{"Abbreviation":"DOTFM","Aliases":["Racemic DOTFM","2-(2,5-Dimethoxy-4-trifluoromethyl-phenyl)-1-methyl-ethylamine","Q4596793","1-[2,5-Dimethoxy-4-(trifluoromethyl)phenyl]-2-propanamine","2,5-Dimethoxy-α-methyl-4-(trifluoromethyl)benzeneethanamine","Benzeneethanamine, 2,5-dimethoxy-α-methyl-4-(trifluoromethyl)-"],"CAS":"159277-07-3","ChEMBL":"CHEMBL6620","ChemicalClasses":["2,5-dimethoxyamphetamine"],"Chirality":"racemic","Classes":["Psychedelic"],"Erowid Experience Reports":[],"Esters":[],"Formating":[],"HeavyAtomCount":18,"IUPACName":"1-[2,5-dimethoxy-4-(trifluoromethyl)phenyl]propan-2-amine","InChI":"InChI=1S/C12H16F3NO2/c1-7(16)4-8-5-11(18-3)9(12(13,14)15)6-10(8)17-2/h5-7H,4,16H2,1-3H3","InChIKey":"WPGOTSORDNBMHP-UHFFFAOYSA-N","MolecularFormula":"C\u003csub\u003e12\u003c/sub\u003eH\u003csub\u003e16\u003c/sub\u003eF\u003csub\u003e3\u003c/sub\u003eNO\u003csub\u003e2\u003c/sub\u003e","MolecularWeight":"263.26 g/mol","Opticalactivity":"( + / - )","PubChemId":10400521,"RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/2,5-Dimethoxy-4-trifluoromethylamphetamine","Name":"2,5-Dimethoxy-4-trifluoromethylamphetamine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/10400521","Name":"2,5-Dimethoxy-4-trifluoromethylamphetamine","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6620","Name":"2,5-Dimethoxy-4-trifluoromethylamphetamine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=159277-07-3","Name":"2,5-Dimethoxy-4-trifluoromethylamphetamine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/NLH3FWZ9T4","Name":"2,5-Dimethoxy-4-trifluoromethylamphetamine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID40439330","Name":"2,5-Dimethoxy-4-trifluoromethylamphetamine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 10400521, 2,5-Dimethoxy-4-trifluoromethylamphetamine. Accessed July 14, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/10400521\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/10400521\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. 2,5-Dimethoxy-4-trifluoromethylamphetamine. UNII: NLH3FWZ9T4. Global Substance Registration System. Accessed July 14, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/NLH3FWZ9T4\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/NLH3FWZ9T4\u003c/a\u003e"],"SMILES":"CC(CC1=CC(=C(C=C1OC)C(F)(F)F)OC)N","SaltData":[],"Salts":[],"StereoisomerData":[{"Aliases":null,"PubChemId":null,"SMILES":"COc1cc(C(F)(F)F)c(OC)cc1C[C@@H](C)N","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 103.641 78.276\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#90e050\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h104v79H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m28.33 1.038 9.914 5.724M41.528 12.579v11.319\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m41.528 23.898-13.208 7.62M41.528 26.713l-10.769 6.214\"/\u003e\u003c/g\u003e\u003cpath d=\"M28.32 31.518v15.24M28.32 46.758 15.123 54.38M15.123 54.38 8.802 43.435M15.123 54.38 4.442 60.55M15.123 54.38l5.556 9.619\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m28.32 46.758 13.208 7.62M30.759 45.35l10.769 6.213\"/\u003e\u003c/g\u003e\u003cpath d=\"M41.528 54.378v11.319M44.804 71.509l9.922 5.729M41.528 54.378l13.208-7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M54.736 46.758v-15.24M52.298 45.35V32.927\"/\u003e\u003c/g\u003e\u003cpath d=\"m41.528 23.898 13.208 7.62M54.736 31.518l13.197-7.622M67.933 23.896l13.2 7.618\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M81.483 31.514h-.7M81.775 34.054h-1.284M82.067 36.594H80.2M82.359 39.134h-2.45M82.651 41.674h-3.034M82.943 44.214h-3.617M83.235 46.754h-4.2\"/\u003e\u003c/g\u003e\u003cpath d=\"m81.133 31.514 10.044-5.801\" class=\"bond\"/\u003e\u003cpath fill=\"#ff0d0d\" stroke=\"none\" d=\"M43.787 8.655q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.309.756.875.256.565.256 1.327m-3.863 0q0 .923.387 1.459.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.459 0-.928-.387-1.452-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.452\" class=\"atom\"/\u003e\u003cpath stroke=\"none\" d=\"M6.748 43.633h-.613v-4.899h2.732v.541H6.748v1.739h1.994v.541H6.748zM1.173 64.452H.56v-4.899h2.732v.541H1.173v1.739h1.994v.541H1.173zM21.992 70.027h-.613v-4.899h2.733v.541h-2.12v1.739h1.995v.541h-1.995z\" class=\"atom\"/\u003e\u003cpath fill=\"#ff0d0d\" stroke=\"none\" d=\"M43.787 69.615q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.309.756.875.256.565.256 1.327m-3.863 0q0 .923.387 1.459.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.459 0-.928-.387-1.452-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.452\" class=\"atom\"/\u003e\u003cg fill=\"#3050f8\" stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M96.27 26.342h-.72l-2.619-4.066h-.03l.03.595q.024.357.024.732v2.739h-.566v-4.9h.714l2.608 4.054h.03l-.018-.327-.024-.476q-.006-.262-.006-.483v-2.768h.577zM100.577 26.342h-.619v-2.286h-2.513v2.286h-.613v-4.9h.613v2.072h2.513v-2.072h.619zM103.081 27.831h-1.943v-.3l.772-.779q.221-.221.371-.393.154-.175.232-.339.079-.168.079-.364 0-.243-.146-.368-.143-.129-.372-.129-.214 0-.378.075-.161.075-.329.207l-.193-.242q.171-.147.393-.247.225-.1.507-.1.411 0 .65.207t.24.575q0 .229-.097.433-.093.2-.264.396-.168.196-.393.418l-.614.604v.017h1.485z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"#ff0d0d\" d=\"M38.244 6.762 33.287 3.9M41.528 12.579v5.66\" class=\"hi\"/\u003e\u003cpath stroke=\"#90e050\" d=\"m8.802 43.435 3.16 5.472M4.442 60.55l5.34-3.085M20.679 63.999l-2.778-4.809\" class=\"hi\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"M41.528 65.697v-5.659M44.804 71.509l4.961 2.865\" class=\"hi\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m91.177 25.713-5.022 2.901\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Title":"(R)-2,5-Dimethoxy-4-trifluoromethylamphetamine","UNII":null},{"Aliases":null,"PubChemId":null,"SMILES":"COc1cc(C(F)(F)F)c(OC)cc1C[C@H](C)N","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 103.641 78.276\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#90e050\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h104v79H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m28.33 1.038 9.914 5.724M41.528 12.579v11.319\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m41.528 23.898-13.208 7.62M41.528 26.713l-10.769 6.214\"/\u003e\u003c/g\u003e\u003cpath d=\"M28.32 31.518v15.24M28.32 46.758 15.123 54.38M15.123 54.38 8.802 43.435M15.123 54.38 4.442 60.55M15.123 54.38l5.556 9.619\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m28.32 46.758 13.208 7.62M30.759 45.35l10.769 6.213\"/\u003e\u003c/g\u003e\u003cpath d=\"M41.528 54.378v11.319M44.804 71.509l9.922 5.729M41.528 54.378l13.208-7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M54.736 46.758v-15.24M52.298 45.35V32.927\"/\u003e\u003c/g\u003e\u003cpath d=\"m41.528 23.898 13.208 7.62M54.736 31.518l13.197-7.622M67.933 23.896l13.2 7.618\" class=\"bond\"/\u003e\u003cpath fill=\"#000\" stroke=\"none\" d=\"M81.483 31.514h-.7l-1.748 15.24h4.2z\" class=\"bond\"/\u003e\u003cpath d=\"m81.133 31.514 10.044-5.801\" class=\"bond\"/\u003e\u003cpath fill=\"#ff0d0d\" stroke=\"none\" d=\"M43.787 8.655q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.309.756.875.256.565.256 1.327m-3.863 0q0 .923.387 1.459.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.459 0-.928-.387-1.452-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.452\" class=\"atom\"/\u003e\u003cpath stroke=\"none\" d=\"M6.748 43.633h-.613v-4.899h2.732v.541H6.748v1.739h1.994v.541H6.748zM1.173 64.452H.56v-4.899h2.732v.541H1.173v1.739h1.994v.541H1.173zM21.992 70.027h-.613v-4.899h2.733v.541h-2.12v1.739h1.995v.541h-1.995z\" class=\"atom\"/\u003e\u003cpath fill=\"#ff0d0d\" stroke=\"none\" d=\"M43.787 69.615q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.309.756.875.256.565.256 1.327m-3.863 0q0 .923.387 1.459.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.459 0-.928-.387-1.452-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.452\" class=\"atom\"/\u003e\u003cg fill=\"#3050f8\" stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M96.27 26.342h-.72l-2.619-4.066h-.03l.03.595q.024.357.024.732v2.739h-.566v-4.9h.714l2.608 4.054h.03l-.018-.327-.024-.476q-.006-.262-.006-.483v-2.768h.577zM100.577 26.342h-.619v-2.286h-2.513v2.286h-.613v-4.9h.613v2.072h2.513v-2.072h.619zM103.081 27.831h-1.943v-.3l.772-.779q.221-.221.371-.393.154-.175.232-.339.079-.168.079-.364 0-.243-.146-.368-.143-.129-.372-.129-.214 0-.378.075-.161.075-.329.207l-.193-.242q.171-.147.393-.247.225-.1.507-.1.411 0 .65.207t.24.575q0 .229-.097.433-.093.2-.264.396-.168.196-.393.418l-.614.604v.017h1.485z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"#ff0d0d\" d=\"M38.244 6.762 33.287 3.9M41.528 12.579v5.66\" class=\"hi\"/\u003e\u003cpath stroke=\"#90e050\" d=\"m8.802 43.435 3.16 5.472M4.442 60.55l5.34-3.085M20.679 63.999l-2.778-4.809\" class=\"hi\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"M41.528 65.697v-5.659M44.804 71.509l4.961 2.865\" class=\"hi\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m91.177 25.713-5.022 2.901\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Title":"(S)-2,5-Dimethoxy-4-trifluoromethylamphetamine","UNII":null}],"StereoisomerType":"enantiomer","Stereoisomers":["(R)-2,5-Dimethoxy-4-trifluoromethylamphetamine","(S)-2,5-Dimethoxy-4-trifluoromethylamphetamine"],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 103.641 78.276\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#90e050\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h104v79H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m81.135 46.754-.002-15.24M81.133 31.514l-13.2-7.618M67.933 23.896l-13.197 7.622\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M54.736 46.758v-15.24M52.298 45.35V32.927\"/\u003e\u003c/g\u003e\u003cpath d=\"m54.736 46.758-13.208 7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m28.32 46.758 13.208 7.62M30.759 45.35l10.769 6.213\"/\u003e\u003c/g\u003e\u003cpath d=\"M28.32 46.758v-15.24\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m41.528 23.898-13.208 7.62M41.528 26.713l-10.769 6.214\"/\u003e\u003c/g\u003e\u003cpath d=\"m54.736 31.518-13.208-7.62M41.528 23.898V12.579M38.244 6.762 28.33 1.038M28.32 46.758 15.123 54.38M15.123 54.38 8.802 43.435M15.123 54.38 4.442 60.55M15.123 54.38l5.556 9.619M41.528 54.378v11.319M44.804 71.509l9.922 5.729M81.133 31.514l10.044-5.801\" class=\"bond\"/\u003e\u003cpath fill=\"#ff0d0d\" stroke=\"none\" d=\"M43.787 8.655q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.309.756.875.256.565.256 1.327m-3.863 0q0 .923.387 1.459.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.459 0-.928-.387-1.452-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.452\" class=\"atom\"/\u003e\u003cpath stroke=\"none\" d=\"M6.748 43.633h-.613v-4.899h2.732v.541H6.748v1.739h1.994v.541H6.748zM1.173 64.452H.56v-4.899h2.732v.541H1.173v1.739h1.994v.541H1.173zM21.992 70.027h-.613v-4.899h2.733v.541h-2.12v1.739h1.995v.541h-1.995z\" class=\"atom\"/\u003e\u003cpath fill=\"#ff0d0d\" stroke=\"none\" d=\"M43.787 69.615q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.309.756.875.256.565.256 1.327m-3.863 0q0 .923.387 1.459.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.459 0-.928-.387-1.452-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.452\" class=\"atom\"/\u003e\u003cg fill=\"#3050f8\" stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M96.27 26.342h-.72l-2.619-4.066h-.03l.03.595q.024.357.024.732v2.739h-.566v-4.9h.714l2.608 4.054h.03l-.018-.327-.024-.476q-.006-.262-.006-.483v-2.768h.577zM100.577 26.342h-.619v-2.286h-2.513v2.286h-.613v-4.9h.613v2.072h2.513v-2.072h.619zM103.081 27.831h-1.943v-.3l.772-.779q.221-.221.371-.393.154-.175.232-.339.079-.168.079-.364 0-.243-.146-.368-.143-.129-.372-.129-.214 0-.378.075-.161.075-.329.207l-.193-.242q.171-.147.393-.247.225-.1.507-.1.411 0 .65.207t.24.575q0 .229-.097.433-.093.2-.264.396-.168.196-.393.418l-.614.604v.017h1.485z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"#ff0d0d\" d=\"M41.528 12.579v5.66M38.244 6.762 33.287 3.9\" class=\"hi\"/\u003e\u003cpath stroke=\"#90e050\" d=\"m8.802 43.435 3.16 5.472M4.442 60.55l5.34-3.085M20.679 63.999l-2.778-4.809\" class=\"hi\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"M41.528 65.697v-5.659M44.804 71.509l4.961 2.865\" class=\"hi\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m91.177 25.713-5.022 2.901\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Subjective Effects":null,"Title":"2,5-Dimethoxy-4-trifluoromethylamphetamine","UNII":"NLH3FWZ9T4","Wikipedia":"2,5-Dimethoxy-4-trifluoromethylamphetamine","XLogP":2.8}