{"Abbreviation":["TCDD"],"Adverse Effects":"Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.","Aliases":["2,3,7,8-Tetrachlorodibenzo-p-dioxin","TCDD","Dioxin","Tetradioxin","Dioxine","TCDBD","2,3,7,8-Tcdd","2,3,7,8-Tetrachlorooxanthrene","Dioksyny","NCI-C03714","PCDD 48","2,3,7,8-Tetrachlorodibenzo-1,4-dioxin","Dibenzo-p-dioxin, 2,3,7,8-tetrachloro-","2,3,7,8-Tetrachlorodibenzo(b,e)(1,4)dioxin","Dibenzo(b,e)(1,4)dioxin, 2,3,7,8-tetrachloro-","2,3,7,8-Czterochlorodwubenzo-p-dwuoksyny","2,3,7,8-tetrachlorodibenzodioxine","2,3,7,8-Tetrachlorodibenzo[b,e][1,4]dioxin","2,3,7,8-Tetrachlorodibenzo(b,e)(1,4)dioxan","Dibenzo[b,e][1,4]dioxin, 2,3,7,8-tetrachloro-","RefChem:441881","217-122-7","Tetrachlorodibenzodioxin","2,3,7,8-Tetrachloro-p-dioxin","2,3,7,8-tetrachloro-dibenzo-p-dioxin"],"Biological Half-Life":"Whole body: 7.1 years (2.9 to 26.9 years); [TDR, p. 1111] Estimated at around 7 years; [Reference #2, p. 379]","Boiling Point":"Decomposes at 932 °F (NTP, 1992)","CAS":"1746-01-6","ChEBI":"CHEBI:28119","ChEMBL":"CHEMBL30327","ChemicalClasses":[],"Chirality":"achiral","Classes":[],"Color/Form":"Colorless needles","Decomposition":"/2,3,7,8-Tetrachlorodibenzo-p-dioxin/ begins to decompose at 500 °C and virtually complete decomposition occurs within 21 seconds at a temp of 800 °C.","Density":"1.8 g/cm³ g/cm\u003csup\u003e3\u003c/sup\u003e","EINECS":"217-122-7","Ecotoxicity Values":"LD50; Species: Colinus virginianus /(Northern Bobwhite)/ oral 0.0150 mg/kg (95% confidence limit: 0.00919-0.0245 mg/kg)","Esters":[],"European Community (EC) Number":"217-122-7","Flash Point":"4 °C (39 °F) - closed cup","Formating":[],"HMDB ID":"HMDB0258755","Health Effects":"Exposure to large amounts of CDDs causes chloracne, a severe skin disease with acne-like lesions that occur mainly on the face and upper body. CDDs may also cause liver damage and induce long-term alterations in glucose metabolism and subtle changes in hormonal levels. In addition, studies have shown that CDDs may disrupt the endocrine system and weaken the immune system, as well as cause reproductive damage and birth defects, central and peripheral nervous system pathologies, thyroid disorders, endometriosis, and diabetes. 2,3,7,8-Tetrachlorodibenzo-p-dioxin is also a known as a human carcinogen. (L177, L178)","HeavyAtomCount":18,"IUPACName":"2,3,7,8-tetrachlorodibenzo-p-dioxin","InChI":"InChI=1S/C12H4Cl4O2/c13-5-1-9-10(2-6(5)14)18-12-4-8(16)7(15)3-11(12)17-9/h1-4H","InChIKey":"HGUFODBRKLSHSI-UHFFFAOYSA-N","Interactions":"In mice, increased incidences in frequency of cleft palates .../were/ noted in combination experiments involving TCDD and other teratogens such as 2,4,5-T, dexamethasone, cyclophosphamide and 6-aminonicotinamide, admin at 'sub-threshold' and 'threshold' doses during days 6-15 of pregnancy. When 30 mg/kg bw 2,4,5-T, which produced no significant increase in incidence of cleft palate compared with that of controls, or half this dose, was combined with 2 ug/kg bw TCDD, potentiating effects were observed. However, 1/10 of TCDD dose (0.2 ug/kg bw) induced no detectable effect with either dose of 2,4,5-T.","LD50":[{"dosages":[{"amount":"20 μg/kg","route":"oral"},{"amount":"24600 ng/kg","route":"intraperitoneal"}],"organism":"Rat"},{"dosages":[{"amount":"114 μg/kg","route":"oral"},{"amount":"120 μg/kg","route":"intraperitoneal"}],"organism":"Mouse"},{"dosages":[{"amount":"1 μg/kg","route":"oral"}],"organism":"Dog"},{"dosages":[{"amount":"2 μg/kg","route":"oral"}],"organism":"Monkey"},{"dosages":[{"amount":"115 μg/kg","route":"oral"},{"amount":"275 μg/kg","route":"skin"},{"amount":"252 μg/kg","route":"intraperitoneal"}],"organism":"Rabbit"},{"dosages":[{"amount":"500 ng/kg","route":"oral"}],"organism":"Guinea pig"},{"dosages":[{"amount":"1157 μg/kg","route":"oral"},{"amount":"\u0026gt;3 mg/kg","route":"intraperitoneal"}],"organism":"Hamster"},{"dosages":[{"amount":"4200 ng/kg","route":"oral"}],"organism":"Mammal (species unspecified)"},{"dosages":[{"amount":"1 mg/kg","route":"oral"}],"organism":"Frog"}],"LDLo":[{"dosages":[{"amount":"80 μg/kg","route":"skin"}],"organism":"Mouse"},{"dosages":[{"amount":"25 μg/kg","route":"oral"},{"amount":"25 μg/kg","route":"intraperitoneal"}],"organism":"Chicken"}],"MeSH Pharmacological Classification":"Substances or energies, for example heat or light, which when introduced into the air, water, or land threaten life or health of individuals or ECOSYSTEMS.","Melting Point":"563 °","MolecularFormula":"C\u003csub\u003e12\u003c/sub\u003eH\u003csub\u003e4\u003c/sub\u003eCl\u003csub\u003e4\u003c/sub\u003eO\u003csub\u003e2\u003c/sub\u003e","MolecularWeight":"322.0 g/mol","Non-Human Toxicity Values":"LD50 Dog oral 1 ug/kg","Physical Description":"2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) appears as white crystals or tan crystalline powder. (NTP, 1992)","PubChemId":15625,"RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/2,3,7,8-Tetrachlorodibenzodioxin","Name":"2,3,7,8-Tetrachlorodibenzodioxin","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q52822","Name":"2,3,7,8-Tetrachlorodibenzodioxin","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/15625","Name":"2,3,7,8-Tetrachlorodibenzodioxin","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL30327","Name":"2,3,7,8-Tetrachlorodibenzodioxin","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28119","Name":"2,3,7,8-Tetrachlorodibenzodioxin","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=1746-01-6","Name":"2,3,7,8-Tetrachlorodibenzodioxin","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0258755","Name":"2,3,7,8-Tetrachlorodibenzodioxin","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C07557","Name":"2,3,7,8-Tetrachlorodibenzodioxin","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/DO80M48B6O","Name":"2,3,7,8-Tetrachlorodibenzodioxin","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021315","Name":"2,3,7,8-Tetrachlorodibenzodioxin","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 15625, 2,3,7,8-Tetrachlorodibenzodioxin. Accessed September 15, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/15625\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/15625\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. 2,3,7,8-Tetrachlorodibenzodioxin. UNII: DO80M48B6O. Global Substance Registration System. Accessed September 15, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/DO80M48B6O\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/DO80M48B6O\u003c/a\u003e"],"SMILES":"C1=C2C(=CC(=C1Cl)Cl)OC3=CC(=C(C=C3O2)Cl)Cl","SaltData":[],"Salts":[],"Solubility":"less than 1 mg/mL at 77 °F (NTP, 1992)","Stability/Shelf Life":"Changed chemically when exposed in isooctane or n-octanol to UV light.","StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 114.756 37.034\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#1ff01f\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h115v38H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cg 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(L346)","UNII":"DO80M48B6O","Wikidata":"Q52822","Wikipedia":"2,3,7,8-Tetrachlorodibenzodioxin","XLogP":6.4}