethyl-1-propanol","3-Methylbutan-3-ol","Dimethyl ethyl carbinol","Ethyl dimethyl carbinol","2-Methyl butanol-2","Amylenum hydratum","Amylalkohol, tertiaerer","RefChem:557962","200-908-9","methyl butanol","tert-amylalcohol","tert-n-Amyl alcohol","3-Methyl-butanol-(3)","tertiary amyl alcohol"],"Associated Disorders and Diseases":"Encephalopathy, chronic solvent [Category: Chronic Poisoning]","Biological Half-Life":"Upon repeated exposure to 50 ppm, the material /2-methyl-2-butanol/ was cleared by rats (t1/2 = 47 min) and dogs (t1/2 = 69 min) in an apparent first-order manner.","Boiling Point":"102.4 °C","CAS":"75-85-4","ChEBI":"CHEBI:132750","ChEMBL":"CHEMBL44658","ChemicalClasses":[],"Chirality":"achiral","Color/Form":"Colorless liquid","Density":"0.8096 at 20 °C/4 °C g/cm\u003csup\u003e3\u003c/sup\u003e","EINECS":"200-908-9","Ecotoxicity Values":"EC50; Species: Daphnia magna (Water flea); Conditions: freshwater, static, pH 8; Concentration: 3185 mg/L for 24 hr; Effect: behavior, equilibrium","Esters":[],"European Community (EC) Number":"200-908-9","Flash Point":"67 °F (NFPA, 2010)","Formating":[],"HMDB ID":"HMDB0033772","HeavyAtomCount":6,"IUPACName":"2-methylbutan-2-ol","InChI":"InChI=1S/C5H12O/c1-4-5(2,3)6/h6H,4H2,1-3H3","InChIKey":"MSXVEPNJUHWQHW-UHFFFAOYSA-N","Interactions":"2-Methyl-2-butanol (4.1 mmol/kg) induced a behavioral intoxication in rats (male, Sprague-Dawley, 160 to 300 g) at 8 min after the intraperitoneal administration of the pentanol. The intoxication was scored on a scale of 0 to 4, where 3 = 'very little or no recovery of righting reflex, heavy sedation, no spontaneous locomotor activity, flaccid muscles, absence of pelvic and abdominal elevation' and 2 = 'heavy sedation, pronounced motor coordination and sluggish movement, limbs extended away from the body'. After 2-methyl-2-butanol alone the intoxication was scored as approximately 2.9. The prior administration of the imidazobenzodiazepine Ro15-4513 (5 min before the alcohol) partially reversed the intoxication by 2-methyl-2-butanol and the score decreased to approximately 1.8. The Ro15-4513 was more effective at reducing the intoxication after treatment with ethanol than after treatment with the pentanol.","LD50":[{"dosages":[{"amount":"1 gm/kg","route":"oral"}],"organism":"Rat"},{"dosages":[{"amount":"2100 mg/kg","route":"subcutaneous"},{"amount":"610 mg/kg","route":"intravenous"}],"organism":"Mouse"},{"dosages":[{"amount":"2028 mg/kg","route":"oral"}],"organism":"Rabbit"}],"LDLo":[{"dosages":[{"amount":"1530 mg/kg","route":"intraperitoneal"},{"amount":"1400 mg/kg","route":"subcutaneous"},{"amount":"1400 mg/kg","route":"rectal"}],"organism":"Rat"},{"dosages":[{"amount":"2500 mg/kg","route":"oral"},{"amount":"2 gm/kg","route":"intraperitoneal"}],"organism":"Mouse"},{"dosages":[{"amount":"4 gm/kg","route":"parenteral"}],"organism":"Frog"}],"Melting Point":"-9.1 °C","MolecularFormula":"C\u003csub\u003e5\u003c/sub\u003eH\u003csub\u003e12\u003c/sub\u003eO","MolecularWeight":"88.15 g/mol","Non-Human Toxicity Values":"LD50 Rat oral 1.0-2.0 g/kg","Odor":"Characteristic odor","Physical Description":"Tert-amyl alcohol appears as a clear, colorless liquid with an odor of camphor. Slightly soluble in water.","PubChemId":6405,"Record Description":["Wikipedia|List of designer drugs|Sedatives|Misc"],"RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Tert-Amyl_alcohol","Name":"2-Methyl-2-butanol","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q209428","Name":"2-Methyl-2-butanol","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/6405","Name":"2-Methyl-2-butanol","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL44658","Name":"2-Methyl-2-butanol","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:132750","Name":"2-Methyl-2-butanol","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=75-85-4","Name":"2-Methyl-2-butanol","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0033772","Name":"2-Methyl-2-butanol","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C21401","Name":"2-Methyl-2-butanol","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/69C393R11Z","Name":"2-Methyl-2-butanol","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID0041436","Name":"2-Methyl-2-butanol","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 6405, 2-Methyl-2-butanol. Accessed September 1, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/6405\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/6405\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. 2-Methyl-2-butanol. UNII: 69C393R11Z. Global Substance Registration System. Accessed September 1, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/69C393R11Z\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/69C393R11Z\u003c/a\u003e"],"SMILES":"CCC(C)(C)O","SaltData":[],"Salts":[],"Solubility":"Solubility in water: 12.1%wt at 20 °C; 11.0%wt at 25 °C; 10.1%wt at 30 °C","Stability/Shelf Life":"SENSITIVE TO LIGHT","StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 41.671 30.516\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h42v31H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m40.633 14.236-13.198-7.62M27.435 6.616l-13.199 7.62M14.236 14.236 6.616 1.038M14.236 14.236l-13.198 7.62M14.236 14.236l5.651 9.787\" class=\"bond\"/\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M24.116 27.432q0 .756-.256 1.327-.256.566-.756.881t-1.245.316q-.756 0-1.262-.316-.506-.315-.756-.887-.244-.571-.244-1.333 0-.75.244-1.31.25-.565.756-.881t1.274-.316q.733 0 1.233.316.5.31.756.875.256.566.256 1.328m-3.864 0q0 .922.387 1.458.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.458 0-.929-.387-1.453-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.453M28.422 29.884h-.619v-2.286H25.29v2.286h-.613v-4.899h.613v2.072h2.513v-2.072h.619z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m19.887 24.023-2.825-4.893\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Taste":"Burning taste","Title":"2-Methyl-2-butanol","Toxicity Data":"LCLo (rat) = 5,700 ppm/6h","UNII":"69C393R11Z","Wikidata":"Q209428","Wikipedia":"Tert-Amyl_alcohol","XLogP":0.9,"pH":"Solution neutral to litmus"}