{"Abbreviation":["2C-B"],"Aliases":["4-Bromo-2,5-dimethoxyphenethylamine","2-(4-Bromo-2,5-dimethoxyphenyl)ethylamine","2-(4-Bromo-2,5-dimethoxyphenyl)ethanamine","4-Bromo-2,5-dimethoxyphenylethylamine","Benzeneethanamine, 4-bromo-2,5-dimethoxy-","2C-B","Nexus","BDMPEA","2-CB","4-Bromo-2,5-dimethoxybenzeneethanamine","4-Bromo-2,5dimethoxyphenethylamine","α-Desmethyl dob","GTPL13549","Bromo-2,5-dimethoxyphenylethylamine","Pdsp1_001367","Pdsp2_001351","DB01537","Ncgc00168259-01","MFT","J456.895H","2-(4-bromanyl-2,5-dimethoxy-phenyl)ethanamine","2-(4-bromo-2,5-dimethoxy-phenyl)-ethyl-amine","2-(4-Bromo-2,5-dimethoxy-phenyl)-ethylamine","2-(4-Bromo-2,5-dimethoxyphenyl)ethanamine #","C22775"],"CAS":"66142-81-2","ChEBI":"CHEBI:189669","ChEMBL":"CHEMBL292821","ChemicalClasses":["2,5-dimethoxyphenethylamine"],"Chirality":"achiral","Classes":["Psychedelic"],"DBI-IGS":["2C-B"],"DEA no":7392,"Dosing Info":[{"Method":"Insufflated","Tiers":{"Common":{"Entries":20,"Lower":8.3,"Percentage":34.5,"Unit":"mg","Upper":10},"Extreme":{"Entries":6,"Lower":17.3,"Percentage":10.3,"Unit":"mg","Upper":17.3},"Heavy":{"Entries":9,"Lower":13.8,"Percentage":15.5,"Unit":"mg","Upper":17.3},"Light":{"Entries":21,"Lower":8.3,"Percentage":36.2,"Unit":"mg","Upper":8.3},"Strong":{"Entries":2,"Lower":10,"Percentage":3.4,"Unit":"mg","Upper":13.8}}},{"Method":"Oral","Tiers":{"Common":{"Entries":3,"Lower":17,"Percentage":21.4,"Unit":"mg","Upper":21},"Extreme":{"Entries":2,"Lower":34.4,"Percentage":14.3,"Unit":"mg","Upper":34.4},"Heavy":{"Entries":1,"Lower":25,"Percentage":7.1,"Unit":"mg","Upper":34.4},"Light":{"Entries":4,"Lower":17,"Percentage":28.6,"Unit":"mg","Upper":17},"Strong":{"Entries":4,"Lower":21,"Percentage":28.6,"Unit":"mg","Upper":25}}},{"Method":"Intrarectal","Tiers":{"Common":{"Entries":0,"Lower":12.4,"Percentage":0,"Unit":"mg","Upper":13.5},"Extreme":{"Entries":2,"Lower":24,"Percentage":16.7,"Unit":"mg","Upper":24},"Heavy":{"Entries":0,"Lower":20,"Percentage":0,"Unit":"mg","Upper":24},"Light":{"Entries":6,"Lower":12.4,"Percentage":50,"Unit":"mg","Upper":12.4},"Strong":{"Entries":4,"Lower":13.5,"Percentage":33.3,"Unit":"mg","Upper":20}}}],"DurationOfAction":"Oral: 2 – 8 hours\u003ca href='#cite_note-5'\u003e\u003csup\u003e[5]\u003c/sup\u003e\u003c/a\u003e","EliminationHalfLife":"1.2 – 2.5 hours\u003ca href='#cite_note-3'\u003e\u003csup\u003e[3]\u003c/sup\u003e\u003c/a\u003e\u003ca href='#cite_note-4'\u003e\u003csup\u003e[4]\u003c/sup\u003e\u003c/a\u003e","Esters":[],"European Community (EC) Number":"636-275-4","Formating":[],"HeavyAtomCount":14,"IUPACName":"2-(4-bromo-2,5-dimethoxyphenyl)ethanamine","InChI":"InChI=1S/C10H14BrNO2/c1-13-9-6-8(11)10(14-2)5-7(9)3-4-12/h5-6H,3-4,12H2,1-2H3","InChIKey":"YMHOBZXQZVXHBM-UHFFFAOYSA-N","MeSH Pharmacological Classification":"Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT2 RECEPTORS. Included under this heading are agonists for one or more of the specific 5-HT2 receptor subtypes.","MolecularFormula":"C\u003csub\u003e10\u003c/sub\u003eH\u003csub\u003e14\u003c/sub\u003eBrNO\u003csub\u003e2\u003c/sub\u003e","MolecularWeight":"260.13 g/mol","PD":"PD008796","PubChemId":98527,"Record Description":["Wikipedia|PiHKAL|Phenethylamines","Wikipedia|List of designer drugs|Psychedelics|2C-x (2,5-dimethoxy-phenethylamine derivatives)"],"RefChem":"82888","RefCount":6,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/2C-B","Name":"2,5-Dimethoxy-4-bromophenethylamine","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q229942","Name":"2,5-Dimethoxy-4-bromophenethylamine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB01537","Name":"2,5-Dimethoxy-4-bromophenethylamine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/98527","Name":"2,5-Dimethoxy-4-bromophenethylamine","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL292821","Name":"2,5-Dimethoxy-4-bromophenethylamine","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:189669","Name":"2,5-Dimethoxy-4-bromophenethylamine","Sub":false}]},{"Name":"Probes \u0026 Drugs","Urls":[{"Link":"https://www.probes-drugs.org/compound/PD008796","Name":"2,5-Dimethoxy-4-bromophenethylamine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=66142-81-2","Name":"2,5-Dimethoxy-4-bromophenethylamine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C22775","Name":"2,5-Dimethoxy-4-bromophenethylamine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/V77772N32H","Name":"2,5-Dimethoxy-4-bromophenethylamine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID10216332","Name":"2,5-Dimethoxy-4-bromophenethylamine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 98527, 2,5-Dimethoxy-4-bromophenethylamine. Accessed October 14, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/98527\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/98527\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. 2,5-Dimethoxy-4-bromophenethylamine. UNII: V77772N32H. Global Substance Registration System. Accessed October 14, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/V77772N32H\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/V77772N32H\u003c/a\u003e","Papaseit E, Farré M, Pérez-Mañá C, Torrens M, Ventura M, Pujadas M, de la Torre R, González D. Acute Pharmacological Effects of 2C-B in Humans: An Observational Study. Frontiers in Pharmacology. 2018; 9","Thomann J, Rudin D, Kraus S, Arikci D, Holze F, Liechti ME, Luethi D. LC–MS/MS-based pharmacokinetic and metabolic analysis of 4-bromo-2,5-dimethoxyphenethylamine (2C-B) and its metabolites in human plasma. Drug Metabolism and Disposition. 2025; 53(6)","Inan F, Brunt TM, Contrucci RR, Hondebrink L, Franssen EJ. Novel Phenethylamines and Their Potential Interactions With Prescription Drugs: A Systematic Critical Review. Ther Drug Monit. April 1, 2020; 42(2):271–281."],"SMILES":"COC1=CC(=C(C=C1CCN)OC)Br","SaltData":[{"AcidCount":1,"Amine":"2,5-Dimethoxy-4-bromophenethylamine","AmineCount":1,"Formula":"Cl","Name":"hydrochloride","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 117.432 78.276\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#3050f8\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h118v79H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m19.213 1.038 9.914 5.724M32.411 12.579v11.319\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m32.411 23.898-13.208 7.62M32.411 26.713l-10.77 6.214\"/\u003e\u003c/g\u003e\u003cpath d=\"M19.203 31.518v15.24\" class=\"bond\"/\u003e\u003cg 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